SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4hh2'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HRC_A_CHDA702_0
(FERROCHELATASE)		 4hh2 TRANSCRIPTIONAL
REGULATOR, PPSR
(Rhodobacter
sphaeroides) 		4 / 7 MET A 115
ARG A  71
VAL A  61
TRP A  53
 None
 1.37A 2hrcA-4hh2A:
undetectable		 2hrcA-4hh2A:
23.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W3B_A_FOLA401_0
(DIHYDROFOLATE
REDUCTASE)		 4hh2 TRANSCRIPTIONAL
REGULATOR, PPSR
(Rhodobacter
sphaeroides) 		6 / 12 ILE A 195
ARG A 233
PHE A 199
PRO A 161
LEU A 183
THR A 210
 None
 1.46A 2w3bA-4hh2A:
undetectable		 2w3bA-4hh2A:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NVK_I_SAMI228_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 4hh2 TRANSCRIPTIONAL
REGULATOR, PPSR
(Rhodobacter
sphaeroides) 		5 / 12 GLY A 288
ILE A 314
ASP A 316
ALA A 315
ASP A 287
 None
 0.96A 3nvkI-4hh2A:
undetectable		 3nvkI-4hh2A:
23.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGJ_A_1PQA304_0
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 4hh2 TRANSCRIPTIONAL
REGULATOR, PPSR
(Rhodobacter
sphaeroides) 		5 / 8 PHE A 317
ILE A 314
PHE A 297
GLY A 292
ASN A 294
 None
 1.47A 4fgjA-4hh2A:
undetectable
4fgjB-4hh2A:
undetectable		 4fgjA-4hh2A:
20.47
4fgjB-4hh2A:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJV_D_RITD500_1
(PROTEASE)		 4hh2 TRANSCRIPTIONAL
REGULATOR, PPSR
(Rhodobacter
sphaeroides) 		5 / 11 GLY A 321
ASP A 316
ILE A 290
GLY A 288
ILE A 329
 None
 0.92A 4njvC-4hh2A:
undetectable		 4njvC-4hh2A:
13.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QGI_A_ROCA101_1
(PROTEASE)		 4hh2 TRANSCRIPTIONAL
REGULATOR, PPSR
(Rhodobacter
sphaeroides) 		6 / 11 GLY A 321
ALA A 315
ASP A 316
ILE A 290
THR A 289
GLY A 288
 None
 1.44A 4qgiA-4hh2A:
undetectable		 4qgiA-4hh2A:
12.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1K_B_LOCB502_1
(TUBULIN ALPHA CHAIN
TUBULIN BETA CHAIN)		 4hh2 TRANSCRIPTIONAL
REGULATOR, PPSR
(Rhodobacter
sphaeroides) 		5 / 12 VAL A 237
LEU A 181
LEU A 183
ALA A 179
ALA A 227
 None
 1.26A 4x1kA-4hh2A:
undetectable
4x1kB-4hh2A:
undetectable		 4x1kA-4hh2A:
21.56
4x1kB-4hh2A:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YIA_B_IMNB401_2
(THYROXINE-BINDING
GLOBULIN)		 4hh2 TRANSCRIPTIONAL
REGULATOR, PPSR
(Rhodobacter
sphaeroides) 		3 / 3 LEU A 155
ARG A 152
ARG A 187
 None
 0.92A 4yiaB-4hh2A:
undetectable		 4yiaB-4hh2A:
9.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LBT_A_6T0A303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 4hh2 TRANSCRIPTIONAL
REGULATOR, PPSR
(Rhodobacter
sphaeroides) 		5 / 10 PHE A 317
ILE A 314
GLY A 292
TYR A 274
ASN A 294
 None
 1.41A 5lbtA-4hh2A:
undetectable
5lbtB-4hh2A:
undetectable		 5lbtA-4hh2A:
19.40
5lbtB-4hh2A:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WYQ_A_SAMA401_0
(TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE)		 4hh2 TRANSCRIPTIONAL
REGULATOR, PPSR
(Rhodobacter
sphaeroides) 		5 / 12 LEU A 338
GLY A 336
SER A 358
VAL A 371
LEU A 370
 None
 1.11A 5wyqA-4hh2A:
undetectable		 5wyqA-4hh2A:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G2P_A_TRPA502_0
(FLAVIN-DEPENDENT
L-TRYPTOPHAN OXIDASE
VIOA)		 4hh2 TRANSCRIPTIONAL
REGULATOR, PPSR
(Rhodobacter
sphaeroides) 		4 / 7 TYR A 102
HIS A  90
VAL A  35
TRP A  53
 None
 1.22A 6g2pA-4hh2A:
undetectable		 6g2pA-4hh2A:
25.63