SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4hjh'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HBP_A_RTLA184_0
(RETINOL BINDING
PROTEIN)		 4hjh PHOSPHOMANNOMUTASE
(Brucella
melitensis) 		5 / 11 LEU A 190
ALA A 265
ALA A 263
VAL A 239
LEU A 356
 None
 1.36A 1hbpA-4hjhA:
undetectable		 1hbpA-4hjhA:
18.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J8U_A_H4BA429_1
(PHENYLALANINE-4-HYDR
OXYLASE)		 4hjh PHOSPHOMANNOMUTASE
(Brucella
melitensis) 		4 / 7 SER A 391
PHE A 394
LEU A 395
ALA A 437
 None
 0.64A 1j8uA-4hjhA:
undetectable		 1j8uA-4hjhA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQT_A_ACTA1869_0
(FPRA)		 4hjh PHOSPHOMANNOMUTASE
(Brucella
melitensis) 		4 / 4 ASP A 214
HIS A 105
ARG A 445
GLU A 443
 None
SEP  A 104 (-3.7A)
G6Q  A 544 (-4.0A)
None
 1.13A 1lqtA-4hjhA:
undetectable		 1lqtA-4hjhA:
25.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MUI_B_AB1B100_1
(PROTEASE)		 4hjh PHOSPHOMANNOMUTASE
(Brucella
melitensis) 		5 / 10 GLY A 272
ALA A 273
VAL A 293
GLY A 264
ILE A 266
 None
 0.95A 1muiA-4hjhA:
undetectable		 1muiA-4hjhA:
12.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N49_B_RITB301_2
(PROTEASE)		 4hjh PHOSPHOMANNOMUTASE
(Brucella
melitensis) 		5 / 11 ASN A 111
GLY A 103
ILE A  99
GLY A  51
ILE A  61
 None
SEP  A 104 ( 2.4A)
None
None
None
 0.96A 1n49B-4hjhA:
undetectable		 1n49B-4hjhA:
12.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N49_D_RITD401_1
(PROTEASE)		 4hjh PHOSPHOMANNOMUTASE
(Brucella
melitensis) 		5 / 11 ASN A 111
GLY A 103
ILE A  99
GLY A  51
ILE A  61
 None
SEP  A 104 ( 2.4A)
None
None
None
 0.94A 1n49C-4hjhA:
undetectable		 1n49C-4hjhA:
12.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PJ7_A_FFOA2887_1
(N,N-DIMETHYLGLYCINE
OXIDASE)		 4hjh PHOSPHOMANNOMUTASE
(Brucella
melitensis) 		3 / 3 ASP A 421
THR A 281
GLU A 216
 None
EDO  A 548 (-4.6A)
G6Q  A 544 (-4.3A)
 0.77A 1pj7A-4hjhA:
2.9		 1pj7A-4hjhA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XF1_B_ACTB1108_0
(C5A PEPTIDASE)		 4hjh PHOSPHOMANNOMUTASE
(Brucella
melitensis) 		4 / 6 LEU A  82
GLY A  80
ASN A  78
PHE A  49
 None
 0.79A 1xf1B-4hjhA:
2.3		 1xf1B-4hjhA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOH_C_FRDC305_1
(POL POLYPROTEIN
PEPTIDE INHIBITOR)		 4hjh PHOSPHOMANNOMUTASE
(Brucella
melitensis) 		4 / 5 LEU A 156
GLY A 243
PRO A  85
ALA A  86
 None
SEP  A 104 ( 4.6A)
None
None
 0.69A 2aohA-4hjhA:
undetectable		 2aohA-4hjhA:
11.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PNJ_B_CHDB502_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4hjh PHOSPHOMANNOMUTASE
(Brucella
melitensis) 		4 / 7 ILE A 106
ARG A 110
PRO A 301
GLY A   9
 IOD  A 516 ( 4.5A)
IOD  A 516 (-3.2A)
None
None
 1.10A 2pnjB-4hjhA:
2.3		 2pnjB-4hjhA:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ROX_B_T44B128_1
(TRANSTHYRETIN)		 4hjh PHOSPHOMANNOMUTASE
(Brucella
melitensis) 		4 / 6 GLU A  70
ALA A  68
LEU A  64
THR A  29
 None
 1.11A 2roxB-4hjhA:
undetectable		 2roxB-4hjhA:
15.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XFH_A_CL6A1413_1
(ERYTHROMYCIN B/D
C-12 HYDROXYLASE)		 4hjh PHOSPHOMANNOMUTASE
(Brucella
melitensis) 		4 / 6 ALA A  62
ALA A  65
THR A  29
PHE A 115
 None
 1.02A 2xfhA-4hjhA:
undetectable		 2xfhA-4hjhA:
23.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DTU_C_DXCC576_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2)		 4hjh PHOSPHOMANNOMUTASE
(Brucella
melitensis) 		4 / 8 PRO A 301
ALA A 305
ALA A 308
GLU A 127
 None
IOD  A 521 ( 4.1A)
IOD  A 506 ( 4.4A)
None
 0.58A 3dtuC-4hjhA:
undetectable
3dtuD-4hjhA:
undetectable		 3dtuC-4hjhA:
23.47
3dtuD-4hjhA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IJD_B_C2FB314_0
(UNCHARACTERIZED
PROTEIN)		 4hjh PHOSPHOMANNOMUTASE
(Brucella
melitensis) 		6 / 12 LEU A 197
VAL A 177
GLY A 178
LEU A 235
ILE A 250
LEU A 353
 None
 1.49A 3ijdB-4hjhA:
undetectable		 3ijdB-4hjhA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OZK_B_T44B128_1
(TRANSTHYRETIN)		 4hjh PHOSPHOMANNOMUTASE
(Brucella
melitensis) 		4 / 7 LEU A 194
LEU A 197
SER A 171
VAL A 359
 None
None
EDO  A 546 ( 4.3A)
None
 0.86A 3ozkB-4hjhA:
undetectable		 3ozkB-4hjhA:
15.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PP7_B_SVRB499_1
(PYRUVATE KINASE)		 4hjh PHOSPHOMANNOMUTASE
(Brucella
melitensis) 		5 / 10 THR A 241
PRO A  85
TYR A 159
GLY A 243
ALA A 245
 None
None
None
SEP  A 104 ( 4.6A)
None
 1.41A 3pp7B-4hjhA:
4.0		 3pp7B-4hjhA:
23.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TWP_D_SALD404_1
(ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE)		 4hjh PHOSPHOMANNOMUTASE
(Brucella
melitensis) 		4 / 5 ALA A  25
PRO A  24
TYR A  26
ALA A 143
 None
None
None
IOD  A 517 ( 3.8A)
 1.41A 3twpD-4hjhA:
undetectable		 3twpD-4hjhA:
26.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U7S_A_017A201_1
(POL POLYPROTEIN)		 4hjh PHOSPHOMANNOMUTASE
(Brucella
melitensis) 		5 / 9 LEU A  42
GLY A  73
ALA A  72
GLY A  67
VAL A  33
 None
 0.93A 3u7sA-4hjhA:
undetectable		 3u7sA-4hjhA:
13.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA1_A_08YA600_1
(CYTOCHROME P450 3A4)		 4hjh PHOSPHOMANNOMUTASE
(Brucella
melitensis) 		5 / 12 ASP A 123
ILE A  99
PHE A   8
ALA A  27
ALA A 133
 None
 1.36A 3ua1A-4hjhA:
undetectable		 3ua1A-4hjhA:
23.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HFP_B_15UB402_1
(PROTHROMBIN)		 4hjh PHOSPHOMANNOMUTASE
(Brucella
melitensis) 		5 / 12 LEU A   6
ALA A  65
ASP A  53
GLY A 112
GLY A 103
 None
None
None
None
SEP  A 104 ( 2.4A)
 1.24A 4hfpB-4hjhA:
undetectable		 4hfpB-4hjhA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NED_A_PFNA709_1
(LACTOTRANSFERRIN)		 4hjh PHOSPHOMANNOMUTASE
(Brucella
melitensis) 		4 / 6 ASP A 261
VAL A 258
SER A 372
ALA A 285
 None
IOD  A 534 ( 4.6A)
IOD  A 508 ( 4.3A)
None
 1.19A 4nedA-4hjhA:
undetectable		 4nedA-4hjhA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R29_D_SAMD301_1
(UNCHARACTERIZED
PROTEIN)		 4hjh PHOSPHOMANNOMUTASE
(Brucella
melitensis) 		3 / 3 ARG A 445
GLU A 322
TYR A 447
 G6Q  A 544 (-4.0A)
G6Q  A 544 (-2.3A)
EDO  A 548 (-4.8A)
 0.97A 4r29D-4hjhA:
undetectable		 4r29D-4hjhA:
17.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1K_D_LOCD502_1
(TUBULIN ALPHA CHAIN
TUBULIN BETA CHAIN)		 4hjh PHOSPHOMANNOMUTASE
(Brucella
melitensis) 		4 / 4 ASN A 283
SER A 380
ALA A 378
VAL A 377
 None
 1.30A 4x1kC-4hjhA:
undetectable		 4x1kC-4hjhA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XE3_A_CL6A502_1
(CYTOCHROME P-450)		 4hjh PHOSPHOMANNOMUTASE
(Brucella
melitensis) 		4 / 5 ALA A  25
THR A  29
VAL A  50
ILE A  99
 None
 0.94A 4xe3A-4hjhA:
undetectable		 4xe3A-4hjhA:
24.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YMG_B_SAMB1001_1
(PUTATIVE
SAM-DEPENDENT
O-METHYLTRANFERASE)		 4hjh PHOSPHOMANNOMUTASE
(Brucella
melitensis) 		3 / 3 SER A 306
GLU A 287
GLU A 449
 IOD  A 505 ( 4.8A)
None
EDO  A 548 ( 4.9A)
 0.67A 4ymgB-4hjhA:
undetectable		 4ymgB-4hjhA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B2Q_A_ACTA1728_0
(CRISPR-ASSOCIATED
ENDONUCLEASE CAS9)		 4hjh PHOSPHOMANNOMUTASE
(Brucella
melitensis) 		3 / 3 ASN A 440
SER A  11
ARG A 346
 G6Q  A 544 ( 3.6A)
G6Q  A 544 (-2.4A)
SEP  A 104 ( 2.9A)
 0.95A 5b2qA-4hjhA:
2.2		 5b2qA-4hjhA:
14.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTA_G_MFXG101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 4hjh PHOSPHOMANNOMUTASE
(Brucella
melitensis) 		4 / 7 SER A  88
ASP A 242
ARG A 247
GLY A 326
 None
MG  A 552 (-2.4A)
G6Q  A 544 (-3.2A)
None
 0.98A 5btaA-4hjhA:
3.2
5btaC-4hjhA:
3.2
5btaD-4hjhA:
undetectable		 5btaA-4hjhA:
23.19
5btaC-4hjhA:
23.19
5btaD-4hjhA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ERG_B_SAMB401_1
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
CATALYTIC SUBUNIT
TRM61)		 4hjh PHOSPHOMANNOMUTASE
(Brucella
melitensis) 		4 / 7 GLY A 299
GLU A 322
ASP A 261
ASP A 421
 G6Q  A 544 (-3.4A)
G6Q  A 544 (-2.3A)
None
None
 0.83A 5ergB-4hjhA:
undetectable		 5ergB-4hjhA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GWX_A_SAMA301_1
(GLYCINE SARCOSINE
N-METHYLTRANSFERASE)		 4hjh PHOSPHOMANNOMUTASE
(Brucella
melitensis) 		3 / 3 ARG A 445
ASN A 440
ASP A 244
 G6Q  A 544 (-4.0A)
G6Q  A 544 ( 3.6A)
MG  A 552 (-2.7A)
 0.90A 5gwxA-4hjhA:
undetectable		 5gwxA-4hjhA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IWU_A_ACTA402_0
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 4hjh PHOSPHOMANNOMUTASE
(Brucella
melitensis) 		4 / 6 PHE A 427
VAL A 433
TYR A 435
ILE A 466
 EDO  A 550 (-3.2A)
None
None
None
 1.13A 5iwuA-4hjhA:
undetectable		 5iwuA-4hjhA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NM5_B_LOCB502_1
(TUBULIN ALPHA-1B
CHAIN
TUBULIN BETA-2B
CHAIN)		 4hjh PHOSPHOMANNOMUTASE
(Brucella
melitensis) 		4 / 4 ASN A 283
SER A 380
ALA A 378
VAL A 377
 None
 1.26A 5nm5A-4hjhA:
undetectable		 5nm5A-4hjhA:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XU8_A_DX4A701_0
(UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 2)		 4hjh PHOSPHOMANNOMUTASE
(Brucella
melitensis) 		4 / 8 GLY A 463
LEU A 464
GLN A 460
ALA A 457
 None
EDO  A 551 (-4.4A)
None
None
 0.99A 5xu8A-4hjhA:
undetectable		 5xu8A-4hjhA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BQG_A_ERMA1201_2
(5-HYDROXYTRYPTAMINE
RECEPTOR 2C,SOLUBLE
CYTOCHROME B562)		 4hjh PHOSPHOMANNOMUTASE
(Brucella
melitensis) 		4 / 5 THR A 215
LEU A 190
VAL A 177
LEU A 204
 None
 1.03A 6bqgA-4hjhA:
undetectable		 6bqgA-4hjhA:
13.29