SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4hh1'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4F_C_ADNC603_2
(S-ADENOSYLHOMOCYSTEI
NE HYDROLASE)		 4hh1 APPA PROTEIN
(Rhodobacter
sphaeroides) 		4 / 5 THR A 220
THR A 138
HIS A 386
LEU A 227
 None
 1.40A 1d4fC-4hh1A:
3.8		 1d4fC-4hh1A:
23.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FKO_A_EFZA999_1
(HIV-1 RT, A-CHAIN)		 4hh1 APPA PROTEIN
(Rhodobacter
sphaeroides) 		5 / 10 LEU A 394
VAL A 300
VAL A 273
GLY A 301
LEU A 390
 None
 1.40A 1fkoA-4hh1A:
3.4		 1fkoA-4hh1A:
20.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_B_115B1_1
(HMG-COA REDUCTASE)		 4hh1 APPA PROTEIN
(Rhodobacter
sphaeroides) 		5 / 9 GLU A 289
LEU A 256
ALA A 252
LEU A 199
LEU A 235
 None
 1.44A 1hwiA-4hh1A:
3.1		 1hwiA-4hh1A:
23.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_D_FUAD705_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4hh1 APPA PROTEIN
(Rhodobacter
sphaeroides) 		5 / 12 THR A 324
SER A 322
LEU A 350
VAL A 312
ALA A 314
 None
 1.32A 1q23D-4hh1A:
1.4
1q23E-4hh1A:
undetectable		 1q23D-4hh1A:
17.91
1q23E-4hh1A:
17.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A7Q_A_CFBA328_2
(DEOXYCYTIDINE KINASE)		 4hh1 APPA PROTEIN
(Rhodobacter
sphaeroides) 		4 / 4 ILE A  79
ASP A  36
LEU A  29
ARG A  81
 FMN  A 500 (-4.1A)
None
None
None
 1.28A 2a7qA-4hh1A:
undetectable		 2a7qA-4hh1A:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AXN_A_EDTA737_0
(6-PHOSPHOFRUCTO-2-KI
NASE/FRUCTOSE-2,6-BI
PHOSPHATASE 3
(6PF-2-K/FRU-
2,6-P2ASE
BRAIN/PLACENTA-TYPE
ISOZYME) (IPFK-2)
[INCLUDES: 6-
PHOSPHOFRUCTO-2-KINA
SE (EC 2.7.1.105)
FRUCTOSE-2,6-BISPHO
SPHATASE (EC
3.1.3.46)])		 4hh1 APPA PROTEIN
(Rhodobacter
sphaeroides) 		5 / 12 PRO A 219
PHE A 141
ARG A 226
ALA A 221
THR A 220
 None
 1.16A 2axnA-4hh1A:
2.6		 2axnA-4hh1A:
24.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B8J_B_ADNB331_1
(CLASS B ACID
PHOSPHATASE)		 4hh1 APPA PROTEIN
(Rhodobacter
sphaeroides) 		5 / 10 SER A 142
PHE A 141
LEU A 227
GLY A 187
THR A 220
 None
 1.37A 2b8jB-4hh1A:
3.1		 2b8jB-4hh1A:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXF_B_DZPB2001_1
(SERUM ALBUMIN)		 4hh1 APPA PROTEIN
(Rhodobacter
sphaeroides) 		5 / 12 LEU A  91
ILE A  90
CYH A  19
GLU A  89
ARG A  22
 None
 1.22A 2bxfB-4hh1A:
undetectable		 2bxfB-4hh1A:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QL8_A_BEZA143_0
(PUTATIVE REDOX
PROTEIN)		 4hh1 APPA PROTEIN
(Rhodobacter
sphaeroides) 		4 / 7 ALA A 221
THR A 220
ALA A 218
ARG A 188
 None
 0.97A 2ql8A-4hh1A:
undetectable
2ql8B-4hh1A:
undetectable		 2ql8A-4hh1A:
16.42
2ql8B-4hh1A:
16.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RIW_A_T44A1395_1
(THYROXINE-BINDING
GLOBULIN)		 4hh1 APPA PROTEIN
(Rhodobacter
sphaeroides) 		5 / 10 LEU A 277
LEU A 327
LEU A 350
LEU A 319
ARG A 318
 None
 1.15A 2riwA-4hh1A:
undetectable
2riwB-4hh1A:
undetectable		 2riwA-4hh1A:
22.85
2riwB-4hh1A:
10.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN6_A_T44A1370_1
(THYROXINE-BINDING
GLOBULIN)		 4hh1 APPA PROTEIN
(Rhodobacter
sphaeroides) 		5 / 10 LEU A 277
LEU A 327
LEU A 350
LEU A 319
ARG A 318
 None
 1.18A 2xn6A-4hh1A:
undetectable
2xn6B-4hh1A:
undetectable		 2xn6A-4hh1A:
22.41
2xn6B-4hh1A:
8.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3APX_A_Z80A190_1
(ALPHA-1-ACID
GLYCOPROTEIN 2)		 4hh1 APPA PROTEIN
(Rhodobacter
sphaeroides) 		5 / 12 PHE A 384
VAL A 328
THR A 304
LEU A 260
ALA A 225
 None
 1.22A 3apxA-4hh1A:
undetectable		 3apxA-4hh1A:
17.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LP1_A_NVPA701_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		 4hh1 APPA PROTEIN
(Rhodobacter
sphaeroides) 		5 / 10 LEU A 394
VAL A 300
VAL A 273
GLY A 301
LEU A 390
 None
 1.48A 3lp1A-4hh1A:
2.6		 3lp1A-4hh1A:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDR_B_GJZB506_1
(CHOLESTEROL
24-HYDROXYLASE)		 4hh1 APPA PROTEIN
(Rhodobacter
sphaeroides) 		4 / 6 PHE A  62
ILE A 146
ALA A 222
THR A 220
 None
 0.97A 3mdrB-4hh1A:
undetectable		 3mdrB-4hh1A:
24.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_H_ZPCH1318_2
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 4hh1 APPA PROTEIN
(Rhodobacter
sphaeroides) 		4 / 7 GLU A  94
ILE A  96
GLU A  66
PHE A 101
 None
 0.94A 4a97H-4hh1A:
undetectable		 4a97H-4hh1A:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J6C_B_STRB503_1
(CYTOCHROME P450
MONOOXYGENASE)		 4hh1 APPA PROTEIN
(Rhodobacter
sphaeroides) 		5 / 10 ALA A 314
ALA A 317
ALA A 316
THR A 354
LEU A 327
 None
 1.12A 4j6cB-4hh1A:
undetectable		 4j6cB-4hh1A:
24.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J6D_A_TESA503_1
(CYTOCHROME P450
MONOOXYGENASE)		 4hh1 APPA PROTEIN
(Rhodobacter
sphaeroides) 		5 / 12 ALA A 314
ALA A 317
ALA A 316
THR A 354
LEU A 327
 None
 1.11A 4j6dA-4hh1A:
undetectable		 4j6dA-4hh1A:
24.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J6D_B_TESB502_1
(CYTOCHROME P450
MONOOXYGENASE)		 4hh1 APPA PROTEIN
(Rhodobacter
sphaeroides) 		5 / 12 ALA A 314
ALA A 317
ALA A 316
THR A 354
LEU A 327
 None
 1.10A 4j6dB-4hh1A:
undetectable		 4j6dB-4hh1A:
24.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RYA_A_MTLA501_0
(ABC TRANSPORTER
SUBSTRATE BINDING
PROTEIN (SORBITOL))		 4hh1 APPA PROTEIN
(Rhodobacter
sphaeroides) 		5 / 12 ARG A 188
GLY A 184
ALA A 183
VAL A 134
GLN A 182
 None
 1.42A 4ryaA-4hh1A:
undetectable		 4ryaA-4hh1A:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DB5_A_CYSA503_0
(CYSTEINE DESULFURASE)		 4hh1 APPA PROTEIN
(Rhodobacter
sphaeroides) 		4 / 8 ALA A 299
ASN A  87
HIS A 264
THR A 220
 None
 1.07A 5db5A-4hh1A:
3.3
5db5B-4hh1A:
2.3		 5db5A-4hh1A:
22.91
5db5B-4hh1A:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LJB_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 1)		 4hh1 APPA PROTEIN
(Rhodobacter
sphaeroides) 		5 / 12 PHE A 346
LEU A 277
ALA A 279
PRO A 282
ARG A 318
 None
 1.16A 5ljbA-4hh1A:
undetectable		 5ljbA-4hh1A:
15.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B0C_D_TA1D502_1
(TUBULIN BETA CHAIN)		 4hh1 APPA PROTEIN
(Rhodobacter
sphaeroides) 		5 / 12 LEU A 359
LEU A 350
LEU A 327
THR A 326
GLY A 383
 None
 0.95A 6b0cD-4hh1A:
4.0		 6b0cD-4hh1A:
11.00