SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4hg2'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GLU_A_SAMA301_0
(YCGJ)		 4hg2 METHYLTRANSFERASE
TYPE 11
(Anaeromyxobacter
dehalogenans) 		5 / 12 GLY A  44
GLY A  46
ASP A  65
ALA A  87
GLU A  88
 None
 0.69A 2gluA-4hg2A:
15.8		 2gluA-4hg2A:
26.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FPJ_B_SAMB301_1
(PUTATIVE
UNCHARACTERIZED
PROTEIN)		 4hg2 METHYLTRANSFERASE
TYPE 11
(Anaeromyxobacter
dehalogenans) 		4 / 7 GLN A  49
GLY A  44
GLY A  46
GLU A  88
 None
 0.73A 3fpjB-4hg2A:
11.9		 3fpjB-4hg2A:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G88_A_SAMA303_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE G)		 4hg2 METHYLTRANSFERASE
TYPE 11
(Anaeromyxobacter
dehalogenans) 		5 / 11 GLY A  44
GLY A  46
ASP A  65
GLU A  88
ALA A 103
 None
 1.01A 3g88A-4hg2A:
10.6		 3g88A-4hg2A:
25.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G88_B_SAMB303_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE G)		 4hg2 METHYLTRANSFERASE
TYPE 11
(Anaeromyxobacter
dehalogenans) 		5 / 11 GLY A  44
GLY A  46
ASP A  65
GLU A  88
ALA A 103
 None
 1.00A 3g88B-4hg2A:
10.5		 3g88B-4hg2A:
25.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G89_A_SAMA303_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE G)		 4hg2 METHYLTRANSFERASE
TYPE 11
(Anaeromyxobacter
dehalogenans) 		5 / 12 GLY A  44
GLY A  46
ASP A  65
ALA A  87
GLU A  88
 None
 0.81A 3g89A-4hg2A:
10.7		 3g89A-4hg2A:
25.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G89_A_SAMA303_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE G)		 4hg2 METHYLTRANSFERASE
TYPE 11
(Anaeromyxobacter
dehalogenans) 		5 / 12 GLY A  44
GLY A  46
ASP A  65
GLU A  88
ALA A 103
 None
 1.00A 3g89A-4hg2A:
10.7		 3g89A-4hg2A:
25.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G89_B_SAMB303_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE G)		 4hg2 METHYLTRANSFERASE
TYPE 11
(Anaeromyxobacter
dehalogenans) 		5 / 11 GLY A  44
GLY A  46
ASP A  65
ALA A  87
GLU A  88
 None
 0.81A 3g89B-4hg2A:
10.7		 3g89B-4hg2A:
25.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G89_B_SAMB303_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE G)		 4hg2 METHYLTRANSFERASE
TYPE 11
(Anaeromyxobacter
dehalogenans) 		5 / 11 GLY A  44
GLY A  46
ASP A  65
GLU A  88
ALA A 103
 None
 1.01A 3g89B-4hg2A:
10.7		 3g89B-4hg2A:
25.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G8B_A_SAMA303_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE G)		 4hg2 METHYLTRANSFERASE
TYPE 11
(Anaeromyxobacter
dehalogenans) 		5 / 12 GLY A  44
GLY A  46
ASP A  65
ALA A  87
GLU A  88
 None
 0.77A 3g8bA-4hg2A:
10.6		 3g8bA-4hg2A:
25.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G8B_A_SAMA303_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE G)		 4hg2 METHYLTRANSFERASE
TYPE 11
(Anaeromyxobacter
dehalogenans) 		5 / 12 GLY A  44
GLY A  46
ASP A  65
GLU A  88
ALA A 103
 None
 0.97A 3g8bA-4hg2A:
10.6		 3g8bA-4hg2A:
25.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G8B_B_SAMB303_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE G)		 4hg2 METHYLTRANSFERASE
TYPE 11
(Anaeromyxobacter
dehalogenans) 		5 / 12 GLY A  44
GLY A  46
ASP A  65
GLU A  88
ALA A 103
 None
 1.01A 3g8bB-4hg2A:
9.6		 3g8bB-4hg2A:
25.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CEV_C_GAIC409_0
(PROTEIN (ARGINASE))		 4hg2 METHYLTRANSFERASE
TYPE 11
(Anaeromyxobacter
dehalogenans) 		4 / 6 ASP A 215
ARG A 209
HIS A 208
LEU A 149
 None
 1.50A 4cevA-4hg2A:
3.3
4cevC-4hg2A:
3.4		 4cevA-4hg2A:
20.86
4cevC-4hg2A:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CEV_D_GAID410_0
(PROTEIN (ARGINASE))		 4hg2 METHYLTRANSFERASE
TYPE 11
(Anaeromyxobacter
dehalogenans) 		4 / 6 ARG A 209
HIS A 208
LEU A 149
ASP A 215
 None
 1.49A 4cevD-4hg2A:
undetectable
4cevE-4hg2A:
3.2		 4cevD-4hg2A:
20.86
4cevE-4hg2A:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J6D_B_TESB502_1
(CYTOCHROME P450
MONOOXYGENASE)		 4hg2 METHYLTRANSFERASE
TYPE 11
(Anaeromyxobacter
dehalogenans) 		5 / 12 PHE A 109
PHE A 114
ALA A 100
VAL A 121
LEU A  92
 None
 1.08A 4j6dB-4hg2A:
undetectable		 4j6dB-4hg2A:
23.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JBT_A_ASDA501_1
(CYTOCHROME P450
MONOOXYGENASE)		 4hg2 METHYLTRANSFERASE
TYPE 11
(Anaeromyxobacter
dehalogenans) 		5 / 12 PHE A 109
PHE A 114
ALA A 100
VAL A 121
LEU A  92
 None
 1.10A 4jbtA-4hg2A:
undetectable		 4jbtA-4hg2A:
23.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BW4_A_SAMA301_0
(16S RRNA
(ADENINE(1408)-N(1))
-METHYLTRANSFERASE)		 4hg2 METHYLTRANSFERASE
TYPE 11
(Anaeromyxobacter
dehalogenans) 		5 / 12 GLY A  44
GLY A  46
ASP A  65
PRO A  66
GLU A  88
 None
 0.78A 5bw4A-4hg2A:
10.1		 5bw4A-4hg2A:
26.76