SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4hkg'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1MZ9_D_VDYD1001_4 (CARTILAGE OLIGOMERIC MATRIX PROTEIN)	4hkg	PHOSPHOPANTETHEINE ATTACHMENT SITE FAMILY PROTEIN (Acinetobacter baumannii)	4 / 4	THR A 34 LEU A 38 VAL A 16 LEU A 15	MRD A 100 (-4.2A) None None None	0.85A	1mz9D-4hkgA: undetectable	1mz9D-4hkgA: 22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3OZV_B_ECNB411_1 (FLAVOHEMOGLOBIN)	4hkg	PHOSPHOPANTETHEINE ATTACHMENT SITE FAMILY PROTEIN (Acinetobacter baumannii)	5 / 9	ILE A 12 ILE A 11 TYR A 7 LEU A 76 ALA A 73	None	0.91A	3ozvB-4hkgA: undetectable	3ozvB-4hkgA: 10.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4YB6_A_HISA302_0 (ATP PHOSPHORIBOSYLTRANSF ERASE)	4hkg	PHOSPHOPANTETHEINE ATTACHMENT SITE FAMILY PROTEIN (Acinetobacter baumannii)	5 / 10	GLY A 48 VAL A 46 THR A 54 LEU A 53 LEU A 72	None	1.16A	4yb6A-4hkgA: undetectable 4yb6E-4hkgA: undetectable	4yb6A-4hkgA: 14.88 4yb6E-4hkgA: 14.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4YB6_B_HISB302_0 (ATP PHOSPHORIBOSYLTRANSF ERASE)	4hkg	PHOSPHOPANTETHEINE ATTACHMENT SITE FAMILY PROTEIN (Acinetobacter baumannii)	5 / 10	GLY A 48 VAL A 46 THR A 54 LEU A 53 LEU A 72	None	1.17A	4yb6B-4hkgA: undetectable 4yb6C-4hkgA: undetectable	4yb6B-4hkgA: 14.88 4yb6C-4hkgA: 14.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4YB6_C_HISC302_0 (ATP PHOSPHORIBOSYLTRANSF ERASE)	4hkg	PHOSPHOPANTETHEINE ATTACHMENT SITE FAMILY PROTEIN (Acinetobacter baumannii)	5 / 10	GLY A 48 VAL A 46 THR A 54 LEU A 53 LEU A 72	None	1.26A	4yb6C-4hkgA: undetectable 4yb6F-4hkgA: undetectable	4yb6C-4hkgA: 14.88 4yb6F-4hkgA: 14.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4YB6_D_HISD302_0 (ATP PHOSPHORIBOSYLTRANSF ERASE)	4hkg	PHOSPHOPANTETHEINE ATTACHMENT SITE FAMILY PROTEIN (Acinetobacter baumannii)	5 / 10	LEU A 53 LEU A 72 GLY A 48 VAL A 46 THR A 54	None	1.28A	4yb6A-4hkgA: undetectable 4yb6D-4hkgA: undetectable	4yb6A-4hkgA: 14.88 4yb6D-4hkgA: 14.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4YB6_E_HISE302_0 (ATP PHOSPHORIBOSYLTRANSF ERASE)	4hkg	PHOSPHOPANTETHEINE ATTACHMENT SITE FAMILY PROTEIN (Acinetobacter baumannii)	5 / 10	LEU A 53 LEU A 72 GLY A 48 VAL A 46 THR A 54	None	1.24A	4yb6D-4hkgA: undetectable 4yb6E-4hkgA: undetectable	4yb6D-4hkgA: 14.88 4yb6E-4hkgA: 14.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4YB6_F_HISF302_0 (ATP PHOSPHORIBOSYLTRANSF ERASE)	4hkg	PHOSPHOPANTETHEINE ATTACHMENT SITE FAMILY PROTEIN (Acinetobacter baumannii)	5 / 10	LEU A 53 LEU A 72 GLY A 48 VAL A 46 THR A 54	None	1.17A	4yb6B-4hkgA: undetectable 4yb6F-4hkgA: undetectable	4yb6B-4hkgA: 14.88 4yb6F-4hkgA: 14.88

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1MZ9_D_VDYD1001_4","CARTILAGE OLIGOMERIC MATRIX PROTEIN","4hkg","PHOSPHOPANTETHEINE ATTACHMENT SITE FAMILY PROTEIN","Acinetobacter baumannii",4,"THR A  34;LEU A  38;VAL A  16;LEU A  15","MRD A 100 (-4.2A);None;None;None","0.85A","1mz9D-4hkgA:undetectable","1mz9D-4hkgA:22.09"],["3OZV_B_ECNB411_1","FLAVOHEMOGLOBIN","4hkg","PHOSPHOPANTETHEINE ATTACHMENT SITE FAMILY PROTEIN","Acinetobacter baumannii",5,"ILE A  12;ILE A  11;TYR A   7;LEU A  76;ALA A  73","None","0.91A","3ozvB-4hkgA:undetectable","3ozvB-4hkgA:10.92"],["4YB6_A_HISA302_0","ATP PHOSPHORIBOSYLTRANSFERASE","4hkg","PHOSPHOPANTETHEINE ATTACHMENT SITE FAMILY PROTEIN","Acinetobacter baumannii",5,"GLY A  48;VAL A  46;THR A  54;LEU A  53;LEU A  72","None","1.16A","4yb6A-4hkgA:undetectable;4yb6E-4hkgA:undetectable","4yb6A-4hkgA:14.88;4yb6E-4hkgA:14.88"],["4YB6_B_HISB302_0","ATP PHOSPHORIBOSYLTRANSFERASE","4hkg","PHOSPHOPANTETHEINE ATTACHMENT SITE FAMILY PROTEIN","Acinetobacter baumannii",5,"GLY A  48;VAL A  46;THR A  54;LEU A  53;LEU A  72","None","1.17A","4yb6B-4hkgA:undetectable;4yb6C-4hkgA:undetectable","4yb6B-4hkgA:14.88;4yb6C-4hkgA:14.88"],["4YB6_C_HISC302_0","ATP PHOSPHORIBOSYLTRANSFERASE","4hkg","PHOSPHOPANTETHEINE ATTACHMENT SITE FAMILY PROTEIN","Acinetobacter baumannii",5,"GLY A  48;VAL A  46;THR A  54;LEU A  53;LEU A  72","None","1.26A","4yb6C-4hkgA:undetectable;4yb6F-4hkgA:undetectable","4yb6C-4hkgA:14.88;4yb6F-4hkgA:14.88"],["4YB6_D_HISD302_0","ATP PHOSPHORIBOSYLTRANSFERASE","4hkg","PHOSPHOPANTETHEINE ATTACHMENT SITE FAMILY PROTEIN","Acinetobacter baumannii",5,"LEU A  53;LEU A  72;GLY A  48;VAL A  46;THR A  54","None","1.28A","4yb6A-4hkgA:undetectable;4yb6D-4hkgA:undetectable","4yb6A-4hkgA:14.88;4yb6D-4hkgA:14.88"],["4YB6_E_HISE302_0","ATP PHOSPHORIBOSYLTRANSFERASE","4hkg","PHOSPHOPANTETHEINE ATTACHMENT SITE FAMILY PROTEIN","Acinetobacter baumannii",5,"LEU A  53;LEU A  72;GLY A  48;VAL A  46;THR A  54","None","1.24A","4yb6D-4hkgA:undetectable;4yb6E-4hkgA:undetectable","4yb6D-4hkgA:14.88;4yb6E-4hkgA:14.88"],["4YB6_F_HISF302_0","ATP PHOSPHORIBOSYLTRANSFERASE","4hkg","PHOSPHOPANTETHEINE ATTACHMENT SITE FAMILY PROTEIN","Acinetobacter baumannii",5,"LEU A  53;LEU A  72;GLY A  48;VAL A  46;THR A  54","None","1.17A","4yb6B-4hkgA:undetectable;4yb6F-4hkgA:undetectable","4yb6B-4hkgA:14.88;4yb6F-4hkgA:14.88"]]