SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4he8'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A3Y_A_OBNA6000_1
(NA, K-ATPASE ALPHA
SUBUNIT)		 4he8 NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT 10
NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT 8
(Thermus
thermophilus) 		5 / 10 GLU H 130
ALA H 142
PHE H 137
PHE J  69
LEU H 153
 None
 1.40A 3a3yA-4he8H:
undetectable		 3a3yA-4he8H:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_G_SVRG506_1
(PHOSPHOLIPASE A2)		 4he8 NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT 8
(Thermus
thermophilus) 		4 / 8 VAL H  20
VAL H  21
GLY H  23
LYS H  16
 None
 0.87A 3bjwA-4he8H:
undetectable		 3bjwA-4he8H:
11.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLD_B_GW6B2_2
(GLUCOCORTICOID
RECEPTOR)		 4he8 NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT 8
(Thermus
thermophilus) 		4 / 8 LEU H 153
ALA H 142
TYR H 134
ILE H 160
 None
 0.91A 3cldB-4he8H:
undetectable		 3cldB-4he8H:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_L_TFPL202_1
(PROTEIN S100-A4)		 4he8 NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT 8
(Thermus
thermophilus) 		5 / 12 LEU H  84
LEU H 138
SER H 139
ILE H  88
PHE H 244
 None
 1.09A 3ko0K-4he8H:
1.0
3ko0L-4he8H:
undetectable
3ko0M-4he8H:
0.9
3ko0N-4he8H:
undetectable		 3ko0K-4he8H:
13.81
3ko0L-4he8H:
13.81
3ko0M-4he8H:
13.81
3ko0N-4he8H:
13.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_M_TFPM202_1
(PROTEIN S100-A4)		 4he8 NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT 8
(Thermus
thermophilus) 		5 / 12 LEU H 138
SER H 139
ILE H  88
LEU H  84
PHE H 244
 None
 1.11A 3ko0M-4he8H:
0.9
3ko0N-4he8H:
undetectable
3ko0O-4he8H:
undetectable
3ko0P-4he8H:
undetectable		 3ko0M-4he8H:
13.81
3ko0N-4he8H:
13.81
3ko0O-4he8H:
13.81
3ko0P-4he8H:
13.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9T_B_BEZB264_0
(ECHA1_1)		 4he8 NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT 8
(Thermus
thermophilus) 		4 / 7 ILE H 122
LEU H 262
ALA H 169
ALA H 202
 None
 0.86A 3r9tB-4he8H:
undetectable		 3r9tB-4he8H:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TBG_A_RTZA1_1
(CYTOCHROME P450 2D6)		 4he8 NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT 8
(Thermus
thermophilus) 		5 / 12 PHE H  97
LEU H  24
PHE H 290
SER H 256
PHE H 280
 None
 1.28A 3tbgA-4he8H:
undetectable		 3tbgA-4he8H:
24.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PE5_B_QELB920_1
(GLUTAMATE RECEPTOR
IONOTROPIC, NMDA 1
GLUTAMATE RECEPTOR
IONOTROPIC, NMDA 2B)		 4he8 NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT 8
(Thermus
thermophilus) 		5 / 10 TYR H 249
LEU H  33
ALA H  27
ILE H 253
PHE H 252
 None
 1.48A 4pe5A-4he8H:
undetectable
4pe5B-4he8H:
undetectable		 4pe5A-4he8H:
17.90
4pe5B-4he8H:
17.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QZT_C_RTLC201_0
(RETINOL-BINDING
PROTEIN 2)		 4he8 NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT 8
NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT 10
(Thermus
thermophilus;
Thermus
thermophilus) 		5 / 12 ILE J  71
ALA J  28
TYR H 134
LEU J  68
LEU H  81
 None
 1.49A 4qztC-4he8J:
undetectable		 4qztC-4he8J:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RKU_A_PQNA5001_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
PHOTOSYSTEM I
REACTION CENTER
SUBUNIT IX)		 4he8 NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT 8
(Thermus
thermophilus) 		4 / 8 PHE H 298
ARG H 301
LEU H 300
PHE H 200
 None
 0.86A 4rkuA-4he8H:
4.3
4rkuJ-4he8H:
undetectable		 4rkuA-4he8H:
20.47
4rkuJ-4he8H:
7.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_E_CHDE104_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 4he8 NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT 8
(Thermus
thermophilus) 		5 / 11 GLU H 163
LEU H 125
LEU H 258
LEU H 262
LEU H 182
 None
 0.97A 4wg0C-4he8H:
undetectable
4wg0D-4he8H:
undetectable
4wg0E-4he8H:
undetectable		 4wg0C-4he8H:
3.06
4wg0D-4he8H:
3.06
4wg0E-4he8H:
3.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_G_CHDG103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 4he8 NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT 8
(Thermus
thermophilus) 		5 / 11 GLU H 163
LEU H 125
LEU H 258
LEU H 262
LEU H 182
 None
 1.00A 4wg0E-4he8H:
undetectable
4wg0F-4he8H:
undetectable
4wg0G-4he8H:
undetectable		 4wg0E-4he8H:
3.06
4wg0F-4he8H:
3.06
4wg0G-4he8H:
3.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZVC_A_BEZA301_0
(DIGUANYLATE CYCLASE
DOSC)		 4he8 NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT 8
(Thermus
thermophilus) 		4 / 8 ILE H 185
LEU H 262
LEU H 170
LEU H 180
 None
 0.77A 4zvcA-4he8H:
undetectable
4zvcB-4he8H:
undetectable		 4zvcA-4he8H:
17.13
4zvcB-4he8H:
17.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZVC_A_BEZA301_0
(DIGUANYLATE CYCLASE
DOSC)		 4he8 NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT 8
(Thermus
thermophilus) 		4 / 8 LEU H 170
LEU H 180
ILE H 185
LEU H 262
 None
 0.78A 4zvcA-4he8H:
undetectable
4zvcB-4he8H:
undetectable		 4zvcA-4he8H:
17.13
4zvcB-4he8H:
17.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H2U_A_1N1A501_1
(PROTEIN-TYROSINE
KINASE 6)		 4he8 NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT 8
(Thermus
thermophilus) 		6 / 12 LEU H  95
VAL H 128
LEU H 118
GLY H  98
LEU H  99
GLY H 121
 None
 1.16A 5h2uA-4he8H:
undetectable		 5h2uA-4he8H:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MSD_A_BEZA1202_0
(CARBOXYLIC ACID
REDUCTASE)		 4he8 NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT 8
(Thermus
thermophilus) 		4 / 5 ILE H  88
PHE H 244
SER H 139
ALA H 132
 None
 1.05A 5msdA-4he8H:
undetectable		 5msdA-4he8H:
15.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ODQ_D_ACTD202_0
(METHYL-VIOLOGEN
REDUCING
HYDROGENASE, SUBUNIT
D)		 4he8 NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT 8
(Thermus
thermophilus) 		3 / 3 HIS H 192
GLU H 191
TRP H 188
 None
 0.98A 5odqD-4he8H:
undetectable		 5odqD-4he8H:
15.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ODR_D_ACTD202_0
(METHYL-VIOLOGEN
REDUCING
HYDROGENASE, SUBUNIT
D)		 4he8 NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT 8
(Thermus
thermophilus) 		3 / 3 HIS H 192
GLU H 191
TRP H 188
 None
 0.90A 5odrD-4he8H:
undetectable		 5odrD-4he8H:
15.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC1_A_486A801_1
(GLUCOCORTICOID
RECEPTOR)		 4he8 NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT 8
(Thermus
thermophilus) 		5 / 12 LEU H 264
GLY H 265
GLY H 266
VAL H 186
LEU H 197
 None
 1.15A 5uc1A-4he8H:
undetectable		 5uc1A-4he8H:
11.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC1_B_486B801_2
(GLUCOCORTICOID
RECEPTOR)		 4he8 NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT 8
(Thermus
thermophilus) 		5 / 12 LEU H 264
GLY H 265
GLY H 266
VAL H 186
LEU H 197
 None
 1.15A 5uc1B-4he8H:
undetectable		 5uc1B-4he8H:
11.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A94_A_ZOTA3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		 4he8 NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT 8
NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT 10
(Thermus
thermophilus;
Thermus
thermophilus) 		5 / 12 LEU J  37
VAL J  56
GLY J  61
PHE H  92
VAL H  91
 None
 1.05A 6a94A-4he8J:
2.3		 6a94A-4he8J:
20.81