SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4hhe'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OMB_D_IPHD2002_0
(BENCE JONES KWR
PROTEIN -
IMMUNOGLOBULIN LIGHT
CHAIN)		 4hhe QUINOLINATE SYNTHASE
A
(Pyrococcus
furiosus) 		4 / 7 HIS A  97
PRO A 169
HIS A 173
TYR A 175
 None
 1.28A 2ombC-4hheA:
undetectable
2ombD-4hheA:
undetectable		 2ombC-4hheA:
19.28
2ombD-4hheA:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZB_E_ACTE403_0
(PROTON-GATED ION
CHANNEL)		 4hhe QUINOLINATE SYNTHASE
A
(Pyrococcus
furiosus) 		3 / 3 ARG A  13
TYR A 272
GLU A  10
 None
 0.68A 4zzbE-4hheA:
undetectable		 4zzbE-4hheA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6D9H_R_ADNR400_1
(CHIMERA PROTEIN OF
MUSCARINIC
ACETYLCHOLINE
RECEPTOR M4 AND
ADENOSINE RECEPTOR
A1)		 4hhe QUINOLINATE SYNTHASE
A
(Pyrococcus
furiosus) 		5 / 10 VAL A 157
THR A 161
PHE A 147
LEU A 140
ILE A 136
 None
 1.42A 6d9hR-4hheA:
undetectable		 6d9hR-4hheA:
12.75