SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4hgv'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7C_A_HLTA4002_1
(SERUM ALBUMIN)		 4hgv FUMARATE HYDRATASE
CLASS II
(Sinorhizobium
meliloti) 		4 / 5 ARG A  67
ALA A  66
ALA A  87
LYS A  85
 None
 1.11A 1e7cA-4hgvA:
undetectable		 1e7cA-4hgvA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JIN_A_KTNA801_1
(CYTOCHROME P450
107A1)		 4hgv FUMARATE HYDRATASE
CLASS II
(Sinorhizobium
meliloti) 		5 / 11 ALA A 290
VAL A 383
LEU A 386
ALA A 387
ALA A 173
 None
 1.09A 1jinA-4hgvA:
0.0		 1jinA-4hgvA:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZF_A_FOLA605_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4hgv FUMARATE HYDRATASE
CLASS II
(Sinorhizobium
meliloti) 		5 / 12 LEU A 418
ASP A 413
LEU A 412
THR A 468
ILE A 470
 None
 1.01A 1qzfA-4hgvA:
undetectable		 1qzfA-4hgvA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZF_B_FOLB609_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4hgv FUMARATE HYDRATASE
CLASS II
(Sinorhizobium
meliloti) 		5 / 12 LEU A 418
ASP A 413
LEU A 412
THR A 468
ILE A 470
 None
 1.00A 1qzfB-4hgvA:
undetectable		 1qzfB-4hgvA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZF_C_FOLC613_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4hgv FUMARATE HYDRATASE
CLASS II
(Sinorhizobium
meliloti) 		5 / 12 LEU A 418
ASP A 413
LEU A 412
THR A 468
ILE A 470
 None
 1.01A 1qzfC-4hgvA:
undetectable		 1qzfC-4hgvA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZF_D_FOLD617_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4hgv FUMARATE HYDRATASE
CLASS II
(Sinorhizobium
meliloti) 		5 / 12 LEU A 418
ASP A 413
LEU A 412
THR A 468
ILE A 470
 None
 1.01A 1qzfD-4hgvA:
undetectable		 1qzfD-4hgvA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZF_E_FOLE621_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4hgv FUMARATE HYDRATASE
CLASS II
(Sinorhizobium
meliloti) 		5 / 12 LEU A 418
ASP A 413
LEU A 412
THR A 468
ILE A 470
 None
 1.01A 1qzfE-4hgvA:
undetectable		 1qzfE-4hgvA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RL8_A_RITA9001_1
(PROTEASE RETROPEPSIN)		 4hgv FUMARATE HYDRATASE
CLASS II
(Sinorhizobium
meliloti) 		6 / 12 ALA A  66
VAL A 144
GLY A  59
ILE A  91
ALA A 124
ILE A  83
 None
 1.25A 1rl8A-4hgvA:
undetectable		 1rl8A-4hgvA:
11.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T9W_A_NFNA6001_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 4hgv FUMARATE HYDRATASE
CLASS II
(Sinorhizobium
meliloti) 		3 / 3 SER A 310
GLY A 309
ARG A 196
 None
 0.67A 1t9wA-4hgvA:
undetectable		 1t9wA-4hgvA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FR3_A_REAA300_1
(CELLULAR RETINOIC
ACID BINDING PROTEIN
2)		 4hgv FUMARATE HYDRATASE
CLASS II
(Sinorhizobium
meliloti) 		5 / 12 LEU A 380
ALA A  53
ALA A  57
THR A 264
LEU A 235
 None
 1.10A 2fr3A-4hgvA:
undetectable		 2fr3A-4hgvA:
15.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_B_SC2B1290_1
(FICOLIN-2)		 4hgv FUMARATE HYDRATASE
CLASS II
(Sinorhizobium
meliloti) 		4 / 8 LEU A 412
SER A 415
LEU A 418
ASP A 201
 None
 0.97A 2j2pA-4hgvA:
undetectable
2j2pB-4hgvA:
undetectable		 2j2pA-4hgvA:
17.29
2j2pB-4hgvA:
17.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OIP_D_MTXD617_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 4hgv FUMARATE HYDRATASE
CLASS II
(Sinorhizobium
meliloti) 		5 / 12 LEU A 418
ASP A 413
LEU A 412
THR A 468
ILE A 470
 None
 1.07A 2oipD-4hgvA:
undetectable		 2oipD-4hgvA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OIP_E_MTXE621_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 4hgv FUMARATE HYDRATASE
CLASS II
(Sinorhizobium
meliloti) 		5 / 12 LEU A 418
ASP A 413
LEU A 412
THR A 468
ILE A 470
 None
 0.97A 2oipE-4hgvA:
undetectable		 2oipE-4hgvA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QBN_A_CAMA442_0
(CYTOCHROME P450-CAM)		 4hgv FUMARATE HYDRATASE
CLASS II
(Sinorhizobium
meliloti) 		4 / 7 VAL A 464
VAL A 450
ASP A 457
VAL A 455
 None
 1.02A 2qbnA-4hgvA:
undetectable		 2qbnA-4hgvA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKP_C_478C200_1
(PROTEASE)		 4hgv FUMARATE HYDRATASE
CLASS II
(Sinorhizobium
meliloti) 		6 / 10 ALA A  66
VAL A 144
GLY A  59
ILE A  91
ALA A 124
ILE A  83
 None
 1.24A 3ekpC-4hgvA:
undetectable		 3ekpC-4hgvA:
11.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKT_B_017B200_2
(PROTEASE)		 4hgv FUMARATE HYDRATASE
CLASS II
(Sinorhizobium
meliloti) 		6 / 9 ALA A  66
VAL A 144
GLY A  59
ILE A  91
ALA A 124
ILE A  83
 None
 1.26A 3ektB-4hgvA:
undetectable		 3ektB-4hgvA:
11.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCO_B_CHDB1_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4hgv FUMARATE HYDRATASE
CLASS II
(Sinorhizobium
meliloti) 		4 / 4 LEU A 101
PRO A 100
LEU A  40
ARG A  38
 None
 1.12A 3hcoB-4hgvA:
undetectable		 3hcoB-4hgvA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HJ3_D_MTXD615_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 4hgv FUMARATE HYDRATASE
CLASS II
(Sinorhizobium
meliloti) 		5 / 12 LEU A 418
ASP A 413
LEU A 412
THR A 468
ILE A 470
 None
 0.98A 3hj3D-4hgvA:
undetectable		 3hj3D-4hgvA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP6_B_SALB3008_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 4hgv FUMARATE HYDRATASE
CLASS II
(Sinorhizobium
meliloti) 		4 / 7 GLU A 259
GLN A  63
VAL A  84
ALA A  66
 None
 0.99A 3kp6B-4hgvA:
undetectable		 3kp6B-4hgvA:
14.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MTE_B_SAMB220_0
(16S RRNA METHYLASE)		 4hgv FUMARATE HYDRATASE
CLASS II
(Sinorhizobium
meliloti) 		5 / 12 GLY A 239
GLY A 245
ASN A 247
ALA A 271
LEU A 278
 None
 1.03A 3mteB-4hgvA:
undetectable		 3mteB-4hgvA:
17.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AZW_A_SAMA1451_0
(WBDD)		 4hgv FUMARATE HYDRATASE
CLASS II
(Sinorhizobium
meliloti) 		5 / 12 ALA A  65
GLN A  63
ARG A  56
ILE A 160
GLU A 164
 None
 1.26A 4azwA-4hgvA:
undetectable		 4azwA-4hgvA:
24.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJH_A_SAMA302_0
(7-CARBOXY-7-DEAZAGUA
NINE SYNTHASE)		 4hgv FUMARATE HYDRATASE
CLASS II
(Sinorhizobium
meliloti) 		5 / 12 THR A 110
ASN A 115
LYS A  62
VAL A 144
ASP A 142
 None
 1.39A 4njhA-4hgvA:
undetectable		 4njhA-4hgvA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJI_B_SAMB302_0
(7-CARBOXY-7-DEAZAGUA
NINE SYNTHASE)		 4hgv FUMARATE HYDRATASE
CLASS II
(Sinorhizobium
meliloti) 		5 / 12 THR A 110
ASN A 115
LYS A  62
VAL A 144
ASP A 142
 None
 1.38A 4njiB-4hgvA:
undetectable		 4njiB-4hgvA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJK_A_SAMA302_0
(7-CARBOXY-7-DEAZAGUA
NINE SYNTHASE)		 4hgv FUMARATE HYDRATASE
CLASS II
(Sinorhizobium
meliloti) 		5 / 12 THR A 110
ASN A 115
LYS A  62
VAL A 144
ASP A 142
 None
 1.40A 4njkA-4hgvA:
undetectable		 4njkA-4hgvA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KOX_A_RFPA502_1
(PENTACHLOROPHENOL
4-MONOOXYGENASE)		 4hgv FUMARATE HYDRATASE
CLASS II
(Sinorhizobium
meliloti) 		5 / 12 GLY A 133
VAL A 144
ILE A  79
GLY A 129
GLY A 130
 None
 0.94A 5koxA-4hgvA:
undetectable		 5koxA-4hgvA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZW4_A_SAMA302_1
(PUTATIVE
O-METHYLTRANSFERASE
YRRM)		 4hgv FUMARATE HYDRATASE
CLASS II
(Sinorhizobium
meliloti) 		4 / 6 SER A 415
GLU A 318
ASP A 304
ASP A 201
 None
 1.26A 5zw4A-4hgvA:
undetectable		 5zw4A-4hgvA:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AJI_A_AY6A1001_0
(DRUG EXPORTERS OF
THE RND
SUPERFAMILY-LIKE
PROTEIN,ENDOLYSIN)		 4hgv FUMARATE HYDRATASE
CLASS II
(Sinorhizobium
meliloti) 		5 / 12 ILE A 225
LEU A 386
PHE A 379
ALA A 297
LEU A 298
 None
 0.81A 6ajiA-4hgvA:
undetectable		 6ajiA-4hgvA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CK2_C_IPHC101_0
(INSULIN A CHAIN
INSULIN B CHAIN)		 4hgv FUMARATE HYDRATASE
CLASS II
(Sinorhizobium
meliloti) 		4 / 4 ILE A 222
LEU A 298
HIS A 176
ALA A 390
 None
 0.99A 6ck2C-4hgvA:
undetectable
6ck2D-4hgvA:
undetectable		 6ck2C-4hgvA:
4.30
6ck2D-4hgvA:
4.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_A_ADNA503_1
(ADENOSYLHOMOCYSTEINA
SE)		 4hgv FUMARATE HYDRATASE
CLASS II
(Sinorhizobium
meliloti) 		3 / 3 LEU A  40
GLN A  37
LYS A  49
 None
 0.84A 6exiB-4hgvA:
undetectable		 6exiB-4hgvA:
10.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_B_ADNB503_0
(ADENOSYLHOMOCYSTEINA
SE)		 4hgv FUMARATE HYDRATASE
CLASS II
(Sinorhizobium
meliloti) 		3 / 3 LEU A  40
GLN A  37
LYS A  49
 None
 0.82A 6exiA-4hgvA:
undetectable		 6exiA-4hgvA:
10.30