SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4hgx'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VYW_C_SAMC401_1
(MNMC2)		 4hgx XYLOSE ISOMERASE
DOMAIN CONTAINING
PROTEIN
(Salmonella
enterica) 		4 / 6 GLY A 136
ASP A 170
ASN A  71
GLU A 245
 None
ZN  A 301 (-3.0A)
None
ZN  A 301 (-2.1A)
 1.05A 3vywC-4hgxA:
undetectable		 3vywC-4hgxA:
23.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_D_SORD1343_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 4hgx XYLOSE ISOMERASE
DOMAIN CONTAINING
PROTEIN
(Salmonella
enterica) 		4 / 5 ALA A  72
ARG A  39
HIS A 173
GLU A 245
 None
None
None
ZN  A 301 (-2.1A)
 1.31A 5a06C-4hgxA:
2.0
5a06D-4hgxA:
undetectable		 5a06C-4hgxA:
22.44
5a06D-4hgxA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DWK_C_ACTC207_0
(DIACYLGLYCEROL
KINASE)		 4hgx XYLOSE ISOMERASE
DOMAIN CONTAINING
PROTEIN
(Salmonella
enterica) 		4 / 5 GLU A 245
ALA A 243
GLU A  37
GLU A 139
 ZN  A 301 (-2.1A)
None
None
ZN  A 301 (-2.4A)
 0.91A 5dwkC-4hgxA:
undetectable		 5dwkC-4hgxA:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TJY_A_BEZA304_0
(4-HYDROXY-TETRAHYDRO
DIPICOLINATE
REDUCTASE)		 4hgx XYLOSE ISOMERASE
DOMAIN CONTAINING
PROTEIN
(Salmonella
enterica) 		3 / 3 MET A  42
GLU A  37
ARG A  39
 None
 1.06A 5tjyA-4hgxA:
2.1		 5tjyA-4hgxA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TJZ_A_BEZA302_0
(4-HYDROXY-TETRAHYDRO
DIPICOLINATE
REDUCTASE)		 4hgx XYLOSE ISOMERASE
DOMAIN CONTAINING
PROTEIN
(Salmonella
enterica) 		3 / 3 MET A  42
GLU A  37
ARG A  39
 None
 1.01A 5tjzA-4hgxA:
2.0		 5tjzA-4hgxA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZW4_A_SAMA302_1
(PUTATIVE
O-METHYLTRANSFERASE
YRRM)		 4hgx XYLOSE ISOMERASE
DOMAIN CONTAINING
PROTEIN
(Salmonella
enterica) 		4 / 6 SER A 199
GLU A  37
ARG A  39
ASP A 170
 None
None
None
ZN  A 301 (-3.0A)
 1.31A 5zw4A-4hgxA:
undetectable		 5zw4A-4hgxA:
22.86