SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4hea'

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)	View	Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1E6W_C_ESTC302_1 (SHORT CHAIN 3-HYDROXYACYL-COA DEHYDROGENASE)	4hea	NADH-QUINONE OXIDOREDUCTASE SUBUNIT 11 NADH-QUINONE OXIDOREDUCTASE SUBUNIT 14 (Thermus thermophilus)	4 / 4	ALA N 259 GLN N 251 TYR N 260 LEU K  93	None	1.43A	1e6wC-4heaN: undetectable	1e6wC-4heaN: 22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1E7C_A_HLTA4007_1 (SERUM ALBUMIN)	4hea	NADH-QUINONE OXIDOREDUCTASE SUBUNIT 13 (Thermus thermophilus)	4 / 8	LEU M  31 ASN M  36 LEU M   4 LEU M   8	None	0.95A	1e7cA-4heaM: 1.6	1e7cA-4heaM: 20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1GFZ_A_CFFA940_1 (GLYCOGEN PHOSPHORYLASE)	4hea	NADH-QUINONE OXIDOREDUCTASE SUBUNIT 14 (Thermus thermophilus)	4 / 6	PHE N  48 ALA N  54 GLY N  51 TYR N  53	None	1.11A	1gfzA-4heaN: undetectable	1gfzA-4heaN: 19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1GMK_A_DVAA6_0 (GRAMICIDIN A)	4hea	NADH-QUINONE OXIDOREDUCTASE SUBUNIT 12 (Thermus thermophilus)	3 / 3	ALA L 285 VAL L 295 TRP L 420	None	1.02A	1gmkA-4heaL: undetectable 1gmkB-4heaL: undetectable	1gmkA-4heaL: 3.06 1gmkB-4heaL: 3.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1HK1_A_T44A3004_1 (SERUM ALBUMIN)	4hea	NADH-QUINONE OXIDOREDUCTASE SUBUNIT 13 (Thermus thermophilus)	4 / 6	PHE M 122 PHE M 201 LEU M 115 VAL M 163	None	1.06A	1hk1A-4heaM: 1.8	1hk1A-4heaM: 20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1HWK_A_117A2_2 (HMG-COA REDUCTASE)	4hea	NADH-QUINONE OXIDOREDUCTASE SUBUNIT 13 (Thermus thermophilus)	5 / 11	GLU M  92 SER M 224 LEU M 226 ALA M 229 LEU M 230	None	1.13A	1hwkB-4heaM: undetectable	1hwkB-4heaM: 22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1HWK_B_117B1_1 (HMG-COA REDUCTASE)	4hea	NADH-QUINONE OXIDOREDUCTASE SUBUNIT 13 (Thermus thermophilus)	5 / 11	GLU M  92 SER M 224 LEU M 226 ALA M 229 LEU M 230	None	1.15A	1hwkA-4heaM: undetectable	1hwkA-4heaM: 22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1HWK_C_117C4_2 (HMG-COA REDUCTASE)	4hea	NADH-QUINONE OXIDOREDUCTASE SUBUNIT 13 (Thermus thermophilus)	5 / 11	GLU M  92 SER M 224 LEU M 226 ALA M 229 LEU M 230	None	1.14A	1hwkD-4heaM: undetectable	1hwkD-4heaM: 22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1HWK_D_117D3_1 (HMG-COA REDUCTASE)	4hea	NADH-QUINONE OXIDOREDUCTASE SUBUNIT 13 (Thermus thermophilus)	5 / 11	GLU M  92 SER M 224 LEU M 226 ALA M 229 LEU M 230	None	1.14A	1hwkC-4heaM: undetectable	1hwkC-4heaM: 22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1ICT_C_T44C128_1 (TRANSTHYRETIN)	4hea	NADH-QUINONE OXIDOREDUCTASE SUBUNIT 11 NADH-QUINONE OXIDOREDUCTASE SUBUNIT 14 (Thermus thermophilus)	5 / 11	LEU N 174 LEU K   5 ALA K   8 LEU K   4 SER K  41	None	1.05A	1ictA-4heaN: undetectable 1ictC-4heaN: undetectable	1ictA-4heaN: 14.43 1ictC-4heaN: 14.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1ICT_C_T44C128_1 (TRANSTHYRETIN)	4hea	NADH-QUINONE OXIDOREDUCTASE SUBUNIT 13 (Thermus thermophilus)	5 / 11	ALA M 202 LEU M 260 ALA M 297 LEU M 263 SER M 267	None	1.23A	1ictA-4heaM: undetectable 1ictC-4heaM: undetectable	1ictA-4heaM: 13.33 1ictC-4heaM: 13.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1ICT_D_T44D129_1 (TRANSTHYRETIN)	4hea	NADH-QUINONE OXIDOREDUCTASE SUBUNIT 13 (Thermus thermophilus)	4 / 6	LEU M 260 ALA M 297 LEU M 263 SER M 267	None	0.90A	1ictB-4heaM: undetectable	1ictB-4heaM: 13.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1IE4_A_T44A128_1 (TRANSTHYRETIN)	4hea	NADH-QUINONE OXIDOREDUCTASE SUBUNIT 11 NADH-QUINONE OXIDOREDUCTASE SUBUNIT 14 (Thermus thermophilus)	5 / 10	LEU K   5 ALA K   8 LEU K   4 LEU N 174 LEU N 153	None	1.34A	1ie4A-4heaK: undetectable 1ie4C-4heaK: undetectable	1ie4A-4heaK: 23.48 1ie4C-4heaK: 23.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1IKE_A_HSMA190_1 (NITROPHORIN 4)	4hea	NADH-QUINONE OXIDOREDUCTASE SUBUNIT 12 (Thermus thermophilus)	3 / 3	ASP L 386 LEU L 393 LEU L 389	None	0.75A	1ikeA-4heaL: undetectable	1ikeA-4heaL: 14.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1IOL_A_ESTA400_1 (ESTROGENIC 17-BETA HYDROXYSTEROID DEHYDROGENASE)	4hea	NADH-QUINONE OXIDOREDUCTASE SUBUNIT 14 (Thermus thermophilus)	5 / 11	SER N 240 VAL N 241 GLY N 267 GLY N 244 TYR N 288	None	1.34A	1iolA-4heaN: undetectable	1iolA-4heaN: 25.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1JIN_A_KTNA801_1 (CYTOCHROME P450 107A1)	4hea	NADH-QUINONE OXIDOREDUCTASE SUBUNIT 14 (Thermus thermophilus)	6 / 11	PHE N 349 ALA N 272 LEU N 223 ALA N 219 ALA N 218 LEU N 281	None	1.36A	1jinA-4heaN: undetectable	1jinA-4heaN: 23.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1KIA_D_SAMD3293_0 (GLYCINE N-METHYLTRANSFERASE)	4hea	NADH-QUINONE OXIDOREDUCTASE SUBUNIT 13 (Thermus thermophilus)	5 / 12	VAL M 238 ALA M 288 SER M 291 SER M 318 LEU M 325	None	1.36A	1kiaD-4heaM: undetectable	1kiaD-4heaM: 20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1L5Q_B_CFFB1863_1 (GLYCOGEN PHOSPHORYLASE, LIVER FORM)	4hea	NADH-QUINONE OXIDOREDUCTASE SUBUNIT 14 (Thermus thermophilus)	4 / 6	PHE N  48 ALA N  54 GLY N  51 TYR N  53	None	1.14A	1l5qB-4heaN: 2.3	1l5qB-4heaN: 18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1L7X_A_CFFA863_1 (GLYCOGEN PHOSPHORYLASE, LIVER FORM)	4hea	NADH-QUINONE OXIDOREDUCTASE SUBUNIT 14 (Thermus thermophilus)	4 / 6	PHE N  48 ALA N  54 GLY N  51 TYR N  53	None	1.12A	1l7xA-4heaN: undetectable	1l7xA-4heaN: 18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1L7X_B_CFFB1863_1 (GLYCOGEN PHOSPHORYLASE, LIVER FORM)	4hea	NADH-QUINONE OXIDOREDUCTASE SUBUNIT 14 (Thermus thermophilus)	4 / 6	PHE N  48 ALA N  54 GLY N  51 TYR N  53	None	1.13A	1l7xB-4heaN: undetectable	1l7xB-4heaN: 18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1MX1_A_THAA1_1 (LIVER CARBOXYLESTERASE I)	4hea	NADH-QUINONE OXIDOREDUCTASE SUBUNIT 14 (Thermus thermophilus)	6 / 11	LEU N 148 GLY N 150 VAL N 226 LEU N 104 LEU N 108 MET N 107	None	1.31A	1mx1A-4heaN: undetectable	1mx1A-4heaN: 23.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1NP1_B_HSMB304_1 (NITROPHORIN 1)	4hea	NADH-QUINONE OXIDOREDUCTASE SUBUNIT 12 (Thermus thermophilus)	3 / 3	ASP L 386 LEU L 393 LEU L 389	None	0.79A	1np1B-4heaL: undetectable	1np1B-4heaL: 14.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1P33_C_MTXC353_1 (PTERIDINE REDUCTASE 1)	4hea	NADH-QUINONE OXIDOREDUCTASE SUBUNIT 14 (Thermus thermophilus)	5 / 12	SER N 300 PHE N 296 LEU N 309 LEU N 378 MET N 330	None	1.34A	1p33C-4heaN: undetectable	1p33C-4heaN: 24.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1QAB_E_RTLE1_0 (PROTEIN (RETINOL BINDING PROTEIN))	4hea	NADH-QUINONE OXIDOREDUCTASE SUBUNIT 12 (Thermus thermophilus)	5 / 11	PHE L 258 LEU L 259 ALA L 205 VAL L 262 TYR L 180	None	1.16A	1qabE-4heaL: undetectable	1qabE-4heaL: 15.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1QAB_F_RTLF2_0 (PROTEIN (RETINOL BINDING PROTEIN))	4hea	NADH-QUINONE OXIDOREDUCTASE SUBUNIT 13 NADH-QUINONE OXIDOREDUCTASE SUBUNIT 14 (Thermus thermophilus; Thermus thermophilus)	5 / 12	ALA M 229 ALA M 227 LEU N 380 GLY M 231 LEU M 130	None	1.13A	1qabF-4heaM: undetectable	1qabF-4heaM: 15.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1QZR_B_CDXB901_1 (DNA TOPOISOMERASE II)	4hea	NADH-QUINONE OXIDOREDUCTASE SUBUNIT 13 (Thermus thermophilus)	4 / 7	HIS M 292 THR M 322 TYR M 321 LEU M 440	None	1.10A	1qzrA-4heaM: undetectable	1qzrA-4heaM: 17.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1QZR_B_CDXB901_2 (DNA TOPOISOMERASE II)	4hea	NADH-QUINONE OXIDOREDUCTASE SUBUNIT 13 (Thermus thermophilus)	4 / 7	HIS M 292 THR M 322 TYR M 321 LEU M 440	None	1.09A	1qzrB-4heaM: undetectable	1qzrB-4heaM: 17.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1RJD_A_SAMA801_0 (CARBOXY METHYL TRANSFERASE FOR PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT)	4hea	NADH-QUINONE OXIDOREDUCTASE SUBUNIT 13 (Thermus thermophilus)	5 / 12	ILE M 360 ALA M 317 GLY M 370 GLY M 444 LEU M 368	None	1.07A	1rjdA-4heaM: undetectable	1rjdA-4heaM: 20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1RJD_B_SAMB802_0 (CARBOXY METHYL TRANSFERASE FOR PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT)	4hea	NADH-QUINONE OXIDOREDUCTASE SUBUNIT 13 (Thermus thermophilus)	5 / 12	ILE M 360 ALA M 317 GLY M 370 GLY M 444 LEU M 368	None	1.06A	1rjdB-4heaM: undetectable	1rjdB-4heaM: 20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1RJD_C_SAMC803_0 (CARBOXY METHYL TRANSFERASE FOR PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT)	4hea	NADH-QUINONE OXIDOREDUCTASE SUBUNIT 13 (Thermus thermophilus)	5 / 12	ILE M 360 ALA M 317 GLY M 370 GLY M 444 LEU M 368	None	1.05A	1rjdC-4heaM: undetectable	1rjdC-4heaM: 20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1RV7_B_AB1B1001_1 (PROTEASE)	4hea	NADH-QUINONE OXIDOREDUCTASE SUBUNIT 14 (Thermus thermophilus)	5 / 11	ALA N  28 LEU N  89 THR N  73 ALA N  70 VAL N  88	None	1.20A	1rv7A-4heaN: undetectable 1rv7B-4heaN: undetectable	1rv7A-4heaN: 13.18 1rv7B-4heaN: 13.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1SN0_B_T44B602_1 (TRANSTHYRETIN)	4hea	NADH-QUINONE OXIDOREDUCTASE SUBUNIT 13 (Thermus thermophilus)	4 / 7	GLU M 103 ALA M   5 LEU M  67 ALA M 111	None	1.14A	1sn0B-4heaM: undetectable 1sn0D-4heaM: undetectable	1sn0B-4heaM: 14.38 1sn0D-4heaM: 14.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1T9W_A_NFNA6002_1 (ACRIFLAVINE RESISTANCE PROTEIN B)	4hea	NADH-QUINONE OXIDOREDUCTASE SUBUNIT 13 (Thermus thermophilus)	4 / 7	MET M 132 ALA M  99 ARG M 331 GLU M  92	None	1.04A	1t9wA-4heaM: undetectable	1t9wA-4heaM: 21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1TT6_A_DESA129_1 (TRANSTHYRETIN)	4hea	NADH-QUINONE OXIDOREDUCTASE SUBUNIT 13 (Thermus thermophilus)	4 / 4	LYS M   1 LEU M   4 LEU M   8 SER M  32	None	1.45A	1tt6A-4heaM: undetectable	1tt6A-4heaM: 13.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1TZ8_B_DESB128_1 (TRANSTHYRETIN)	4hea	NADH-QUINONE OXIDOREDUCTASE SUBUNIT 11 NADH-QUINONE OXIDOREDUCTASE SUBUNIT 14 (Thermus thermophilus)	6 / 11	LEU K   5 ALA K   8 LEU K   4 SER K  41 LEU N 174 LEU N 153	None	1.32A	1tz8A-4heaK: undetectable 1tz8B-4heaK: undetectable	1tz8A-4heaK: 20.93 1tz8B-4heaK: 20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1TZ8_B_DESB128_1 (TRANSTHYRETIN)	4hea	NADH-QUINONE OXIDOREDUCTASE SUBUNIT 11 NADH-QUINONE OXIDOREDUCTASE SUBUNIT 14 (Thermus thermophilus)	6 / 11	LEU N 174 LEU N 153 LEU K   5 ALA K   8 LEU K   4 SER K  41	None	1.33A	1tz8A-4heaN: undetectable 1tz8B-4heaN: undetectable	1tz8A-4heaN: 14.43 1tz8B-4heaN: 14.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1TZ8_B_DESB128_1 (TRANSTHYRETIN)	4hea	NADH-QUINONE OXIDOREDUCTASE SUBUNIT 13 (Thermus thermophilus)	5 / 11	ALA M 202 LEU M 260 ALA M 297 LEU M 263 SER M 267	None	1.14A	1tz8A-4heaM: undetectable 1tz8B-4heaM: undetectable	1tz8A-4heaM: 13.33 1tz8B-4heaM: 13.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1TZ8_B_DESB128_1 (TRANSTHYRETIN)	4hea	NADH-QUINONE OXIDOREDUCTASE SUBUNIT 13 (Thermus thermophilus)	5 / 11	LEU M 260 ALA M 297 LEU M 263 SER M 267 ALA M 202	None	1.16A	1tz8A-4heaM: undetectable 1tz8B-4heaM: undetectable	1tz8A-4heaM: 13.33 1tz8B-4heaM: 13.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1TZ8_D_DESD128_1 (TRANSTHYRETIN)	4hea	NADH-QUINONE OXIDOREDUCTASE SUBUNIT 13 (Thermus thermophilus)	4 / 4	LYS M   1 LEU M   4 LEU M   8 SER M  32	None	1.41A	1tz8D-4heaM: undetectable	1tz8D-4heaM: 13.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1U18_B_HSMB402_1 (NITROPHORIN 1)	4hea	NADH-QUINONE OXIDOREDUCTASE SUBUNIT 12 (Thermus thermophilus)	5 / 5	ASP L 386 GLU L 490 THR L 392 LEU L 393 LEU L 389	None	1.23A	1u18B-4heaL: undetectable	1u18B-4heaL: 14.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1XZ1_A_HLTA2001_1 (FERRITIN LIGHT CHAIN)	4hea	NADH-QUINONE OXIDOREDUCTASE SUBUNIT 12 (Thermus thermophilus)	4 / 4	LEU L 283 SER L 284 TYR L 416 LEU L 412	None	1.14A	1xz1A-4heaL: 2.7	1xz1A-4heaL: 15.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1XZ3_A_ICFA201_1 (FERRITIN LIGHT CHAIN)	4hea	NADH-QUINONE OXIDOREDUCTASE SUBUNIT 12 (Thermus thermophilus)	4 / 4	LEU L 283 SER L 284 TYR L 416 LEU L 412	None	1.15A	1xz3A-4heaL: 2.6	1xz3A-4heaL: 15.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1YA3_C_STRC3001_1 (MINERALOCORTICOID RECEPTOR)	4hea	NADH-QUINONE OXIDOREDUCTASE SUBUNIT 12 NADH-QUINONE OXIDOREDUCTASE SUBUNIT 14 (Thermus thermophilus)	5 / 12	LEU L 592 LEU L 595 LEU L 598 ALA L 597 LEU N 239	None	1.11A	1ya3C-4heaL: undetectable	1ya3C-4heaL: 17.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1YA4_B_CTXB1283_1 (CES1 PROTEIN)	4hea	NADH-QUINONE OXIDOREDUCTASE SUBUNIT 12 (Thermus thermophilus)	4 / 7	PRO L 445 LEU L 334 GLY L 337 PRO L 439	None	0.84A	1ya4B-4heaL: 0.0	1ya4B-4heaL: 21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1YAJ_D_BEZD2385_0 (CES1 PROTEIN)	4hea	NADH-QUINONE OXIDOREDUCTASE SUBUNIT 14 (Thermus thermophilus)	4 / 5	SER N 240 LEU N 273 LEU N 271 LEU N 223	None	0.91A	1yajD-4heaN: undetectable	1yajD-4heaN: 23.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2B60_B_RITB100_2 (GAG-POL POLYPROTEIN)	4hea	NADH-QUINONE OXIDOREDUCTASE SUBUNIT 12 (Thermus thermophilus)	5 / 11	GLY L 311 ALA L 310 GLY L 304 ALA L 213 ILE L 253	None	1.01A	2b60B-4heaL: undetectable	2b60B-4heaL: 9.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2BDM_A_TMIA502_1 (CYTOCHROME P450 2B4)	4hea	NADH-QUINONE OXIDOREDUCTASE SUBUNIT 13 (Thermus thermophilus)	5 / 12	PHE M 194 LEU M 260 LEU M 261 ILE M 246 LEU M 465	None	1.05A	2bdmA-4heaM: 0.7	2bdmA-4heaM: 23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2BM9_F_SAMF301_0 (CEPHALOSPORIN HYDROXYLASE CMCI)	4hea	NADH-QUINONE OXIDOREDUCTASE SUBUNIT 14 (Thermus thermophilus)	5 / 12	GLY N 159 LEU N 161 GLY N 150 ALA N 175 ALA N 173	None	1.03A	2bm9F-4heaN: undetectable	2bm9F-4heaN: 18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2BXE_A_1FLA2002_1 (SERUM ALBUMIN)	4hea	NADH-QUINONE OXIDOREDUCTASE SUBUNIT 12 (Thermus thermophilus)	5 / 10	PHE L 323 ALA L 326 ALA L 330 LEU L 334 LEU L 449	None	1.19A	2bxeA-4heaL: undetectable	2bxeA-4heaL: 21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2BXE_B_1FLB2002_1 (SERUM ALBUMIN)	4hea	NADH-QUINONE OXIDOREDUCTASE SUBUNIT 12 (Thermus thermophilus)	5 / 11	ALA L 417 ALA L 370 LEU L 332 ALA L 335 VAL L 295	None	0.97A	2bxeB-4heaL: 2.8	2bxeB-4heaL: 21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2DCF_A_ACAA502_1 (6-AMINOHEXANOATE-DIM ER HYDROLASE)	4hea	NADH-QUINONE OXIDOREDUCTASE SUBUNIT 12 (Thermus thermophilus)	5 / 12	ALA L 213 TYR L 260 VAL L 266 GLY L 249 ILE L 253	None	1.06A	2dcfA-4heaL: undetectable	2dcfA-4heaL: 21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2OC8_A_HU5A999_1 (HEPATITIS C VIRUS)	4hea	NADH-QUINONE OXIDOREDUCTASE SUBUNIT 14 (Thermus thermophilus)	5 / 12	ARG N 354 LEU N 361 GLY N 359 ALA N 355 ALA N 352	None	0.89A	2oc8A-4heaN: undetectable	2oc8A-4heaN: 18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2OPX_A_DXCA1002_0 (ALDEHYDE DEHYDROGENASE A)	4hea	NADH-QUINONE OXIDOREDUCTASE SUBUNIT 11 NADH-QUINONE OXIDOREDUCTASE SUBUNIT 12 (Thermus thermophilus; Thermus thermophilus)	3 / 3	GLY L 584 ARG K  94 TYR L 589	None	0.81A	2opxA-4heaL: undetectable	2opxA-4heaL: 21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2V0M_B_KLNB1498_1 (CYTOCHROME P450 3A4)	4hea	NADH-QUINONE OXIDOREDUCTASE SUBUNIT 12 NADH-QUINONE OXIDOREDUCTASE SUBUNIT 13 (Thermus thermophilus)	5 / 9	LEU M 394 ALA M 384 GLU L 132 GLY L 168 LEU L 171	None	1.29A	2v0mB-4heaM: undetectable	2v0mB-4heaM: 22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2V2G_A_BEZA1222_0 (PEROXIREDOXIN 6)	4hea	NADH-QUINONE OXIDOREDUCTASE SUBUNIT 12 (Thermus thermophilus)	4 / 7	THR L 234 PRO L 235 VAL L 236 SER L 237	None	0.74A	2v2gA-4heaL: undetectable 2v2gB-4heaL: undetectable	2v2gA-4heaL: 14.52 2v2gB-4heaL: 14.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2V2G_B_BEZB1220_0 (PEROXIREDOXIN 6)	4hea	NADH-QUINONE OXIDOREDUCTASE SUBUNIT 12 (Thermus thermophilus)	4 / 7	THR L 234 PRO L 235 VAL L 236 SER L 237	None	0.75A	2v2gA-4heaL: undetectable 2v2gB-4heaL: undetectable	2v2gA-4heaL: 14.52 2v2gB-4heaL: 14.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2V2G_C_BEZC1222_0 (PEROXIREDOXIN 6)	4hea	NADH-QUINONE OXIDOREDUCTASE SUBUNIT 12 (Thermus thermophilus)	4 / 7	THR L 234 PRO L 235 VAL L 236 SER L 237	None	0.74A	2v2gC-4heaL: undetectable 2v2gD-4heaL: undetectable	2v2gC-4heaL: 14.52 2v2gD-4heaL: 14.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2V2G_D_BEZD1221_0 (PEROXIREDOXIN 6)	4hea	NADH-QUINONE OXIDOREDUCTASE SUBUNIT 12 (Thermus thermophilus)	4 / 7	THR L 234 PRO L 235 VAL L 236 SER L 237	None	0.76A	2v2gC-4heaL: undetectable 2v2gD-4heaL: undetectable	2v2gC-4heaL: 14.52 2v2gD-4heaL: 14.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2V32_A_BEZA1222_0 (PEROXIREDOXIN 6)	4hea	NADH-QUINONE OXIDOREDUCTASE SUBUNIT 12 (Thermus thermophilus)	4 / 8	THR L 234 PRO L 235 VAL L 236 SER L 237	None	0.78A	2v32A-4heaL: undetectable 2v32B-4heaL: undetectable	2v32A-4heaL: 14.52 2v32B-4heaL: 14.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2V32_B_BEZB1220_0 (PEROXIREDOXIN 6)	4hea	NADH-QUINONE OXIDOREDUCTASE SUBUNIT 12 (Thermus thermophilus)	4 / 8	THR L 234 PRO L 235 VAL L 236 SER L 237	None	0.76A	2v32A-4heaL: undetectable 2v32B-4heaL: undetectable	2v32A-4heaL: 14.52 2v32B-4heaL: 14.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2V32_C_BEZC1222_0 (PEROXIREDOXIN 6)	4hea	NADH-QUINONE OXIDOREDUCTASE SUBUNIT 12 (Thermus thermophilus)	4 / 8	THR L 234 PRO L 235 VAL L 236 SER L 237	None	0.73A	2v32C-4heaL: undetectable 2v32D-4heaL: undetectable	2v32C-4heaL: 14.52 2v32D-4heaL: 14.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2V32_D_BEZD1221_0 (PEROXIREDOXIN 6)	4hea	NADH-QUINONE OXIDOREDUCTASE SUBUNIT 12 (Thermus thermophilus)	4 / 8	THR L 234 PRO L 235 VAL L 236 SER L 237	None	0.77A	2v32C-4heaL: undetectable 2v32D-4heaL: undetectable	2v32C-4heaL: 14.52 2v32D-4heaL: 14.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2V41_C_BEZC1218_0 (PEROXIREDOXIN 6.)	4hea	NADH-QUINONE OXIDOREDUCTASE SUBUNIT 12 (Thermus thermophilus)	4 / 8	THR L 234 PRO L 235 VAL L 236 SER L 237	None	0.77A	2v41C-4heaL: undetectable 2v41D-4heaL: undetectable	2v41C-4heaL: 14.52 2v41D-4heaL: 14.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2V41_D_BEZD1222_0 (PEROXIREDOXIN 6.)	4hea	NADH-QUINONE OXIDOREDUCTASE SUBUNIT 12 (Thermus thermophilus)	4 / 8	THR L 234 PRO L 235 VAL L 236 SER L 237	None	0.76A	2v41C-4heaL: undetectable 2v41D-4heaL: undetectable	2v41C-4heaL: 14.52 2v41D-4heaL: 14.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2V41_E_BEZE1222_0 (PEROXIREDOXIN 6.)	4hea	NADH-QUINONE OXIDOREDUCTASE SUBUNIT 12 (Thermus thermophilus)	4 / 7	THR L 234 PRO L 235 VAL L 236 SER L 237	None	0.80A	2v41E-4heaL: undetectable 2v41F-4heaL: undetectable	2v41E-4heaL: 14.52 2v41F-4heaL: 14.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2V41_F_BEZF1222_0 (PEROXIREDOXIN 6.)	4hea	NADH-QUINONE OXIDOREDUCTASE SUBUNIT 12 (Thermus thermophilus)	4 / 7	THR L 234 PRO L 235 VAL L 236 SER L 237	None	0.82A	2v41E-4heaL: undetectable 2v41F-4heaL: undetectable	2v41E-4heaL: 14.52 2v41F-4heaL: 14.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2V41_G_BEZG1222_0 (PEROXIREDOXIN 6.)	4hea	NADH-QUINONE OXIDOREDUCTASE SUBUNIT 12 (Thermus thermophilus)	4 / 8	THR L 234 PRO L 235 VAL L 236 SER L 237	None	0.74A	2v41G-4heaL: undetectable 2v41H-4heaL: undetectable	2v41G-4heaL: 14.52 2v41H-4heaL: 14.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2V41_H_BEZH1222_0 (PEROXIREDOXIN 6.)	4hea	NADH-QUINONE OXIDOREDUCTASE SUBUNIT 12 (Thermus thermophilus)	4 / 8	THR L 234 PRO L 235 VAL L 236 SER L 237	None	0.78A	2v41G-4heaL: undetectable 2v41H-4heaL: undetectable	2v41G-4heaL: 14.52 2v41H-4heaL: 14.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2VCV_B_ASDB1224_1 (GLUTATHIONE S-TRANSFERASE A3)	4hea	NADH-QUINONE OXIDOREDUCTASE SUBUNIT 14 (Thermus thermophilus)	4 / 6	LEU N  89 ALA N  70 LEU N  67 ALA N  34	None	0.96A	2vcvB-4heaN: 0.9	2vcvB-4heaN: 19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2VMY_B_FFOB505_0 (SERINE HYDROXYMETHYLTRANSFE RASE)	4hea	NADH-QUINONE OXIDOREDUCTASE SUBUNIT 13 NADH-QUINONE OXIDOREDUCTASE SUBUNIT 14 (Thermus thermophilus; Thermus thermophilus)	5 / 12	LEU M 160 LEU M 116 VAL M 120 ALA N 353 GLY N 344	None	1.05A	2vmyA-4heaM: undetectable	2vmyA-4heaM: 22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2W9G_A_TOPA1159_1 (DIHYDROFOLATE REDUCTASE)	4hea	NADH-QUINONE OXIDOREDUCTASE SUBUNIT 14 (Thermus thermophilus)	5 / 10	LEU N 423 LEU N 290 VAL N 419 SER N 332 PHE N 283	None	1.12A	2w9gA-4heaN: undetectable	2w9gA-4heaN: 14.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2X2N_C_X2NC1479_1 (LANOSTEROL 14-ALPHA-DEMETHYLASE)	4hea	NADH-QUINONE OXIDOREDUCTASE SUBUNIT 11 NADH-QUINONE OXIDOREDUCTASE SUBUNIT 12 NADH-QUINONE OXIDOREDUCTASE SUBUNIT 14 (Thermus thermophilus)	5 / 12	PHE K  11 VAL K  15 ALA N 151 ALA N 175 LEU L 601	None	1.29A	2x2nC-4heaK: undetectable	2x2nC-4heaK: 13.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2X2N_D_X2ND1479_1 (LANOSTEROL 14-ALPHA-DEMETHYLASE)	4hea	NADH-QUINONE OXIDOREDUCTASE SUBUNIT 12 (Thermus thermophilus)	5 / 12	ILE L 542 ALA L 238 ALA L 242 THR L 247 LEU L 303	None	1.36A	2x2nD-4heaL: undetectable	2x2nD-4heaL: 21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2X2N_D_X2ND1479_1 (LANOSTEROL 14-ALPHA-DEMETHYLASE)	4hea	NADH-QUINONE OXIDOREDUCTASE SUBUNIT 14 (Thermus thermophilus)	5 / 12	ILE N   5 PHE N 185 ALA N 143 ALA N 141 LEU N 116	None	1.36A	2x2nD-4heaN: undetectable	2x2nD-4heaN: 21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2XN5_A_FUNA1356_1 (THYROXINE-BINDING GLOBULIN)	4hea	NADH-QUINONE OXIDOREDUCTASE SUBUNIT 12 NADH-QUINONE OXIDOREDUCTASE SUBUNIT 13 (Thermus thermophilus)	5 / 11	SER M 402 ALA M 401 LEU L 222 SER M 398 LEU L 211	None	1.08A	2xn5A-4heaM: undetectable	2xn5A-4heaM: 21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2ZM9_A_ACAA502_1 (6-AMINOHEXANOATE-DIM ER HYDROLASE)	4hea	NADH-QUINONE OXIDOREDUCTASE SUBUNIT 12 (Thermus thermophilus)	4 / 8	ALA L 213 TYR L 260 GLY L 249 ILE L 253	None	0.86A	2zm9A-4heaL: undetectable	2zm9A-4heaL: 21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3A65_A_ACAA601_1 (6-AMINOHEXANOATE-DIM ER HYDROLASE)	4hea	NADH-QUINONE OXIDOREDUCTASE SUBUNIT 12 (Thermus thermophilus)	5 / 12	ALA L 213 TYR L 260 VAL L 266 GLY L 249 ILE L 253	None	1.14A	3a65A-4heaL: undetectable	3a65A-4heaL: 21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3BGD_B_PM6B301_1 (THIOPURINE S-METHYLTRANSFERASE)	4hea	NADH-QUINONE OXIDOREDUCTASE SUBUNIT 13 (Thermus thermophilus)	4 / 8	PHE M 110 GLY M 108 VAL M   6 ARG M 243	None	1.05A	3bgdB-4heaM: undetectable	3bgdB-4heaM: 18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3BGD_B_PM6B301_1 (THIOPURINE S-METHYLTRANSFERASE)	4hea	NADH-QUINONE OXIDOREDUCTASE SUBUNIT 13 NADH-QUINONE OXIDOREDUCTASE SUBUNIT 14 (Thermus thermophilus)	4 / 8	PHE N 383 ARG N 317 GLY N 314 ARG M 141	None	1.12A	3bgdB-4heaN: undetectable	3bgdB-4heaN: 19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3BJW_F_SVRF509_2 (PHOSPHOLIPASE A2)	4hea	NADH-QUINONE OXIDOREDUCTASE SUBUNIT 12 (Thermus thermophilus)	4 / 8	TYR L 297 LYS L 293 LYS L 292 PHE L 425	None	1.41A	3bjwD-4heaL: undetectable	3bjwD-4heaL: 9.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3C6G_A_VD3A701_1 (CYTOCHROME P450 2R1)	4hea	NADH-QUINONE OXIDOREDUCTASE SUBUNIT 13 (Thermus thermophilus)	6 / 12	LEU M 100 LEU M 233 ALA M  29 ALA M  89 GLY M 324 ILE M  78	None	1.39A	3c6gA-4heaM: undetectable	3c6gA-4heaM: 22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3CFQ_A_DIFA1_1 (TRANSTHYRETIN)	4hea	NADH-QUINONE OXIDOREDUCTASE SUBUNIT 13 (Thermus thermophilus)	4 / 6	LEU M 260 ALA M 297 LEU M 263 SER M 267	None	0.89A	3cfqA-4heaM: undetectable	3cfqA-4heaM: 14.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3DAT_A_MTXA201_1 (DIHYDROFOLATE REDUCTASE)	4hea	NADH-QUINONE OXIDOREDUCTASE SUBUNIT 11 NADH-QUINONE OXIDOREDUCTASE SUBUNIT 14 (Thermus thermophilus)	5 / 12	ALA N 144 LEU K  35 GLU N 112 LEU K  72 PHE N 137	None	1.17A	3datA-4heaN: undetectable	3datA-4heaN: 13.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3DD1_A_CFFA903_1 (GLYCOGEN PHOSPHORYLASE, LIVER FORM)	4hea	NADH-QUINONE OXIDOREDUCTASE SUBUNIT 14 (Thermus thermophilus)	4 / 6	PHE N  48 ALA N  54 GLY N  51 TYR N  53	None	1.13A	3dd1A-4heaN: 2.2	3dd1A-4heaN: 18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3DD1_B_CFFB903_1 (GLYCOGEN PHOSPHORYLASE, LIVER FORM)	4hea	NADH-QUINONE OXIDOREDUCTASE SUBUNIT 14 (Thermus thermophilus)	4 / 6	PHE N  48 ALA N  54 GLY N  51 TYR N  53	None	1.11A	3dd1B-4heaN: undetectable	3dd1B-4heaN: 18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3DDS_B_CFFB903_1 (GLYCOGEN PHOSPHORYLASE, LIVER FORM)	4hea	NADH-QUINONE OXIDOREDUCTASE SUBUNIT 14 (Thermus thermophilus)	4 / 6	PHE N  48 ALA N  54 GLY N  51 TYR N  53	None	1.12A	3ddsB-4heaN: undetectable	3ddsB-4heaN: 18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3DDW_B_CFFB903_1 (GLYCOGEN PHOSPHORYLASE, LIVER FORM)	4hea	NADH-QUINONE OXIDOREDUCTASE SUBUNIT 14 (Thermus thermophilus)	4 / 6	PHE N  48 ALA N  54 GLY N  51 TYR N  53	None	1.11A	3ddwB-4heaN: undetectable	3ddwB-4heaN: 18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3DH0_B_SAMB300_0 (SAM DEPENDENT METHYLTRANSFERASE)	4hea	NADH-QUINONE OXIDOREDUCTASE SUBUNIT 13 (Thermus thermophilus)	5 / 12	LEU M  96 GLY M  97 VAL M  10 ALA M 227 LEU M 106	None	1.05A	3dh0B-4heaM: undetectable	3dh0B-4heaM: 19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3ELZ_A_CHDA152_0 (ILEAL BILE ACID-BINDING PROTEIN)	4hea	NADH-QUINONE OXIDOREDUCTASE SUBUNIT 7 (Thermus thermophilus)	3 / 3	VAL A  54 LYS A  55 HIS A  60	None	0.90A	3elzA-4heaA: undetectable	3elzA-4heaA: 21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3EM3_B_478B200_1 (PROTEASE)	4hea	NADH-QUINONE OXIDOREDUCTASE SUBUNIT 11 NADH-QUINONE OXIDOREDUCTASE SUBUNIT 14 (Thermus thermophilus)	6 / 10	GLY N 140 ALA N 141 GLY K  71 LEU K  74 VAL K  27 ILE K  31	None	1.07A	3em3A-4heaN: undetectable	3em3A-4heaN: 13.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3EM4_A_DR7A100_1 (PROTEASE)	4hea	NADH-QUINONE OXIDOREDUCTASE SUBUNIT 11 NADH-QUINONE OXIDOREDUCTASE SUBUNIT 14 (Thermus thermophilus)	5 / 11	GLY N 140 ALA N 141 GLY K  71 LEU K  74 ILE K  31	None	0.93A	3em4A-4heaN: undetectable	3em4A-4heaN: 13.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3ETE_C_H3PC552_1 (GLUTAMATE DEHYDROGENASE)	4hea	NADH-QUINONE OXIDOREDUCTASE SUBUNIT 11 NADH-QUINONE OXIDOREDUCTASE SUBUNIT 12 NADH-QUINONE OXIDOREDUCTASE SUBUNIT 14 (Thermus thermophilus)	3 / 3	TYR N 260 TYR L 589 GLY K  95	None	0.75A	3eteB-4heaN: undetectable 3eteD-4heaN: undetectable 3eteF-4heaN: undetectable	3eteB-4heaN: 19.14 3eteD-4heaN: 19.14 3eteF-4heaN: 19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3FPJ_B_SAMB301_1 (PUTATIVE UNCHARACTERIZED PROTEIN)	4hea	NADH-QUINONE OXIDOREDUCTASE SUBUNIT 14 (Thermus thermophilus)	4 / 7	GLN N  60 GLY N 427 GLY N  45 ALA N 422	None	0.86A	3fpjB-4heaN: undetectable	3fpjB-4heaN: 21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3FRB_X_TOPX300_1 (DIHYDROFOLATE REDUCTASE)	4hea	NADH-QUINONE OXIDOREDUCTASE SUBUNIT 14 (Thermus thermophilus)	5 / 11	LEU N 423 LEU N 290 VAL N 419 SER N 332 PHE N 283	None	1.11A	3frbX-4heaN: undetectable	3frbX-4heaN: 14.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3FW1_A_STIA233_1 (RIBOSYLDIHYDRONICOTI NAMIDE DEHYDROGENASE [QUINONE])	4hea	NADH-QUINONE OXIDOREDUCTASE SUBUNIT 12 (Thermus thermophilus)	5 / 10	PHE L 327 GLY L  84 GLY L  82 THR L  81 ILE L 112	None	1.36A	3fw1A-4heaL: undetectable	3fw1A-4heaL: 17.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3G2O_A_SAMA500_0 (PCZA361.24)	4hea	NADH-QUINONE OXIDOREDUCTASE SUBUNIT 12 (Thermus thermophilus)	5 / 12	ALA L 372 GLY L 381 LEU L 376 GLY L 452 SER L 453	None	1.08A	3g2oA-4heaL: undetectable	3g2oA-4heaL: 20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3G2O_A_SAMA500_0 (PCZA361.24)	4hea	NADH-QUINONE OXIDOREDUCTASE SUBUNIT 11 NADH-QUINONE OXIDOREDUCTASE SUBUNIT 14 (Thermus thermophilus; Thermus thermophilus)	5 / 12	ALA N 120 LEU N 130 LEU N 121 SER N 115 GLY K  73	None	1.06A	3g2oA-4heaN: undetectable	3g2oA-4heaN: 24.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3G2O_B_SAMB600_0 (PCZA361.24)	4hea	NADH-QUINONE OXIDOREDUCTASE SUBUNIT 12 (Thermus thermophilus)	5 / 12	ALA L 372 GLY L 381 LEU L 376 GLY L 452 SER L 453	None	1.03A	3g2oB-4heaL: undetectable	3g2oB-4heaL: 20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3GP0_A_NILA1_2 (MITOGEN-ACTIVATED PROTEIN KINASE 11)	4hea	NADH-QUINONE OXIDOREDUCTASE SUBUNIT 13 (Thermus thermophilus)	4 / 7	VAL M 399 LEU M 298 LEU M 290 ILE M 400	None	0.94A	3gp0A-4heaM: undetectable	3gp0A-4heaM: 21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3HCR_A_CHDA4_0 (FERROCHELATASE, MITOCHONDRIAL)	4hea	NADH-QUINONE OXIDOREDUCTASE SUBUNIT 14 (Thermus thermophilus)	3 / 3	LEU N 118 PRO N 117 LEU N 121	None	0.47A	3hcrA-4heaN: undetectable	3hcrA-4heaN: 20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3HM1_A_J3ZA2_1 (ESTROGEN RECEPTOR)	4hea	NADH-QUINONE OXIDOREDUCTASE SUBUNIT 13 (Thermus thermophilus)	5 / 12	LEU M  76 THR M  77 GLU M 103 LEU M  84 MET M 443	None	1.03A	3hm1A-4heaM: undetectable	3hm1A-4heaM: 21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3HRD_B_NIOB5661_1 (NICOTINATE DEHYDROGENASE LARGE MOLYBDOPTERIN SUBUNIT NICOTINATE DEHYDROGENASE MEDIUM MOLYBDOPTERIN SUBUNIT)	4hea	NADH-QUINONE OXIDOREDUCTASE SUBUNIT 13 (Thermus thermophilus)	4 / 8	ALA M 317 THR M  77 LEU M  73 ALA M 439	None	0.89A	3hrdA-4heaM: undetectable 3hrdB-4heaM: undetectable	3hrdA-4heaM: 20.45 3hrdB-4heaM: 22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3HRD_B_NIOB5661_1 (NICOTINATE DEHYDROGENASE LARGE MOLYBDOPTERIN SUBUNIT NICOTINATE DEHYDROGENASE MEDIUM MOLYBDOPTERIN SUBUNIT)	4hea	NADH-QUINONE OXIDOREDUCTASE SUBUNIT 13 (Thermus thermophilus)	4 / 8	ILE M 341 ALA M 409 PHE M 362 ALA M 358	None	0.90A	3hrdA-4heaM: undetectable 3hrdB-4heaM: undetectable	3hrdA-4heaM: 20.45 3hrdB-4heaM: 22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3J6G_B_TA1B502_1 (TUBULIN BETA CHAIN)	4hea	NADH-QUINONE OXIDOREDUCTASE SUBUNIT 11 NADH-QUINONE OXIDOREDUCTASE SUBUNIT 14 (Thermus thermophilus)	5 / 10	LEU K  42 SER K   7 PHE K  45 THR N 158 LEU N 171	None	1.33A	3j6gB-4heaK: undetectable	3j6gB-4heaK: 13.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3J6G_D_TA1D502_1 (TUBULIN BETA CHAIN)	4hea	NADH-QUINONE OXIDOREDUCTASE SUBUNIT 11 NADH-QUINONE OXIDOREDUCTASE SUBUNIT 14 (Thermus thermophilus)	5 / 10	LEU K  42 SER K   7 PHE K  45 THR N 158 LEU N 171	None	1.33A	3j6gD-4heaK: undetectable	3j6gD-4heaK: 13.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3J6G_F_TA1F502_1 (TUBULIN BETA CHAIN)	4hea	NADH-QUINONE OXIDOREDUCTASE SUBUNIT 11 NADH-QUINONE OXIDOREDUCTASE SUBUNIT 14 (Thermus thermophilus)	5 / 10	LEU K  42 SER K   7 PHE K  45 THR N 158 LEU N 171	None	1.33A	3j6gF-4heaK: undetectable	3j6gF-4heaK: 13.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3J6G_H_TA1H502_1 (TUBULIN BETA CHAIN)	4hea	NADH-QUINONE OXIDOREDUCTASE SUBUNIT 11 NADH-QUINONE OXIDOREDUCTASE SUBUNIT 14 (Thermus thermophilus)	5 / 10	LEU K  42 SER K   7 PHE K  45 THR N 158 LEU N 171	None	1.33A	3j6gH-4heaK: undetectable	3j6gH-4heaK: 13.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3J6G_J_TA1J502_1 (TUBULIN BETA CHAIN)	4hea	NADH-QUINONE OXIDOREDUCTASE SUBUNIT 11 NADH-QUINONE OXIDOREDUCTASE SUBUNIT 14 (Thermus thermophilus)	5 / 10	LEU K  42 SER K   7 PHE K  45 THR N 158 LEU N 171	None	1.33A	3j6gJ-4heaK: undetectable	3j6gJ-4heaK: 13.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3J6G_L_TA1L502_1 (TUBULIN BETA CHAIN)	4hea	NADH-QUINONE OXIDOREDUCTASE SUBUNIT 11 NADH-QUINONE OXIDOREDUCTASE SUBUNIT 14 (Thermus thermophilus)	5 / 10	LEU K  42 SER K   7 PHE K  45 THR N 158 LEU N 171	None	1.33A	3j6gL-4heaK: undetectable	3j6gL-4heaK: 13.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3J6G_N_TA1N502_1 (TUBULIN BETA CHAIN)	4hea	NADH-QUINONE OXIDOREDUCTASE SUBUNIT 11 NADH-QUINONE OXIDOREDUCTASE SUBUNIT 14 (Thermus thermophilus)	5 / 10	LEU K  42 SER K   7 PHE K  45 THR N 158 LEU N 171	None	1.33A	3j6gN-4heaK: undetectable	3j6gN-4heaK: 13.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3J6G_P_TA1P502_1 (TUBULIN BETA CHAIN)	4hea	NADH-QUINONE OXIDOREDUCTASE SUBUNIT 11 NADH-QUINONE OXIDOREDUCTASE SUBUNIT 14 (Thermus thermophilus)	5 / 10	LEU K  42 SER K   7 PHE K  45 THR N 158 LEU N 171	None	1.33A	3j6gP-4heaK: undetectable	3j6gP-4heaK: 13.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3J6G_R_TA1R502_1 (TUBULIN BETA CHAIN)	4hea	NADH-QUINONE OXIDOREDUCTASE SUBUNIT 11 NADH-QUINONE OXIDOREDUCTASE SUBUNIT 14 (Thermus thermophilus)	5 / 10	LEU K  42 SER K   7 PHE K  45 THR N 158 LEU N 171	None	1.33A	3j6gR-4heaK: undetectable	3j6gR-4heaK: 13.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3JW5_A_TOPA208_1 (DIHYDROFOLATE REDUCTASE)	4hea	NADH-QUINONE OXIDOREDUCTASE SUBUNIT 11 NADH-QUINONE OXIDOREDUCTASE SUBUNIT 14 (Thermus thermophilus)	5 / 11	ALA N 144 ASN K  36 LEU K  35 GLU N 112 PHE K  28	None	1.09A	3jw5A-4heaN: undetectable	3jw5A-4heaN: 12.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3JW5_B_TOPB208_1 (DIHYDROFOLATE REDUCTASE)	4hea	NADH-QUINONE OXIDOREDUCTASE SUBUNIT 11 NADH-QUINONE OXIDOREDUCTASE SUBUNIT 14 (Thermus thermophilus)	5 / 10	ALA N 144 LEU K  35 GLU N 112 LEU K  72 PHE N 137	None	1.20A	3jw5B-4heaN: undetectable	3jw5B-4heaN: 12.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3KO0_B_TFPB201_1 (PROTEIN S100-A4)	4hea	NADH-QUINONE OXIDOREDUCTASE SUBUNIT 12 (Thermus thermophilus)	4 / 8	GLY L 508 ILE L 294 PHE L 532 PHE L 524	None	0.85A	3ko0B-4heaL: 0.5 3ko0J-4heaL: undetectable	3ko0B-4heaL: 10.77 3ko0J-4heaL: 10.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3KO0_K_TFPK201_1 (PROTEIN S100-A4)	4hea	NADH-QUINONE OXIDOREDUCTASE SUBUNIT 12 (Thermus thermophilus)	4 / 8	GLY L 508 ILE L 294 PHE L 532 PHE L 524	None	0.94A	3ko0K-4heaL: 0.5 3ko0S-4heaL: undetectable	3ko0K-4heaL: 10.77 3ko0S-4heaL: 10.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3LM8_B_VIBB223_1 (THIAMINE PYROPHOSPHOKINASE)	4hea	NADH-QUINONE OXIDOREDUCTASE SUBUNIT 14 (Thermus thermophilus)	4 / 7	TYR N 375 LEU N 376 LEU N 331 THR N 287	None	0.93A	3lm8B-4heaN: undetectable 3lm8D-4heaN: undetectable	3lm8B-4heaN: 16.94 3lm8D-4heaN: 16.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3M7R_A_VDXA425_1 (VITAMIN D3 RECEPTOR)	4hea	NADH-QUINONE OXIDOREDUCTASE SUBUNIT 14 (Thermus thermophilus)	5 / 12	LEU N 233 LEU N 236 VAL N 237 SER N 240 LEU N 281	None	1.24A	3m7rA-4heaN: undetectable	3m7rA-4heaN: 17.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3MTE_B_SAMB220_0 (16S RRNA METHYLASE)	4hea	NADH-QUINONE OXIDOREDUCTASE SUBUNIT 12 NADH-QUINONE OXIDOREDUCTASE SUBUNIT 13 (Thermus thermophilus; Thermus thermophilus)	5 / 12	ALA M 395 ALA M 392 PHE L 169 THR M 380 LEU M 381	None	0.96A	3mteB-4heaM: undetectable	3mteB-4heaM: 17.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3NT1_B_NPSB4_1 (PROSTAGLANDIN-ENDOPE ROXIDE SYNTHASE 2)	4hea	NADH-QUINONE OXIDOREDUCTASE SUBUNIT 12 NADH-QUINONE OXIDOREDUCTASE SUBUNIT 14 (Thermus thermophilus)	5 / 12	VAL N 181 LEU N 178 VAL L 594 GLY L 596 LEU L 601	None	1.09A	3nt1B-4heaN: undetectable	3nt1B-4heaN: 20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3OZK_B_T44B128_1 (TRANSTHYRETIN)	4hea	NADH-QUINONE OXIDOREDUCTASE SUBUNIT 11 (Thermus thermophilus)	4 / 7	LEU K   5 ALA K   8 LEU K   4 SER K  41	None	1.02A	3ozkB-4heaK: undetectable	3ozkB-4heaK: 21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3P2K_A_SAMA6735_0 (16S RRNA METHYLASE)	4hea	NADH-QUINONE OXIDOREDUCTASE SUBUNIT 12 NADH-QUINONE OXIDOREDUCTASE SUBUNIT 13 (Thermus thermophilus; Thermus thermophilus)	5 / 12	ALA M 395 ALA M 392 PHE L 169 THR M 380 LEU M 381	None	0.99A	3p2kA-4heaM: undetectable	3p2kA-4heaM: 17.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3P2K_D_SAMD6735_0 (16S RRNA METHYLASE)	4hea	NADH-QUINONE OXIDOREDUCTASE SUBUNIT 13 (Thermus thermophilus)	5 / 12	GLY M 376 ALA M 268 ALA M 395 LEU M 382 LEU M 298	None	1.06A	3p2kD-4heaM: undetectable	3p2kD-4heaM: 17.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3RD0_A_EDPA175_1 (FERRITIN LIGHT CHAIN)	4hea	NADH-QUINONE OXIDOREDUCTASE SUBUNIT 12 (Thermus thermophilus)	4 / 6	LEU L 183 TYR L 180 ALA L 178 LEU L 188	None	1.09A	3rd0A-4heaL: 2.7	3rd0A-4heaL: 15.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3ROD_A_NCAA302_0 (NICOTINAMIDE N-METHYLTRANSFERASE)	4hea	NADH-QUINONE OXIDOREDUCTASE SUBUNIT 13 (Thermus thermophilus)	4 / 8	LEU M 115 ALA M 166 SER M 170 SER M 172	None	1.04A	3rodA-4heaM: undetectable	3rodA-4heaM: 20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3ROZ_A_NCAA266_0 (APOLIPOPROTEIN A-I-BINDING PROTEIN)	4hea	NADH-QUINONE OXIDOREDUCTASE SUBUNIT 13 (Thermus thermophilus)	4 / 6	ASP M 114 LEU M 176 ALA M  59 LEU M  56	None	1.06A	3rozA-4heaM: undetectable	3rozA-4heaM: 19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3SI7_C_ACTC4_0 (CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR)	4hea	NADH-QUINONE OXIDOREDUCTASE SUBUNIT 12 (Thermus thermophilus)	4 / 4	GLY L 401 GLY L 399 THR L 392 LEU L 308	None	0.78A	3si7C-4heaL: undetectable 3si7D-4heaL: undetectable	3si7C-4heaL: 19.97 3si7D-4heaL: 19.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3SI7_D_ACTD4_0 (CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR)	4hea	NADH-QUINONE OXIDOREDUCTASE SUBUNIT 14 (Thermus thermophilus)	4 / 5	LEU N 334 LEU N 376 GLY N 377 GLY N 379	None	0.80A	3si7C-4heaN: undetectable 3si7D-4heaN: undetectable	3si7C-4heaN: 18.97 3si7D-4heaN: 18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3SUF_A_SUEA1201_1 (NS3 PROTEASE, NS4A PROTEIN)	4hea	NADH-QUINONE OXIDOREDUCTASE SUBUNIT 14 (Thermus thermophilus)	5 / 12	ARG N 354 LEU N 361 GLY N 359 ALA N 355 ALA N 352	None	0.99A	3sufA-4heaN: undetectable	3sufA-4heaN: 20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3T3Z_A_9PLA501_1 (CYTOCHROME P450 2E1)	4hea	NADH-QUINONE OXIDOREDUCTASE SUBUNIT 14 (Thermus thermophilus)	4 / 6	PHE N 326 LEU N 257 ALA N 311 LEU N 299	None	1.00A	3t3zA-4heaN: undetectable	3t3zA-4heaN: 23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3T3Z_B_9PLB501_1 (CYTOCHROME P450 2E1)	4hea	NADH-QUINONE OXIDOREDUCTASE SUBUNIT 14 (Thermus thermophilus)	4 / 6	PHE N 326 LEU N 257 ALA N 311 LEU N 299	None	0.98A	3t3zB-4heaN: undetectable	3t3zB-4heaN: 23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3T3Z_D_9PLD501_1 (CYTOCHROME P450 2E1)	4hea	NADH-QUINONE OXIDOREDUCTASE SUBUNIT 14 (Thermus thermophilus)	4 / 6	PHE N 326 LEU N 257 ALA N 311 LEU N 299	None	1.00A	3t3zD-4heaN: undetectable	3t3zD-4heaN: 23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3TBG_A_RTZA1_1 (CYTOCHROME P450 2D6)	4hea	NADH-QUINONE OXIDOREDUCTASE SUBUNIT 13 (Thermus thermophilus)	5 / 12	LEU M  67 LEU M  70 GLY M 108 LEU M 109 PHE M  65	None	1.25A	3tbgA-4heaM: undetectable	3tbgA-4heaM: 24.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3TBG_A_RTZA1_1 (CYTOCHROME P450 2D6)	4hea	NADH-QUINONE OXIDOREDUCTASE SUBUNIT 13 NADH-QUINONE OXIDOREDUCTASE SUBUNIT 14 (Thermus thermophilus)	5 / 12	LEU N 334 LEU M 160 PHE M 122 SER M 156 PHE N 349	None	1.32A	3tbgA-4heaN: undetectable	3tbgA-4heaN: 24.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3TBG_C_RTZC1_1 (CYTOCHROME P450 2D6)	4hea	NADH-QUINONE OXIDOREDUCTASE SUBUNIT 13 (Thermus thermophilus)	5 / 12	LEU M  67 LEU M  70 GLY M 108 LEU M 109 PHE M  65	None	1.27A	3tbgC-4heaM: undetectable	3tbgC-4heaM: 24.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3THR_A_C2FA1100_0 (GLYCINE N-METHYLTRANSFERASE)	4hea	NADH-QUINONE OXIDOREDUCTASE SUBUNIT 14 (Thermus thermophilus)	4 / 6	SER N 100 LEU N  98 MET N 107 ARG N 225	None	1.24A	3thrB-4heaN: undetectable	3thrB-4heaN: 21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3U9F_B_CLMB221_0 (CHLORAMPHENICOL ACETYLTRANSFERASE)	4hea	NADH-QUINONE OXIDOREDUCTASE SUBUNIT 14 (Thermus thermophilus)	5 / 12	SER N 262 TYR N 288 LEU N 299 VAL N 298 PHE N 326	None	1.29A	3u9fB-4heaN: undetectable 3u9fC-4heaN: undetectable	3u9fB-4heaN: 16.36 3u9fC-4heaN: 16.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3U9F_H_CLMH221_0 (CHLORAMPHENICOL ACETYLTRANSFERASE)	4hea	NADH-QUINONE OXIDOREDUCTASE SUBUNIT 14 (Thermus thermophilus)	5 / 12	SER N 262 TYR N 288 LEU N 299 VAL N 298 PHE N 326	None	1.35A	3u9fH-4heaN: undetectable 3u9fI-4heaN: undetectable	3u9fH-4heaN: 16.36 3u9fI-4heaN: 16.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3U9F_J_CLMJ221_0 (CHLORAMPHENICOL ACETYLTRANSFERASE)	4hea	NADH-QUINONE OXIDOREDUCTASE SUBUNIT 14 (Thermus thermophilus)	5 / 12	SER N 262 TYR N 288 LEU N 299 VAL N 298 PHE N 326	None	1.33A	3u9fJ-4heaN: undetectable 3u9fK-4heaN: undetectable	3u9fJ-4heaN: 16.36 3u9fK-4heaN: 16.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3U9F_K_CLMK221_0 (CHLORAMPHENICOL ACETYLTRANSFERASE)	4hea	NADH-QUINONE OXIDOREDUCTASE SUBUNIT 14 (Thermus thermophilus)	5 / 10	SER N 262 TYR N 288 LEU N 299 VAL N 298 PHE N 326	None	1.26A	3u9fK-4heaN: undetectable	3u9fK-4heaN: 16.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3U9F_L_CLML221_0 (CHLORAMPHENICOL ACETYLTRANSFERASE)	4hea	NADH-QUINONE OXIDOREDUCTASE SUBUNIT 14 (Thermus thermophilus)	5 / 12	SER N 262 TYR N 288 LEU N 299 VAL N 298 PHE N 326	None	1.29A	3u9fJ-4heaN: undetectable 3u9fL-4heaN: undetectable	3u9fJ-4heaN: 16.36 3u9fL-4heaN: 16.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3U9F_P_CLMP221_0 (CHLORAMPHENICOL ACETYLTRANSFERASE)	4hea	NADH-QUINONE OXIDOREDUCTASE SUBUNIT 14 (Thermus thermophilus)	5 / 9	SER N 262 TYR N 288 LEU N 299 VAL N 298 PHE N 326	None	1.30A	3u9fP-4heaN: undetectable	3u9fP-4heaN: 16.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3U9F_R_CLMR221_0 (CHLORAMPHENICOL ACETYLTRANSFERASE)	4hea	NADH-QUINONE OXIDOREDUCTASE SUBUNIT 14 (Thermus thermophilus)	5 / 10	SER N 262 TYR N 288 LEU N 299 VAL N 298 PHE N 326	None	1.34A	3u9fR-4heaN: undetectable	3u9fR-4heaN: 16.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3U9F_S_CLMS221_0 (CHLORAMPHENICOL ACETYLTRANSFERASE)	4hea	NADH-QUINONE OXIDOREDUCTASE SUBUNIT 14 (Thermus thermophilus)	5 / 12	SER N 262 TYR N 288 LEU N 299 VAL N 298 PHE N 326	None	1.33A	3u9fP-4heaN: undetectable 3u9fS-4heaN: undetectable	3u9fP-4heaN: 16.36 3u9fS-4heaN: 16.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3UCB_B_017B202_1 (PROTEASE)	4hea	NADH-QUINONE OXIDOREDUCTASE SUBUNIT 14 (Thermus thermophilus)	4 / 7	PRO N 304 ARG N 392 GLY N 394 PRO N 395	None	1.12A	3ucbB-4heaN: undetectable	3ucbB-4heaN: 13.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3VW1_B_CVIB301_0 (PUTATIVE REGULATORY PROTEIN)	4hea	NADH-QUINONE OXIDOREDUCTASE SUBUNIT 13 (Thermus thermophilus)	5 / 12	LEU M 233 SER M 318 ALA M  86 LEU M 327 LEU M 357	None	1.45A	3vw1B-4heaM: 2.4	3vw1B-4heaM: 22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3VW7_A_VPXA2001_1 (PROTEINASE-ACTIVATED RECEPTOR 1, LYSOZYME)	4hea	NADH-QUINONE OXIDOREDUCTASE SUBUNIT 12 (Thermus thermophilus)	5 / 12	TYR L 124 LEU L 176 LEU L 263 LEU L 252 ALA L 310	None	1.16A	3vw7A-4heaL: 3.0	3vw7A-4heaL: 22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3WRI_A_CAMA502_0 (CAMPHOR 5-MONOOXYGENASE)	4hea	NADH-QUINONE OXIDOREDUCTASE SUBUNIT 12 NADH-QUINONE OXIDOREDUCTASE SUBUNIT 13 (Thermus thermophilus; Thermus thermophilus)	4 / 5	LEU L 211 GLY L 168 ILE M 400 VAL M 399	None	0.83A	3wriA-4heaL: undetectable	3wriA-4heaL: 21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4DC3_A_ADNA401_2 (ADENOSINE KINASE)	4hea	NADH-QUINONE OXIDOREDUCTASE SUBUNIT 12 (Thermus thermophilus)	4 / 4	LEU L 252 ILE L 270 GLY L 249 PHE L 210	None	1.06A	4dc3A-4heaL: undetectable	4dc3A-4heaL: 20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4DXU_A_ACAA711_1 (LACTOTRANSFERRIN)	4hea	NADH-QUINONE OXIDOREDUCTASE SUBUNIT 13 (Thermus thermophilus)	4 / 6	GLY M 225 VAL M  91 PRO M 223 GLY M 137	None	0.83A	4dxuA-4heaM: undetectable	4dxuA-4heaM: 20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4GC9_A_SAMA401_0 (DIMETHYLADENOSINE TRANSFERASE 1, MITOCHONDRIAL)	4hea	NADH-QUINONE OXIDOREDUCTASE SUBUNIT 13 (Thermus thermophilus)	5 / 12	GLY M 311 GLY M 376 PRO M 375 VAL M 238 LEU M 312	None	1.05A	4gc9A-4heaM: undetectable	4gc9A-4heaM: 22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4IKI_B_IMNB201_1 (TRANSTHYRETIN)	4hea	NADH-QUINONE OXIDOREDUCTASE SUBUNIT 11 (Thermus thermophilus)	4 / 6	LEU K   5 ALA K   8 LEU K   4 SER K  41	None	1.03A	4ikiB-4heaK: undetectable	4ikiB-4heaK: 20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4IKI_B_IMNB201_1 (TRANSTHYRETIN)	4hea	NADH-QUINONE OXIDOREDUCTASE SUBUNIT 13 (Thermus thermophilus)	4 / 6	LEU M 260 ALA M 297 LEU M 263 SER M 267	None	0.94A	4ikiB-4heaM: undetectable	4ikiB-4heaM: 13.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4IKL_A_SUZA201_1 (TRANSTHYRETIN)	4hea	NADH-QUINONE OXIDOREDUCTASE SUBUNIT 13 (Thermus thermophilus)	4 / 7	LEU M 260 ALA M 297 LEU M 263 SER M 267	None	0.94A	4iklA-4heaM: undetectable 4iklB-4heaM: undetectable	4iklA-4heaM: 13.33 4iklB-4heaM: 13.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4LB2_B_DM5B602_1 (SERUM ALBUMIN)	4hea	NADH-QUINONE OXIDOREDUCTASE SUBUNIT 13 NADH-QUINONE OXIDOREDUCTASE SUBUNIT 14 (Thermus thermophilus)	5 / 9	PRO M 158 VAL N 366 ALA N 364 PHE N 349 TYR N 346	None	1.50A	4lb2B-4heaM: 2.2	4lb2B-4heaM: 20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4M11_D_MXMD606_1 (PROSTAGLANDIN G/H SYNTHASE 2)	4hea	NADH-QUINONE OXIDOREDUCTASE SUBUNIT 12 NADH-QUINONE OXIDOREDUCTASE SUBUNIT 13 (Thermus thermophilus)	5 / 12	ILE M 400 VAL M 399 LEU L 167 VAL M 295 LEU M 269	None	1.38A	4m11D-4heaM: undetectable	4m11D-4heaM: 21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4NED_A_PFNA709_1 (LACTOTRANSFERRIN)	4hea	NADH-QUINONE OXIDOREDUCTASE SUBUNIT 13 (Thermus thermophilus)	4 / 6	VAL M 120 SER M 156 ALA M 240 PHE M 239	None	1.21A	4nedA-4heaM: undetectable	4nedA-4heaM: 21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4O33_A_TZNA501_1 (PHOSPHOGLYCERATE KINASE 1)	4hea	NADH-QUINONE OXIDOREDUCTASE SUBUNIT 12 NADH-QUINONE OXIDOREDUCTASE SUBUNIT 14 (Thermus thermophilus)	5 / 12	GLY L 566 GLY L 569 GLY L 568 THR N 367 LEU L 574	None	0.83A	4o33A-4heaL: undetectable	4o33A-4heaL: 22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4O3F_A_TZNA501_1 (PHOSPHOGLYCERATE KINASE 1)	4hea	NADH-QUINONE OXIDOREDUCTASE SUBUNIT 12 NADH-QUINONE OXIDOREDUCTASE SUBUNIT 14 (Thermus thermophilus)	5 / 12	GLY L 566 GLY L 569 GLY L 568 THR N 367 LEU L 574	None	0.80A	4o3fA-4heaL: undetectable	4o3fA-4heaL: 22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4QA2_A_SHHA404_2 (HISTONE DEACETYLASE 8)	4hea	NADH-QUINONE OXIDOREDUCTASE SUBUNIT 12 (Thermus thermophilus)	3 / 3	PRO L 125 MET L 127 TYR L 124	None	0.94A	4qa2B-4heaL: undetectable	4qa2B-4heaL: 19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4QZT_C_RTLC201_0 (RETINOL-BINDING PROTEIN 2)	4hea	NADH-QUINONE OXIDOREDUCTASE SUBUNIT 14 (Thermus thermophilus)	5 / 12	PHE N 326 ALA N 295 TYR N 374 SER N 261 LEU N 257	None	1.46A	4qztC-4heaN: undetectable	4qztC-4heaN: 13.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4RKU_A_PQNA5001_1 (PHOTOSYSTEM I P700 CHLOROPHYLL A APOPROTEIN A1 PHOTOSYSTEM I REACTION CENTER SUBUNIT IX)	4hea	NADH-QUINONE OXIDOREDUCTASE SUBUNIT 12 (Thermus thermophilus)	4 / 8	SER L 453 ALA L 335 LEU L 332 PHE L 517	None	1.03A	4rkuA-4heaL: 3.3 4rkuJ-4heaL: undetectable	4rkuA-4heaL: 23.80 4rkuJ-4heaL: 7.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4RN6_A_15UA301_1 (THROMBIN HEAVY CHAIN)	4hea	NADH-QUINONE OXIDOREDUCTASE SUBUNIT 12 NADH-QUINONE OXIDOREDUCTASE SUBUNIT 13 (Thermus thermophilus)	5 / 10	LEU L 209 LEU M 381 ALA M 393 ALA L 174 GLY L 168	None	1.06A	4rn6A-4heaL: undetectable	4rn6A-4heaL: 16.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4RP8_C_ASCC501_1 (ASCORBATE-SPECIFIC PERMEASE IIC COMPONENT ULAA)	4hea	NADH-QUINONE OXIDOREDUCTASE SUBUNIT 12 (Thermus thermophilus)	3 / 3	SER L  73 TYR L 251 ASP L 122	None	0.81A	4rp8C-4heaL: 2.7	4rp8C-4heaL: 23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4U8V_B_MIYB1103_1 (MULTIDRUG EFFLUX PUMP SUBUNIT ACRB)	4hea	NADH-QUINONE OXIDOREDUCTASE SUBUNIT 13 (Thermus thermophilus)	5 / 12	GLY M 237 ALA M 297 PHE M 301 VAL M 300 PHE M 242	None	1.15A	4u8vB-4heaM: 1.6	4u8vB-4heaM: 21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4U8Y_B_MIYB1102_1 (MULTIDRUG EFFLUX PUMP SUBUNIT ACRB)	4hea	NADH-QUINONE OXIDOREDUCTASE SUBUNIT 13 (Thermus thermophilus)	5 / 12	GLY M 237 ALA M 297 PHE M 301 VAL M 300 PHE M 242	None	1.13A	4u8yB-4heaM: undetectable	4u8yB-4heaM: 21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4UBE_A_2FAA401_2 (ADENOSINE KINASE)	4hea	NADH-QUINONE OXIDOREDUCTASE SUBUNIT 13 (Thermus thermophilus)	4 / 4	ALA M 264 VAL M 300 GLY M 310 THR M 380	None	0.87A	4ubeA-4heaM: undetectable	4ubeA-4heaM: 24.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4WG0_B_CHDB102_0 (NUCLEAR RECEPTOR COACTIVATOR 2)	4hea	NADH-QUINONE OXIDOREDUCTASE SUBUNIT 14 (Thermus thermophilus)	5 / 11	LEU N 365 LEU N 361 GLU N 351 LEU N 271 TYR N 268	None	1.13A	4wg0B-4heaN: undetectable 4wg0C-4heaN: undetectable 4wg0D-4heaN: undetectable	4wg0B-4heaN: 3.75 4wg0C-4heaN: 3.75 4wg0D-4heaN: 3.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4WG0_J_CHDJ103_0 (NUCLEAR RECEPTOR COACTIVATOR 2)	4hea	NADH-QUINONE OXIDOREDUCTASE SUBUNIT 14 (Thermus thermophilus)	5 / 11	LEU N 365 LEU N 361 GLU N 351 LEU N 271 TYR N 268	None	1.07A	4wg0J-4heaN: undetectable 4wg0K-4heaN: undetectable 4wg0L-4heaN: undetectable	4wg0J-4heaN: 3.75 4wg0K-4heaN: 3.75 4wg0L-4heaN: 3.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4WNV_A_QI9A602_0 (CYTOCHROME P450 2D6)	4hea	NADH-QUINONE OXIDOREDUCTASE SUBUNIT 12 (Thermus thermophilus)	5 / 9	PHE L 425 LEU L 355 GLU L 437 VAL L 339 LEU L 443	None	1.32A	4wnvA-4heaL: 1.9	4wnvA-4heaL: 22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4XUM_B_IMNB501_1 (PEROXISOME PROLIFERATOR-ACTIVAT ED RECEPTOR GAMMA)	4hea	NADH-QUINONE OXIDOREDUCTASE SUBUNIT 12 (Thermus thermophilus)	5 / 11	GLY L 249 ALA L 243 ILE L  79 LEU L 116 MET L 127	None	1.13A	4xumB-4heaL: undetectable	4xumB-4heaL: 18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4Y4D_A_CFFA411_1 (ENDOTHIAPEPSIN)	4hea	NADH-QUINONE OXIDOREDUCTASE SUBUNIT 13 (Thermus thermophilus)	4 / 6	LEU M  70 PHE M 239 ILE M 246 PHE M 242	None	1.26A	4y4dA-4heaM: undetectable	4y4dA-4heaM: 22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5A06_C_SORC1341_0 (ALDOSE-ALDOSE OXIDOREDUCTASE)	4hea	NADH-QUINONE OXIDOREDUCTASE SUBUNIT 12 (Thermus thermophilus)	4 / 7	ARG L 103 PHE L 139 TYR L 146 TYR L 107	None	1.50A	5a06C-4heaL: undetectable	5a06C-4heaL: 20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5BOJ_B_4TXB201_1 (TRANSTHYRETIN)	4hea	NADH-QUINONE OXIDOREDUCTASE SUBUNIT 14 (Thermus thermophilus)	4 / 7	THR N 123 ALA N 120 LEU N 116 SER N 115	None	1.02A	5bojB-4heaN: undetectable	5bojB-4heaN: 14.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5DX3_A_ESTA601_1 (ESTROGEN RECEPTOR)	4hea	NADH-QUINONE OXIDOREDUCTASE SUBUNIT 13 NADH-QUINONE OXIDOREDUCTASE SUBUNIT 14 (Thermus thermophilus)	5 / 10	LEU N 376 ALA N 372 LEU M 150 GLY M 155 LEU M 157	None	1.13A	5dx3A-4heaN: undetectable	5dx3A-4heaN: 21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5ECO_A_LEUA602_0 (JASMONIC ACID-AMIDO SYNTHETASE JAR1)	4hea	NADH-QUINONE OXIDOREDUCTASE SUBUNIT 14 (Thermus thermophilus)	4 / 6	THR N 196 VAL N 199 TYR N 200 HIS N 193	None	0.97A	5ecoA-4heaN: undetectable	5ecoA-4heaN: 19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5HHJ_A_GLYA403_0 (RETRON-TYPE REVERSE TRANSCRIPTASE)	4hea	NADH-QUINONE OXIDOREDUCTASE SUBUNIT 7 (Thermus thermophilus)	4 / 4	LEU A  70 LEU A 103 GLY A 106 GLU A 110	None	1.04A	5hhjA-4heaA: undetectable	5hhjA-4heaA: 16.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5I73_A_68PA701_1 (SODIUM-DEPENDENT SEROTONIN TRANSPORTER)	4hea	NADH-QUINONE OXIDOREDUCTASE SUBUNIT 14 (Thermus thermophilus)	6 / 12	ALA N 372 TYR N 374 GLY N 335 LEU N 336 GLY N 244 VAL N 241	None	1.15A	5i73A-4heaN: 3.1	5i73A-4heaN: 25.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5I75_A_68PA701_1 (SODIUM-DEPENDENT SEROTONIN TRANSPORTER)	4hea	NADH-QUINONE OXIDOREDUCTASE SUBUNIT 14 (Thermus thermophilus)	5 / 12	ALA N 372 GLY N 335 LEU N 336 GLY N 244 VAL N 241	None	1.06A	5i75A-4heaN: 2.4	5i75A-4heaN: 25.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5I75_A_68PA701_1 (SODIUM-DEPENDENT SEROTONIN TRANSPORTER)	4hea	NADH-QUINONE OXIDOREDUCTASE SUBUNIT 14 (Thermus thermophilus)	5 / 12	ALA N 372 TYR N 374 GLY N 335 LEU N 336 GLY N 244	None	1.00A	5i75A-4heaN: 2.4	5i75A-4heaN: 25.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5IMS_A_ACTA708_0 (ACETOLACTATE SYNTHASE CATALYTIC SUBUNIT, MITOCHONDRIAL)	4hea	NADH-QUINONE OXIDOREDUCTASE SUBUNIT 12 (Thermus thermophilus)	3 / 3	GLY L 375 GLY L 374 GLN L 302	None	0.41A	5imsA-4heaL: undetectable	5imsA-4heaL: 21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5JGL_A_SAMA301_0 (UBIE/COQ5 FAMILY METHYLTRANSFERASE, PUTATIVE)	4hea	NADH-QUINONE OXIDOREDUCTASE SUBUNIT 13 (Thermus thermophilus)	5 / 12	ALA M 166 LEU M 164 LEU M 116 ALA M 249 PHE M 194	None	1.31A	5jglA-4heaM: undetectable	5jglA-4heaM: 20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5KIR_A_RCXA601_1 (PROSTAGLANDIN G/H SYNTHASE 2)	4hea	NADH-QUINONE OXIDOREDUCTASE SUBUNIT 14 (Thermus thermophilus)	5 / 12	LEU N 290 ALA N 401 ALA N 329 SER N 332 LEU N 333	None	1.09A	5kirA-4heaN: undetectable	5kirA-4heaN: 20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5LF3_K_BO2K305_1 (PROTEASOME SUBUNIT BETA TYPE-5 PROTEASOME SUBUNIT BETA TYPE-1)	4hea	NADH-QUINONE OXIDOREDUCTASE SUBUNIT 12 (Thermus thermophilus)	5 / 11	ALA L 174 ALA L 205 GLY L 181 ALA L 178 TYR L 124	None	1.03A	5lf3K-4heaL: undetectable 5lf3L-4heaL: undetectable	5lf3K-4heaL: 15.53 5lf3L-4heaL: 16.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5LF3_Y_BO2Y305_1 (PROTEASOME SUBUNIT BETA TYPE-5 PROTEASOME SUBUNIT BETA TYPE-1)	4hea	NADH-QUINONE OXIDOREDUCTASE SUBUNIT 12 (Thermus thermophilus)	5 / 11	ALA L 174 ALA L 205 GLY L 181 ALA L 178 TYR L 124	None	1.03A	5lf3Y-4heaL: undetectable 5lf3Z-4heaL: undetectable	5lf3Y-4heaL: 15.53 5lf3Z-4heaL: 16.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5LJB_A_RTLA201_1 (RETINOL-BINDING PROTEIN 1)	4hea	NADH-QUINONE OXIDOREDUCTASE SUBUNIT 13 (Thermus thermophilus)	4 / 8	LEU M 285 LEU M 361 ILE M  78 THR M  81	None	0.98A	5ljbA-4heaM: undetectable	5ljbA-4heaM: 13.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5NWV_A_ACAA18_2 (SCRFP-TAG,GP41)	4hea	NADH-QUINONE OXIDOREDUCTASE SUBUNIT 12 (Thermus thermophilus)	4 / 7	GLN L 582 LEU L 592 ALA L 597 LEU L 600	None	1.12A	5nwvA-4heaL: undetectable	5nwvA-4heaL: 4.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5O96_G_SAMG501_0 (RIBOSOMAL RNA SMALL SUBUNIT METHYLTRANSFERASE E)	4hea	NADH-QUINONE OXIDOREDUCTASE SUBUNIT 13 (Thermus thermophilus)	5 / 11	LEU M 312 GLY M 310 GLY M 376 LEU M  70 ARG M 452	None	0.86A	5o96G-4heaM: undetectable	5o96G-4heaM: 20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5OY0_2_PQN2843_1 (PHOTOSYSTEM I P700 CHLOROPHYLL A APOPROTEIN A2)	4hea	NADH-QUINONE OXIDOREDUCTASE SUBUNIT 12 (Thermus thermophilus)	5 / 12	TRP L 316 MET L  76 PHE L  75 ALA L 478 LEU L 473	None	1.27A	5oy02-4heaL: 3.3	5oy02-4heaL: 11.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5SYE_B_TA1B502_1 (TUBULIN BETA CHAIN)	4hea	NADH-QUINONE OXIDOREDUCTASE SUBUNIT 13 (Thermus thermophilus)	5 / 12	GLU M  92 VAL M  91 LEU M 106 ALA M 227 GLY M 324	None	1.17A	5syeB-4heaM: undetectable	5syeB-4heaM: 21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5TOA_A_ESTA601_1 (ESTROGEN RECEPTOR BETA)	4hea	NADH-QUINONE OXIDOREDUCTASE SUBUNIT 12 (Thermus thermophilus)	5 / 12	LEU L 116 LEU L  67 LEU L  69 LEU L  47 LEU L   8	None	0.96A	5toaA-4heaL: undetectable	5toaA-4heaL: 18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5TZO_A_7V7A202_1 (ENDO-1,4-BETA-XYLANA SE A)	4hea	NADH-QUINONE OXIDOREDUCTASE SUBUNIT 13 (Thermus thermophilus)	5 / 12	SER M 267 ALA M 296 PRO M 209 ALA M 297 GLY M 294	None	1.33A	5tzoA-4heaM: undetectable	5tzoA-4heaM: 18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5TZO_C_7V7C201_1 (ENDO-1,4-BETA-XYLANA SE A)	4hea	NADH-QUINONE OXIDOREDUCTASE SUBUNIT 13 (Thermus thermophilus)	5 / 12	SER M 267 ALA M 296 PRO M 209 ALA M 297 GLY M 294	None	1.33A	5tzoC-4heaM: undetectable	5tzoC-4heaM: 18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5UC1_A_486A801_1 (GLUCOCORTICOID RECEPTOR)	4hea	NADH-QUINONE OXIDOREDUCTASE SUBUNIT 13 (Thermus thermophilus)	5 / 12	LEU M 328 LEU M 325 GLY M 324 GLY M 323 VAL M 320	None	0.89A	5uc1A-4heaM: 2.1	5uc1A-4heaM: 10.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5UC1_B_486B801_2 (GLUCOCORTICOID RECEPTOR)	4hea	NADH-QUINONE OXIDOREDUCTASE SUBUNIT 13 (Thermus thermophilus)	5 / 12	LEU M 328 LEU M 325 GLY M 324 GLY M 323 VAL M 320	None	0.93A	5uc1B-4heaM: undetectable	5uc1B-4heaM: 10.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5VKQ_A_PCFA1808_0 (NO MECHANORECEPTOR POTENTIAL C ISOFORM L)	4hea	NADH-QUINONE OXIDOREDUCTASE SUBUNIT 12 (Thermus thermophilus)	4 / 5	LEU L 201 ALA L 205 LEU L 208 LEU L 259	None	0.86A	5vkqA-4heaL: 5.5 5vkqD-4heaL: 5.5	5vkqA-4heaL: 17.30 5vkqD-4heaL: 17.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5YN6_A_SAMA401_0 (NSP16 PROTEIN)	4hea	NADH-QUINONE OXIDOREDUCTASE SUBUNIT 13 (Thermus thermophilus)	5 / 12	PRO M  44 GLY M  45 ASN M  36 ASP M  68 PHE M 239	None	1.08A	5yn6A-4heaM: undetectable	5yn6A-4heaM: 20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5YOD_D_BEZD201_0 (NS3 PROTEASE)	4hea	NADH-QUINONE OXIDOREDUCTASE SUBUNIT 13 (Thermus thermophilus)	4 / 5	HIS M 222 ALA M  89 SER M 224 GLY M 225	None	1.14A	5yodD-4heaM: undetectable	5yodD-4heaM: 16.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6AYB_A_KKKA508_1 (CYP51, STEROL 14ALPHA-DEMETHYLASE)	4hea	NADH-QUINONE OXIDOREDUCTASE SUBUNIT 13 (Thermus thermophilus)	5 / 12	PHE M 118 ALA M 227 ALA M 229 THR M  81 LEU M 106	None	1.22A	6aybA-4heaM: undetectable	6aybA-4heaM: 21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6F88_A_STRA502_1 (CYTOCHROME P450 CYP260A1)	4hea	NADH-QUINONE OXIDOREDUCTASE SUBUNIT 13 (Thermus thermophilus)	4 / 6	PHE M 396 ALA M 395 SER M 388 THR M 304	None	0.96A	6f88A-4heaM: undetectable	6f88A-4heaM: 10.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6MDQ_A_TESA604_0 (SERUM ALBUMIN)	4hea	NADH-QUINONE OXIDOREDUCTASE SUBUNIT 13 NADH-QUINONE OXIDOREDUCTASE SUBUNIT 14 (Thermus thermophilus; Thermus thermophilus)	4 / 8	ARG M 143 GLY N 377 LEU N 376 ALA N 372	None	0.79A	6mdqA-4heaM: undetectable	6mdqA-4heaM: 9.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6MVX_A_K4DA1304_0 (ION TRANSPORT PROTEIN)	4hea	NADH-QUINONE OXIDOREDUCTASE SUBUNIT 14 (Thermus thermophilus)	4 / 6	THR N  73 LEU N  76 THR N 213 LEU N 299	None	1.22A	6mvxA-4heaN: 4.4 6mvxB-4heaN: undetectable 6mvxC-4heaN: undetectable	6mvxA-4heaN: 19.54 6mvxB-4heaN: 19.54 6mvxC-4heaN: 19.54