SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4hjj'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7W_A_MTXA301_1
(PTERIDINE REDUCTASE)		 4hjj ANTI-IL12 ANTI-IL18
DFAB HEAVY CHAIN
(Homo
sapiens) 		5 / 12 ARG H  68
PRO H  43
LEU H  20
LEU H  18
ASP H  91
 None
 1.36A 1e7wA-4hjjH:
undetectable		 1e7wA-4hjjH:
23.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1H8S_A_AICA1000_1
(MUTANT AL2 6E7P9G)		 4hjj ANTI-IL12 ANTI-IL18
DFAB HEAVY CHAIN
ANTI-IL12 ANTI-IL18
DFAB LIGHT CHAIN
(Homo
sapiens) 		7 / 12 TYR L 149
GLN L 202
PHE L 212
TRP H 158
VAL H 162
ALA H 222
TRP H 236
 None
 0.67A 1h8sA-4hjjL:
22.6		 1h8sA-4hjjL:
36.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_A_CFXA1300_2
(BETA-LACTAMASE)		 4hjj ANTI-IL12 ANTI-IL18
DFAB LIGHT CHAIN
(Homo
sapiens) 		4 / 5 TYR L 254
PRO L 128
LEU L 191
THR L 123
 None
 1.31A 1i2wA-4hjjL:
undetectable		 1i2wA-4hjjL:
23.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICT_D_T44D129_2
(TRANSTHYRETIN)		 4hjj ANTI-IL12 ANTI-IL18
DFAB LIGHT CHAIN
(Homo
sapiens) 		4 / 7 LEU L 249
THR L 286
SER L 276
THR L 278
 None
None
GOL  L 401 (-3.3A)
None
 0.74A 1ictD-4hjjL:
undetectable		 1ictD-4hjjL:
18.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NOD_B_H4BB902_1
(NITRIC OXIDE
SYNTHASE)		 4hjj ANTI-IL12 ANTI-IL18
DFAB HEAVY CHAIN
(Homo
sapiens) 		3 / 3 ARG H 100
ILE H  39
TRP H  49
 None
 1.04A 1nodB-4hjjH:
undetectable		 1nodB-4hjjH:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOJ_C_FRDC305_1
(POL POLYPROTEIN
PEPTIDE INHIBITOR)		 4hjj ANTI-IL12 ANTI-IL18
DFAB LIGHT CHAIN
(Homo
sapiens) 		4 / 5 LEU L 293
GLY L 242
PRO L 234
VAL L 246
 None
 0.83A 2aojA-4hjjL:
undetectable		 2aojA-4hjjL:
15.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q8H_A_TF4A438_1
([PYRUVATE
DEHYDROGENASE
[LIPOAMIDE]] KINASE
ISOZYME 1)		 4hjj ANTI-IL12 ANTI-IL18
DFAB LIGHT CHAIN
(Homo
sapiens) 		5 / 6 LEU L 186
TYR L 199
ILE L 171
ILE L 188
ARG L 174
 None
 1.33A 2q8hA-4hjjL:
undetectable		 2q8hA-4hjjL:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K9W_A_ACTA170_0
(PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE)		 4hjj ANTI-IL12 ANTI-IL18
DFAB LIGHT CHAIN
(Homo
sapiens) 		3 / 3 SER L 241
GLY L 242
THR L 243
 None
 0.20A 3k9wA-4hjjL:
undetectable		 3k9wA-4hjjL:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEE_B_30BB500_2
(GENOME POLYPROTEIN)		 4hjj ANTI-IL12 ANTI-IL18
DFAB LIGHT CHAIN
(Homo
sapiens) 		3 / 3 PHE L  71
TYR L  92
LEU L  47
 None
 0.80A 3keeB-4hjjL:
undetectable		 3keeB-4hjjL:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D1Y_A_RBFA1176_1
(PUTATIVE PROTEASE I)		 4hjj ANTI-IL12 ANTI-IL18
DFAB LIGHT CHAIN
(Homo
sapiens) 		4 / 8 GLN L 202
TRP L 207
GLN L 203
ASN L 145
 None
 1.44A 4d1yA-4hjjL:
undetectable
4d1yB-4hjjL:
undetectable		 4d1yA-4hjjL:
21.09
4d1yB-4hjjL:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D1Y_A_RBFA1176_1
(PUTATIVE PROTEASE I)		 4hjj ANTI-IL12 ANTI-IL18
DFAB LIGHT CHAIN
(Homo
sapiens) 		4 / 8 GLN L 203
ASN L 145
GLN L 202
TRP L 207
 None
 1.42A 4d1yA-4hjjL:
undetectable
4d1yB-4hjjL:
undetectable		 4d1yA-4hjjL:
21.09
4d1yB-4hjjL:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_G_HCYG900_2
(GLUCOCORTICOID
RECEPTOR)		 4hjj ANTI-IL12 ANTI-IL18
DFAB HEAVY CHAIN
ANTI-IL12 ANTI-IL18
DFAB LIGHT CHAIN
(Homo
sapiens) 		3 / 3 LEU H  47
MET H 106
TYR L  86
 None
 0.96A 4p6xG-4hjjH:
undetectable		 4p6xG-4hjjH:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZE1_A_X2NA602_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 4hjj ANTI-IL12 ANTI-IL18
DFAB HEAVY CHAIN
ANTI-IL12 ANTI-IL18
DFAB LIGHT CHAIN
(Homo
sapiens) 		4 / 5 TYR L  87
ILE L  21
PRO L  40
THR H 194
 None
 1.31A 4ze1A-4hjjL:
undetectable		 4ze1A-4hjjL:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSD_A_1GNA607_1
(PHIAB6 TAILSPIKE)		 4hjj ANTI-IL12 ANTI-IL18
DFAB HEAVY CHAIN
(Homo
sapiens) 		3 / 3 THR H 153
SER H 156
TYR H 157
 None
 0.74A 5jsdA-4hjjH:
undetectable		 5jsdA-4hjjH:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSD_B_1GNB618_1
(PHIAB6 TAILSPIKE)		 4hjj ANTI-IL12 ANTI-IL18
DFAB HEAVY CHAIN
(Homo
sapiens) 		3 / 3 THR H 153
SER H 156
TYR H 157
 None
 0.75A 5jsdB-4hjjH:
undetectable		 5jsdB-4hjjH:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSD_C_1GNC608_1
(PHIAB6 TAILSPIKE)		 4hjj ANTI-IL12 ANTI-IL18
DFAB HEAVY CHAIN
(Homo
sapiens) 		3 / 3 THR H 153
SER H 156
TYR H 157
 None
 0.74A 5jsdC-4hjjH:
undetectable		 5jsdC-4hjjH:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSE_A_1GNA608_1
(PHIAB6 TAILSPIKE)		 4hjj ANTI-IL12 ANTI-IL18
DFAB HEAVY CHAIN
(Homo
sapiens) 		3 / 3 THR H 153
SER H 156
TYR H 157
 None
 0.76A 5jseA-4hjjH:
undetectable		 5jseA-4hjjH:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSE_B_1GNB611_1
(PHIAB6 TAILSPIKE)		 4hjj ANTI-IL12 ANTI-IL18
DFAB HEAVY CHAIN
(Homo
sapiens) 		3 / 3 THR H 153
SER H 156
TYR H 157
 None
 0.76A 5jseB-4hjjH:
undetectable		 5jseB-4hjjH:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSE_C_1GNC611_1
(PHIAB6 TAILSPIKE)		 4hjj ANTI-IL12 ANTI-IL18
DFAB HEAVY CHAIN
(Homo
sapiens) 		3 / 3 THR H 153
SER H 156
TYR H 157
 None
 0.76A 5jseC-4hjjH:
2.3		 5jseC-4hjjH:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L4E_D_EDPD402_1
(PROTON-GATED ION
CHANNEL)		 4hjj ANTI-IL12 ANTI-IL18
DFAB LIGHT CHAIN
(Homo
sapiens) 		4 / 8 THR L  74
SER L  63
THR L  72
SER L  65
 None
 1.00A 5l4eA-4hjjL:
undetectable
5l4eB-4hjjL:
undetectable
5l4eC-4hjjL:
undetectable
5l4eD-4hjjL:
undetectable
5l4eE-4hjjL:
undetectable		 5l4eA-4hjjL:
21.05
5l4eB-4hjjL:
21.05
5l4eC-4hjjL:
21.05
5l4eD-4hjjL:
21.05
5l4eE-4hjjL:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_A_ACRA608_0
(ALPHA-AMYLASE)		 4hjj ANTI-IL12 ANTI-IL18
DFAB HEAVY CHAIN
ANTI-IL12 ANTI-IL18
DFAB LIGHT CHAIN
(Homo
sapiens;
Homo
sapiens) 		4 / 6 PHE H 175
GLY H 160
GLN L 202
TYR L 149
 None
 0.98A 6ag0A-4hjjH:
undetectable		 6ag0A-4hjjH:
12.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_C_ACRC606_0
(ALPHA-AMYLASE)		 4hjj ANTI-IL12 ANTI-IL18
DFAB HEAVY CHAIN
ANTI-IL12 ANTI-IL18
DFAB LIGHT CHAIN
(Homo
sapiens;
Homo
sapiens) 		4 / 6 PHE H 175
GLY H 160
GLN L 202
TYR L 149
 None
 0.98A 6ag0C-4hjjH:
undetectable		 6ag0C-4hjjH:
12.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GTQ_B_ACTB207_0
(DUF1778
DOMAIN-CONTAINING
PROTEIN
N-ACETYLTRANSFERASE)		 4hjj ANTI-IL12 ANTI-IL18
DFAB HEAVY CHAIN
ANTI-IL12 ANTI-IL18
DFAB LIGHT CHAIN
(Homo
sapiens;
Homo
sapiens) 		4 / 6 LEU L 159
THR H 232
GLY H 225
ARG H 223
 None
 1.28A 6gtqB-4hjjL:
undetectable
6gtqD-4hjjL:
undetectable		 6gtqB-4hjjL:
19.15
6gtqD-4hjjL:
8.92