SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4hjw'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_A_DCFA353_1
(ADENOSINE DEAMINASE)		 4hjw URACIL-5-CARBOXYLATE
DECARBOXYLASE
(Metarhizium
anisopliae) 		5 / 12 HIS A  12
HIS A  14
HIS A 195
HIS A 251
ASP A 323
 ZN  A 401 (-3.6A)
ZN  A 401 (-3.5A)
ZN  A 401 (-3.5A)
None
ZN  A 401 (-2.8A)
 0.95A 1a4lA-4hjwA:
13.4		 1a4lA-4hjwA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_C_DCFC1353_1
(ADENOSINE DEAMINASE)		 4hjw URACIL-5-CARBOXYLATE
DECARBOXYLASE
(Metarhizium
anisopliae) 		5 / 12 HIS A  12
HIS A  14
HIS A 195
HIS A 251
ASP A 323
 ZN  A 401 (-3.6A)
ZN  A 401 (-3.5A)
ZN  A 401 (-3.5A)
None
ZN  A 401 (-2.8A)
 0.86A 1a4lC-4hjwA:
14.0		 1a4lC-4hjwA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I9G_A_SAMA301_0
(HYPOTHETICAL PROTEIN
RV2118C)		 4hjw URACIL-5-CARBOXYLATE
DECARBOXYLASE
(Metarhizium
anisopliae) 		5 / 12 ILE A 150
GLY A 135
GLY A 161
ALA A 154
LEU A  96
 None
 1.22A 1i9gA-4hjwA:
undetectable		 1i9gA-4hjwA:
25.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NW5_A_SAMA401_1
(MODIFICATION
METHYLASE RSRI)		 4hjw URACIL-5-CARBOXYLATE
DECARBOXYLASE
(Metarhizium
anisopliae) 		3 / 3 ASP A  85
HIS A 127
ASP A  78
 None
 0.90A 1nw5A-4hjwA:
undetectable		 1nw5A-4hjwA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OIP_A_VIVA1278_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 4hjw URACIL-5-CARBOXYLATE
DECARBOXYLASE
(Metarhizium
anisopliae) 		5 / 12 ILE A  30
LEU A 139
ILE A 112
LEU A  96
VAL A 116
 None
 0.99A 1oipA-4hjwA:
2.9		 1oipA-4hjwA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P7L_C_SAMC685_0
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 4hjw URACIL-5-CARBOXYLATE
DECARBOXYLASE
(Metarhizium
anisopliae) 		4 / 8 HIS A 251
ASP A 297
PHE A 193
ASP A 323
 None
None
None
ZN  A 401 (-2.8A)
 1.16A 1p7lC-4hjwA:
undetectable		 1p7lC-4hjwA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P7L_C_SAMC885_1
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 4hjw URACIL-5-CARBOXYLATE
DECARBOXYLASE
(Metarhizium
anisopliae) 		4 / 8 HIS A 251
ASP A 297
PHE A 193
ASP A 323
 None
None
None
ZN  A 401 (-2.8A)
 1.14A 1p7lD-4hjwA:
undetectable		 1p7lD-4hjwA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG9_A_SAMA385_0
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 4hjw URACIL-5-CARBOXYLATE
DECARBOXYLASE
(Metarhizium
anisopliae) 		4 / 8 HIS A 251
ASP A 297
PHE A 193
ASP A 323
 None
None
None
ZN  A 401 (-2.8A)
 1.14A 1rg9A-4hjwA:
undetectable		 1rg9A-4hjwA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG9_B_SAMB485_1
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 4hjw URACIL-5-CARBOXYLATE
DECARBOXYLASE
(Metarhizium
anisopliae) 		4 / 8 HIS A 251
ASP A 297
PHE A 193
ASP A 323
 None
None
None
ZN  A 401 (-2.8A)
 1.15A 1rg9B-4hjwA:
undetectable		 1rg9B-4hjwA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG9_C_SAMC585_0
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 4hjw URACIL-5-CARBOXYLATE
DECARBOXYLASE
(Metarhizium
anisopliae) 		4 / 8 HIS A 251
ASP A 297
PHE A 193
ASP A 323
 None
None
None
ZN  A 401 (-2.8A)
 1.14A 1rg9C-4hjwA:
undetectable		 1rg9C-4hjwA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG9_C_SAMC685_1
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 4hjw URACIL-5-CARBOXYLATE
DECARBOXYLASE
(Metarhizium
anisopliae) 		4 / 8 HIS A 251
ASP A 297
PHE A 193
ASP A 323
 None
None
None
ZN  A 401 (-2.8A)
 1.13A 1rg9D-4hjwA:
undetectable		 1rg9D-4hjwA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HYY_A_STIA600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 4hjw URACIL-5-CARBOXYLATE
DECARBOXYLASE
(Metarhizium
anisopliae) 		4 / 6 LEU A 169
VAL A 294
VAL A 238
ILE A 192
 None
 0.89A 2hyyA-4hjwA:
undetectable		 2hyyA-4hjwA:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HYY_B_STIB600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 4hjw URACIL-5-CARBOXYLATE
DECARBOXYLASE
(Metarhizium
anisopliae) 		4 / 6 LEU A 169
VAL A 294
VAL A 238
ILE A 192
 None
 0.90A 2hyyB-4hjwA:
undetectable		 2hyyB-4hjwA:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JIH_A_097A1001_1
(ADAMTS-1)		 4hjw URACIL-5-CARBOXYLATE
DECARBOXYLASE
(Metarhizium
anisopliae) 		5 / 9 LEU A 164
HIS A 195
HIS A  14
HIS A  12
LEU A 194
 None
ZN  A 401 (-3.5A)
ZN  A 401 (-3.5A)
ZN  A 401 (-3.6A)
None
 1.49A 2jihA-4hjwA:
undetectable		 2jihA-4hjwA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OBV_A_SAMA501_0
(S-ADENOSYLMETHIONINE
SYNTHETASE ISOFORM
TYPE-1)		 4hjw URACIL-5-CARBOXYLATE
DECARBOXYLASE
(Metarhizium
anisopliae) 		4 / 8 HIS A 251
ASP A 297
PHE A 193
ASP A 323
 None
None
None
ZN  A 401 (-2.8A)
 1.12A 2obvA-4hjwA:
undetectable		 2obvA-4hjwA:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OW9_A_HAEA502_1
(COLLAGENASE 3)		 4hjw URACIL-5-CARBOXYLATE
DECARBOXYLASE
(Metarhizium
anisopliae) 		4 / 6 LEU A 218
HIS A  12
HIS A  14
HIS A 195
 None
ZN  A 401 (-3.6A)
ZN  A 401 (-3.5A)
ZN  A 401 (-3.5A)
 0.76A 2ow9A-4hjwA:
undetectable		 2ow9A-4hjwA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OZR_F_HAEF3004_1
(COLLAGENASE 3)		 4hjw URACIL-5-CARBOXYLATE
DECARBOXYLASE
(Metarhizium
anisopliae) 		3 / 3 HIS A  12
HIS A  14
HIS A 195
 ZN  A 401 (-3.6A)
ZN  A 401 (-3.5A)
ZN  A 401 (-3.5A)
 0.40A 2ozrF-4hjwA:
undetectable		 2ozrF-4hjwA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OZR_F_HAEF3004_1
(COLLAGENASE 3)		 4hjw URACIL-5-CARBOXYLATE
DECARBOXYLASE
(Metarhizium
anisopliae) 		3 / 3 HIS A 251
HIS A  12
HIS A 195
 None
ZN  A 401 (-3.6A)
ZN  A 401 (-3.5A)
 0.50A 2ozrF-4hjwA:
undetectable		 2ozrF-4hjwA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2P02_A_SAMA2_0
(S-ADENOSYLMETHIONINE
SYNTHETASE ISOFORM
TYPE-2)		 4hjw URACIL-5-CARBOXYLATE
DECARBOXYLASE
(Metarhizium
anisopliae) 		4 / 8 HIS A 251
ASP A 297
PHE A 193
ASP A 323
 None
None
None
ZN  A 401 (-2.8A)
 1.14A 2p02A-4hjwA:
undetectable		 2p02A-4hjwA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PGF_A_ADNA501_1
(ADENOSINE DEAMINASE)		 4hjw URACIL-5-CARBOXYLATE
DECARBOXYLASE
(Metarhizium
anisopliae) 		5 / 12 HIS A  14
ILE A 163
HIS A 195
HIS A 251
ASP A 323
 ZN  A 401 (-3.5A)
None
ZN  A 401 (-3.5A)
None
ZN  A 401 (-2.8A)
 1.21A 2pgfA-4hjwA:
13.1		 2pgfA-4hjwA:
24.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PGR_A_DCFA501_1
(ADENOSINE DEAMINASE)		 4hjw URACIL-5-CARBOXYLATE
DECARBOXYLASE
(Metarhizium
anisopliae) 		6 / 12 HIS A  12
HIS A  14
ILE A 163
HIS A 195
HIS A 251
ASP A 323
 ZN  A 401 (-3.6A)
ZN  A 401 (-3.5A)
None
ZN  A 401 (-3.5A)
None
ZN  A 401 (-2.8A)
 1.16A 2pgrA-4hjwA:
12.6		 2pgrA-4hjwA:
24.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM0_A_CHDA153_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 4hjw URACIL-5-CARBOXYLATE
DECARBOXYLASE
(Metarhizium
anisopliae) 		4 / 5 ILE A 330
THR A  71
PHE A  74
PHE A 326
 None
 1.08A 3em0A-4hjwA:
undetectable		 3em0A-4hjwA:
15.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K5V_A_STIA2_2
(TYROSINE-PROTEIN
KINASE ABL1)		 4hjw URACIL-5-CARBOXYLATE
DECARBOXYLASE
(Metarhizium
anisopliae) 		4 / 6 LEU A 169
VAL A 294
VAL A 238
ILE A 192
 None
 0.88A 3k5vA-4hjwA:
undetectable		 3k5vA-4hjwA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K5V_B_STIB2_2
(TYROSINE-PROTEIN
KINASE ABL1)		 4hjw URACIL-5-CARBOXYLATE
DECARBOXYLASE
(Metarhizium
anisopliae) 		4 / 6 LEU A 169
VAL A 294
VAL A 238
ILE A 192
 None
 0.85A 3k5vB-4hjwA:
undetectable		 3k5vB-4hjwA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OCT_A_1N1A663_2
(TYROSINE-PROTEIN
KINASE BTK)		 4hjw URACIL-5-CARBOXYLATE
DECARBOXYLASE
(Metarhizium
anisopliae) 		4 / 5 PHE A 133
ILE A  91
MET A  15
PHE A 132
 None
 1.40A 3octA-4hjwA:
undetectable		 3octA-4hjwA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_A_06XA502_1
(CYTOCHROME P450 2B6)		 4hjw URACIL-5-CARBOXYLATE
DECARBOXYLASE
(Metarhizium
anisopliae) 		5 / 11 ARG A  27
LEU A  24
ARG A  68
PRO A 325
PHE A  74
 None
 1.35A 3ua5A-4hjwA:
undetectable		 3ua5A-4hjwA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DTZ_B_LDPB501_1
(CYTOCHROME P450 BM3
VARIANT 8C8)		 4hjw URACIL-5-CARBOXYLATE
DECARBOXYLASE
(Metarhizium
anisopliae) 		4 / 6 ALA A 260
ALA A 231
LEU A 256
THR A 227
 None
 1.06A 4dtzB-4hjwA:
undetectable		 4dtzB-4hjwA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KTT_A_SAMA405_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 4hjw URACIL-5-CARBOXYLATE
DECARBOXYLASE
(Metarhizium
anisopliae) 		4 / 8 HIS A 251
ASP A 297
PHE A 193
ASP A 323
 None
None
None
ZN  A 401 (-2.8A)
 1.12A 4kttA-4hjwA:
undetectable		 4kttA-4hjwA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KTT_C_SAMC404_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 4hjw URACIL-5-CARBOXYLATE
DECARBOXYLASE
(Metarhizium
anisopliae) 		4 / 8 HIS A 251
ASP A 297
PHE A 193
ASP A 323
 None
None
None
ZN  A 401 (-2.8A)
 1.09A 4kttC-4hjwA:
undetectable		 4kttC-4hjwA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M2X_E_TMQE202_1
(DIHYDROFOLATE
REDUCTASE)		 4hjw URACIL-5-CARBOXYLATE
DECARBOXYLASE
(Metarhizium
anisopliae) 		5 / 12 ILE A 179
ILE A 150
LEU A 139
PRO A 138
LEU A 169
 None
 1.00A 4m2xE-4hjwA:
undetectable		 4m2xE-4hjwA:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NDN_C_SAMC405_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 4hjw URACIL-5-CARBOXYLATE
DECARBOXYLASE
(Metarhizium
anisopliae) 		4 / 7 HIS A 251
ASP A 297
PHE A 193
ASP A 323
 None
None
None
ZN  A 401 (-2.8A)
 1.12A 4ndnC-4hjwA:
undetectable		 4ndnC-4hjwA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ODJ_A_SAMA500_0
(S-ADENOSYLMETHIONINE
SYNTHASE)		 4hjw URACIL-5-CARBOXYLATE
DECARBOXYLASE
(Metarhizium
anisopliae) 		4 / 7 HIS A 251
ASP A 297
PHE A 193
ASP A 323
 None
None
None
ZN  A 401 (-2.8A)
 1.13A 4odjA-4hjwA:
undetectable		 4odjA-4hjwA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R88_A_1LDA501_0
(CYTOSINE DEAMINASE)		 4hjw URACIL-5-CARBOXYLATE
DECARBOXYLASE
(Metarhizium
anisopliae) 		5 / 12 HIS A  14
HIS A 195
HIS A 251
LEU A 218
ASP A 323
 ZN  A 401 (-3.5A)
ZN  A 401 (-3.5A)
None
None
ZN  A 401 (-2.8A)
 1.06A 4r88A-4hjwA:
5.5		 4r88A-4hjwA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UIN_H_QI9H1226_0
(FAB 314.3)		 4hjw URACIL-5-CARBOXYLATE
DECARBOXYLASE
(Metarhizium
anisopliae) 		5 / 12 GLU A  50
GLY A  67
GLY A 213
LEU A 218
PRO A 217
 None
 0.90A 4uinH-4hjwA:
undetectable
4uinL-4hjwA:
undetectable		 4uinH-4hjwA:
19.95
4uinL-4hjwA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XI3_B_29SB601_2
(ESTROGEN RECEPTOR)		 4hjw URACIL-5-CARBOXYLATE
DECARBOXYLASE
(Metarhizium
anisopliae) 		4 / 5 LEU A  44
GLU A  25
LEU A  96
HIS A 197
 None
 1.24A 4xi3B-4hjwA:
undetectable		 4xi3B-4hjwA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZVM_A_DM2A303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 4hjw URACIL-5-CARBOXYLATE
DECARBOXYLASE
(Metarhizium
anisopliae) 		5 / 12 GLY A 321
THR A 322
ILE A  89
PHE A 134
PHE A 193
 None
 1.27A 4zvmA-4hjwA:
undetectable
4zvmB-4hjwA:
undetectable		 4zvmA-4hjwA:
21.20
4zvmB-4hjwA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A1I_A_ADNA407_1
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 4hjw URACIL-5-CARBOXYLATE
DECARBOXYLASE
(Metarhizium
anisopliae) 		4 / 8 HIS A 251
ASP A 297
PHE A 193
ASP A 323
 None
None
None
ZN  A 401 (-2.8A)
 1.12A 5a1iA-4hjwA:
undetectable		 5a1iA-4hjwA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A1I_A_SAMA405_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 4hjw URACIL-5-CARBOXYLATE
DECARBOXYLASE
(Metarhizium
anisopliae) 		4 / 7 HIS A 251
ASP A 297
PHE A 193
ASP A 323
 None
None
None
ZN  A 401 (-2.8A)
 1.12A 5a1iA-4hjwA:
undetectable		 5a1iA-4hjwA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D75_A_FK5A301_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP3)		 4hjw URACIL-5-CARBOXYLATE
DECARBOXYLASE
(Metarhizium
anisopliae) 		5 / 11 LEU A 139
VAL A 162
ILE A 192
ALA A 229
PHE A 182
 None
 1.04A 5d75A-4hjwA:
undetectable		 5d75A-4hjwA:
16.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GPG_A_RAPA301_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP3)		 4hjw URACIL-5-CARBOXYLATE
DECARBOXYLASE
(Metarhizium
anisopliae) 		5 / 11 LEU A 139
VAL A 162
ILE A 192
ALA A 229
PHE A 182
 None
 1.10A 5gpgA-4hjwA:
undetectable		 5gpgA-4hjwA:
15.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MLM_A_STRA401_1
(-)		 4hjw URACIL-5-CARBOXYLATE
DECARBOXYLASE
(Metarhizium
anisopliae) 		5 / 12 PHE A 182
ILE A 181
MET A 247
ALA A 154
ILE A 150
 None
 1.16A 5mlmA-4hjwA:
undetectable		 5mlmA-4hjwA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NZW_A_9F2A1102_1
(DNA CROSS-LINK
REPAIR 1A PROTEIN)		 4hjw URACIL-5-CARBOXYLATE
DECARBOXYLASE
(Metarhizium
anisopliae) 		5 / 10 HIS A  14
HIS A  12
ASP A 323
THR A 166
HIS A 251
 ZN  A 401 (-3.5A)
ZN  A 401 (-3.6A)
ZN  A 401 (-2.8A)
None
None
 1.08A 5nzwA-4hjwA:
undetectable		 5nzwA-4hjwA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5T8S_B_SAMB402_1
(S-ADENOSYLMETHIONINE
SYNTHASE)		 4hjw URACIL-5-CARBOXYLATE
DECARBOXYLASE
(Metarhizium
anisopliae) 		4 / 8 HIS A 251
ASP A 297
PHE A 193
ASP A 323
 None
None
None
ZN  A 401 (-2.8A)
 1.12A 5t8sB-4hjwA:
undetectable		 5t8sB-4hjwA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIP_A_HFGA1003_1
(PROLYL-TRNA
SYNTHETASE, PUTATIVE)		 4hjw URACIL-5-CARBOXYLATE
DECARBOXYLASE
(Metarhizium
anisopliae) 		3 / 3 GLU A 225
TRP A 100
HIS A 251
 None
 1.10A 5xipA-4hjwA:
undetectable		 5xipA-4hjwA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRD_C_CUC605_0
(TYROSINASE)		 4hjw URACIL-5-CARBOXYLATE
DECARBOXYLASE
(Metarhizium
anisopliae) 		4 / 5 HIS A  12
HIS A 251
HIS A 195
PHE A 193
 ZN  A 401 (-3.6A)
None
ZN  A 401 (-3.5A)
None
 1.17A 5zrdC-4hjwA:
undetectable		 5zrdC-4hjwA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRD_D_CUD606_0
(TYROSINASE)		 4hjw URACIL-5-CARBOXYLATE
DECARBOXYLASE
(Metarhizium
anisopliae) 		4 / 5 HIS A  12
HIS A 251
HIS A 195
PHE A 193
 ZN  A 401 (-3.6A)
None
ZN  A 401 (-3.5A)
None
 1.19A 5zrdD-4hjwA:
undetectable		 5zrdD-4hjwA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FBN_B_SAMB401_1
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 4hjw URACIL-5-CARBOXYLATE
DECARBOXYLASE
(Metarhizium
anisopliae) 		4 / 8 HIS A 251
ASP A 297
PHE A 193
ASP A 323
 None
None
None
ZN  A 401 (-2.8A)
 1.12A 6fbnB-4hjwA:
undetectable		 6fbnB-4hjwA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FBO_A_ADNA406_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 4hjw URACIL-5-CARBOXYLATE
DECARBOXYLASE
(Metarhizium
anisopliae) 		4 / 8 HIS A 251
ASP A 297
PHE A 193
ASP A 323
 None
None
None
ZN  A 401 (-2.8A)
 1.09A 6fboA-4hjwA:
undetectable		 6fboA-4hjwA:
11.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FCB_A_SAMA405_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 4hjw URACIL-5-CARBOXYLATE
DECARBOXYLASE
(Metarhizium
anisopliae) 		4 / 8 HIS A 251
ASP A 297
PHE A 193
ASP A 323
 None
None
None
ZN  A 401 (-2.8A)
 1.10A 6fcbA-4hjwA:
undetectable		 6fcbA-4hjwA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FCD_A_ADNA405_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 4hjw URACIL-5-CARBOXYLATE
DECARBOXYLASE
(Metarhizium
anisopliae) 		4 / 8 HIS A 251
ASP A 297
PHE A 193
ASP A 323
 None
None
None
ZN  A 401 (-2.8A)
 1.11A 6fcdA-4hjwA:
undetectable		 6fcdA-4hjwA:
11.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G6R_A_SAMA406_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 4hjw URACIL-5-CARBOXYLATE
DECARBOXYLASE
(Metarhizium
anisopliae) 		4 / 7 HIS A 251
ASP A 297
PHE A 193
ASP A 323
 None
None
None
ZN  A 401 (-2.8A)
 1.11A 6g6rA-4hjwA:
undetectable		 6g6rA-4hjwA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6N91_A_DCFA401_0
(ADENOSINE DEAMINASE)		 4hjw URACIL-5-CARBOXYLATE
DECARBOXYLASE
(Metarhizium
anisopliae) 		5 / 12 HIS A  14
ILE A 163
HIS A 195
HIS A 251
ASP A 323
 ZN  A 401 (-3.5A)
None
ZN  A 401 (-3.5A)
None
ZN  A 401 (-2.8A)
 1.25A 6n91A-4hjwA:
7.5		 6n91A-4hjwA:
12.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6N91_B_DCFB401_0
(ADENOSINE DEAMINASE)		 4hjw URACIL-5-CARBOXYLATE
DECARBOXYLASE
(Metarhizium
anisopliae) 		5 / 12 HIS A  14
ILE A 163
HIS A 195
HIS A 251
ASP A 323
 ZN  A 401 (-3.5A)
None
ZN  A 401 (-3.5A)
None
ZN  A 401 (-2.8A)
 1.25A 6n91B-4hjwA:
7.3		 6n91B-4hjwA:
12.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6QXS_B_FOZB403_0
(THYMIDYLATE SYNTHASE)		 4hjw URACIL-5-CARBOXYLATE
DECARBOXYLASE
(Metarhizium
anisopliae) 		5 / 12 PRO A  17
ILE A  94
LEU A 371
GLY A 135
PHE A 120
 None
 1.09A 6qxsB-4hjwA:
undetectable		 6qxsB-4hjwA:
22.41