SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4hg0'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XWF_A_ADNA433_2
(ADENOSYLHOMOCYSTEINA
SE)		 4hg0 MAGNESIUM AND COBALT
EFFLUX PROTEIN CORC
(Escherichia
coli) 		3 / 3 THR A 213
GLU A 191
HIS A 210
 None
 0.83A 1xwfA-4hg0A:
undetectable		 1xwfA-4hg0A:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XWF_B_ADNB433_2
(ADENOSYLHOMOCYSTEINA
SE)		 4hg0 MAGNESIUM AND COBALT
EFFLUX PROTEIN CORC
(Escherichia
coli) 		3 / 3 THR A 213
GLU A 191
HIS A 210
 None
 0.82A 1xwfB-4hg0A:
undetectable		 1xwfB-4hg0A:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XWF_C_ADNC433_2
(ADENOSYLHOMOCYSTEINA
SE)		 4hg0 MAGNESIUM AND COBALT
EFFLUX PROTEIN CORC
(Escherichia
coli) 		3 / 3 THR A 213
GLU A 191
HIS A 210
 None
 0.80A 1xwfC-4hg0A:
undetectable		 1xwfC-4hg0A:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XWF_D_ADND433_2
(ADENOSYLHOMOCYSTEINA
SE)		 4hg0 MAGNESIUM AND COBALT
EFFLUX PROTEIN CORC
(Escherichia
coli) 		3 / 3 THR A 213
GLU A 191
HIS A 210
 None
 0.84A 1xwfD-4hg0A:
undetectable		 1xwfD-4hg0A:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KPB_A_SAMA1000_0
(UNCHARACTERIZED
PROTEIN MJ0100)		 4hg0 MAGNESIUM AND COBALT
EFFLUX PROTEIN CORC
(Escherichia
coli) 		5 / 12 THR A 180
ASP A 183
ILE A  80
SER A 101
PRO A 104
 AMP  A 301 (-3.8A)
AMP  A 301 (-3.3A)
AMP  A 301 (-3.8A)
AMP  A 301 (-2.7A)
AMP  A 301 (-4.7A)
 0.83A 3kpbA-4hg0A:
12.5		 3kpbA-4hg0A:
18.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3OI8_A_ADNA2_1
(UNCHARACTERIZED
PROTEIN)		 4hg0 MAGNESIUM AND COBALT
EFFLUX PROTEIN CORC
(Escherichia
coli) 		5 / 6 ILE A  74
HIS A 100
PRO A 104
LEU A 178
ASP A 183
 AMP  A 301 (-4.5A)
AMP  A 301 (-3.3A)
AMP  A 301 (-4.7A)
None
AMP  A 301 (-3.3A)
 0.54A 3oi8A-4hg0A:
18.4		 3oi8A-4hg0A:
47.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3OI8_B_ADNB1_1
(UNCHARACTERIZED
PROTEIN)		 4hg0 MAGNESIUM AND COBALT
EFFLUX PROTEIN CORC
(Escherichia
coli) 		5 / 9 ILE A  74
HIS A 100
PRO A 104
GLU A 182
ASP A 183
 AMP  A 301 (-4.5A)
AMP  A 301 (-3.3A)
AMP  A 301 (-4.7A)
AMP  A 301 (-3.8A)
AMP  A 301 (-3.3A)
 0.84A 3oi8A-4hg0A:
18.4
3oi8B-4hg0A:
18.2		 3oi8A-4hg0A:
47.25
3oi8B-4hg0A:
47.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3OI8_B_ADNB1_1
(UNCHARACTERIZED
PROTEIN)		 4hg0 MAGNESIUM AND COBALT
EFFLUX PROTEIN CORC
(Escherichia
coli) 		6 / 9 ILE A  74
HIS A 100
PRO A 104
LEU A 178
THR A 180
ASP A 183
 AMP  A 301 (-4.5A)
AMP  A 301 (-3.3A)
AMP  A 301 (-4.7A)
None
AMP  A 301 (-3.8A)
AMP  A 301 (-3.3A)
 0.53A 3oi8A-4hg0A:
18.4
3oi8B-4hg0A:
18.2		 3oi8A-4hg0A:
47.25
3oi8B-4hg0A:
47.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGL_A_CLQA303_0
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 4hg0 MAGNESIUM AND COBALT
EFFLUX PROTEIN CORC
(Escherichia
coli) 		5 / 12 GLY A 240
GLY A 241
ILE A 220
VAL A 279
PHE A 247
 None
 1.22A 4fglA-4hg0A:
undetectable
4fglB-4hg0A:
undetectable		 4fglA-4hg0A:
22.59
4fglB-4hg0A:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MKE_D_FK5D201_0
(PEPTIDYLPROLYL
ISOMERASE)		 4hg0 MAGNESIUM AND COBALT
EFFLUX PROTEIN CORC
(Escherichia
coli) 		4 / 4 ASP A 121
ILE A 116
PRO A 104
LEU A 117
 None
None
AMP  A 301 (-4.7A)
None
 1.06A 6mkeA-4hg0A:
undetectable		 6mkeA-4hg0A:
13.78