SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4hgz'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SN5_D_T3D602_1
(TRANSTHYRETIN)		 4hgz CCBJ
(Streptomyces
caelestis) 		5 / 12 GLU A  66
ALA A  57
VAL A  51
LEU A  80
ALA A  84
 None
 1.12A 1sn5B-4hgzA:
undetectable
1sn5D-4hgzA:
undetectable		 1sn5B-4hgzA:
18.28
1sn5D-4hgzA:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SN5_D_T3D602_1
(TRANSTHYRETIN)		 4hgz CCBJ
(Streptomyces
caelestis) 		5 / 12 LEU A  80
ALA A  84
GLU A  66
ALA A  57
VAL A  51
 None
 1.11A 1sn5B-4hgzA:
undetectable
1sn5D-4hgzA:
undetectable		 1sn5B-4hgzA:
18.28
1sn5D-4hgzA:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VDV_E_SAME1287_0
(TRNA
(GUANINE-N(7)-)-METH
YLTRANSFERASE)		 4hgz CCBJ
(Streptomyces
caelestis) 		5 / 12 GLY A  50
GLY A  52
GLU A  71
ASN A  99
PHE A 117
 None
 1.16A 2vdvE-4hgzA:
9.7		 2vdvE-4hgzA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VDV_F_SAMF1287_0
(TRNA
(GUANINE-N(7)-)-METH
YLTRANSFERASE)		 4hgz CCBJ
(Streptomyces
caelestis) 		5 / 11 GLY A  50
GLY A  52
GLU A  71
ASN A  99
PHE A 117
 None
 1.16A 2vdvF-4hgzA:
9.8		 2vdvF-4hgzA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZGW_A_ADNA1301_1
(BIOTIN--[ACETYL-COA-
CARBOXYLASE] LIGASE)		 4hgz CCBJ
(Streptomyces
caelestis) 		4 / 7 ARG A  55
ALA A  33
PRO A  59
ALA A  34
 None
 0.97A 2zgwA-4hgzA:
undetectable		 2zgwA-4hgzA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DH0_B_SAMB300_0
(SAM DEPENDENT
METHYLTRANSFERASE)		 4hgz CCBJ
(Streptomyces
caelestis) 		6 / 12 ARG A  55
GLY A  50
GLY A  52
MET A  76
ALA A 116
THR A 119
 None
 1.14A 3dh0B-4hgzA:
15.9		 3dh0B-4hgzA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DH0_B_SAMB300_0
(SAM DEPENDENT
METHYLTRANSFERASE)		 4hgz CCBJ
(Streptomyces
caelestis) 		5 / 12 ARG A  55
GLY A  50
GLY A  52
MET A  76
LEU A 123
 None
 1.13A 3dh0B-4hgzA:
15.9		 3dh0B-4hgzA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FZG_A_SAMA300_0
(16S RRNA METHYLASE)		 4hgz CCBJ
(Streptomyces
caelestis) 		5 / 12 SER A  72
GLY A  52
GLY A  50
LEU A  77
MET A  76
 None
 1.12A 3fzgA-4hgzA:
11.0		 3fzgA-4hgzA:
17.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TBG_A_RTZA1_1
(CYTOCHROME P450 2D6)		 4hgz CCBJ
(Streptomyces
caelestis) 		5 / 12 LEU A 216
LEU A 151
GLY A 125
LEU A 124
GLN A 129
 None
None
SO4  A 302 (-3.0A)
None
None
 1.35A 3tbgA-4hgzA:
undetectable		 3tbgA-4hgzA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TBG_C_RTZC1_1
(CYTOCHROME P450 2D6)		 4hgz CCBJ
(Streptomyces
caelestis) 		5 / 12 LEU A 216
LEU A 151
GLY A 125
LEU A 124
GLN A 129
 None
None
SO4  A 302 (-3.0A)
None
None
 1.35A 3tbgC-4hgzA:
undetectable		 3tbgC-4hgzA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UHX_A_RTZA3009_1
(ALDEHYDE OXIDASE)		 4hgz CCBJ
(Streptomyces
caelestis) 		4 / 8 GLU A 235
ASP A  29
ARG A  55
ARG A  31
 None
 1.13A 4uhxA-4hgzA:
undetectable		 4uhxA-4hgzA:
11.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AMK_A_EF2A151_1
(CEREBLON ISOFORM 4)		 4hgz CCBJ
(Streptomyces
caelestis) 		4 / 8 ASN A 152
PRO A 153
PHE A 239
TYR A 250
 None
 0.99A 5amkA-4hgzA:
undetectable		 5amkA-4hgzA:
18.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OTR_A_ACTA402_0
(CASEIN KINASE II
SUBUNIT ALPHA)		 4hgz CCBJ
(Streptomyces
caelestis) 		4 / 5 VAL A  56
ASP A  29
PRO A  27
ALA A  33
 None
 1.07A 5otrA-4hgzA:
undetectable		 5otrA-4hgzA:
25.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6D8F_A_ACTA803_0
(UNCHARACTERIZED
PROTEIN)		 4hgz CCBJ
(Streptomyces
caelestis) 		3 / 3 GLU A  71
LEU A  80
ARG A  81
 None
 0.64A 6d8fA-4hgzA:
undetectable		 6d8fA-4hgzA:
18.76