SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4hfs'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQC_K_AG2K671_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 4hfs UNCHARACTERIZED
PROTEIN YNCM
(Bacillus
subtilis) 		5 / 8 ILE A 207
ARG A 204
ASP A 233
LEU A  51
GLY A  54
 None
 1.31A 2qqcH-4hfsA:
undetectable
2qqcK-4hfsA:
undetectable		 2qqcH-4hfsA:
17.84
2qqcK-4hfsA:
13.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T01_A_PPFA503_1
(PHOSPHONOACETATE
HYDROLASE)		 4hfs UNCHARACTERIZED
PROTEIN YNCM
(Bacillus
subtilis) 		4 / 7 PHE A 215
THR A 245
ASN A 216
ILE A  72
 None
 1.11A 3t01A-4hfsA:
undetectable		 3t01A-4hfsA:
18.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TPX_E_ACTE204_0
(E3 UBIQUITIN-PROTEIN
LIGASE MDM2)		 4hfs UNCHARACTERIZED
PROTEIN YNCM
(Bacillus
subtilis) 		3 / 3 LYS A 115
PRO A 116
LEU A 117
 SO4  A 302 (-2.9A)
None
None
 0.71A 3tpxE-4hfsA:
undetectable		 3tpxE-4hfsA:
15.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_D_HCYD1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		 4hfs UNCHARACTERIZED
PROTEIN YNCM
(Bacillus
subtilis) 		5 / 12 GLN A 148
THR A 150
ILE A 218
ASN A 242
PHE A  68
 None
 1.39A 4c49D-4hfsA:
undetectable		 4c49D-4hfsA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GC9_A_ACTA402_0
(DIMETHYLADENOSINE
TRANSFERASE 1,
MITOCHONDRIAL)		 4hfs UNCHARACTERIZED
PROTEIN YNCM
(Bacillus
subtilis) 		3 / 3 LYS A 191
TYR A  60
ARG A  58
 SO4  A 301 (-2.6A)
SO4  A 301 (-4.4A)
SO4  A 301 (-4.1A)
 1.38A 4gc9A-4hfsA:
undetectable		 4gc9A-4hfsA:
17.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_A_LEVA801_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		 4hfs UNCHARACTERIZED
PROTEIN YNCM
(Bacillus
subtilis) 		3 / 3 LYS A 189
LEU A 193
ASP A 230
 None
SO4  A 301 ( 4.9A)
None
 0.73A 5zv2A-4hfsA:
undetectable		 5zv2A-4hfsA:
15.27