SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4hem'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCT_D_ASDD1223_1
(GLUTATHIONE
S-TRANSFERASE A2)		 4hem BPP
(Lactococcus
phage
TP901-1) 		4 / 7 TYR A  88
ILE A  90
GLY A 156
PHE A 132
 None
 0.97A 2vctD-4hemA:
undetectable		 2vctD-4hemA:
21.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QXT_A_MTXA2000_1
(ANTI-METHOTREXATE
CDR1-3 GRAFT VHH)		 4hem ANTI-BASEPLATE
TP901-1 LLAMA VHH 02
(Lama
glama) 		5 / 12 ALA E  24
MET E  34
ARG E  72
VAL E  79
ALA E  98
 None
 0.57A 3qxtA-4hemE:
23.2		 3qxtA-4hemE:
74.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QXT_B_MTXB2000_1
(ANTI-METHOTREXATE
CDR1-3 GRAFT VHH)		 4hem ANTI-BASEPLATE
TP901-1 LLAMA VHH 02
(Lama
glama) 		7 / 12 LEU E   4
ALA E  24
MET E  34
ARG E  72
VAL E  79
ALA E  98
TYR E 112
 None
 0.54A 3qxtB-4hemE:
23.4		 3qxtB-4hemE:
74.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QXV_A_MTXA2000_1
(ANTI-METHOTREXATE
CDR1-4 GRAFT VHH)		 4hem ANTI-BASEPLATE
TP901-1 LLAMA VHH 02
(Lama
glama) 		7 / 12 ALA E  24
MET E  34
ARG E  72
ASN E  74
VAL E  79
ALA E  98
TYR E 112
 None
 0.62A 3qxvA-4hemE:
23.0		 3qxvA-4hemE:
73.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QXV_B_MTXB2000_1
(ANTI-METHOTREXATE
CDR1-4 GRAFT VHH)		 4hem ANTI-BASEPLATE
TP901-1 LLAMA VHH 02
(Lama
glama) 		6 / 12 ALA E  24
MET E  34
ARG E  72
VAL E  79
ALA E  98
TYR E 112
 None
 0.68A 3qxvB-4hemE:
22.9		 3qxvB-4hemE:
73.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QXV_C_MTXC2000_1
(ANTI-METHOTREXATE
CDR1-4 GRAFT VHH)		 4hem ANTI-BASEPLATE
TP901-1 LLAMA VHH 02
(Lama
glama) 		6 / 11 ALA E  24
MET E  34
ARG E  72
ASN E  74
VAL E  79
ALA E  98
 None
 0.68A 3qxvC-4hemE:
23.2		 3qxvC-4hemE:
73.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QXV_D_MTXD2000_1
(ANTI-METHOTREXATE
CDR1-4 GRAFT VHH)		 4hem ANTI-BASEPLATE
TP901-1 LLAMA VHH 02
(Lama
glama) 		6 / 12 ALA E  24
MET E  34
ARG E  72
VAL E  79
ALA E  98
TYR E 112
 None
 0.64A 3qxvD-4hemE:
22.6		 3qxvD-4hemE:
73.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QXV_E_MTXE2000_1
(ANTI-METHOTREXATE
CDR1-4 GRAFT VHH)		 4hem ANTI-BASEPLATE
TP901-1 LLAMA VHH 02
(Lama
glama) 		6 / 12 ALA E  24
MET E  34
ARG E  72
VAL E  79
ALA E  98
TYR E 112
 None
 0.68A 3qxvE-4hemE:
19.7		 3qxvE-4hemE:
73.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FJ3_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4hem ANTI-BASEPLATE
TP901-1 LLAMA VHH 02
(Lama
glama) 		4 / 7 GLU E  26
SER E  25
VAL E   2
ARG E  72
 None
 1.45A 5fj3A-4hemE:
undetectable
5fj3B-4hemE:
undetectable		 5fj3A-4hemE:
17.17
5fj3B-4hemE:
17.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J4N_A_AG2A501_1
(ARGININE/AGMATINE
ANTIPORTER)		 4hem BPP
(Lactococcus
phage
TP901-1) 		4 / 6 SER A 102
GLY A  73
ILE A 134
TRP A 144
 None
 1.14A 5j4nA-4hemA:
undetectable		 5j4nA-4hemA:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VV7_B_H4BB502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4hem ANTI-BASEPLATE
TP901-1 LLAMA VHH 02
(Lama
glama) 		4 / 7 GLU E  26
SER E  25
VAL E   2
ARG E  72
 None
 1.44A 5vv7A-4hemE:
undetectable
5vv7B-4hemE:
undetectable		 5vv7A-4hemE:
17.17
5vv7B-4hemE:
17.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VVN_B_H4BB502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4hem ANTI-BASEPLATE
TP901-1 LLAMA VHH 02
(Lama
glama) 		4 / 7 GLU E  26
SER E  25
VAL E   2
ARG E  72
 None
 1.42A 5vvnA-4hemE:
undetectable
5vvnB-4hemE:
undetectable		 5vvnA-4hemE:
17.17
5vvnB-4hemE:
17.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6CJK_B_ACTB302_0
(IMMUNOGLOBULIN FAB
HEAVY CHAIN)		 4hem ANTI-BASEPLATE
TP901-1 LLAMA VHH 02
(Lama
glama) 		3 / 3 TYR E  60
GLY E  66
THR E  69
 None
 0.14A 6cjkB-4hemE:
18.6		 6cjkB-4hemE:
34.02