SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4hk9'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XMU_A_ROFA101_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		 4hk9 ENDO-1,4-BETA-XYLANA
SE 2
(Trichoderma
reesei) 		4 / 5 ASN A  57
THR A  55
MET A 169
GLN A 172
 None
 1.49A 1xmuA-4hk9A:
undetectable		 1xmuA-4hk9A:
18.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XMU_B_ROFB102_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		 4hk9 ENDO-1,4-BETA-XYLANA
SE 2
(Trichoderma
reesei) 		4 / 5 ASN A  57
THR A  55
MET A 169
GLN A 172
 None
 1.46A 1xmuB-4hk9A:
undetectable		 1xmuB-4hk9A:
18.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3APW_B_DP0B190_1
(ALPHA-1-ACID
GLYCOPROTEIN 2)		 4hk9 ENDO-1,4-BETA-XYLANA
SE 2
(Trichoderma
reesei) 		5 / 12 VAL A 150
ILE A  60
LEU A 166
GLN A 172
ALA A 158
 None
 1.25A 3apwB-4hk9A:
undetectable		 3apwB-4hk9A:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GYQ_A_SAMA270_0
(RRNA
(ADENOSINE-2'-O-)-ME
THYLTRANSFERASE)		 4hk9 ENDO-1,4-BETA-XYLANA
SE 2
(Trichoderma
reesei) 		5 / 12 ALA A 175
GLY A 178
ILE A 187
SER A  75
LEU A  74
 None
 1.27A 3gyqA-4hk9A:
undetectable
3gyqB-4hk9A:
undetectable		 3gyqA-4hk9A:
22.09
3gyqB-4hk9A:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GYQ_B_SAMB270_0
(RRNA
(ADENOSINE-2'-O-)-ME
THYLTRANSFERASE)		 4hk9 ENDO-1,4-BETA-XYLANA
SE 2
(Trichoderma
reesei) 		5 / 11 ALA A 175
GLY A 178
ILE A 187
SER A  75
LEU A  74
 None
 1.14A 3gyqB-4hk9A:
undetectable		 3gyqB-4hk9A:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JX4_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4hk9 ENDO-1,4-BETA-XYLANA
SE 2
(Trichoderma
reesei) 		4 / 6 VAL A  46
ARG A 122
TRP A  18
TRP A  79
 XYP  A 202 (-4.9A)
XYP  A 203 (-3.7A)
XYP  A 202 (-4.1A)
XYP  A 202 (-4.7A)
 1.43A 3jx4A-4hk9A:
undetectable
3jx4B-4hk9A:
undetectable		 3jx4A-4hk9A:
16.38
3jx4B-4hk9A:
16.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N5P_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE)		 4hk9 ENDO-1,4-BETA-XYLANA
SE 2
(Trichoderma
reesei) 		4 / 6 TRP A  79
VAL A  46
ARG A 122
TRP A  18
 XYP  A 202 (-4.7A)
XYP  A 202 (-4.9A)
XYP  A 203 (-3.7A)
XYP  A 202 (-4.1A)
 1.43A 3n5pA-4hk9A:
undetectable
3n5pB-4hk9A:
undetectable		 3n5pA-4hk9A:
18.41
3n5pB-4hk9A:
18.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G19_D_ACTD302_0
(GLUTATHIONE
TRANSFERASE GTE1)		 4hk9 ENDO-1,4-BETA-XYLANA
SE 2
(Trichoderma
reesei) 		3 / 3 TYR A 115
PHE A  62
ARG A 141
 None
 1.05A 4g19D-4hk9A:
undetectable		 4g19D-4hk9A:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MA3_L_ACTL301_0
(C2095 HEAVY CHAIN
C2095 LIGHT CHAIN)		 4hk9 ENDO-1,4-BETA-XYLANA
SE 2
(Trichoderma
reesei) 		3 / 3 PRO A  68
ASN A  92
HIS A 144
 None
 0.97A 4ma3H-4hk9A:
undetectable
4ma3L-4hk9A:
undetectable		 4ma3H-4hk9A:
23.01
4ma3L-4hk9A:
24.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ADE_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4hk9 ENDO-1,4-BETA-XYLANA
SE 2
(Trichoderma
reesei) 		4 / 6 VAL A  46
ARG A 122
TRP A  18
TRP A  79
 XYP  A 202 (-4.9A)
XYP  A 203 (-3.7A)
XYP  A 202 (-4.1A)
XYP  A 202 (-4.7A)
 1.49A 5adeA-4hk9A:
undetectable
5adeB-4hk9A:
undetectable		 5adeA-4hk9A:
16.38
5adeB-4hk9A:
16.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L1F_D_6ZPD902_1
(GLUTAMATE RECEPTOR 2)		 4hk9 ENDO-1,4-BETA-XYLANA
SE 2
(Trichoderma
reesei) 		5 / 10 SER A 181
PRO A  68
TYR A  66
ASN A  67
ASN A  71
 None
 1.49A 5l1fD-4hk9A:
undetectable		 5l1fD-4hk9A:
12.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5TZO_A_7V7A201_1
(ENDO-1,4-BETA-XYLANA
SE A)		 4hk9 ENDO-1,4-BETA-XYLANA
SE 2
(Trichoderma
reesei) 		6 / 8 THR A 100
TYR A 118
THR A 120
ARG A 122
GLN A 136
TRP A 138
 None
None
None
XYP  A 203 (-3.7A)
XYP  A 203 (-4.0A)
None
 0.94A 5tzoA-4hk9A:
29.2		 5tzoA-4hk9A:
50.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5TZO_A_7V7A202_1
(ENDO-1,4-BETA-XYLANA
SE A)		 4hk9 ENDO-1,4-BETA-XYLANA
SE 2
(Trichoderma
reesei) 		7 / 12 VAL A  46
TRP A  79
TYR A  88
PRO A 126
TRP A 138
TYR A 171
GLY A 178
 XYP  A 202 (-4.9A)
XYP  A 202 (-4.7A)
None
XYP  A 203 ( 4.0A)
None
XYP  A 202 (-4.7A)
None
 0.72A 5tzoA-4hk9A:
29.2		 5tzoA-4hk9A:
50.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5TZO_B_7V7B201_1
(ENDO-1,4-BETA-XYLANA
SE A)		 4hk9 ENDO-1,4-BETA-XYLANA
SE 2
(Trichoderma
reesei) 		6 / 12 VAL A  46
TRP A  79
TYR A  88
TRP A 138
TYR A 171
GLY A 178
 XYP  A 202 (-4.9A)
XYP  A 202 (-4.7A)
None
None
XYP  A 202 (-4.7A)
None
 0.71A 5tzoB-4hk9A:
29.4		 5tzoB-4hk9A:
50.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5TZO_B_7V7B201_2
(ENDO-1,4-BETA-XYLANA
SE A)		 4hk9 ENDO-1,4-BETA-XYLANA
SE 2
(Trichoderma
reesei) 		3 / 3 ARG A 122
PRO A 126
TYR A 179
 XYP  A 203 (-3.7A)
XYP  A 203 ( 4.0A)
None
 0.36A 5tzoB-4hk9A:
29.4		 5tzoB-4hk9A:
50.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5TZO_B_7V7B202_1
(ENDO-1,4-BETA-XYLANA
SE A)		 4hk9 ENDO-1,4-BETA-XYLANA
SE 2
(Trichoderma
reesei) 		6 / 8 THR A 100
TYR A 118
THR A 120
ARG A 122
GLN A 136
TRP A 138
 None
None
None
XYP  A 203 (-3.7A)
XYP  A 203 (-4.0A)
None
 0.88A 5tzoB-4hk9A:
29.4		 5tzoB-4hk9A:
50.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5TZO_C_7V7C201_1
(ENDO-1,4-BETA-XYLANA
SE A)		 4hk9 ENDO-1,4-BETA-XYLANA
SE 2
(Trichoderma
reesei) 		7 / 12 VAL A  46
TRP A  79
TYR A  88
PRO A 126
TRP A 138
TYR A 171
GLY A 178
 XYP  A 202 (-4.9A)
XYP  A 202 (-4.7A)
None
XYP  A 203 ( 4.0A)
None
XYP  A 202 (-4.7A)
None
 0.79A 5tzoC-4hk9A:
29.1		 5tzoC-4hk9A:
50.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5TZO_C_7V7C202_1
(ENDO-1,4-BETA-XYLANA
SE A)		 4hk9 ENDO-1,4-BETA-XYLANA
SE 2
(Trichoderma
reesei) 		6 / 8 THR A 100
TYR A 118
THR A 120
ARG A 122
GLN A 136
TRP A 138
 None
None
None
XYP  A 203 (-3.7A)
XYP  A 203 (-4.0A)
None
 0.91A 5tzoC-4hk9A:
29.1		 5tzoC-4hk9A:
50.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6JMJ_A_ASCA201_0
(PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE)		 4hk9 ENDO-1,4-BETA-XYLANA
SE 2
(Trichoderma
reesei) 		4 / 5 GLY A  94
THR A  95
SER A 182
SER A 181
 None
 0.88A 6jmjA-4hk9A:
undetectable		 6jmjA-4hk9A:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6JNH_A_ASCA201_0
(PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE)		 4hk9 ENDO-1,4-BETA-XYLANA
SE 2
(Trichoderma
reesei) 		4 / 7 GLY A  94
THR A  95
SER A 182
SER A 181
 None
 0.83A 6jnhA-4hk9A:
undetectable		 6jnhA-4hk9A:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6JOG_A_ASCA201_0
(PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE)		 4hk9 ENDO-1,4-BETA-XYLANA
SE 2
(Trichoderma
reesei) 		4 / 6 GLY A  94
THR A  95
SER A 182
SER A 181
 None
 0.84A 6jogA-4hk9A:
undetectable		 6jogA-4hk9A:
21.58