SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4hiz'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQB_A_BEZA524_0
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 4hiz ENDOSIALIDASE
(Enterobacteria
phage
phi92) 		4 / 6 SER A 543
PHE A 561
GLU A 564
GLY A 563
 None
 1.16A 1kqbA-4hizA:
undetectable
1kqbB-4hizA:
undetectable		 1kqbA-4hizA:
14.59
1kqbB-4hizA:
14.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQB_D_BEZD523_0
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 4hiz ENDOSIALIDASE
(Enterobacteria
phage
phi92) 		4 / 6 PHE A 561
GLU A 564
GLY A 563
SER A 543
 None
 1.12A 1kqbC-4hizA:
undetectable
1kqbD-4hizA:
undetectable		 1kqbC-4hizA:
14.59
1kqbD-4hizA:
14.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q6H_A_CXXA802_1
(TRANSPORTER)		 4hiz ENDOSIALIDASE
(Enterobacteria
phage
phi92) 		4 / 7 ILE A 425
SER A 367
PHE A 474
ILE A 483
 None
 1.11A 2q6hA-4hizA:
undetectable		 2q6hA-4hizA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QB4_A_DSMA802_1
(TRANSPORTER)		 4hiz ENDOSIALIDASE
(Enterobacteria
phage
phi92) 		4 / 7 ILE A 425
SER A 367
PHE A 474
ILE A 483
 None
 1.11A 2qb4A-4hizA:
undetectable		 2qb4A-4hizA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VOU_B_ACTB1391_0
(2,6-DIHYDROXYPYRIDIN
E HYDROXYLASE)		 4hiz ENDOSIALIDASE
(Enterobacteria
phage
phi92) 		3 / 3 PRO A 473
GLY A 548
TYR A 559
 None
 0.62A 2vouB-4hizA:
undetectable		 2vouB-4hizA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VOU_C_ACTC1391_0
(2,6-DIHYDROXYPYRIDIN
E HYDROXYLASE)		 4hiz ENDOSIALIDASE
(Enterobacteria
phage
phi92) 		3 / 3 PRO A 473
GLY A 548
TYR A 559
 None
 0.63A 2vouC-4hizA:
undetectable		 2vouC-4hizA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_C_ACHC1211_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 4hiz ENDOSIALIDASE
(Enterobacteria
phage
phi92) 		4 / 8 THR A 159
SER A 549
TYR A 558
TRP A 199
 None
NA  A 826 ( 4.5A)
None
None
 1.38A 2xz5A-4hizA:
undetectable
2xz5C-4hizA:
undetectable		 2xz5A-4hizA:
14.72
2xz5C-4hizA:
14.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A50_B_VD3B2001_1
(VITAMIN D
HYDROXYLASE)		 4hiz ENDOSIALIDASE
(Enterobacteria
phage
phi92) 		5 / 11 ILE A 309
LEU A 278
ASN A 229
ILE A 276
THR A 266
 None
 1.37A 3a50B-4hizA:
undetectable		 3a50B-4hizA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AI8_B_HNQB255_1
(CATHEPSIN B)		 4hiz ENDOSIALIDASE
(Enterobacteria
phage
phi92) 		4 / 6 GLN A 160
GLY A 548
HIS A 180
TRP A 158
 None
None
CL  A 821 (-4.8A)
EDO  A 810 (-3.5A)
 1.48A 3ai8B-4hizA:
undetectable		 3ai8B-4hizA:
17.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AQL_A_TXCA1452_2
(GUANINE DEAMINASE)		 4hiz ENDOSIALIDASE
(Enterobacteria
phage
phi92) 		4 / 5 HIS A 220
LEU A 349
LEU A 395
ASP A 351
 EDO  A 810 (-3.9A)
None
None
None
 1.16A 4aqlA-4hizA:
undetectable		 4aqlA-4hizA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNU_D_QDND602_1
(CYTOCHROME P450 2D6)		 4hiz ENDOSIALIDASE
(Enterobacteria
phage
phi92) 		5 / 10 PHE A 154
GLY A 181
GLU A 178
ALA A 157
ALA A 176
 None
EDO  A 810 (-4.1A)
None
None
None
 1.21A 4wnuD-4hizA:
undetectable		 4wnuD-4hizA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YMG_B_SAMB1001_1
(PUTATIVE
SAM-DEPENDENT
O-METHYLTRANFERASE)		 4hiz ENDOSIALIDASE
(Enterobacteria
phage
phi92) 		3 / 3 SER A 446
GLU A 492
GLU A 564
 None
 0.81A 4ymgB-4hizA:
undetectable		 4ymgB-4hizA:
15.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B58_A_ACTA607_0
(FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT)		 4hiz ENDOSIALIDASE
(Enterobacteria
phage
phi92) 		4 / 4 GLY A 282
ARG A 259
ASN A 229
LEU A 283
 EDO  A 805 (-3.5A)
None
None
None
 1.30A 6b58A-4hizA:
undetectable		 6b58A-4hizA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BRD_C_RFPC502_1
(RIFAMPIN
MONOOXYGENASE)		 4hiz ENDOSIALIDASE
(Enterobacteria
phage
phi92) 		5 / 12 VAL A 305
VAL A 289
GLY A 263
THR A 297
GLY A 298
 None
None
None
SLB  A 801 ( 4.5A)
SLB  A 801 (-3.5A)
 1.05A 6brdC-4hizA:
undetectable		 6brdC-4hizA:
7.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BRD_C_RFPC502_1
(RIFAMPIN
MONOOXYGENASE)		 4hiz ENDOSIALIDASE
(Enterobacteria
phage
phi92) 		5 / 12 VAL A 305
VAL A 289
GLY A 264
THR A 297
GLY A 298
 None
None
None
SLB  A 801 ( 4.5A)
SLB  A 801 (-3.5A)
 1.17A 6brdC-4hizA:
undetectable		 6brdC-4hizA:
7.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HLO_A_GBQA1501_0
(SUBSTANCE-P
RECEPTOR,GLGA
GLYCOGEN
SYNTHASE,SUBSTANCE-P
RECEPTOR)		 4hiz ENDOSIALIDASE
(Enterobacteria
phage
phi92) 		5 / 12 PRO A 389
ILE A 412
TYR A 382
HIS A 383
THR A 363
 None
None
None
None
EDO  A 813 (-4.5A)
 1.38A 6hloA-4hizA:
0.0		 6hloA-4hizA:
20.95