SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4hfv'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RH3_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 4hfv UNCHARACTERIZED
PROTEIN
(Legionella
pneumophila) 		5 / 12 ILE A  87
PHE A 101
SER A  14
ILE A  15
LEU A  55
 None
 1.31A 1rh3A-4hfvA:
undetectable		 1rh3A-4hfvA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGZ_B_CQAB302_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 4hfv UNCHARACTERIZED
PROTEIN
(Legionella
pneumophila) 		4 / 8 SER A  40
GLU A  60
GLY A  13
ARG A  16
 None
 1.00A 4fgzA-4hfvA:
undetectable
4fgzB-4hfvA:
undetectable		 4fgzA-4hfvA:
21.90
4fgzB-4hfvA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PEV_C_ADNC501_2
(MEMBRANE LIPOPROTEIN
FAMILY PROTEIN)		 4hfv UNCHARACTERIZED
PROTEIN
(Legionella
pneumophila) 		3 / 3 PRO A  50
VAL A  44
HIS A  26
 None
None
CIT  A 301 (-3.6A)
 0.83A 4pevC-4hfvA:
undetectable		 4pevC-4hfvA:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PXM_A_ESTA2000_1
(ESTROGEN RECEPTOR)		 4hfv UNCHARACTERIZED
PROTEIN
(Legionella
pneumophila) 		5 / 12 LEU A  76
LEU A  79
ALA A  78
LEU A 105
LEU A   5
 None
 1.09A 4pxmA-4hfvA:
undetectable		 4pxmA-4hfvA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MXB_A_ML1A220_1
(CLASS 10 PLANT
PATHOGENESIS-RELATED
PROTEIN)		 4hfv UNCHARACTERIZED
PROTEIN
(Legionella
pneumophila) 		5 / 9 LEU A 129
VAL A  75
LEU A 109
THR A  58
VAL A  54
 None
 1.22A 5mxbA-4hfvA:
undetectable		 5mxbA-4hfvA:
16.32