SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4hfk'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_C_TRPC81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 4hfk PUTATIVE CYTOPLASMIC
PROTEIN
(Enterobacter
cloacae) 		5 / 10 GLY A 127
HIS A 142
ALA A 157
THR A 155
HIS A 120
 None
 1.39A 1c9sB-4hfkA:
undetectable
1c9sC-4hfkA:
undetectable		 1c9sB-4hfkA:
17.47
1c9sC-4hfkA:
17.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_I_TRPI81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))		 4hfk PUTATIVE CYTOPLASMIC
PROTEIN
(Enterobacter
cloacae) 		5 / 10 GLY A 127
HIS A 142
ALA A 157
THR A 155
HIS A 120
 None
 1.41A 1gtfH-4hfkA:
undetectable
1gtfI-4hfkA:
undetectable		 1gtfH-4hfkA:
17.47
1gtfI-4hfkA:
17.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_J_TRPJ81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))		 4hfk PUTATIVE CYTOPLASMIC
PROTEIN
(Enterobacter
cloacae) 		5 / 9 GLY A 127
HIS A 142
ALA A 157
THR A 155
HIS A 120
 None
 1.39A 1gtfI-4hfkA:
undetectable
1gtfJ-4hfkA:
undetectable		 1gtfI-4hfkA:
17.47
1gtfJ-4hfkA:
17.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_A_TRPA81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4hfk PUTATIVE CYTOPLASMIC
PROTEIN
(Enterobacter
cloacae) 		5 / 9 GLY A 127
HIS A 142
ALA A 157
THR A 155
HIS A 120
 None
 1.40A 1utdA-4hfkA:
undetectable
1utdB-4hfkA:
undetectable		 1utdA-4hfkA:
17.47
1utdB-4hfkA:
17.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O1Z_B_MXMB807_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 4hfk PUTATIVE CYTOPLASMIC
PROTEIN
(Enterobacter
cloacae) 		5 / 12 MET A  50
VAL A  53
LEU A  54
LEU A 131
ALA A  10
 None
 1.11A 4o1zB-4hfkA:
undetectable		 4o1zB-4hfkA:
15.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YV5_A_SVRA205_1
(BASIC PHOSPHOLIPASE
A2 HOMOLOG 2)		 4hfk PUTATIVE CYTOPLASMIC
PROTEIN
(Enterobacter
cloacae) 		4 / 7 ASN A  19
TYR A  52
TYR A  78
PHE A  80
 None
 1.12A 4yv5A-4hfkA:
undetectable		 4yv5A-4hfkA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YV5_B_SVRB207_2
(BASIC PHOSPHOLIPASE
A2 HOMOLOG 2)		 4hfk PUTATIVE CYTOPLASMIC
PROTEIN
(Enterobacter
cloacae) 		4 / 7 ASN A  19
TYR A  52
TYR A  78
PHE A  42
 None
 0.95A 4yv5B-4hfkA:
undetectable		 4yv5B-4hfkA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YV5_B_SVRB207_2
(BASIC PHOSPHOLIPASE
A2 HOMOLOG 2)		 4hfk PUTATIVE CYTOPLASMIC
PROTEIN
(Enterobacter
cloacae) 		4 / 7 ASN A  19
TYR A  52
TYR A  78
PHE A  80
 None
 1.18A 4yv5B-4hfkA:
undetectable		 4yv5B-4hfkA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEZ_J_TRPJ101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4hfk PUTATIVE CYTOPLASMIC
PROTEIN
(Enterobacter
cloacae) 		5 / 9 GLY A 127
HIS A 142
ALA A 157
THR A 155
HIS A 120
 None
 1.41A 5eezJ-4hfkA:
undetectable
5eezK-4hfkA:
undetectable		 5eezJ-4hfkA:
17.47
5eezK-4hfkA:
17.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF0_J_TRPJ101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4hfk PUTATIVE CYTOPLASMIC
PROTEIN
(Enterobacter
cloacae) 		5 / 9 GLY A 127
HIS A 142
ALA A 157
THR A 155
HIS A 120
 None
 1.41A 5ef0J-4hfkA:
undetectable
5ef0K-4hfkA:
undetectable		 5ef0J-4hfkA:
17.47
5ef0K-4hfkA:
17.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF1_J_TRPJ101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4hfk PUTATIVE CYTOPLASMIC
PROTEIN
(Enterobacter
cloacae) 		5 / 9 GLY A 127
HIS A 142
ALA A 157
THR A 155
HIS A 120
 None
 1.40A 5ef1J-4hfkA:
undetectable
5ef1K-4hfkA:
undetectable		 5ef1J-4hfkA:
17.47
5ef1K-4hfkA:
17.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF2_J_TRPJ101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4hfk PUTATIVE CYTOPLASMIC
PROTEIN
(Enterobacter
cloacae) 		5 / 9 GLY A 127
HIS A 142
ALA A 157
THR A 155
HIS A 120
 None
 1.40A 5ef2J-4hfkA:
undetectable
5ef2K-4hfkA:
undetectable		 5ef2J-4hfkA:
17.47
5ef2K-4hfkA:
17.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF3_J_TRPJ101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4hfk PUTATIVE CYTOPLASMIC
PROTEIN
(Enterobacter
cloacae) 		5 / 9 GLY A 127
HIS A 142
ALA A 157
THR A 155
HIS A 120
 None
 1.41A 5ef3J-4hfkA:
undetectable
5ef3K-4hfkA:
undetectable		 5ef3J-4hfkA:
17.47
5ef3K-4hfkA:
17.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EUM_B_ACTB603_0
(LIPID A EXPORT
ATP-BINDING/PERMEASE
PROTEIN MSBA)		 4hfk PUTATIVE CYTOPLASMIC
PROTEIN
(Enterobacter
cloacae) 		4 / 4 ALA A  45
ASN A  44
ARG A  49
ILE A  48
 None
 1.22A 5eumB-4hfkA:
undetectable		 5eumB-4hfkA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_C_ACRC607_0
(ALPHA-AMYLASE)		 4hfk PUTATIVE CYTOPLASMIC
PROTEIN
(Enterobacter
cloacae) 		4 / 6 GLY A 113
ASP A  97
GLY A 134
GLY A 110
 None
 0.73A 6ag0C-4hfkA:
undetectable		 6ag0C-4hfkA:
14.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GB9_A_ACTA508_0
(MOLYBDOPTERIN
BIOSYNTHESIS PROTEIN
CNX1)		 4hfk PUTATIVE CYTOPLASMIC
PROTEIN
(Enterobacter
cloacae) 		3 / 3 VAL A 100
ALA A 157
GLN A 107
 None
 0.68A 6gb9A-4hfkA:
undetectable		 6gb9A-4hfkA:
16.13