SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4heh'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FKO_A_EFZA999_1
(HIV-1 RT, A-CHAIN)		 4heh APPA PROTEIN
(Rhodobacter
sphaeroides) 		5 / 10 LEU A 394
VAL A 300
VAL A 273
GLY A 301
LEU A 390
 None
 1.39A 1fkoA-4hehA:
undetectable		 1fkoA-4hehA:
17.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H9Z_A_RWFA3001_1
(SERUM ALBUMIN)		 4heh APPA PROTEIN
(Rhodobacter
sphaeroides) 		5 / 11 PHE A 224
ALA A 259
LEU A 198
SER A 200
ALA A 252
 None
 1.14A 1h9zA-4hehA:
3.4		 1h9zA-4hehA:
17.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_B_115B1_1
(HMG-COA REDUCTASE)		 4heh APPA PROTEIN
(Rhodobacter
sphaeroides) 		5 / 9 GLU A 289
LEU A 256
ALA A 252
LEU A 199
LEU A 235
 None
 1.34A 1hwiA-4hehA:
undetectable		 1hwiA-4hehA:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XDK_A_9CRA500_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4heh APPA PROTEIN
(Rhodobacter
sphaeroides) 		5 / 12 ALA A 368
GLN A 369
ALA A 385
VAL A 281
LEU A 344
 None
 1.11A 1xdkA-4hehA:
undetectable		 1xdkA-4hehA:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2KAW_A_SUZA91_1
(SEGMENT POLARITY
PROTEIN DISHEVELLED
HOMOLOG DVL-1)		 4heh APPA PROTEIN
(Rhodobacter
sphaeroides) 		5 / 11 GLY A 358
SER A 360
ILE A 361
VAL A 347
LEU A 350
 None
 1.03A 2kawA-4hehA:
undetectable		 2kawA-4hehA:
15.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO5_B_CHDB501_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4heh APPA PROTEIN
(Rhodobacter
sphaeroides) 		5 / 11 LEU A 319
LEU A 359
LEU A 394
VAL A 397
VAL A 329
 None
 1.34A 2po5B-4hehA:
6.5		 2po5B-4hehA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3APX_A_Z80A190_1
(ALPHA-1-ACID
GLYCOPROTEIN 2)		 4heh APPA PROTEIN
(Rhodobacter
sphaeroides) 		5 / 12 PHE A 384
VAL A 328
THR A 304
LEU A 260
ALA A 225
 None
 1.24A 3apxA-4hehA:
undetectable		 3apxA-4hehA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CWK_A_REAA300_1
(CELLULAR RETINOIC
ACID-BINDING PROTEIN
2)		 4heh APPA PROTEIN
(Rhodobacter
sphaeroides) 		5 / 12 LEU A 390
ALA A 293
PRO A 286
VAL A 281
VAL A 306
 None
 1.25A 3cwkA-4hehA:
undetectable		 3cwkA-4hehA:
18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LP1_A_NVPA701_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		 4heh APPA PROTEIN
(Rhodobacter
sphaeroides) 		5 / 10 LEU A 394
VAL A 300
VAL A 273
GLY A 301
LEU A 390
 None
 1.46A 3lp1A-4hehA:
undetectable		 3lp1A-4hehA:
16.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X30_A_T44A401_1
(THYROXINE-BINDING
GLOBULIN)		 4heh APPA PROTEIN
(Rhodobacter
sphaeroides) 		5 / 9 ALA A 218
LEU A 198
LEU A 214
LEU A 195
ARG A 194
 None
 1.43A 4x30A-4hehA:
undetectable		 4x30A-4hehA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B0C_D_TA1D502_1
(TUBULIN BETA CHAIN)		 4heh APPA PROTEIN
(Rhodobacter
sphaeroides) 		5 / 12 LEU A 359
LEU A 350
LEU A 327
THR A 326
GLY A 383
 None
 0.93A 6b0cD-4hehA:
4.0		 6b0cD-4hehA:
16.04