SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4hka'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DTL_A_BEPA204_1
(CARDIAC TROPONIN C)		 4hka TRYPTOPHAN
2,3-DIOXYGENASE
(Drosophila
melanogaster) 		5 / 11 PHE A  75
ILE A  78
LEU A  99
LEU A 106
VAL A 189
 None
 0.94A 1dtlA-4hkaA:
undetectable		 1dtlA-4hkaA:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FDU_B_ESTB354_1
(17-BETA-HYDROXYSTERO
ID DEHYDROGENASE)		 4hka TRYPTOPHAN
2,3-DIOXYGENASE
(Drosophila
melanogaster) 		4 / 8 VAL A 166
TYR A 159
TYR A 344
VAL A 151
 None
HEM  A 401 (-4.4A)
None
None
 1.10A 1fduB-4hkaA:
undetectable		 1fduB-4hkaA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PXX_A_DIFA701_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4hka TRYPTOPHAN
2,3-DIOXYGENASE
(Drosophila
melanogaster) 		5 / 10 VAL A 189
LEU A 199
GLY A 275
ALA A 276
LEU A 295
 None
 1.02A 1pxxA-4hkaA:
undetectable		 1pxxA-4hkaA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PXX_C_DIFC2701_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4hka TRYPTOPHAN
2,3-DIOXYGENASE
(Drosophila
melanogaster) 		5 / 12 VAL A 189
LEU A 199
GLY A 275
ALA A 276
LEU A 295
 None
 1.02A 1pxxC-4hkaA:
undetectable		 1pxxC-4hkaA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WSV_A_THHA3001_1
(AMINOMETHYLTRANSFERA
SE)		 4hka TRYPTOPHAN
2,3-DIOXYGENASE
(Drosophila
melanogaster) 		3 / 3 ASP A 165
GLU A 180
TYR A 344
 None
 0.82A 1wsvA-4hkaA:
undetectable		 1wsvA-4hkaA:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PLW_A_SAMA203_0
(RIBOSOMAL RNA
METHYLTRANSFERASE,
PUTATIVE)		 4hka TRYPTOPHAN
2,3-DIOXYGENASE
(Drosophila
melanogaster) 		5 / 12 GLY A 275
PRO A 197
GLY A 198
ALA A 276
LEU A 350
 None
 0.95A 2plwA-4hkaA:
undetectable		 2plwA-4hkaA:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RCT_A_RTLA140_0
(RETINOL-BINDING
PROTEIN II, CELLULAR)		 4hka TRYPTOPHAN
2,3-DIOXYGENASE
(Drosophila
melanogaster) 		5 / 12 PHE A 206
ILE A 363
TYR A 248
VAL A 247
LEU A 273
 None
 1.22A 2rctA-4hkaA:
undetectable		 2rctA-4hkaA:
16.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_B_KLNB1499_1
(CYTOCHROME P450 3A4)		 4hka TRYPTOPHAN
2,3-DIOXYGENASE
(Drosophila
melanogaster) 		4 / 7 PHE A 167
PHE A  68
ILE A  71
ILE A 301
 None
HEM  A 401 (-4.7A)
None
None
 0.91A 2v0mB-4hkaA:
undetectable		 2v0mB-4hkaA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EBZ_B_017B201_1
(PROTEASE)		 4hka TRYPTOPHAN
2,3-DIOXYGENASE
(Drosophila
melanogaster) 		5 / 11 LEU A 109
ASP A 302
ILE A 301
ILE A  72
ILE A 105
 None
 1.14A 3ebzA-4hkaA:
undetectable		 3ebzA-4hkaA:
14.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8Z_B_FLPB1701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 4hka TRYPTOPHAN
2,3-DIOXYGENASE
(Drosophila
melanogaster) 		5 / 12 VAL A 189
LEU A 199
GLY A 275
ALA A 276
LEU A 295
 None
 0.91A 3n8zB-4hkaA:
undetectable		 3n8zB-4hkaA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L1X_A_STRA402_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 4hka TRYPTOPHAN
2,3-DIOXYGENASE
(Drosophila
melanogaster) 		4 / 8 TYR A 159
LEU A 336
TYR A 335
VAL A 316
 HEM  A 401 (-4.4A)
HEM  A 401 (-4.5A)
HEM  A 401 (-4.5A)
HEM  A 401 (-3.9A)
 1.02A 4l1xA-4hkaA:
undetectable		 4l1xA-4hkaA:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWZ_B_CQAB303_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 4hka TRYPTOPHAN
2,3-DIOXYGENASE
(Drosophila
melanogaster) 		4 / 8 GLY A 198
GLY A 275
ILE A 279
LEU A 193
 None
 0.83A 4mwzB-4hkaA:
undetectable		 4mwzB-4hkaA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OTY_B_LURB705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4hka TRYPTOPHAN
2,3-DIOXYGENASE
(Drosophila
melanogaster) 		5 / 12 VAL A 189
LEU A 199
GLY A 275
ALA A 276
LEU A 295
 None
 1.06A 4otyB-4hkaA:
undetectable		 4otyB-4hkaA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QYN_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 2)		 4hka TRYPTOPHAN
2,3-DIOXYGENASE
(Drosophila
melanogaster) 		5 / 12 PHE A 206
ILE A 363
TYR A 248
VAL A 247
LEU A 273
 None
 1.26A 4qynA-4hkaA:
undetectable		 4qynA-4hkaA:
15.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRX_A_LURA706_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4hka TRYPTOPHAN
2,3-DIOXYGENASE
(Drosophila
melanogaster) 		5 / 12 VAL A 189
LEU A 199
GLY A 275
ALA A 276
LEU A 295
 None
 0.95A 4rrxA-4hkaA:
undetectable		 4rrxA-4hkaA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRX_B_LURB706_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4hka TRYPTOPHAN
2,3-DIOXYGENASE
(Drosophila
melanogaster) 		5 / 12 VAL A 189
LEU A 199
GLY A 275
ALA A 276
LEU A 295
 None
 0.94A 4rrxB-4hkaA:
undetectable		 4rrxB-4hkaA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKQ_A_JMSA602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4hka TRYPTOPHAN
2,3-DIOXYGENASE
(Drosophila
melanogaster) 		5 / 12 VAL A 189
LEU A 199
GLY A 275
ALA A 276
LEU A 295
 None
 1.00A 5ikqA-4hkaA:
undetectable		 5ikqA-4hkaA:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKQ_B_JMSB602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4hka TRYPTOPHAN
2,3-DIOXYGENASE
(Drosophila
melanogaster) 		5 / 12 VAL A 189
LEU A 199
GLY A 275
ALA A 276
LEU A 295
 None
 1.00A 5ikqB-4hkaA:
undetectable		 5ikqB-4hkaA:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_A_TLFA601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4hka TRYPTOPHAN
2,3-DIOXYGENASE
(Drosophila
melanogaster) 		5 / 12 VAL A 189
LEU A 199
GLY A 275
ALA A 276
LEU A 295
 None
 1.01A 5iktA-4hkaA:
undetectable		 5iktA-4hkaA:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IY5_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4hka TRYPTOPHAN
2,3-DIOXYGENASE
(Drosophila
melanogaster) 		4 / 7 PHE A 127
MET A 119
THR A 118
LEU A 116
 None
None
None
HEM  A 401 (-4.7A)
 0.87A 5iy5N-4hkaA:
1.0
5iy5W-4hkaA:
undetectable		 5iy5N-4hkaA:
19.34
5iy5W-4hkaA:
10.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6A4I_A_TRPA403_0
(TRYPTOPHAN
2,3-DIOXYGENASE)		 4hka TRYPTOPHAN
2,3-DIOXYGENASE
(Drosophila
melanogaster) 		6 / 8 TRP A 192
ARG A 195
THR A 196
PRO A 197
ILE A 279
PRO A 291
 None
 0.74A 6a4iA-4hkaA:
35.9		 6a4iA-4hkaA:
52.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6A4I_B_TRPB403_0
(TRYPTOPHAN
2,3-DIOXYGENASE)		 4hka TRYPTOPHAN
2,3-DIOXYGENASE
(Drosophila
melanogaster) 		5 / 7 TRP A 192
ARG A 195
THR A 196
PRO A 197
PRO A 291
 None
 0.73A 6a4iB-4hkaA:
34.3		 6a4iB-4hkaA:
52.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6A4I_D_TRPD403_0
(TRYPTOPHAN
2,3-DIOXYGENASE)		 4hka TRYPTOPHAN
2,3-DIOXYGENASE
(Drosophila
melanogaster) 		5 / 9 TRP A 192
ARG A 195
THR A 196
PRO A 197
PRO A 291
 None
 0.75A 6a4iD-4hkaA:
31.8		 6a4iD-4hkaA:
52.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6A4I_D_TRPD403_0
(TRYPTOPHAN
2,3-DIOXYGENASE)		 4hka TRYPTOPHAN
2,3-DIOXYGENASE
(Drosophila
melanogaster) 		5 / 9 TRP A 192
THR A 196
PRO A 197
ILE A 279
PRO A 291
 None
 0.64A 6a4iD-4hkaA:
31.8		 6a4iD-4hkaA:
52.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A93_B_8NUB3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		 4hka TRYPTOPHAN
2,3-DIOXYGENASE
(Drosophila
melanogaster) 		5 / 12 VAL A 214
SER A 213
PHE A 206
PHE A 281
LEU A 199
 None
 1.34A 6a93B-4hkaA:
undetectable		 6a93B-4hkaA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_B_EY4B500_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 4hka TRYPTOPHAN
2,3-DIOXYGENASE
(Drosophila
melanogaster) 		4 / 6 GLN A 112
VAL A 110
TRP A 308
THR A 306
 None
 0.94A 6cduB-4hkaA:
1.2
6cduC-4hkaA:
1.5		 6cduB-4hkaA:
20.77
6cduC-4hkaA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_I_EY4I500_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 4hka TRYPTOPHAN
2,3-DIOXYGENASE
(Drosophila
melanogaster) 		4 / 5 GLN A 112
VAL A 110
TRP A 308
THR A 306
 None
 0.94A 6cduI-4hkaA:
1.2
6cduJ-4hkaA:
undetectable		 6cduI-4hkaA:
20.77
6cduJ-4hkaA:
20.77