SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4het'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KYV_C_RBFC503_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 4het HYPOTHETICAL
GLYCOSIDE HYDROLASE
(Bacteroides
thetaiotaomicron) 		5 / 12 ILE A 371
LEU A 370
GLY A 247
LEU A 346
ILE A 344
 None
 1.07A 1kyvB-4hetA:
undetectable
1kyvC-4hetA:
undetectable		 1kyvB-4hetA:
17.78
1kyvC-4hetA:
17.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NPN_A_SAMA4633_0
(PUTATIVE COBALAMIN
SYNTHESIS RELATED
PROTEIN)		 4het HYPOTHETICAL
GLYCOSIDE HYDROLASE
(Bacteroides
thetaiotaomicron) 		5 / 9 THR A 362
GLY A 360
TYR A 257
THR A 195
LEU A 363
 None
 1.29A 2npnA-4hetA:
undetectable		 2npnA-4hetA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RHM_B_BEZB194_0
(PUTATIVE KINASE)		 4het HYPOTHETICAL
GLYCOSIDE HYDROLASE
(Bacteroides
thetaiotaomicron) 		4 / 5 PRO A 306
ILE A 304
ARG A 303
ASP A 272
 None
 1.02A 2rhmB-4hetA:
undetectable		 2rhmB-4hetA:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RHM_D_BEZD194_0
(PUTATIVE KINASE)		 4het HYPOTHETICAL
GLYCOSIDE HYDROLASE
(Bacteroides
thetaiotaomicron) 		4 / 5 PRO A 306
ILE A 304
ARG A 303
ASP A 272
 None
 0.98A 2rhmD-4hetA:
undetectable		 2rhmD-4hetA:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AY0_A_ADNA401_1
(UNCHARACTERIZED
PROTEIN MJ0883)		 4het HYPOTHETICAL
GLYCOSIDE HYDROLASE
(Bacteroides
thetaiotaomicron) 		5 / 10 ASN A 223
ALA A 231
VAL A 205
LEU A 167
PHE A 201
 None
 1.37A 3ay0A-4hetA:
undetectable		 3ay0A-4hetA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CB8_A_SAMA501_0
(PYRUVATE
FORMATE-LYASE
1-ACTIVATING ENZYME)		 4het HYPOTHETICAL
GLYCOSIDE HYDROLASE
(Bacteroides
thetaiotaomicron) 		5 / 12 ASP A 272
ARG A 303
VAL A 276
LEU A 301
TYR A 278
 None
 1.35A 3cb8A-4hetA:
undetectable		 3cb8A-4hetA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E7G_A_ACTA514_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 4het HYPOTHETICAL
GLYCOSIDE HYDROLASE
(Bacteroides
thetaiotaomicron) 		4 / 4 ALA A  59
VAL A  55
ASP A  38
LEU A  66
 None
 1.15A 4e7gA-4hetA:
undetectable		 4e7gA-4hetA:
24.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MS4_A_2C0A501_1
(GAMMA-AMINOBUTYRIC
ACID TYPE B RECEPTOR
SUBUNIT 1)		 4het HYPOTHETICAL
GLYCOSIDE HYDROLASE
(Bacteroides
thetaiotaomicron) 		4 / 8 SER A 347
SER A 349
ILE A 209
GLU A 194
 None
 1.26A 4ms4A-4hetA:
undetectable		 4ms4A-4hetA:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E72_A_SAMA400_0
(N2,
N2-DIMETHYLGUANOSINE
TRNA
METHYLTRANSFERASE)		 4het HYPOTHETICAL
GLYCOSIDE HYDROLASE
(Bacteroides
thetaiotaomicron) 		5 / 12 PHE A 322
GLY A 327
ALA A 275
PRO A 242
LEU A 370
 None
 1.03A 5e72A-4hetA:
undetectable		 5e72A-4hetA:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5F_H_BO2H301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 4het HYPOTHETICAL
GLYCOSIDE HYDROLASE
(Bacteroides
thetaiotaomicron) 		5 / 12 SER A  93
GLN A  64
ALA A  83
GLY A  84
ASP A  60
 None
 1.18A 5l5fH-4hetA:
undetectable
5l5fI-4hetA:
undetectable		 5l5fH-4hetA:
20.65
5l5fI-4hetA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5F_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 4het HYPOTHETICAL
GLYCOSIDE HYDROLASE
(Bacteroides
thetaiotaomicron) 		5 / 12 SER A  93
GLN A  64
ALA A  83
GLY A  84
ASP A  60
 None
 1.18A 5l5fV-4hetA:
undetectable
5l5fW-4hetA:
undetectable		 5l5fV-4hetA:
20.65
5l5fW-4hetA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5Z_H_BO2H301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 4het HYPOTHETICAL
GLYCOSIDE HYDROLASE
(Bacteroides
thetaiotaomicron) 		5 / 12 SER A  93
GLN A  64
ALA A  83
GLY A  84
ASP A  60
 None
 1.16A 5l5zH-4hetA:
undetectable
5l5zI-4hetA:
undetectable		 5l5zH-4hetA:
20.65
5l5zI-4hetA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5Z_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 4het HYPOTHETICAL
GLYCOSIDE HYDROLASE
(Bacteroides
thetaiotaomicron) 		5 / 12 SER A  93
GLN A  64
ALA A  83
GLY A  84
ASP A  60
 None
 1.18A 5l5zV-4hetA:
undetectable
5l5zW-4hetA:
undetectable		 5l5zV-4hetA:
20.65
5l5zW-4hetA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L66_H_BO2H301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 4het HYPOTHETICAL
GLYCOSIDE HYDROLASE
(Bacteroides
thetaiotaomicron) 		5 / 12 SER A  93
GLN A  64
ALA A  83
GLY A  84
ASP A  60
 None
 1.13A 5l66H-4hetA:
undetectable
5l66I-4hetA:
undetectable		 5l66H-4hetA:
20.65
5l66I-4hetA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L66_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 4het HYPOTHETICAL
GLYCOSIDE HYDROLASE
(Bacteroides
thetaiotaomicron) 		5 / 12 SER A  93
GLN A  64
ALA A  83
GLY A  84
ASP A  60
 None
 1.15A 5l66V-4hetA:
undetectable
5l66W-4hetA:
undetectable		 5l66V-4hetA:
20.65
5l66W-4hetA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M0I_B_ACTB303_0
(SWI5-DEPENDENT HO
EXPRESSION PROTEIN 2)		 4het HYPOTHETICAL
GLYCOSIDE HYDROLASE
(Bacteroides
thetaiotaomicron) 		4 / 5 VAL A 191
THR A 179
ASN A 162
LEU A 214
 None
 1.33A 5m0iB-4hetA:
undetectable		 5m0iB-4hetA:
22.92