SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4hhd'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PKV_A_RBFA100_1
(RIBOFLAVIN SYNTHASE
ALPHA CHAIN)		 4hhd PHOTOTROPIN-1
(Arabidopsis
thaliana) 		5 / 11 LEU A 558
THR A 539
ILE A 479
THR A 480
VAL A 478
 None
None
None
FMN  A 701 (-3.2A)
None
 1.17A 1pkvA-4hhdA:
undetectable
1pkvB-4hhdA:
undetectable		 1pkvA-4hhdA:
24.68
1pkvB-4hhdA:
24.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4KUK_A_RBFA201_1
(BLUE-LIGHT
PHOTORECEPTOR)		 4hhd PHOTOTROPIN-1
(Arabidopsis
thaliana) 		8 / 12 VAL A 478
ASN A 487
ASN A 511
ARG A 513
GLN A 516
ASN A 544
ASN A 554
GLN A 575
 None
FMN  A 701 (-3.7A)
FMN  A 701 (-2.9A)
FMN  A 701 (-2.6A)
FMN  A 701 (-3.3A)
FMN  A 701 (-2.8A)
FMN  A 701 (-3.8A)
FMN  A 701 (-3.6A)
 0.57A 4kukA-4hhdA:
19.2		 4kukA-4hhdA:
32.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4KUK_A_RBFA201_1
(BLUE-LIGHT
PHOTORECEPTOR)		 4hhd PHOTOTROPIN-1
(Arabidopsis
thaliana) 		8 / 12 VAL A 478
ASN A 487
ASN A 511
CYH A 512
ARG A 513
GLN A 516
ASN A 554
GLN A 575
 None
FMN  A 701 (-3.7A)
FMN  A 701 (-2.9A)
FMN  A 701 (-3.7A)
FMN  A 701 (-2.6A)
FMN  A 701 (-3.3A)
FMN  A 701 (-3.8A)
FMN  A 701 (-3.6A)
 0.81A 4kukA-4hhdA:
19.2		 4kukA-4hhdA:
32.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4KUK_A_RBFA201_2
(BLUE-LIGHT
PHOTORECEPTOR)		 4hhd PHOTOTROPIN-1
(Arabidopsis
thaliana) 		6 / 9 LEU A 515
VAL A 525
ILE A 528
ARG A 529
PHE A 571
GLY A 573
 FMN  A 701 (-4.4A)
FMN  A 701 (-4.9A)
FMN  A 701 ( 4.1A)
None
FMN  A 701 (-4.9A)
FMN  A 701 (-3.7A)
 0.80A 4kukA-4hhdA:
19.2		 4kukA-4hhdA:
32.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4KUO_A_RBFA500_1
(BLUE-LIGHT
PHOTORECEPTOR)		 4hhd PHOTOTROPIN-1
(Arabidopsis
thaliana) 		8 / 12 VAL A 478
ASN A 487
ASN A 511
ARG A 513
GLN A 516
ASN A 544
ASN A 554
GLN A 575
 None
FMN  A 701 (-3.7A)
FMN  A 701 (-2.9A)
FMN  A 701 (-2.6A)
FMN  A 701 (-3.3A)
FMN  A 701 (-2.8A)
FMN  A 701 (-3.8A)
FMN  A 701 (-3.6A)
 0.70A 4kuoA-4hhdA:
19.3		 4kuoA-4hhdA:
32.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4KUO_A_RBFA500_1
(BLUE-LIGHT
PHOTORECEPTOR)		 4hhd PHOTOTROPIN-1
(Arabidopsis
thaliana) 		8 / 12 VAL A 478
ASN A 487
ASN A 511
CYH A 512
ARG A 513
GLN A 516
ASN A 554
GLN A 575
 None
FMN  A 701 (-3.7A)
FMN  A 701 (-2.9A)
FMN  A 701 (-3.7A)
FMN  A 701 (-2.6A)
FMN  A 701 (-3.3A)
FMN  A 701 (-3.8A)
FMN  A 701 (-3.6A)
 0.89A 4kuoA-4hhdA:
19.3		 4kuoA-4hhdA:
32.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4R38_A_RBFA201_1
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 4hhd PHOTOTROPIN-1
(Arabidopsis
thaliana) 		7 / 12 ARG A 513
GLN A 516
ILE A 532
ASN A 544
ASN A 554
GLY A 573
GLN A 575
 FMN  A 701 (-2.6A)
FMN  A 701 (-3.3A)
FMN  A 701 (-4.7A)
FMN  A 701 (-2.8A)
FMN  A 701 (-3.8A)
FMN  A 701 (-3.7A)
FMN  A 701 (-3.6A)
 0.68A 4r38A-4hhdA:
19.1		 4r38A-4hhdA:
31.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4R38_A_RBFA201_1
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 4hhd PHOTOTROPIN-1
(Arabidopsis
thaliana) 		6 / 12 CYH A 512
ARG A 513
GLN A 516
ILE A 532
GLY A 573
GLN A 575
 FMN  A 701 (-3.7A)
FMN  A 701 (-2.6A)
FMN  A 701 (-3.3A)
FMN  A 701 (-4.7A)
FMN  A 701 (-3.7A)
FMN  A 701 (-3.6A)
 0.88A 4r38A-4hhdA:
19.1		 4r38A-4hhdA:
31.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4R38_A_RBFA201_2
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 4hhd PHOTOTROPIN-1
(Arabidopsis
thaliana) 		4 / 8 ASN A 511
LEU A 515
VAL A 525
PHE A 571
 FMN  A 701 (-2.9A)
FMN  A 701 (-4.4A)
FMN  A 701 (-4.9A)
FMN  A 701 (-4.9A)
 0.66A 4r38A-4hhdA:
19.1		 4r38A-4hhdA:
31.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4R38_B_RBFB201_1
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 4hhd PHOTOTROPIN-1
(Arabidopsis
thaliana) 		8 / 12 ASN A 511
ARG A 513
GLN A 516
ILE A 532
ASN A 544
ASN A 554
GLY A 573
GLN A 575
 FMN  A 701 (-2.9A)
FMN  A 701 (-2.6A)
FMN  A 701 (-3.3A)
FMN  A 701 (-4.7A)
FMN  A 701 (-2.8A)
FMN  A 701 (-3.8A)
FMN  A 701 (-3.7A)
FMN  A 701 (-3.6A)
 0.65A 4r38B-4hhdA:
19.2		 4r38B-4hhdA:
31.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4R38_B_RBFB201_1
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 4hhd PHOTOTROPIN-1
(Arabidopsis
thaliana) 		7 / 12 ASN A 511
CYH A 512
ARG A 513
GLN A 516
ILE A 532
GLY A 573
GLN A 575
 FMN  A 701 (-2.9A)
FMN  A 701 (-3.7A)
FMN  A 701 (-2.6A)
FMN  A 701 (-3.3A)
FMN  A 701 (-4.7A)
FMN  A 701 (-3.7A)
FMN  A 701 (-3.6A)
 0.85A 4r38B-4hhdA:
19.2		 4r38B-4hhdA:
31.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4R38_C_RBFC201_1
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 4hhd PHOTOTROPIN-1
(Arabidopsis
thaliana) 		7 / 12 ARG A 513
GLN A 516
ILE A 532
ASN A 544
ASN A 554
GLY A 573
GLN A 575
 FMN  A 701 (-2.6A)
FMN  A 701 (-3.3A)
FMN  A 701 (-4.7A)
FMN  A 701 (-2.8A)
FMN  A 701 (-3.8A)
FMN  A 701 (-3.7A)
FMN  A 701 (-3.6A)
 0.68A 4r38C-4hhdA:
9.1		 4r38C-4hhdA:
31.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4R38_C_RBFC201_1
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 4hhd PHOTOTROPIN-1
(Arabidopsis
thaliana) 		6 / 12 CYH A 512
ARG A 513
GLN A 516
ILE A 532
GLY A 573
GLN A 575
 FMN  A 701 (-3.7A)
FMN  A 701 (-2.6A)
FMN  A 701 (-3.3A)
FMN  A 701 (-4.7A)
FMN  A 701 (-3.7A)
FMN  A 701 (-3.6A)
 0.90A 4r38C-4hhdA:
9.1		 4r38C-4hhdA:
31.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4R38_D_RBFD201_1
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 4hhd PHOTOTROPIN-1
(Arabidopsis
thaliana) 		7 / 12 ARG A 513
GLN A 516
ILE A 532
ASN A 544
ASN A 554
GLY A 573
GLN A 575
 FMN  A 701 (-2.6A)
FMN  A 701 (-3.3A)
FMN  A 701 (-4.7A)
FMN  A 701 (-2.8A)
FMN  A 701 (-3.8A)
FMN  A 701 (-3.7A)
FMN  A 701 (-3.6A)
 0.67A 4r38D-4hhdA:
8.0		 4r38D-4hhdA:
31.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4R38_D_RBFD201_1
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 4hhd PHOTOTROPIN-1
(Arabidopsis
thaliana) 		7 / 12 CYH A 512
ARG A 513
GLN A 516
ILE A 532
ASN A 554
GLY A 573
GLN A 575
 FMN  A 701 (-3.7A)
FMN  A 701 (-2.6A)
FMN  A 701 (-3.3A)
FMN  A 701 (-4.7A)
FMN  A 701 (-3.8A)
FMN  A 701 (-3.7A)
FMN  A 701 (-3.6A)
 0.89A 4r38D-4hhdA:
8.0		 4r38D-4hhdA:
31.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R3A_A_RBFA402_1
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 4hhd PHOTOTROPIN-1
(Arabidopsis
thaliana) 		7 / 12 CYH A 512
ARG A 513
GLN A 516
ILE A 532
ASN A 544
ASN A 554
GLN A 575
 FMN  A 701 (-3.7A)
FMN  A 701 (-2.6A)
FMN  A 701 (-3.3A)
FMN  A 701 (-4.7A)
FMN  A 701 (-2.8A)
FMN  A 701 (-3.8A)
FMN  A 701 (-3.6A)
 0.78A 4r3aA-4hhdA:
16.7		 4r3aA-4hhdA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R3A_B_RBFB402_1
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 4hhd PHOTOTROPIN-1
(Arabidopsis
thaliana) 		5 / 10 ASN A 511
LEU A 515
GLN A 516
VAL A 525
PHE A 571
 FMN  A 701 (-2.9A)
FMN  A 701 (-4.4A)
FMN  A 701 (-3.3A)
FMN  A 701 (-4.9A)
FMN  A 701 (-4.9A)
 0.66A 4r3aB-4hhdA:
16.8		 4r3aB-4hhdA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R3A_B_RBFB402_2
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 4hhd PHOTOTROPIN-1
(Arabidopsis
thaliana) 		7 / 12 CYH A 512
ARG A 513
ILE A 532
ASN A 544
ASN A 554
GLY A 573
GLN A 575
 FMN  A 701 (-3.7A)
FMN  A 701 (-2.6A)
FMN  A 701 (-4.7A)
FMN  A 701 (-2.8A)
FMN  A 701 (-3.8A)
FMN  A 701 (-3.7A)
FMN  A 701 (-3.6A)
 0.75A 4r3aB-4hhdA:
16.8		 4r3aB-4hhdA:
20.51