SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4hi0'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CQP_A_803A311_1
(ANTIGEN CD11A (P180))		 4hi0 UREASE ACCESSORY
PROTEIN UREH
(Helicobacter
pylori) 		5 / 10 LEU B  35
ILE B  48
LEU B 107
LEU B  67
VAL B  65
 None
 1.18A 1cqpA-4hi0B:
undetectable
1cqpB-4hi0B:
undetectable		 1cqpA-4hi0B:
21.69
1cqpB-4hi0B:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DDS_B_MTXB201_1
(DIHYDROFOLATE
REDUCTASE)		 4hi0 UREASE ACCESSORY
PROTEIN UREH
(Helicobacter
pylori) 		5 / 12 ILE B 207
ALA B 254
LEU B 200
SER B 219
ILE B 216
 None
 1.18A 1ddsB-4hi0B:
undetectable		 1ddsB-4hi0B:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK3_A_T44A3002_1
(SERUM ALBUMIN)		 4hi0 UREASE ACCESSORY
PROTEIN UREH
(Helicobacter
pylori) 		4 / 8 GLN B  80
LEU B  75
ARG B  76
LEU B  67
 None
 1.06A 1hk3A-4hi0B:
undetectable		 1hk3A-4hi0B:
17.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIF_A_BEZA349_0
(D-AMINO ACID OXIDASE)		 4hi0 UREASE ACCESSORY
PROTEIN UREH
(Helicobacter
pylori) 		4 / 5 TYR B 138
ILE B 128
ARG B  95
GLY B 124
 None
 1.30A 1kifA-4hi0B:
undetectable		 1kifA-4hi0B:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIF_B_BEZB349_0
(D-AMINO ACID OXIDASE)		 4hi0 UREASE ACCESSORY
PROTEIN UREH
(Helicobacter
pylori) 		4 / 5 TYR B 138
ILE B 128
ARG B  95
GLY B 124
 None
 1.30A 1kifB-4hi0B:
undetectable		 1kifB-4hi0B:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIF_C_BEZC349_0
(D-AMINO ACID OXIDASE)		 4hi0 UREASE ACCESSORY
PROTEIN UREH
(Helicobacter
pylori) 		4 / 5 TYR B 138
ILE B 128
ARG B  95
GLY B 124
 None
 1.30A 1kifC-4hi0B:
undetectable		 1kifC-4hi0B:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIF_D_BEZD349_0
(D-AMINO ACID OXIDASE)		 4hi0 UREASE ACCESSORY
PROTEIN UREH
(Helicobacter
pylori) 		4 / 5 TYR B 138
ILE B 128
ARG B  95
GLY B 124
 None
 1.30A 1kifD-4hi0B:
undetectable		 1kifD-4hi0B:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIF_E_BEZE349_0
(D-AMINO ACID OXIDASE)		 4hi0 UREASE ACCESSORY
PROTEIN UREH
(Helicobacter
pylori) 		4 / 5 TYR B 138
ILE B 128
ARG B  95
GLY B 124
 None
 1.30A 1kifE-4hi0B:
undetectable		 1kifE-4hi0B:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIF_F_BEZF349_0
(D-AMINO ACID OXIDASE)		 4hi0 UREASE ACCESSORY
PROTEIN UREH
(Helicobacter
pylori) 		4 / 5 TYR B 138
ILE B 128
ARG B  95
GLY B 124
 None
 1.30A 1kifF-4hi0B:
undetectable		 1kifF-4hi0B:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIF_G_BEZG349_0
(D-AMINO ACID OXIDASE)		 4hi0 UREASE ACCESSORY
PROTEIN UREH
(Helicobacter
pylori) 		4 / 5 TYR B 138
ILE B 128
ARG B  95
GLY B 124
 None
 1.30A 1kifG-4hi0B:
undetectable		 1kifG-4hi0B:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIF_H_BEZH349_0
(D-AMINO ACID OXIDASE)		 4hi0 UREASE ACCESSORY
PROTEIN UREH
(Helicobacter
pylori) 		4 / 5 TYR B 138
ILE B 128
ARG B  95
GLY B 124
 None
 1.30A 1kifH-4hi0B:
undetectable		 1kifH-4hi0B:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RX3_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 4hi0 UREASE ACCESSORY
PROTEIN UREH
(Helicobacter
pylori) 		5 / 12 ILE B 207
ALA B 254
LEU B 200
SER B 219
ILE B 216
 None
 1.13A 1rx3A-4hi0B:
undetectable		 1rx3A-4hi0B:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AQJ_A_TRPA650_0
(TRYPTOPHAN
HALOGENASE, PRNA)		 4hi0 UREASE ACCESSORY
PROTEIN UREH
(Helicobacter
pylori) 		5 / 11 ILE B 115
PRO B 116
ILE B 141
HIS B 196
GLU B 151
 None
 1.34A 2aqjA-4hi0B:
0.0		 2aqjA-4hi0B:
18.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKC_A_TRPA1520_0
(FLAVIN-DEPENDENT
TRYPTOPHAN
HALOGENASE PRNA)		 4hi0 UREASE ACCESSORY
PROTEIN UREH
(Helicobacter
pylori) 		5 / 10 ILE B 115
PRO B 116
ILE B 141
HIS B 196
GLU B 151
 None
 1.28A 2jkcA-4hi0B:
0.7		 2jkcA-4hi0B:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PLW_A_SAMA203_0
(RIBOSOMAL RNA
METHYLTRANSFERASE,
PUTATIVE)		 4hi0 UREASE ACCESSORY
PROTEIN UREG
(Helicobacter
pylori) 		5 / 12 ALA E 106
GLY E 100
PRO E   9
GLY E   8
ILE E  38
 None
 1.09A 2plwA-4hi0E:
undetectable		 2plwA-4hi0E:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XKW_A_P1BA1478_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 4hi0 UREASE ACCESSORY
PROTEIN UREG
(Helicobacter
pylori) 		5 / 12 PHE E 118
CYH E   7
SER E  99
HIS E  68
ILE E   4
 None
 1.39A 2xkwA-4hi0E:
undetectable		 2xkwA-4hi0E:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IA4_B_MTXB164_1
(DIHYDROFOLATE
REDUCTASE)		 4hi0 UREASE ACCESSORY
PROTEIN UREH
(Helicobacter
pylori) 		5 / 12 ILE B 207
ALA B 254
LEU B 200
SER B 219
ILE B 216
 None
 1.20A 3ia4B-4hi0B:
undetectable		 3ia4B-4hi0B:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IA4_D_MTXD164_1
(DIHYDROFOLATE
REDUCTASE)		 4hi0 UREASE ACCESSORY
PROTEIN UREH
(Helicobacter
pylori) 		5 / 12 ILE B 207
ALA B 254
LEU B 200
SER B 219
ILE B 216
 None
 1.17A 3ia4D-4hi0B:
undetectable		 3ia4D-4hi0B:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SFU_A_RBVA601_1
(RNA POLYMERASE)		 4hi0 UREASE ACCESSORY
PROTEIN UREH
(Helicobacter
pylori) 		5 / 9 SER B 163
THR B 127
THR B 126
ASN B 125
GLY B 124
 None
 1.25A 3sfuA-4hi0B:
undetectable		 3sfuA-4hi0B:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SFU_C_RBVC601_1
(RNA POLYMERASE)		 4hi0 UREASE ACCESSORY
PROTEIN UREH
(Helicobacter
pylori) 		5 / 11 SER B 163
THR B 127
THR B 126
ASN B 125
GLY B 124
 None
 1.36A 3sfuC-4hi0B:
undetectable		 3sfuC-4hi0B:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GH8_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 4hi0 UREASE ACCESSORY
PROTEIN UREH
(Helicobacter
pylori) 		5 / 12 ILE B 207
ALA B 254
LEU B 200
SER B 219
ILE B 216
 None
 1.17A 4gh8A-4hi0B:
undetectable		 4gh8A-4hi0B:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GH8_B_MTXB201_1
(DIHYDROFOLATE
REDUCTASE)		 4hi0 UREASE ACCESSORY
PROTEIN UREH
(Helicobacter
pylori) 		5 / 12 ILE B 207
ALA B 254
LEU B 200
SER B 219
ILE B 216
 None
 1.20A 4gh8B-4hi0B:
undetectable		 4gh8B-4hi0B:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKV_C_AERC601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 4hi0 UREASE ACCESSORY
PROTEIN UREG
(Helicobacter
pylori) 		4 / 6 ASP E  74
GLU E 111
VAL E  82
ALA E  81
 None
 1.07A 4nkvC-4hi0E:
undetectable		 4nkvC-4hi0E:
17.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_A_STRA601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 4hi0 UREASE ACCESSORY
PROTEIN UREG
(Helicobacter
pylori) 		4 / 6 ASP E  74
GLU E 111
VAL E  82
ALA E  81
 None
 0.99A 4nkxA-4hi0E:
undetectable		 4nkxA-4hi0E:
17.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUM_B_IMNB501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 4hi0 UREASE ACCESSORY
PROTEIN UREG
(Helicobacter
pylori) 		5 / 11 GLY E  60
ALA E  70
ILE E  71
LEU E 112
MET E  85
 None
 1.08A 4xumB-4hi0E:
undetectable		 4xumB-4hi0E:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y8W_A_STRA604_1
(CYTOCHROME P450
21-HYDROXYLASE)		 4hi0 UREASE ACCESSORY
PROTEIN UREG
(Helicobacter
pylori) 		5 / 12 VAL E  33
LEU E  96
ILE E  18
VAL E 187
LEU E 184
 None
 1.10A 4y8wA-4hi0E:
undetectable		 4y8wA-4hi0E:
17.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HI6_B_MTXB201_1
(DIHYDROFOLATE
REDUCTASE)		 4hi0 UREASE ACCESSORY
PROTEIN UREH
(Helicobacter
pylori) 		5 / 12 ILE B 207
ALA B 254
LEU B 200
SER B 219
ILE B 216
 None
 1.19A 5hi6B-4hi0B:
undetectable		 5hi6B-4hi0B:
24.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WWS_A_SAMA501_0
(PUTATIVE
METHYLTRANSFERASE
NSUN6)		 4hi0 UREASE ACCESSORY
PROTEIN UREG
(Helicobacter
pylori) 		5 / 12 ALA E 123
GLY E 154
ASP E 121
ASP E 126
LEU E 104
 None
 1.08A 5wwsA-4hi0E:
undetectable		 5wwsA-4hi0E:
18.30