SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4hk1'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KT5_A_RTLA176_0
(PLASMA
RETINOL-BINDING
PROTEIN)		 4hk1 PROLIFERATING CELL
NUCLEAR ANTIGEN
(Drosophila
melanogaster) 		5 / 12 LEU A  23
LEU A  50
PHE A  60
ALA A   4
LEU A  16
 None
 1.36A 1kt5A-4hk1A:
undetectable		 1kt5A-4hk1A:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P93_B_DEXB2999_1
(GLUCOCORTICOID
RECEPTOR)		 4hk1 PROLIFERATING CELL
NUCLEAR ANTIGEN
(Drosophila
melanogaster) 		5 / 12 MET A  90
GLY A   7
LEU A 244
ILE A 101
PHE A 103
 None
 0.92A 1p93B-4hk1A:
undetectable		 1p93B-4hk1A:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FT9_A_CHDA130_0
(FATTY ACID-BINDING
PROTEIN 2, LIVER)		 4hk1 PROLIFERATING CELL
NUCLEAR ANTIGEN
(Drosophila
melanogaster) 		5 / 12 PHE A 144
VAL A 225
VAL A  45
PHE A 215
LEU A 212
 None
 1.26A 2ft9A-4hk1A:
undetectable		 2ft9A-4hk1A:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J9C_A_ACTA1121_0
(HYPOTHETICAL
NITROGEN REGULATORY
PII-LIKE PROTEIN
MJ0059)		 4hk1 PROLIFERATING CELL
NUCLEAR ANTIGEN
(Drosophila
melanogaster) 		4 / 5 SER A 228
VAL A 236
SER A 134
VAL A 136
 None
 1.40A 2j9cA-4hk1A:
undetectable
2j9cB-4hk1A:
undetectable
2j9cC-4hk1A:
undetectable		 2j9cA-4hk1A:
16.79
2j9cB-4hk1A:
16.79
2j9cC-4hk1A:
16.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DAT_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 4hk1 PROLIFERATING CELL
NUCLEAR ANTIGEN
(Drosophila
melanogaster) 		5 / 12 LEU A  72
LEU A  37
GLN A  38
VAL A  48
ILE A  15
 None
 1.07A 3datA-4hk1A:
undetectable		 3datA-4hk1A:
18.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3VKX_A_T3A301_1
(PROLIFERATING CELL
NUCLEAR ANTIGEN)		 4hk1 PROLIFERATING CELL
NUCLEAR ANTIGEN
(Drosophila
melanogaster) 		4 / 6 MET A  40
LEU A  47
PRO A 234
TYR A 250
 None
 0.46A 3vkxA-4hk1A:
35.0		 3vkxA-4hk1A:
70.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VW7_A_VPXA2001_1
(PROTEINASE-ACTIVATED
RECEPTOR 1, LYSOZYME)		 4hk1 PROLIFERATING CELL
NUCLEAR ANTIGEN
(Drosophila
melanogaster) 		5 / 12 LEU A   6
LEU A  79
LEU A  37
LEU A  50
ALA A  26
 None
 1.09A 3vw7A-4hk1A:
undetectable		 3vw7A-4hk1A:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WG7_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4hk1 PROLIFERATING CELL
NUCLEAR ANTIGEN
(Drosophila
melanogaster) 		4 / 6 ILE A  11
ARG A  53
THR A  51
LEU A  50
 None
 0.85A 3wg7N-4hk1A:
undetectable
3wg7W-4hk1A:
undetectable		 3wg7N-4hk1A:
19.03
3wg7W-4hk1A:
12.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FFW_A_715A801_2
(DIPEPTIDYL PEPTIDASE
4)		 4hk1 PROLIFERATING CELL
NUCLEAR ANTIGEN
(Drosophila
melanogaster) 		3 / 3 PHE A 144
TYR A 249
TYR A 239
 None
 1.02A 4ffwA-4hk1A:
undetectable		 4ffwA-4hk1A:
16.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J24_D_ESTD600_1
(ESTROGEN RECEPTOR
BETA)		 4hk1 PROLIFERATING CELL
NUCLEAR ANTIGEN
(Drosophila
melanogaster) 		5 / 12 MET A  68
LEU A  37
LEU A  16
ILE A 101
LEU A  79
 None
 1.05A 4j24D-4hk1A:
undetectable		 4j24D-4hk1A:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1B_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4hk1 PROLIFERATING CELL
NUCLEAR ANTIGEN
(Drosophila
melanogaster) 		4 / 7 ILE A  11
ARG A  53
THR A  51
LEU A  50
 None
 0.92A 5b1bA-4hk1A:
undetectable
5b1bJ-4hk1A:
undetectable		 5b1bA-4hk1A:
19.03
5b1bJ-4hk1A:
12.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1B_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4hk1 PROLIFERATING CELL
NUCLEAR ANTIGEN
(Drosophila
melanogaster) 		4 / 7 ILE A  11
ARG A  53
THR A  51
LEU A  50
 None
 0.78A 5b1bN-4hk1A:
undetectable
5b1bW-4hk1A:
undetectable		 5b1bN-4hk1A:
19.03
5b1bW-4hk1A:
12.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IY5_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4hk1 PROLIFERATING CELL
NUCLEAR ANTIGEN
(Drosophila
melanogaster) 		4 / 7 ILE A  11
ARG A  53
THR A  51
LEU A  50
 None
 0.96A 5iy5A-4hk1A:
undetectable
5iy5J-4hk1A:
undetectable		 5iy5A-4hk1A:
19.03
5iy5J-4hk1A:
12.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NUN_A_Z80A201_1
(BETA-LACTOGLOBULIN)		 4hk1 PROLIFERATING CELL
NUCLEAR ANTIGEN
(Drosophila
melanogaster) 		5 / 9 ALA A  26
ILE A  15
LEU A  16
ILE A  35
ALA A  39
 None
 1.01A 5nunA-4hk1A:
undetectable		 5nunA-4hk1A:
16.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z86_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4hk1 PROLIFERATING CELL
NUCLEAR ANTIGEN
(Drosophila
melanogaster) 		4 / 6 ILE A  11
ARG A  53
THR A  51
LEU A  50
 None
 1.03A 5z86N-4hk1A:
undetectable
5z86W-4hk1A:
undetectable		 5z86N-4hk1A:
19.03
5z86W-4hk1A:
12.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCQ_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4hk1 PROLIFERATING CELL
NUCLEAR ANTIGEN
(Drosophila
melanogaster) 		4 / 8 ILE A  11
ARG A  53
THR A  51
LEU A  50
 None
 0.88A 5zcqN-4hk1A:
undetectable
5zcqW-4hk1A:
undetectable		 5zcqN-4hk1A:
19.03
5zcqW-4hk1A:
12.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H7L_A_Y00A406_0
(BETA-1 ADRENERGIC
RECEPTOR)		 4hk1 PROLIFERATING CELL
NUCLEAR ANTIGEN
(Drosophila
melanogaster) 		5 / 12 VAL A 137
THR A 206
SER A 172
ASN A 179
VAL A 167
 None
 1.39A 6h7lA-4hk1A:
undetectable		 6h7lA-4hk1A:
14.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H7L_B_Y00B405_0
(BETA-1 ADRENERGIC
RECEPTOR)		 4hk1 PROLIFERATING CELL
NUCLEAR ANTIGEN
(Drosophila
melanogaster) 		5 / 12 VAL A 137
THR A 206
SER A 172
ASN A 179
VAL A 167
 None
 1.40A 6h7lB-4hk1A:
undetectable		 6h7lB-4hk1A:
14.67