SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4hfo'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G70_A_SAMA2001_0
(PHENYLETHANOLAMINE
N-METHYLTRANSFERASE)		 4hfo BIOGENIC
AMINE-BINDING
PROTEIN
(Rhodnius
prolixus) 		5 / 12 GLN A 138
ASP A   8
VAL A   7
ALA A 136
VAL A 159
 None
 1.25A 2g70A-4hfoA:
undetectable		 2g70A-4hfoA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G70_B_SAMB2002_0
(PHENYLETHANOLAMINE
N-METHYLTRANSFERASE)		 4hfo BIOGENIC
AMINE-BINDING
PROTEIN
(Rhodnius
prolixus) 		5 / 12 GLN A 138
ASP A   8
VAL A   7
ALA A 136
VAL A 159
 None
 1.20A 2g70B-4hfoA:
undetectable		 2g70B-4hfoA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2M2O_B_DHIB24_0
(INSULIN B CHAIN)		 4hfo BIOGENIC
AMINE-BINDING
PROTEIN
(Rhodnius
prolixus) 		4 / 6 GLY A  38
PRO A  64
LYS A  67
THR A  68
 None
 0.95A 2m2oB-4hfoA:
undetectable		 2m2oB-4hfoA:
8.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3APW_A_DP0A190_1
(ALPHA-1-ACID
GLYCOPROTEIN 2)		 4hfo BIOGENIC
AMINE-BINDING
PROTEIN
(Rhodnius
prolixus) 		5 / 12 PHE A  59
PHE A  13
ALA A  90
SER A  74
TYR A 111
 None
 1.43A 3apwA-4hfoA:
12.0		 3apwA-4hfoA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OZW_B_KKKB413_1
(FLAVOHEMOGLOBIN)		 4hfo BIOGENIC
AMINE-BINDING
PROTEIN
(Rhodnius
prolixus) 		5 / 12 ILE A  73
HIS A  47
GLN A  48
LEU A 186
GLY A  21
 None
 0.94A 3ozwB-4hfoA:
undetectable		 3ozwB-4hfoA:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_A_TCWA1126_1
(TRANSTHYRETIN)		 4hfo BIOGENIC
AMINE-BINDING
PROTEIN
(Rhodnius
prolixus) 		4 / 6 LEU A 187
LEU A  46
SER A  22
THR A  20
 None
 1.06A 4d7bB-4hfoA:
undetectable		 4d7bB-4hfoA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LU3_A_AZMA302_1
(CARBONIC ANHYDRASE
14)		 4hfo BIOGENIC
AMINE-BINDING
PROTEIN
(Rhodnius
prolixus) 		5 / 11 HIS A  27
LEU A  35
LEU A 172
THR A 170
THR A 171
 None
 1.22A 4lu3A-4hfoA:
undetectable		 4lu3A-4hfoA:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM7_A_29JA603_1
(TRANSPORTER)		 4hfo BIOGENIC
AMINE-BINDING
PROTEIN
(Rhodnius
prolixus) 		5 / 10 ASP A 179
VAL A  95
TYR A  71
SER A  60
ASP A  98
 None
 1.46A 4mm7A-4hfoA:
undetectable		 4mm7A-4hfoA:
15.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BOJ_A_4TXA201_1
(TRANSTHYRETIN)		 4hfo BIOGENIC
AMINE-BINDING
PROTEIN
(Rhodnius
prolixus) 		4 / 6 LEU A 187
LEU A  46
SER A  22
THR A  20
 None
 1.07A 5bojA-4hfoA:
undetectable		 5bojA-4hfoA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BOJ_B_4TXB201_1
(TRANSTHYRETIN)		 4hfo BIOGENIC
AMINE-BINDING
PROTEIN
(Rhodnius
prolixus) 		4 / 7 LEU A 187
LEU A  46
SER A  22
THR A  20
 None
 1.04A 5bojB-4hfoA:
undetectable		 5bojB-4hfoA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L4I_A_6J3A201_0
(TRANSTHYRETIN)		 4hfo BIOGENIC
AMINE-BINDING
PROTEIN
(Rhodnius
prolixus) 		4 / 6 LEU A 187
LEU A  46
SER A  22
THR A  20
 None
 1.04A 5l4iA-4hfoA:
undetectable		 5l4iA-4hfoA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L4I_B_6J3B201_0
(TRANSTHYRETIN)		 4hfo BIOGENIC
AMINE-BINDING
PROTEIN
(Rhodnius
prolixus) 		4 / 6 LEU A 187
LEU A  46
SER A  22
THR A  20
 None
 1.05A 5l4iB-4hfoA:
undetectable		 5l4iB-4hfoA:
20.20