SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4hfn'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICV_A_NIOA704_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 4hfn ALLYL ALCOHOL
DEHYDROGENASE
(Nicotiana
tabacum) 		4 / 4 SER A 160
PHE A 228
GLU A 229
GLY A 253
 None
None
None
NAP  A 400 (-3.1A)
 1.35A 1icvA-4hfnA:
undetectable
1icvB-4hfnA:
undetectable		 1icvA-4hfnA:
22.49
1icvB-4hfnA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIA_C_SAMC2293_0
(GLYCINE
N-METHYLTRANSFERASE)		 4hfn ALLYL ALCOHOL
DEHYDROGENASE
(Nicotiana
tabacum) 		5 / 12 ILE A 120
GLY A 101
VAL A  82
GLY A 135
LEU A 283
 None
None
None
None
NAP  A 400 ( 4.3A)
 0.83A 1kiaC-4hfnA:
7.7		 1kiaC-4hfnA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBH_B_SAMB1293_0
(GLYCINE
N-METHYLTRANSFERASE)		 4hfn ALLYL ALCOHOL
DEHYDROGENASE
(Nicotiana
tabacum) 		5 / 12 ILE A 120
GLY A 101
VAL A  82
GLY A 135
LEU A 283
 None
None
None
None
NAP  A 400 ( 4.3A)
 0.83A 1nbhB-4hfnA:
7.3		 1nbhB-4hfnA:
21.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2W98_B_P1ZB1356_1
(PROSTAGLANDIN
REDUCTASE 2)		 4hfn ALLYL ALCOHOL
DEHYDROGENASE
(Nicotiana
tabacum) 		4 / 8 TYR A  55
TYR A 258
LEU A 283
VAL A 284
 CIY  A 401 (-4.5A)
NAP  A 400 ( 4.3A)
NAP  A 400 ( 4.3A)
NAP  A 400 (-3.6A)
 0.52A 2w98B-4hfnA:
43.6		 2w98B-4hfnA:
35.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2WEK_B_DIFB1376_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 4hfn ALLYL ALCOHOL
DEHYDROGENASE
(Nicotiana
tabacum) 		4 / 7 TYR A 206
VAL A 231
GLY A 233
MET A 235
 NAP  A 400 (-4.4A)
NAP  A 400 ( 4.5A)
None
None
 0.51A 2wekB-4hfnA:
36.4		 2wekB-4hfnA:
31.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2WEK_B_DIFB1376_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 4hfn ALLYL ALCOHOL
DEHYDROGENASE
(Nicotiana
tabacum) 		4 / 7 VAL A 231
GLY A 233
MET A 235
SER A 256
 NAP  A 400 ( 4.5A)
None
None
NAP  A 400 (-4.9A)
 0.36A 2wekB-4hfnA:
36.4		 2wekB-4hfnA:
31.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AF0_A_PAUA314_0
(PANTOTHENATE KINASE)		 4hfn ALLYL ALCOHOL
DEHYDROGENASE
(Nicotiana
tabacum) 		4 / 8 VAL A  82
LEU A 295
GLY A 135
TYR A 291
 None
 0.87A 3af0A-4hfnA:
undetectable		 3af0A-4hfnA:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOG_C_DHIC8_0
(6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN)		 4hfn ALLYL ALCOHOL
DEHYDROGENASE
(Nicotiana
tabacum) 		3 / 3 SER A 160
GLY A 232
GLY A 253
 None
None
NAP  A 400 (-3.1A)
 0.54A 3bogA-4hfnA:
undetectable
3bogC-4hfnA:
undetectable		 3bogA-4hfnA:
undetectable
3bogC-4hfnA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_N_TFPN201_1
(PROTEIN S100-A4)		 4hfn ALLYL ALCOHOL
DEHYDROGENASE
(Nicotiana
tabacum) 		5 / 10 GLY A 167
PHE A 228
GLY A 334
ILE A 255
PHE A 282
 None
None
None
NAP  A 400 (-3.8A)
NAP  A 400 (-4.6A)
 1.40A 3ko0L-4hfnA:
undetectable
3ko0N-4hfnA:
undetectable		 3ko0L-4hfnA:
14.83
3ko0N-4hfnA:
14.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q5S_A_ACHA1289_0
(MULTIDRUG-EFFLUX
TRANSPORTER 1
REGULATOR)		 4hfn ALLYL ALCOHOL
DEHYDROGENASE
(Nicotiana
tabacum) 		4 / 6 VAL A 239
ASN A 268
TYR A 227
GLU A 229
 None
 1.14A 3q5sA-4hfnA:
undetectable		 3q5sA-4hfnA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T7V_A_SAMA992_0
(METHYLORNITHINE
SYNTHASE PYLB)		 4hfn ALLYL ALCOHOL
DEHYDROGENASE
(Nicotiana
tabacum) 		5 / 12 GLY A  81
GLY A 104
GLN A 336
VAL A 338
ALA A 314
 None
 1.24A 3t7vA-4hfnA:
undetectable		 3t7vA-4hfnA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K36_A_SAMA504_0
(ANAEROBIC
SULFATASE-MATURATING
ENZYME)		 4hfn ALLYL ALCOHOL
DEHYDROGENASE
(Nicotiana
tabacum) 		5 / 12 TYR A 294
TYR A 130
GLU A 311
VAL A 298
ILE A 299
 None
 1.23A 4k36A-4hfnA:
undetectable		 4k36A-4hfnA:
23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K36_B_SAMB504_0
(ANAEROBIC
SULFATASE-MATURATING
ENZYME)		 4hfn ALLYL ALCOHOL
DEHYDROGENASE
(Nicotiana
tabacum) 		5 / 12 TYR A 294
TYR A 130
GLU A 311
VAL A 298
ILE A 299
 None
 1.21A 4k36B-4hfnA:
undetectable		 4k36B-4hfnA:
23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K37_A_SAMA504_0
(ANAEROBIC
SULFATASE-MATURATING
ENZYME)		 4hfn ALLYL ALCOHOL
DEHYDROGENASE
(Nicotiana
tabacum) 		5 / 11 TYR A 294
TYR A 130
GLU A 311
VAL A 298
ILE A 299
 None
 1.23A 4k37A-4hfnA:
undetectable		 4k37A-4hfnA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K37_B_SAMB504_0
(ANAEROBIC
SULFATASE-MATURATING
ENZYME)		 4hfn ALLYL ALCOHOL
DEHYDROGENASE
(Nicotiana
tabacum) 		5 / 11 TYR A 294
TYR A 130
GLU A 311
VAL A 298
ILE A 299
 None
 1.19A 4k37B-4hfnA:
undetectable		 4k37B-4hfnA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K38_A_SAMA504_0
(ANAEROBIC
SULFATASE-MATURATING
ENZYME
KP18CYS PEPTIDE)		 4hfn ALLYL ALCOHOL
DEHYDROGENASE
(Nicotiana
tabacum) 		5 / 12 TYR A 294
GLN A 168
GLN A 172
VAL A 298
ILE A 302
 None
 1.36A 4k38A-4hfnA:
undetectable
4k38D-4hfnA:
undetectable		 4k38A-4hfnA:
22.50
4k38D-4hfnA:
5.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K38_A_SAMA504_0
(ANAEROBIC
SULFATASE-MATURATING
ENZYME
KP18CYS PEPTIDE)		 4hfn ALLYL ALCOHOL
DEHYDROGENASE
(Nicotiana
tabacum) 		5 / 12 TYR A 294
TYR A 130
GLU A 311
VAL A 298
ILE A 299
 None
 1.23A 4k38A-4hfnA:
undetectable
4k38D-4hfnA:
undetectable		 4k38A-4hfnA:
22.50
4k38D-4hfnA:
5.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K39_A_SAMA504_0
(ANAEROBIC
SULFATASE-MATURATING
ENZYME)		 4hfn ALLYL ALCOHOL
DEHYDROGENASE
(Nicotiana
tabacum) 		5 / 12 TYR A 294
TYR A 130
GLU A 311
VAL A 298
ILE A 299
 None
 1.24A 4k39A-4hfnA:
undetectable		 4k39A-4hfnA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD4_A_STIA604_1
(TYROSINE-PROTEIN
KINASE ABL1)		 4hfn ALLYL ALCOHOL
DEHYDROGENASE
(Nicotiana
tabacum) 		4 / 5 TYR A 309
VAL A 325
MET A 136
GLY A 138
 None
None
NAP  A 400 (-3.4A)
None
 1.37A 6hd4A-4hfnA:
undetectable		 6hd4A-4hfnA:
14.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MKE_C_FK5C201_0
(PEPTIDYLPROLYL
ISOMERASE)		 4hfn ALLYL ALCOHOL
DEHYDROGENASE
(Nicotiana
tabacum) 		4 / 4 ASP A  24
ILE A  77
PRO A  76
LEU A  12
 None
 1.46A 6mkeB-4hfnA:
undetectable		 6mkeB-4hfnA:
14.93