SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4hkm'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SN5_C_T3C601_2
(TRANSTHYRETIN)
4hkm ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE

(Xanthomonas
campestris)
4 / 8 LEU A 195
GLU A 230
THR A 237
VAL A 252
None
0.97A 1sn5C-4hkmA:
undetectable
1sn5C-4hkmA:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E5D_A_NCAA1501_0
(NICOTINAMIDE
PHOSPHORIBOSYLTRANSF
ERASE)
4hkm ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE

(Xanthomonas
campestris)
4 / 7 PHE A 101
ARG A 328
ALA A 133
ASP A 332
None
0.84A 2e5dA-4hkmA:
undetectable
2e5dB-4hkmA:
undetectable
2e5dA-4hkmA:
21.48
2e5dB-4hkmA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E5D_B_NCAB1502_0
(NICOTINAMIDE
PHOSPHORIBOSYLTRANSF
ERASE)
4hkm ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE

(Xanthomonas
campestris)
4 / 7 ASP A 332
PHE A 101
ARG A 328
ALA A 133
None
0.85A 2e5dA-4hkmA:
undetectable
2e5dB-4hkmA:
undetectable
2e5dA-4hkmA:
21.48
2e5dB-4hkmA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NMY_A_ROCA401_1
(PROTEASE)
4hkm ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE

(Xanthomonas
campestris)
5 / 12 ALA A  60
ILE A  18
GLY A  55
ILE A  54
ILE A 178
None
0.81A 2nmyA-4hkmA:
undetectable
2nmyA-4hkmA:
13.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WD9_C_IBPC1570_1
(ACYL-COENZYME A
SYNTHETASE ACSM2A,
MITOCHONDRIAL)
4hkm ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE

(Xanthomonas
campestris)
5 / 10 THR A  92
ILE A 293
LEU A 231
GLY A 224
GLY A 234
None
1.26A 2wd9C-4hkmA:
3.1
2wd9C-4hkmA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XFS_A_J01A500_1
(ORF12)
4hkm ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE

(Xanthomonas
campestris)
4 / 8 VAL A  80
ARG A 317
GLY A 314
ALA A 318
None
PO4  A 402 (-3.4A)
None
None
0.95A 2xfsA-4hkmA:
undetectable
2xfsA-4hkmA:
24.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XH9_A_J01A1436_1
(ORF12)
4hkm ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE

(Xanthomonas
campestris)
4 / 8 VAL A  80
ARG A 317
GLY A 314
ALA A 318
None
PO4  A 402 (-3.4A)
None
None
0.92A 2xh9A-4hkmA:
undetectable
2xh9A-4hkmA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3APX_A_Z80A190_1
(ALPHA-1-ACID
GLYCOPROTEIN 2)
4hkm ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE

(Xanthomonas
campestris)
5 / 12 PHE A 179
VAL A  40
GLU A  34
ALA A 162
PHE A  67
None
1.46A 3apxA-4hkmA:
undetectable
3apxA-4hkmA:
16.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DL9_A_V2HA602_0
(CYTOCHROME P450 2R1)
4hkm ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE

(Xanthomonas
campestris)
5 / 12 MET A  27
VAL A 165
ALA A 162
VAL A  40
GLU A  34
None
1.23A 3dl9A-4hkmA:
undetectable
3dl9A-4hkmA:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKQ_A_ROCA100_1
(PROTEASE)
4hkm ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE

(Xanthomonas
campestris)
5 / 12 ALA A  60
ILE A  18
GLY A  55
ILE A  54
ILE A 178
None
0.85A 3ekqA-4hkmA:
undetectable
3ekqA-4hkmA:
12.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKW_B_DR7B100_1
(PROTEASE)
4hkm ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE

(Xanthomonas
campestris)
5 / 10 ALA A  60
ILE A  18
GLY A  55
ILE A  54
ILE A 178
None
0.87A 3ekwA-4hkmA:
undetectable
3ekwA-4hkmA:
13.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKX_B_1UNB201_2
(PROTEASE)
4hkm ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE

(Xanthomonas
campestris)
5 / 11 ALA A  60
ILE A  18
GLY A  55
ILE A  54
ILE A 178
None
0.93A 3ekxB-4hkmA:
undetectable
3ekxB-4hkmA:
12.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_A_CHDA151_0
(ILEAL BILE
ACID-BINDING PROTEIN)
4hkm ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE

(Xanthomonas
campestris)
4 / 7 ILE A 178
GLY A  46
VAL A 169
LEU A  26
None
0.86A 3elzA-4hkmA:
0.2
3elzA-4hkmA:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K4V_D_ROCD201_3
(HIV-1 PROTEASE)
4hkm ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE

(Xanthomonas
campestris)
5 / 12 ALA A  60
ILE A  18
GLY A  55
ILE A  54
ILE A 178
None
0.85A 3k4vD-4hkmA:
undetectable
3k4vD-4hkmA:
14.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MG0_H_BO2H1400_1
(PROTEASOME COMPONENT
PUP1
PROTEASOME COMPONENT
PUP3)
4hkm ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE

(Xanthomonas
campestris)
5 / 11 GLN A 320
ALA A 108
GLY A 107
ALA A 105
ASP A 324
None
1.16A 3mg0H-4hkmA:
undetectable
3mg0I-4hkmA:
undetectable
3mg0H-4hkmA:
20.81
3mg0I-4hkmA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDU_A_ROCA101_1
(PROTEASE)
4hkm ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE

(Xanthomonas
campestris)
5 / 12 ALA A  60
ILE A  18
GLY A  55
ILE A  54
ILE A 178
None
0.82A 3nduA-4hkmA:
undetectable
3nduA-4hkmA:
13.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDW_A_RITA100_2
(PROTEASE)
4hkm ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE

(Xanthomonas
campestris)
5 / 9 ALA A  60
ILE A  18
GLY A  55
ILE A  54
ILE A 178
None
0.92A 3ndwB-4hkmA:
undetectable
3ndwB-4hkmA:
14.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDX_A_RITA100_2
(PROTEASE)
4hkm ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE

(Xanthomonas
campestris)
5 / 11 ALA A  60
ILE A  18
GLY A  55
ILE A  54
ILE A 178
None
0.89A 3ndxB-4hkmA:
undetectable
3ndxB-4hkmA:
14.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TKG_B_ROCB801_2
(PROTEASE)
4hkm ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE

(Xanthomonas
campestris)
5 / 12 ALA A  60
ILE A  18
GLY A  55
ILE A  54
ILE A 178
None
0.86A 3tkgB-4hkmA:
undetectable
3tkgB-4hkmA:
14.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TKG_C_ROCC901_1
(PROTEASE)
4hkm ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE

(Xanthomonas
campestris)
5 / 12 ALA A  60
ILE A  18
GLY A  55
ILE A  54
ILE A 178
None
0.87A 3tkgC-4hkmA:
undetectable
3tkgC-4hkmA:
14.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CP3_B_RBTB1129_1
(B-CELL LYMPHOMA 6
PROTEIN)
4hkm ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE

(Xanthomonas
campestris)
5 / 7 LEU A 220
ARG A 218
GLY A 314
TYR A 303
SER A 310
None
1.48A 4cp3A-4hkmA:
undetectable
4cp3B-4hkmA:
undetectable
4cp3A-4hkmA:
18.33
4cp3B-4hkmA:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EAT_A_BEZA1000_0
(BENZOATE-COENZYME A
LIGASE)
4hkm ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE

(Xanthomonas
campestris)
4 / 7 ALA A  60
GLY A  59
ILE A  57
ILE A 178
None
0.65A 4eatA-4hkmA:
undetectable
4eatA-4hkmA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J4V_D_SVRD301_1
(NUCLEOCAPSID PROTEIN)
4hkm ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE

(Xanthomonas
campestris)
5 / 11 ARG A 319
GLN A 281
MET A 278
PHE A  93
ILE A  95
None
1.42A 4j4vD-4hkmA:
undetectable
4j4vE-4hkmA:
undetectable
4j4vD-4hkmA:
21.73
4j4vE-4hkmA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM4_B_8PRB603_1
(TRANSPORTER)
4hkm ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE

(Xanthomonas
campestris)
5 / 12 ASP A 309
ALA A 301
VAL A 304
SER A 310
GLY A 299
None
1.29A 4mm4B-4hkmA:
undetectable
4mm4B-4hkmA:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OBW_B_SAMB601_0
(2-METHOXY-6-POLYPREN
YL-1,4-BENZOQUINOL
METHYLASE,
MITOCHONDRIAL)
4hkm ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE

(Xanthomonas
campestris)
5 / 12 ALA A 301
ASP A  81
ILE A 311
GLY A 314
ASN A 297
None
0.98A 4obwB-4hkmA:
undetectable
4obwB-4hkmA:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVP_H_BO2H301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)
4hkm ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE

(Xanthomonas
campestris)
5 / 12 GLN A 320
ALA A 108
GLY A 107
ALA A 105
ASP A 324
None
0.94A 4qvpH-4hkmA:
undetectable
4qvpI-4hkmA:
undetectable
4qvpH-4hkmA:
21.22
4qvpI-4hkmA:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVP_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)
4hkm ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE

(Xanthomonas
campestris)
5 / 12 GLN A 320
ALA A 108
GLY A 107
ALA A 105
ASP A 324
None
0.94A 4qvpV-4hkmA:
undetectable
4qvpW-4hkmA:
undetectable
4qvpV-4hkmA:
21.22
4qvpW-4hkmA:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVY_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)
4hkm ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE

(Xanthomonas
campestris)
5 / 12 GLN A 320
ALA A 108
GLY A 107
ALA A 105
ASP A 324
None
0.85A 4qvyV-4hkmA:
undetectable
4qvyW-4hkmA:
undetectable
4qvyV-4hkmA:
21.22
4qvyW-4hkmA:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW0_H_BO2H301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)
4hkm ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE

(Xanthomonas
campestris)
5 / 11 GLN A 320
ALA A 108
GLY A 107
ALA A 105
ASP A 324
None
0.91A 4qw0H-4hkmA:
undetectable
4qw0I-4hkmA:
undetectable
4qw0H-4hkmA:
21.22
4qw0I-4hkmA:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW0_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)
4hkm ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE

(Xanthomonas
campestris)
5 / 11 GLN A 320
ALA A 108
GLY A 107
ALA A 105
ASP A 324
None
0.90A 4qw0V-4hkmA:
undetectable
4qw0W-4hkmA:
undetectable
4qw0V-4hkmA:
21.22
4qw0W-4hkmA:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW1_H_BO2H301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)
4hkm ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE

(Xanthomonas
campestris)
5 / 12 GLN A 320
ALA A 108
GLY A 107
ALA A 105
ASP A 324
None
0.93A 4qw1H-4hkmA:
undetectable
4qw1I-4hkmA:
undetectable
4qw1H-4hkmA:
21.22
4qw1I-4hkmA:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW1_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)
4hkm ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE

(Xanthomonas
campestris)
5 / 12 GLN A 320
ALA A 108
GLY A 107
ALA A 105
ASP A 324
None
0.93A 4qw1V-4hkmA:
undetectable
4qw1W-4hkmA:
undetectable
4qw1V-4hkmA:
21.22
4qw1W-4hkmA:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RET_C_DGXC2005_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)
4hkm ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE

(Xanthomonas
campestris)
5 / 12 GLU A 136
LEU A 128
GLU A 140
GLY A 152
ARG A  69
None
1.16A 4retC-4hkmA:
undetectable
4retC-4hkmA:
17.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CZ7_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)
4hkm ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE

(Xanthomonas
campestris)
5 / 12 GLN A 320
ALA A 108
GLY A 107
ALA A 105
ASP A 324
None
0.95A 5cz7V-4hkmA:
undetectable
5cz7W-4hkmA:
undetectable
5cz7V-4hkmA:
21.22
5cz7W-4hkmA:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_4_BEZ4801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)
4hkm ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE

(Xanthomonas
campestris)
4 / 5 LEU A 291
PHE A  93
ILE A 293
ILE A  95
None
1.09A 5dzk4-4hkmA:
undetectable
5dzkg-4hkmA:
undetectable
5dzkm-4hkmA:
undetectable
5dzkn-4hkmA:
undetectable
5dzk4-4hkmA:
0.71
5dzkg-4hkmA:
20.67
5dzkm-4hkmA:
19.55
5dzkn-4hkmA:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KKZ_E_ASCE1004_0
(CYTOCHROME B
UBIQUINOL-CYTOCHROME
C REDUCTASE
IRON-SULFUR SUBUNIT)
4hkm ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE

(Xanthomonas
campestris)
4 / 7 ILE A 135
VAL A 134
TYR A 334
GLN A 141
None
1.19A 5kkzC-4hkmA:
undetectable
5kkzE-4hkmA:
undetectable
5kkzC-4hkmA:
20.79
5kkzE-4hkmA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KKZ_K_ASCK1004_0
(CYTOCHROME B
UBIQUINOL-CYTOCHROME
C REDUCTASE
IRON-SULFUR SUBUNIT)
4hkm ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE

(Xanthomonas
campestris)
4 / 7 ILE A 135
VAL A 134
TYR A 334
GLN A 141
None
1.16A 5kkzK-4hkmA:
undetectable
5kkzQ-4hkmA:
0.0
5kkzK-4hkmA:
22.61
5kkzQ-4hkmA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5F_H_BO2H301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)
4hkm ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE

(Xanthomonas
campestris)
5 / 12 GLN A 320
ALA A 108
GLY A 107
ALA A 105
ASP A 324
None
1.12A 5l5fH-4hkmA:
undetectable
5l5fI-4hkmA:
undetectable
5l5fH-4hkmA:
21.22
5l5fI-4hkmA:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5F_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)
4hkm ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE

(Xanthomonas
campestris)
5 / 12 GLN A 320
ALA A 108
GLY A 107
ALA A 105
ASP A 324
None
1.11A 5l5fV-4hkmA:
undetectable
5l5fW-4hkmA:
undetectable
5l5fV-4hkmA:
21.22
5l5fW-4hkmA:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5Z_H_BO2H301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)
4hkm ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE

(Xanthomonas
campestris)
5 / 12 GLN A 320
ALA A 108
GLY A 107
ALA A 105
ASP A 324
None
1.07A 5l5zH-4hkmA:
undetectable
5l5zI-4hkmA:
undetectable
5l5zH-4hkmA:
21.22
5l5zI-4hkmA:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5Z_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)
4hkm ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE

(Xanthomonas
campestris)
5 / 12 GLN A 320
ALA A 108
GLY A 107
ALA A 105
ASP A 324
None
1.09A 5l5zV-4hkmA:
undetectable
5l5zW-4hkmA:
undetectable
5l5zV-4hkmA:
21.22
5l5zW-4hkmA:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L66_H_BO2H301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)
4hkm ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE

(Xanthomonas
campestris)
5 / 12 GLN A 320
ALA A 108
GLY A 107
ALA A 105
ASP A 324
None
1.00A 5l66H-4hkmA:
undetectable
5l66I-4hkmA:
undetectable
5l66H-4hkmA:
21.22
5l66I-4hkmA:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L66_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)
4hkm ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE

(Xanthomonas
campestris)
5 / 12 GLN A 320
ALA A 108
GLY A 107
ALA A 105
ASP A 324
None
0.99A 5l66V-4hkmA:
undetectable
5l66W-4hkmA:
undetectable
5l66V-4hkmA:
21.22
5l66W-4hkmA:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DIF_B_TPVB201_0
(HIV-1 PROTEASE)
4hkm ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE

(Xanthomonas
campestris)
5 / 12 ALA A  60
ILE A  18
GLY A  55
ILE A  54
ILE A 178
None
0.87A 6difA-4hkmA:
undetectable
6difA-4hkmA:
11.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNE_A_ACRA602_1
(-)
4hkm ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE

(Xanthomonas
campestris)
5 / 12 GLY A 107
GLY A 106
VAL A 102
ASP A 324
GLY A 314
None
1.09A 6gneA-4hkmA:
3.6
6gneA-4hkmA:
23.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNE_B_ACRB602_1
(-)
4hkm ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE

(Xanthomonas
campestris)
5 / 12 GLY A 107
GLY A 106
VAL A 102
ASP A 324
GLY A 314
None
1.09A 6gneB-4hkmA:
3.4
6gneB-4hkmA:
23.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMP_P_CHDP307_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)
4hkm ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE

(Xanthomonas
campestris)
4 / 5 ARG A 328
LEU A 280
GLN A 281
PHE A 101
None
1.47A 6nmpP-4hkmA:
undetectable
6nmpW-4hkmA:
undetectable
6nmpP-4hkmA:
22.32
6nmpW-4hkmA:
11.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6R2E_B_FFOB403_0
(THYMIDYLATE SYNTHASE)
4hkm ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE

(Xanthomonas
campestris)
5 / 10 ILE A  82
ASN A 297
LEU A 231
ASP A 229
GLY A  84
None
1.44A 6r2eB-4hkmA:
undetectable
6r2eB-4hkmA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6R2E_D_FFOD403_0
(THYMIDYLATE SYNTHASE)
4hkm ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE

(Xanthomonas
campestris)
5 / 10 ILE A  82
ASN A 297
LEU A 231
ASP A 229
GLY A  84
None
1.49A 6r2eD-4hkmA:
undetectable
6r2eD-4hkmA:
21.95