SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4hht'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3FHX_B_PXLB313_1 (PYRIDOXAL KINASE)	4hht	RIBONUCLEASE HII (Thermotoga maritima)	4 / 8	SER A 184 VAL A 188 HIS A 181 VAL A 177	None	1.12A	3fhxB-4hhtA: undetectable	3fhxB-4hhtA: 21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4OR0_A_NPSA602_1 (SERUM ALBUMIN)	4hht	RIBONUCLEASE HII (Thermotoga maritima)	5 / 9	ALA A 32 ALA A 93 LEU A 113 SER A 21 VAL A 29	None None None C D 6 ( 4.7A) None	1.35A	4or0A-4hhtA: undetectable	4or0A-4hhtA: 18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5DZK_R_BEZR801_1 (ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 BEZ-LEU-LEU)	4hht	RIBONUCLEASE HII (Thermotoga maritima)	4 / 8	SER A 21 ALA A 20 PRO A 28 LEU A 144	C D 6 ( 4.7A) C D 6 ( 4.0A) None None	0.79A	5dzkd-4hhtA: undetectable 5dzkr-4hhtA: undetectable	5dzkd-4hhtA: 27.05 5dzkr-4hhtA: 3.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5NUK_A_Z80A201_1 (BETA-LACTOGLOBULIN)	4hht	RIBONUCLEASE HII (Thermotoga maritima)	5 / 10	ALA A 33 VAL A 67 ILE A 61 ILE A 43 ALA A 15	None	1.17A	5nukA-4hhtA: undetectable	5nukA-4hhtA: 15.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6AJI_A_AY6A1001_0 (DRUG EXPORTERS OF THE RND SUPERFAMILY-LIKE PROTEIN,ENDOLYSIN)	4hht	RIBONUCLEASE HII (Thermotoga maritima)	5 / 12	VAL A 14 VAL A 115 LEU A 113 ALA A 33 LEU A 94	None	1.20A	6ajiA-4hhtA: undetectable	6ajiA-4hhtA: 14.32

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["3FHX_B_PXLB313_1","PYRIDOXAL KINASE","4hht","RIBONUCLEASE HII","Thermotoga maritima",4,"SER A 184;VAL A 188;HIS A 181;VAL A 177","None","1.12A","3fhxB-4hhtA:undetectable","3fhxB-4hhtA:21.32"],["4OR0_A_NPSA602_1","SERUM ALBUMIN","4hht","RIBONUCLEASE HII","Thermotoga maritima",5,"ALA A  32;ALA A  93;LEU A 113;SER A  21;VAL A  29","None;None;None;  C D   6 ( 4.7A);None","1.35A","4or0A-4hhtA:undetectable","4or0A-4hhtA:18.80"],["5DZK_R_BEZR801_1","ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2;BEZ-LEU-LEU","4hht","RIBONUCLEASE HII","Thermotoga maritima",4,"SER A  21;ALA A  20;PRO A  28;LEU A 144","  C D   6 ( 4.7A);  C D   6 ( 4.0A);None;None","0.79A","5dzkd-4hhtA:undetectable;5dzkr-4hhtA:undetectable","5dzkd-4hhtA:27.05;5dzkr-4hhtA:3.51"],["5NUK_A_Z80A201_1","BETA-LACTOGLOBULIN","4hht","RIBONUCLEASE HII","Thermotoga maritima",5,"ALA A  33;VAL A  67;ILE A  61;ILE A  43;ALA A  15","None","1.17A","5nukA-4hhtA:undetectable","5nukA-4hhtA:15.70"],["6AJI_A_AY6A1001_0","DRUG EXPORTERS OF THE RND SUPERFAMILY-LIKE PROTEIN,ENDOLYSIN","4hht","RIBONUCLEASE HII","Thermotoga maritima",5,"VAL A  14;VAL A 115;LEU A 113;ALA A  33;LEU A  94","None","1.20A","6ajiA-4hhtA:undetectable","6ajiA-4hhtA:14.32"]]