SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4hic'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HPV_B_478B200_2
(HIV-1 PROTEASE)		 4hic TRAK
(Enterococcus
faecalis) 		5 / 9 VAL A 249
GLY A 268
ILE A 269
VAL A 306
ILE A 252
 None
 1.12A 1hpvB-4hicA:
undetectable		 1hpvB-4hicA:
17.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NU9_A_478A401_1
(PROTEASE)		 4hic TRAK
(Enterococcus
faecalis) 		4 / 8 VAL A 249
GLY A 268
ILE A 269
VAL A 306
 None
 0.73A 3nu9A-4hicA:
undetectable		 3nu9A-4hicA:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZMD_A_SALA201_1
(PUTATIVE
TRANSCRIPTIONAL
REGULATOR)		 4hic TRAK
(Enterococcus
faecalis) 		4 / 8 LEU A 107
TYR A 264
GLU A 265
HIS A 289
 None
 1.45A 3zmdA-4hicA:
undetectable
3zmdB-4hicA:
undetectable		 3zmdA-4hicA:
22.63
3zmdB-4hicA:
22.63