SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4hhu'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM0_B_CHDB500_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 4hhu OR280
(synthetic
construct) 		4 / 7 THR A  33
VAL A  46
THR A  48
VAL A   3
 None
 0.49A 3em0B-4hhuA:
undetectable		 3em0B-4hhuA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM0_B_CHDB500_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 4hhu OR280
(synthetic
construct) 		4 / 7 THR A 114
VAL A 127
THR A 129
VAL A  84
 None
 0.61A 3em0B-4hhuA:
undetectable		 3em0B-4hhuA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HKU_A_TORA300_2
(CARBONIC ANHYDRASE 2)		 4hhu OR280
(synthetic
construct) 		3 / 3 GLU A 164
HIS A 166
THR A  37
 None
 0.89A 3hkuA-4hhuA:
undetectable		 3hkuA-4hhuA:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_B_LYAB514_2
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		 4hhu OR280
(synthetic
construct) 		3 / 3 ARG A 136
THR A 118
THR A  37
 None
 0.74A 3k2hB-4hhuA:
undetectable		 3k2hB-4hhuA:
16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CP4_A_CAMA416_0
(CYTOCHROME P450-CAM)		 4hhu OR280
(synthetic
construct) 		4 / 7 THR A 118
LEU A  16
VAL A  88
VAL A 125
 None
 0.91A 4cp4A-4hhuA:
undetectable		 4cp4A-4hhuA:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NM5_B_LOCB502_2
(TUBULIN BETA-2B
CHAIN)		 4hhu OR280
(synthetic
construct) 		5 / 12 LEU A  20
LEU A  65
ILE A   6
ALA A  62
ILE A  47
 AE4  A 201 (-4.8A)
None
None
None
None
 1.06A 5nm5B-4hhuA:
undetectable		 5nm5B-4hhuA:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NM5_B_LOCB502_2
(TUBULIN BETA-2B
CHAIN)		 4hhu OR280
(synthetic
construct) 		5 / 12 LEU A 101
LEU A 146
ILE A  87
ALA A 143
ILE A 128
 None
 1.19A 5nm5B-4hhuA:
undetectable		 5nm5B-4hhuA:
18.92