SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4hj3'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MT1_C_AG2C7004_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN)		 4hj3 LOV PROTEIN
(Rhodobacter
sphaeroides) 		4 / 6 ALA A 167
LEU A 161
LEU A  98
LEU A  81
 None
 0.71A 1mt1D-4hj3A:
undetectable
1mt1E-4hj3A:
undetectable		 1mt1D-4hj3A:
22.99
1mt1E-4hj3A:
13.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PEO_F_CU9F301_2
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 4hj3 LOV PROTEIN
(Rhodobacter
sphaeroides) 		4 / 6 THR A  43
GLN A 118
GLN A  49
ILE A  50
 None
FMN  A 201 (-3.8A)
None
None
 1.18A 3peoG-4hj3A:
undetectable		 3peoG-4hj3A:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KUK_A_RBFA201_1
(BLUE-LIGHT
PHOTORECEPTOR)		 4hj3 LOV PROTEIN
(Rhodobacter
sphaeroides) 		8 / 12 ASN A  54
CYH A  55
ARG A  56
GLN A  59
ASN A  87
ASN A  97
LEU A  99
GLN A 118
 FMN  A 201 (-3.1A)
FMN  A 201 (-3.7A)
FMN  A 201 (-3.4A)
FMN  A 201 (-3.6A)
FMN  A 201 (-2.9A)
FMN  A 201 (-3.8A)
FMN  A 201 (-4.4A)
FMN  A 201 (-3.8A)
 0.73A 4kukA-4hj3A:
15.0		 4kukA-4hj3A:
29.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KUK_A_RBFA201_2
(BLUE-LIGHT
PHOTORECEPTOR)		 4hj3 LOV PROTEIN
(Rhodobacter
sphaeroides) 		5 / 9 LEU A  58
ILE A  71
LEU A  75
PHE A 114
GLY A 116
 FMN  A 201 (-4.4A)
FMN  A 201 ( 4.0A)
FMN  A 201 ( 4.7A)
None
FMN  A 201 (-3.9A)
 0.94A 4kukA-4hj3A:
15.0		 4kukA-4hj3A:
29.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KUO_A_RBFA500_1
(BLUE-LIGHT
PHOTORECEPTOR)		 4hj3 LOV PROTEIN
(Rhodobacter
sphaeroides) 		9 / 12 ASN A  54
CYH A  55
ARG A  56
GLN A  59
LEU A  75
ASN A  87
ASN A  97
LEU A  99
GLN A 118
 FMN  A 201 (-3.1A)
FMN  A 201 (-3.7A)
FMN  A 201 (-3.4A)
FMN  A 201 (-3.6A)
FMN  A 201 ( 4.7A)
FMN  A 201 (-2.9A)
FMN  A 201 (-3.8A)
FMN  A 201 (-4.4A)
FMN  A 201 (-3.8A)
 0.78A 4kuoA-4hj3A:
15.0		 4kuoA-4hj3A:
29.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4R38_A_RBFA201_1
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 4hj3 LOV PROTEIN
(Rhodobacter
sphaeroides) 		7 / 12 ARG A  56
GLN A  59
ASN A  87
ASN A  97
LEU A  99
GLY A 116
GLN A 118
 FMN  A 201 (-3.4A)
FMN  A 201 (-3.6A)
FMN  A 201 (-2.9A)
FMN  A 201 (-3.8A)
FMN  A 201 (-4.4A)
FMN  A 201 (-3.9A)
FMN  A 201 (-3.8A)
 0.44A 4r38A-4hj3A:
15.4		 4r38A-4hj3A:
31.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4R38_A_RBFA201_1
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 4hj3 LOV PROTEIN
(Rhodobacter
sphaeroides) 		7 / 12 CYH A  55
ARG A  56
GLN A  59
ASN A  97
LEU A  99
GLY A 116
GLN A 118
 FMN  A 201 (-3.7A)
FMN  A 201 (-3.4A)
FMN  A 201 (-3.6A)
FMN  A 201 (-3.8A)
FMN  A 201 (-4.4A)
FMN  A 201 (-3.9A)
FMN  A 201 (-3.8A)
 0.80A 4r38A-4hj3A:
15.4		 4r38A-4hj3A:
31.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4R38_A_RBFA201_2
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 4hj3 LOV PROTEIN
(Rhodobacter
sphaeroides) 		4 / 8 THR A  21
ASN A  54
LEU A  58
PHE A 114
 FMN  A 201 (-4.4A)
FMN  A 201 (-3.1A)
FMN  A 201 (-4.4A)
None
 0.31A 4r38A-4hj3A:
15.4		 4r38A-4hj3A:
31.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4R38_B_RBFB201_1
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 4hj3 LOV PROTEIN
(Rhodobacter
sphaeroides) 		9 / 12 ASN A  54
CYH A  55
ARG A  56
GLN A  59
ASN A  87
ASN A  97
LEU A  99
GLY A 116
GLN A 118
 FMN  A 201 (-3.1A)
FMN  A 201 (-3.7A)
FMN  A 201 (-3.4A)
FMN  A 201 (-3.6A)
FMN  A 201 (-2.9A)
FMN  A 201 (-3.8A)
FMN  A 201 (-4.4A)
FMN  A 201 (-3.9A)
FMN  A 201 (-3.8A)
 0.77A 4r38B-4hj3A:
15.4		 4r38B-4hj3A:
31.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4R38_C_RBFC201_1
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 4hj3 LOV PROTEIN
(Rhodobacter
sphaeroides) 		8 / 12 CYH A  55
ARG A  56
GLN A  59
ASN A  87
ASN A  97
LEU A  99
GLY A 116
GLN A 118
 FMN  A 201 (-3.7A)
FMN  A 201 (-3.4A)
FMN  A 201 (-3.6A)
FMN  A 201 (-2.9A)
FMN  A 201 (-3.8A)
FMN  A 201 (-4.4A)
FMN  A 201 (-3.9A)
FMN  A 201 (-3.8A)
 0.71A 4r38C-4hj3A:
15.4		 4r38C-4hj3A:
31.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4R38_D_RBFD201_1
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 4hj3 LOV PROTEIN
(Rhodobacter
sphaeroides) 		7 / 12 ARG A  56
GLN A  59
ASN A  87
ASN A  97
LEU A  99
GLY A 116
GLN A 118
 FMN  A 201 (-3.4A)
FMN  A 201 (-3.6A)
FMN  A 201 (-2.9A)
FMN  A 201 (-3.8A)
FMN  A 201 (-4.4A)
FMN  A 201 (-3.9A)
FMN  A 201 (-3.8A)
 0.45A 4r38D-4hj3A:
15.4		 4r38D-4hj3A:
31.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4R38_D_RBFD201_1
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 4hj3 LOV PROTEIN
(Rhodobacter
sphaeroides) 		7 / 12 CYH A  55
ARG A  56
GLN A  59
ASN A  97
LEU A  99
GLY A 116
GLN A 118
 FMN  A 201 (-3.7A)
FMN  A 201 (-3.4A)
FMN  A 201 (-3.6A)
FMN  A 201 (-3.8A)
FMN  A 201 (-4.4A)
FMN  A 201 (-3.9A)
FMN  A 201 (-3.8A)
 0.80A 4r38D-4hj3A:
15.4		 4r38D-4hj3A:
31.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R3A_A_RBFA402_1
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 4hj3 LOV PROTEIN
(Rhodobacter
sphaeroides) 		7 / 12 CYH A  55
ARG A  56
GLN A  59
ASN A  87
ASN A  97
LEU A  99
GLN A 118
 FMN  A 201 (-3.7A)
FMN  A 201 (-3.4A)
FMN  A 201 (-3.6A)
FMN  A 201 (-2.9A)
FMN  A 201 (-3.8A)
FMN  A 201 (-4.4A)
FMN  A 201 (-3.8A)
 0.77A 4r3aA-4hj3A:
14.8		 4r3aA-4hj3A:
24.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R3A_B_RBFB402_1
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 4hj3 LOV PROTEIN
(Rhodobacter
sphaeroides) 		5 / 10 THR A  21
ASN A  54
LEU A  58
GLN A  59
PHE A 114
 FMN  A 201 (-4.4A)
FMN  A 201 (-3.1A)
FMN  A 201 (-4.4A)
FMN  A 201 (-3.6A)
None
 0.43A 4r3aB-4hj3A:
13.9		 4r3aB-4hj3A:
24.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R3A_B_RBFB402_2
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 4hj3 LOV PROTEIN
(Rhodobacter
sphaeroides) 		8 / 12 LEU A  32
CYH A  55
ARG A  56
ASN A  87
ASN A  97
LEU A  99
GLY A 116
GLN A 118
 None
FMN  A 201 (-3.7A)
FMN  A 201 (-3.4A)
FMN  A 201 (-2.9A)
FMN  A 201 (-3.8A)
FMN  A 201 (-4.4A)
FMN  A 201 (-3.9A)
FMN  A 201 (-3.8A)
 0.78A 4r3aB-4hj3A:
13.9		 4r3aB-4hj3A:
24.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_B_RCXB601_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4hj3 LOV PROTEIN
(Rhodobacter
sphaeroides) 		4 / 4 LEU A  22
ARG A  10
ILE A   9
PHE A  13
 None
 1.34A 5kirB-4hj3A:
undetectable		 5kirB-4hj3A:
14.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KOC_B_SAMB401_0
(PAVINE
N-METHYLTRANSFERASE)		 4hj3 LOV PROTEIN
(Rhodobacter
sphaeroides) 		5 / 12 PHE A 100
GLY A 116
THR A  21
ASN A  36
GLN A 118
 None
FMN  A 201 (-3.9A)
FMN  A 201 (-4.4A)
None
FMN  A 201 (-3.8A)
 1.15A 5kocB-4hj3A:
undetectable		 5kocB-4hj3A:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_D_ADND502_1
(ADENOSYLHOMOCYSTEINA
SE)		 4hj3 LOV PROTEIN
(Rhodobacter
sphaeroides) 		3 / 3 LEU A  32
ASN A  97
LEU A 101
 None
FMN  A 201 (-3.8A)
None
 0.64A 6exiD-4hj3A:
undetectable		 6exiD-4hj3A:
20.34