SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4hi4'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AV2_A_DVAA6_0
(GRAMICIDIN A)		 4hi4 AEROTAXIS TRANSDUCER
AER2
(Pseudomonas
aeruginosa) 		3 / 3 ALA A 184
VAL A 202
TRP A 283
 None
 0.51A 1av2A-4hi4A:
undetectable
1av2B-4hi4A:
undetectable		 1av2A-4hi4A:
8.74
1av2B-4hi4A:
8.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AV2_D_DVAD6_0
(GRAMICIDIN A)		 4hi4 AEROTAXIS TRANSDUCER
AER2
(Pseudomonas
aeruginosa) 		3 / 3 TRP A 283
ALA A 184
VAL A 202
 None
 0.60A 1av2C-4hi4A:
undetectable
1av2D-4hi4A:
undetectable		 1av2C-4hi4A:
8.74
1av2D-4hi4A:
8.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BDW_B_DVAB6_0
(GRAMICIDIN A)		 4hi4 AEROTAXIS TRANSDUCER
AER2
(Pseudomonas
aeruginosa) 		3 / 3 TRP A 283
ALA A 184
VAL A 202
 None
 0.89A 1bdwA-4hi4A:
undetectable
1bdwB-4hi4A:
undetectable		 1bdwA-4hi4A:
8.74
1bdwB-4hi4A:
8.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GMK_A_DVAA6_0
(GRAMICIDIN A)		 4hi4 AEROTAXIS TRANSDUCER
AER2
(Pseudomonas
aeruginosa) 		3 / 3 ALA A 184
VAL A 202
TRP A 283
 None
 0.83A 1gmkA-4hi4A:
undetectable
1gmkB-4hi4A:
undetectable		 1gmkA-4hi4A:
8.74
1gmkB-4hi4A:
8.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GMK_C_DVAC6_0
(GRAMICIDIN A)		 4hi4 AEROTAXIS TRANSDUCER
AER2
(Pseudomonas
aeruginosa) 		3 / 3 ALA A 184
VAL A 202
TRP A 283
 None
 0.93A 1gmkC-4hi4A:
undetectable
1gmkD-4hi4A:
undetectable		 1gmkC-4hi4A:
8.74
1gmkD-4hi4A:
8.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MXD_A_ACRA733_1
(ALPHA AMYLASE)		 4hi4 AEROTAXIS TRANSDUCER
AER2
(Pseudomonas
aeruginosa) 		4 / 6 SER A 183
THR A 201
ASN A 181
ASP A 180
 None
 1.12A 1mxdA-4hi4A:
undetectable		 1mxdA-4hi4A:
14.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MXG_A_ACRA443_1
(ALPHA AMYLASE)		 4hi4 AEROTAXIS TRANSDUCER
AER2
(Pseudomonas
aeruginosa) 		4 / 8 SER A 183
THR A 201
ASN A 181
ASP A 180
 None
 1.11A 1mxgA-4hi4A:
undetectable		 1mxgA-4hi4A:
14.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W5U_A_DVAA6_0
(GRAMICIDIN D)		 4hi4 AEROTAXIS TRANSDUCER
AER2
(Pseudomonas
aeruginosa) 		3 / 3 ALA A 184
VAL A 202
TRP A 283
 None
 0.53A 1w5uA-4hi4A:
undetectable
1w5uB-4hi4A:
undetectable		 1w5uA-4hi4A:
8.74
1w5uB-4hi4A:
8.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W5U_B_DVAB6_0
(GRAMICIDIN D)		 4hi4 AEROTAXIS TRANSDUCER
AER2
(Pseudomonas
aeruginosa) 		3 / 3 TRP A 283
ALA A 184
VAL A 202
 None
 0.58A 1w5uA-4hi4A:
undetectable
1w5uB-4hi4A:
undetectable		 1w5uA-4hi4A:
8.74
1w5uB-4hi4A:
8.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YC2_E_NCAE507_0
(NAD-DEPENDENT
DEACETYLASE 2)		 4hi4 AEROTAXIS TRANSDUCER
AER2
(Pseudomonas
aeruginosa) 		4 / 7 ILE A 230
LEU A 244
ASN A 194
ILE A 196
 HEM  A 301 ( 3.9A)
HEM  A 301 ( 3.9A)
None
None
 0.98A 1yc2E-4hi4A:
undetectable		 1yc2E-4hi4A:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IZQ_A_DVAA6_0
(GRAMICIDIN D)		 4hi4 AEROTAXIS TRANSDUCER
AER2
(Pseudomonas
aeruginosa) 		3 / 3 ALA A 184
VAL A 202
TRP A 283
 None
 0.68A 2izqA-4hi4A:
undetectable
2izqB-4hi4A:
undetectable		 2izqA-4hi4A:
8.74
2izqB-4hi4A:
8.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IZQ_D_DVAD6_0
(GRAMICIDIN D)		 4hi4 AEROTAXIS TRANSDUCER
AER2
(Pseudomonas
aeruginosa) 		3 / 3 TRP A 283
ALA A 184
VAL A 202
 None
 0.60A 2izqC-4hi4A:
undetectable
2izqD-4hi4A:
undetectable		 2izqC-4hi4A:
8.74
2izqD-4hi4A:
8.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L8L_B_DVAB6_0
(GRAMICIDIN D)		 4hi4 AEROTAXIS TRANSDUCER
AER2
(Pseudomonas
aeruginosa) 		3 / 3 TRP A 283
ALA A 184
VAL A 202
 None
 0.76A 3l8lA-4hi4A:
undetectable
3l8lB-4hi4A:
undetectable		 3l8lA-4hi4A:
8.74
3l8lB-4hi4A:
10.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L8L_D_DVAD6_0
(GRAMICIDIN D)		 4hi4 AEROTAXIS TRANSDUCER
AER2
(Pseudomonas
aeruginosa) 		3 / 3 TRP A 283
ALA A 184
VAL A 202
 None
 0.53A 3l8lC-4hi4A:
undetectable
3l8lD-4hi4A:
undetectable		 3l8lC-4hi4A:
8.74
3l8lD-4hi4A:
10.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BYK_A_OAQA302_0
(SULFOTRANSFERASE)		 4hi4 AEROTAXIS TRANSDUCER
AER2
(Pseudomonas
aeruginosa) 		5 / 12 HIS A 234
LEU A 243
VAL A 281
VAL A 266
MET A 187
 HEM  A 301 ( 3.6A)
HEM  A 301 ( 3.7A)
HEM  A 301 (-4.1A)
HEM  A 301 ( 4.5A)
HEM  A 301 (-2.8A)
 1.19A 5bykA-4hi4A:
undetectable		 5bykA-4hi4A:
17.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M24_A_9CRA501_1
(RETINOIC ACID
RECEPTOR GAMMA)		 4hi4 AEROTAXIS TRANSDUCER
AER2
(Pseudomonas
aeruginosa) 		5 / 12 PHE A 233
LEU A 206
ILE A 213
GLY A 223
ILE A 195
 HEM  A 301 (-2.8A)
None
None
None
HEM  A 301 (-4.5A)
 1.13A 5m24A-4hi4A:
undetectable		 5m24A-4hi4A:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOP_B_C2FB3001_1
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 4hi4 AEROTAXIS TRANSDUCER
AER2
(Pseudomonas
aeruginosa) 		3 / 3 ASP A 231
ASN A 229
ASP A 192
 None
 0.89A 5vopB-4hi4A:
undetectable		 5vopB-4hi4A:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B50_A_OAQA302_0
(SULFOTRANSFERASE
OXAMNIQUINE
RESISTANCE PROTEIN)		 4hi4 AEROTAXIS TRANSDUCER
AER2
(Pseudomonas
aeruginosa) 		5 / 12 HIS A 234
LEU A 243
VAL A 281
VAL A 266
MET A 187
 HEM  A 301 ( 3.6A)
HEM  A 301 ( 3.7A)
HEM  A 301 (-4.1A)
HEM  A 301 ( 4.5A)
HEM  A 301 (-2.8A)
 1.20A 6b50A-4hi4A:
undetectable		 6b50A-4hi4A:
17.70