SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4hk0'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1DMI_A_BHSA1610_1 (NITRIC OXIDE SYNTHASE)	4hk0	UCA LIGHT CHAIN (Homo sapiens)	4 / 8	VAL B 107 ARG B 60 ALA B 18 GLU B 82	None	0.94A	1dmiA-4hk0B: undetectable 1dmiB-4hk0B: undetectable	1dmiA-4hk0B: 20.41 1dmiB-4hk0B: 20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1P6K_A_ACTA860_0 (NITRIC-OXIDE SYNTHASE, BRAIN)	4hk0	UCA LIGHT CHAIN (Homo sapiens)	4 / 6	GLY B 23 GLN B 6 VAL B 32 ALA B 70	None	0.80A	1p6kA-4hk0B: undetectable	1p6kA-4hk0B: 19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3HUO_A_PNNA304_0 (CTX-M-9 EXTENDED-SPECTRUM BETA-LACTAMASE)	4hk0	UCA LIGHT CHAIN (Homo sapiens)	4 / 4	GLN B 16 PRO B 14 VAL B 77 GLU B 78	None	1.11A	3huoA-4hk0B: undetectable	3huoA-4hk0B: 21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3WIP_B_ACHB301_0 (ACETYLCHOLINE-BINDIN G PROTEIN)	4hk0	UCA LIGHT CHAIN (Homo sapiens)	4 / 8	THR B 73 TYR B 85 TRP B 34 ARG B 19	None	1.22A	3wipB-4hk0B: undetectable 3wipC-4hk0B: undetectable	3wipB-4hk0B: 22.59 3wipC-4hk0B: 22.59

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1DMI_A_BHSA1610_1","NITRIC OXIDE SYNTHASE;NITRIC OXIDE SYNTHASE","4hk0","UCA LIGHT CHAIN","Homo sapiens",4,"VAL B 107;ARG B  60;ALA B  18;GLU B  82","None","0.94A","1dmiA-4hk0B:undetectable;1dmiB-4hk0B:undetectable","1dmiA-4hk0B:20.41;1dmiB-4hk0B:20.41"],["1P6K_A_ACTA860_0","NITRIC-OXIDE SYNTHASE, BRAIN","4hk0","UCA LIGHT CHAIN","Homo sapiens",4,"GLY B  23;GLN B   6;VAL B  32;ALA B  70","None","0.80A","1p6kA-4hk0B:undetectable","1p6kA-4hk0B:19.75"],["3HUO_A_PNNA304_0","CTX-M-9 EXTENDED-SPECTRUM BETA-LACTAMASE","4hk0","UCA LIGHT CHAIN","Homo sapiens",4,"GLN B  16;PRO B  14;VAL B  77;GLU B  78","None","1.11A","3huoA-4hk0B:undetectable","3huoA-4hk0B:21.17"],["3WIP_B_ACHB301_0","ACETYLCHOLINE-BINDING PROTEIN","4hk0","UCA LIGHT CHAIN","Homo sapiens",4,"THR B  73;TYR B  85;TRP B  34;ARG B  19","None","1.22A","3wipB-4hk0B:undetectable;3wipC-4hk0B:undetectable","3wipB-4hk0B:22.59;3wipC-4hk0B:22.59"]]