SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4hh8'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CMA_A_SAMA105_0
(PROTEIN (MET
REPRESSOR))		 4hh8 BUTYROPHILIN
SUBFAMILY 1 MEMBER
A1
(Bos
taurus) 		5 / 8 GLU A  36
ARG A 101
ARG A  52
LEU A  50
GLU A  60
 None
 1.07A 1cmaA-4hh8A:
undetectable
1cmaB-4hh8A:
undetectable		 1cmaA-4hh8A:
17.27
1cmaB-4hh8A:
17.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CMA_A_SAMA105_0
(PROTEIN (MET
REPRESSOR))		 4hh8 BUTYROPHILIN
SUBFAMILY 1 MEMBER
A1
(Bos
taurus) 		5 / 8 PHE A  99
GLU A  36
ARG A  52
LEU A  50
GLU A  60
 None
 1.14A 1cmaA-4hh8A:
undetectable
1cmaB-4hh8A:
undetectable		 1cmaA-4hh8A:
17.27
1cmaB-4hh8A:
17.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CMA_B_SAMB105_0
(PROTEIN (MET
REPRESSOR))		 4hh8 BUTYROPHILIN
SUBFAMILY 1 MEMBER
A1
(Bos
taurus) 		5 / 11 GLU A  36
ARG A  52
LEU A  50
GLU A  60
PHE A  99
 None
 1.22A 1cmaA-4hh8A:
undetectable
1cmaB-4hh8A:
undetectable		 1cmaA-4hh8A:
17.27
1cmaB-4hh8A:
17.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CMA_B_SAMB105_0
(PROTEIN (MET
REPRESSOR))		 4hh8 BUTYROPHILIN
SUBFAMILY 1 MEMBER
A1
(Bos
taurus) 		5 / 11 GLU A  36
ARG A 101
ARG A  52
LEU A  50
GLU A  60
 None
 1.28A 1cmaA-4hh8A:
undetectable
1cmaB-4hh8A:
undetectable		 1cmaA-4hh8A:
17.27
1cmaB-4hh8A:
17.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CMC_A_SAMA105_0
(MET REPRESSOR)		 4hh8 BUTYROPHILIN
SUBFAMILY 1 MEMBER
A1
(Bos
taurus) 		5 / 10 PHE A  99
GLU A  36
ARG A  52
LEU A  50
GLU A  60
 None
 1.15A 1cmcA-4hh8A:
undetectable
1cmcB-4hh8A:
undetectable		 1cmcA-4hh8A:
17.27
1cmcB-4hh8A:
17.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CMC_B_SAMB105_0
(MET REPRESSOR)		 4hh8 BUTYROPHILIN
SUBFAMILY 1 MEMBER
A1
(Bos
taurus) 		5 / 10 GLU A  36
ARG A  52
LEU A  50
GLU A  60
PHE A  99
 None
 1.17A 1cmcA-4hh8A:
undetectable
1cmcB-4hh8A:
undetectable		 1cmcA-4hh8A:
17.27
1cmcB-4hh8A:
17.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CMC_B_SAMB105_0
(MET REPRESSOR)		 4hh8 BUTYROPHILIN
SUBFAMILY 1 MEMBER
A1
(Bos
taurus) 		5 / 10 GLU A  36
ARG A 101
ARG A  52
GLU A  60
ALA A  47
 None
 1.06A 1cmcA-4hh8A:
undetectable
1cmcB-4hh8A:
undetectable		 1cmcA-4hh8A:
17.27
1cmcB-4hh8A:
17.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CMC_B_SAMB105_0
(MET REPRESSOR)		 4hh8 BUTYROPHILIN
SUBFAMILY 1 MEMBER
A1
(Bos
taurus) 		5 / 10 GLU A  36
ARG A 101
ARG A  52
LEU A  50
GLU A  60
 None
 1.27A 1cmcA-4hh8A:
undetectable
1cmcB-4hh8A:
undetectable		 1cmcA-4hh8A:
17.27
1cmcB-4hh8A:
17.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJ2_A_SAMA2200_0
(PROTEIN (METHIONINE
REPRESSOR))		 4hh8 BUTYROPHILIN
SUBFAMILY 1 MEMBER
A1
(Bos
taurus) 		5 / 12 ALA A  47
GLU A  36
ARG A 101
ARG A  52
GLU A  60
 None
 1.10A 1mj2A-4hh8A:
undetectable
1mj2B-4hh8A:
undetectable		 1mj2A-4hh8A:
18.26
1mj2B-4hh8A:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJ2_A_SAMA2200_0
(PROTEIN (METHIONINE
REPRESSOR))		 4hh8 BUTYROPHILIN
SUBFAMILY 1 MEMBER
A1
(Bos
taurus) 		5 / 12 GLU A  36
ARG A 101
ARG A  52
LEU A  50
GLU A  60
 None
 1.27A 1mj2A-4hh8A:
undetectable
1mj2B-4hh8A:
undetectable		 1mj2A-4hh8A:
18.26
1mj2B-4hh8A:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJ2_A_SAMA2200_0
(PROTEIN (METHIONINE
REPRESSOR))		 4hh8 BUTYROPHILIN
SUBFAMILY 1 MEMBER
A1
(Bos
taurus) 		5 / 12 PHE A  99
GLU A  36
ARG A  52
LEU A  50
GLU A  60
 None
 1.18A 1mj2A-4hh8A:
undetectable
1mj2B-4hh8A:
undetectable		 1mj2A-4hh8A:
18.26
1mj2B-4hh8A:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJ2_A_SAMA2201_0
(PROTEIN (METHIONINE
REPRESSOR))		 4hh8 BUTYROPHILIN
SUBFAMILY 1 MEMBER
A1
(Bos
taurus) 		5 / 9 GLU A  36
ARG A 101
ARG A  52
LEU A  50
GLU A  60
 None
 1.21A 1mj2A-4hh8A:
undetectable		 1mj2A-4hh8A:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJ2_C_SAMC1200_0
(PROTEIN (METHIONINE
REPRESSOR))		 4hh8 BUTYROPHILIN
SUBFAMILY 1 MEMBER
A1
(Bos
taurus) 		5 / 9 GLU A  36
ARG A 101
ARG A  52
LEU A  50
GLU A  60
 None
 1.20A 1mj2C-4hh8A:
undetectable		 1mj2C-4hh8A:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJ2_C_SAMC2199_0
(PROTEIN (METHIONINE
REPRESSOR))		 4hh8 BUTYROPHILIN
SUBFAMILY 1 MEMBER
A1
(Bos
taurus) 		5 / 12 ALA A  47
GLU A  36
ARG A 101
ARG A  52
GLU A  60
 None
 1.03A 1mj2C-4hh8A:
undetectable
1mj2D-4hh8A:
undetectable		 1mj2C-4hh8A:
18.26
1mj2D-4hh8A:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJ2_C_SAMC2199_0
(PROTEIN (METHIONINE
REPRESSOR))		 4hh8 BUTYROPHILIN
SUBFAMILY 1 MEMBER
A1
(Bos
taurus) 		5 / 12 GLU A  36
ARG A 101
ARG A  52
LEU A  50
GLU A  60
 None
 1.21A 1mj2C-4hh8A:
undetectable
1mj2D-4hh8A:
undetectable		 1mj2C-4hh8A:
18.26
1mj2D-4hh8A:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJ2_C_SAMC2199_0
(PROTEIN (METHIONINE
REPRESSOR))		 4hh8 BUTYROPHILIN
SUBFAMILY 1 MEMBER
A1
(Bos
taurus) 		5 / 12 PHE A  99
GLU A  36
ARG A  52
LEU A  50
GLU A  60
 None
 1.17A 1mj2C-4hh8A:
undetectable
1mj2D-4hh8A:
undetectable		 1mj2C-4hh8A:
18.26
1mj2D-4hh8A:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJL_A_SAMA200_0
(METHIONINE REPRESSOR
PROTEIN METJ)		 4hh8 BUTYROPHILIN
SUBFAMILY 1 MEMBER
A1
(Bos
taurus) 		5 / 11 GLU A  36
ARG A 101
ARG A  52
LEU A  50
GLU A  60
 None
 1.20A 1mjlA-4hh8A:
undetectable
1mjlB-4hh8A:
undetectable		 1mjlA-4hh8A:
18.26
1mjlB-4hh8A:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJL_A_SAMA200_0
(METHIONINE REPRESSOR
PROTEIN METJ)		 4hh8 BUTYROPHILIN
SUBFAMILY 1 MEMBER
A1
(Bos
taurus) 		5 / 11 PHE A  99
GLU A  36
ARG A  52
LEU A  50
GLU A  60
 None
 1.10A 1mjlA-4hh8A:
undetectable
1mjlB-4hh8A:
undetectable		 1mjlA-4hh8A:
18.26
1mjlB-4hh8A:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJL_B_SAMB400_0
(METHIONINE REPRESSOR
PROTEIN METJ)		 4hh8 BUTYROPHILIN
SUBFAMILY 1 MEMBER
A1
(Bos
taurus) 		5 / 9 GLU A  36
ARG A  52
LEU A  50
GLU A  60
PHE A  99
 None
 1.10A 1mjlA-4hh8A:
undetectable
1mjlB-4hh8A:
undetectable		 1mjlA-4hh8A:
18.26
1mjlB-4hh8A:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJO_A_SAMA199_0
(METHIONINE REPRESSOR)		 4hh8 BUTYROPHILIN
SUBFAMILY 1 MEMBER
A1
(Bos
taurus) 		5 / 9 GLU A  36
ARG A 101
ARG A  52
LEU A  50
GLU A  60
 None
 1.21A 1mjoA-4hh8A:
undetectable		 1mjoA-4hh8A:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJO_B_SAMB200_1
(METHIONINE REPRESSOR)		 4hh8 BUTYROPHILIN
SUBFAMILY 1 MEMBER
A1
(Bos
taurus) 		5 / 9 GLU A  36
ARG A 101
ARG A  52
LEU A  50
GLU A  60
 None
 1.24A 1mjoB-4hh8A:
undetectable		 1mjoB-4hh8A:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJO_C_SAMC200_0
(METHIONINE REPRESSOR)		 4hh8 BUTYROPHILIN
SUBFAMILY 1 MEMBER
A1
(Bos
taurus) 		5 / 12 ALA A  47
GLU A  36
ARG A 101
ARG A  52
GLU A  60
 None
 1.04A 1mjoC-4hh8A:
undetectable
1mjoD-4hh8A:
undetectable		 1mjoC-4hh8A:
18.26
1mjoD-4hh8A:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJO_C_SAMC200_0
(METHIONINE REPRESSOR)		 4hh8 BUTYROPHILIN
SUBFAMILY 1 MEMBER
A1
(Bos
taurus) 		5 / 12 GLU A  36
ARG A 101
ARG A  52
LEU A  50
GLU A  60
 None
 1.19A 1mjoC-4hh8A:
undetectable
1mjoD-4hh8A:
undetectable		 1mjoC-4hh8A:
18.26
1mjoD-4hh8A:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJO_C_SAMC200_0
(METHIONINE REPRESSOR)		 4hh8 BUTYROPHILIN
SUBFAMILY 1 MEMBER
A1
(Bos
taurus) 		5 / 12 PHE A  99
GLU A  36
ARG A  52
LEU A  50
GLU A  60
 None
 1.15A 1mjoC-4hh8A:
undetectable
1mjoD-4hh8A:
undetectable		 1mjoC-4hh8A:
18.26
1mjoD-4hh8A:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJO_D_SAMD200_0
(METHIONINE REPRESSOR)		 4hh8 BUTYROPHILIN
SUBFAMILY 1 MEMBER
A1
(Bos
taurus) 		5 / 9 GLU A  36
ARG A 101
ARG A  52
LEU A  50
GLU A  60
 None
 1.21A 1mjoC-4hh8A:
undetectable		 1mjoC-4hh8A:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_A_SAMA200_0
(METHIONINE REPRESSOR)		 4hh8 BUTYROPHILIN
SUBFAMILY 1 MEMBER
A1
(Bos
taurus) 		5 / 11 GLU A  36
ARG A  52
LEU A  50
GLU A  60
PHE A  99
 None
 1.12A 1mjqA-4hh8A:
undetectable
1mjqB-4hh8A:
undetectable		 1mjqA-4hh8A:
18.26
1mjqB-4hh8A:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_B_SAMB200_0
(METHIONINE REPRESSOR)		 4hh8 BUTYROPHILIN
SUBFAMILY 1 MEMBER
A1
(Bos
taurus) 		5 / 11 PHE A  99
GLU A  36
ARG A  52
LEU A  50
GLU A  60
 None
 1.12A 1mjqA-4hh8A:
undetectable
1mjqB-4hh8A:
undetectable		 1mjqA-4hh8A:
18.26
1mjqB-4hh8A:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_C_SAMC199_0
(METHIONINE REPRESSOR)		 4hh8 BUTYROPHILIN
SUBFAMILY 1 MEMBER
A1
(Bos
taurus) 		5 / 10 GLU A  36
ARG A  52
LEU A  50
GLU A  60
PHE A  99
 None
 1.15A 1mjqC-4hh8A:
undetectable
1mjqD-4hh8A:
undetectable		 1mjqC-4hh8A:
18.26
1mjqD-4hh8A:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_D_SAMD200_0
(METHIONINE REPRESSOR)		 4hh8 BUTYROPHILIN
SUBFAMILY 1 MEMBER
A1
(Bos
taurus) 		5 / 12 PHE A  99
GLU A  36
ARG A  52
LEU A  50
ALA A  47
 None
 1.14A 1mjqC-4hh8A:
undetectable
1mjqD-4hh8A:
undetectable		 1mjqC-4hh8A:
18.26
1mjqD-4hh8A:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_D_SAMD200_0
(METHIONINE REPRESSOR)		 4hh8 BUTYROPHILIN
SUBFAMILY 1 MEMBER
A1
(Bos
taurus) 		5 / 12 PHE A  99
GLU A  36
ARG A  52
LEU A  50
GLU A  60
 None
 1.03A 1mjqC-4hh8A:
undetectable
1mjqD-4hh8A:
undetectable		 1mjqC-4hh8A:
18.26
1mjqD-4hh8A:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_H_SAMH200_0
(METHIONINE REPRESSOR)		 4hh8 BUTYROPHILIN
SUBFAMILY 1 MEMBER
A1
(Bos
taurus) 		5 / 10 PHE A  99
GLU A  36
ARG A  52
LEU A  50
GLU A  60
 None
 1.11A 1mjqG-4hh8A:
undetectable
1mjqH-4hh8A:
undetectable		 1mjqG-4hh8A:
18.26
1mjqH-4hh8A:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_I_SAMI199_0
(METHIONINE REPRESSOR)		 4hh8 BUTYROPHILIN
SUBFAMILY 1 MEMBER
A1
(Bos
taurus) 		5 / 11 GLU A  36
ARG A  52
LEU A  50
GLU A  60
PHE A  99
 None
 1.14A 1mjqI-4hh8A:
undetectable
1mjqJ-4hh8A:
undetectable		 1mjqI-4hh8A:
18.26
1mjqJ-4hh8A:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_J_SAMJ200_0
(METHIONINE REPRESSOR)		 4hh8 BUTYROPHILIN
SUBFAMILY 1 MEMBER
A1
(Bos
taurus) 		5 / 12 PHE A  99
GLU A  36
ARG A  52
LEU A  50
ALA A  47
 None
 1.14A 1mjqI-4hh8A:
undetectable
1mjqJ-4hh8A:
undetectable		 1mjqI-4hh8A:
18.26
1mjqJ-4hh8A:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_J_SAMJ200_0
(METHIONINE REPRESSOR)		 4hh8 BUTYROPHILIN
SUBFAMILY 1 MEMBER
A1
(Bos
taurus) 		5 / 12 PHE A  99
GLU A  36
ARG A  52
LEU A  50
GLU A  60
 None
 1.03A 1mjqI-4hh8A:
undetectable
1mjqJ-4hh8A:
undetectable		 1mjqI-4hh8A:
18.26
1mjqJ-4hh8A:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R38_A_RBFA201_2
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 4hh8 BUTYROPHILIN
SUBFAMILY 1 MEMBER
A1
(Bos
taurus) 		4 / 8 ILE A 110
VAL A  83
LEU A  22
ILE A  85
 None
 0.77A 4r38A-4hh8A:
undetectable		 4r38A-4hh8A:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YSH_B_GLYB401_0
(GLYCINE OXIDASE)		 4hh8 BUTYROPHILIN
SUBFAMILY 1 MEMBER
A1
(Bos
taurus) 		4 / 6 PHE A 174
GLY A 172
TYR A 144
ALA A  90
 None
 1.09A 4yshB-4hh8A:
undetectable		 4yshB-4hh8A:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA819_0
(GEPHYRIN)		 4hh8 BUTYROPHILIN
SUBFAMILY 1 MEMBER
A1
(Bos
taurus) 		3 / 3 ARG A  66
GLY A  59
GLU A  60
 None
 0.58A 6fgdA-4hh8A:
undetectable		 6fgdA-4hh8A:
19.81