SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4hhq'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DY5_A_ACTA600_0
(RIBONUCLEASE A)		 4hhq SERUM PARAOXONASE BY
DIRECTED EVOLUTION
(synthetic
construct) 		4 / 4 HIS A 243
VAL A  30
ASN A  29
THR A  26
 None
 1.21A 1dy5A-4hhqA:
undetectable		 1dy5A-4hhqA:
17.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DTJ_B_THRB402_0
(ASPARTOKINASE)		 4hhq SERUM PARAOXONASE BY
DIRECTED EVOLUTION
(synthetic
construct) 		5 / 9 ASN A 270
ILE A 271
ASP A 169
ALA A 238
THR A 181
 CA  A 402 ( 3.8A)
None
CA  A 401 (-2.1A)
None
None
 1.39A 2dtjA-4hhqA:
undetectable
2dtjB-4hhqA:
undetectable		 2dtjA-4hhqA:
22.66
2dtjB-4hhqA:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AX7_A_SALA1336_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 4hhq SERUM PARAOXONASE BY
DIRECTED EVOLUTION
(synthetic
construct) 		4 / 8 GLU A  56
VAL A 131
LEU A 129
ALA A 172
 None
 0.91A 3ax7A-4hhqA:
undetectable		 3ax7A-4hhqA:
14.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AXZ_A_ADNA401_1
(TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE)		 4hhq SERUM PARAOXONASE BY
DIRECTED EVOLUTION
(synthetic
construct) 		5 / 12 TYR A 207
SER A 209
PRO A 210
ILE A 159
GLY A 174
 None
 0.90A 3axzA-4hhqA:
undetectable		 3axzA-4hhqA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UNI_A_SALA1344_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 4hhq SERUM PARAOXONASE BY
DIRECTED EVOLUTION
(synthetic
construct) 		4 / 7 GLU A  56
VAL A 131
LEU A 129
ALA A 172
 None
 0.93A 3uniA-4hhqA:
undetectable		 3uniA-4hhqA:
14.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D33_A_ACTA860_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4hhq SERUM PARAOXONASE BY
DIRECTED EVOLUTION
(synthetic
construct) 		4 / 5 GLY A 116
ILE A 117
VAL A 333
SER A  66
 CA  A 401 ( 4.6A)
None
None
None
 1.25A 4d33A-4hhqA:
undetectable		 4d33A-4hhqA:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D33_B_ACTB860_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4hhq SERUM PARAOXONASE BY
DIRECTED EVOLUTION
(synthetic
construct) 		4 / 5 GLY A 116
ILE A 117
VAL A 333
SER A  66
 CA  A 401 ( 4.6A)
None
None
None
 1.23A 4d33B-4hhqA:
undetectable		 4d33B-4hhqA:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D33_B_MTLB870_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4hhq SERUM PARAOXONASE BY
DIRECTED EVOLUTION
(synthetic
construct) 		4 / 7 SER A 272
GLU A  53
ASN A 227
ASP A 169
 None
CA  A 402 (-3.4A)
None
CA  A 401 (-2.1A)
 0.93A 4d33B-4hhqA:
undetectable		 4d33B-4hhqA:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D39_A_MTLA870_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4hhq SERUM PARAOXONASE BY
DIRECTED EVOLUTION
(synthetic
construct) 		4 / 8 SER A 272
GLU A  53
ASN A 227
ASP A 169
 None
CA  A 402 (-3.4A)
None
CA  A 401 (-2.1A)
 0.87A 4d39A-4hhqA:
undetectable		 4d39A-4hhqA:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D39_B_MTLB870_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4hhq SERUM PARAOXONASE BY
DIRECTED EVOLUTION
(synthetic
construct) 		4 / 7 SER A 272
GLU A  53
ASN A 227
ASP A 169
 None
CA  A 402 (-3.4A)
None
CA  A 401 (-2.1A)
 0.94A 4d39B-4hhqA:
undetectable		 4d39B-4hhqA:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7P_A_ACRA1431_1
(GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE)		 4hhq SERUM PARAOXONASE BY
DIRECTED EVOLUTION
(synthetic
construct) 		4 / 7 ASN A 168
ASP A 269
GLY A 344
ASN A 270
 CA  A 402 ( 3.8A)
CA  A 402 (-2.6A)
None
CA  A 402 ( 3.8A)
 1.09A 5x7pA-4hhqA:
undetectable		 5x7pA-4hhqA:
13.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_T_PCFT101_0
(CYTOCHROME B-C1
COMPLEX SUBUNIT 1,
MITOCHONDRIAL
CYTOCHROME B-C1
COMPLEX SUBUNIT 9
CYTOCHROME B-C1
COMPLEX SUBUNIT
RIESKE,
MITOCHONDRIAL)		 4hhq SERUM PARAOXONASE BY
DIRECTED EVOLUTION
(synthetic
construct) 		5 / 10 SER A 203
VAL A 268
GLY A 283
ALA A 335
ASN A 168
 None
None
None
None
CA  A 402 ( 3.8A)
 1.16A 6hu9L-4hhqA:
undetectable
6hu9P-4hhqA:
undetectable
6hu9T-4hhqA:
undetectable		 6hu9L-4hhqA:
24.18
6hu9P-4hhqA:
18.80
6hu9T-4hhqA:
10.58