SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4hi7'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H7X_A_URFA1033_1
(DIHYDROPYRIMIDINE
DEHYDROGENASE)		 4hi7 GI20122
(Drosophila
mojavensis) 		4 / 6 ILE A  65
ASN A  64
ASN A  50
THR A  54
 None
None
None
GSH  A 301 (-4.2A)
 1.16A 1h7xA-4hi7A:
2.2		 1h7xA-4hi7A:
12.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H7X_B_URFB1033_1
(DIHYDROPYRIMIDINE
DEHYDROGENASE)		 4hi7 GI20122
(Drosophila
mojavensis) 		4 / 6 ILE A  65
ASN A  64
ASN A  50
THR A  54
 None
None
None
GSH  A 301 (-4.2A)
 1.17A 1h7xB-4hi7A:
2.7		 1h7xB-4hi7A:
12.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H7X_C_URFC1033_1
(DIHYDROPYRIMIDINE
DEHYDROGENASE)		 4hi7 GI20122
(Drosophila
mojavensis) 		4 / 6 ILE A  65
ASN A  64
ASN A  50
THR A  54
 None
None
None
GSH  A 301 (-4.2A)
 1.14A 1h7xC-4hi7A:
undetectable		 1h7xC-4hi7A:
12.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H7X_D_URFD1033_1
(DIHYDROPYRIMIDINE
DEHYDROGENASE)		 4hi7 GI20122
(Drosophila
mojavensis) 		4 / 6 ILE A  65
ASN A  64
ASN A  50
THR A  54
 None
None
None
GSH  A 301 (-4.2A)
 1.15A 1h7xD-4hi7A:
2.7		 1h7xD-4hi7A:
12.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZUL_A_SAMA376_1
(PROBABLE RIBOSOMAL
RNA SMALL SUBUNIT
METHYLTRANSFERASE)		 4hi7 GI20122
(Drosophila
mojavensis) 		3 / 3 SER A  43
GLU A  59
ASP A  62
 None
 0.75A 2zulA-4hi7A:
undetectable		 2zulA-4hi7A:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_F_SVRF502_2
(PHOSPHOLIPASE A2)		 4hi7 GI20122
(Drosophila
mojavensis) 		4 / 5 ILE A 165
SER A 166
PHE A 108
PRO A  14
 None
None
GSH  A 301 (-4.6A)
GSH  A 301 (-4.6A)
 1.34A 3bjwC-4hi7A:
undetectable		 3bjwC-4hi7A:
16.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DMH_A_SAMA384_1
(PROBABLE RIBOSOMAL
RNA SMALL SUBUNIT
METHYLTRANSFERASE)		 4hi7 GI20122
(Drosophila
mojavensis) 		3 / 3 SER A  43
GLU A  59
ASP A  62
 None
 0.78A 3dmhA-4hi7A:
undetectable		 3dmhA-4hi7A:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TJ7_C_ACTC610_0
(GBAA_1210 PROTEIN)		 4hi7 GI20122
(Drosophila
mojavensis) 		3 / 3 ASN A 110
ALA A 134
ARG A 131
 None
 0.83A 3tj7C-4hi7A:
undetectable
3tj7D-4hi7A:
undetectable		 3tj7C-4hi7A:
20.94
3tj7D-4hi7A:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DLW_A_5D5A905_0
(ECTONUCLEOTIDE
PYROPHOSPHATASE/PHOS
PHODIESTERASE FAMILY
MEMBER 2)		 4hi7 GI20122
(Drosophila
mojavensis) 		5 / 12 LEU A 112
ARG A  16
HIS A  69
VAL A 172
TYR A 139
 None
None
GSH  A 301 (-4.0A)
None
None
 1.16A 5dlwA-4hi7A:
0.6		 5dlwA-4hi7A:
15.89