SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4hku'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJH_B_SAMB302_0
(7-CARBOXY-7-DEAZAGUA
NINE SYNTHASE)		 4hku TETR TRANSCRIPTIONAL
REGULATOR
(Listeria
monocytogenes) 		5 / 12 ASP A  84
GLU A  66
VAL A 132
ASP A  80
GLN A  76
 None
 1.50A 4njhB-4hkuA:
0.0		 4njhB-4hkuA:
23.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEO_A_VDYA206_2
(CDL2.3A)		 4hku TETR TRANSCRIPTIONAL
REGULATOR
(Listeria
monocytogenes) 		4 / 8 ILE A 111
LEU A 125
ILE A 143
LEU A  57
 None
 0.92A 5ieoA-4hkuA:
undetectable		 5ieoA-4hkuA:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_A_RCXA601_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4hku TETR TRANSCRIPTIONAL
REGULATOR
(Listeria
monocytogenes) 		3 / 3 ARG A  65
ILE A  67
PHE A  68
 None
 0.75A 5kirA-4hkuA:
1.6		 5kirA-4hkuA:
14.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N4T_A_BEZA507_0
(BETA-LACTAMASE VIM-2)		 4hku TETR TRANSCRIPTIONAL
REGULATOR
(Listeria
monocytogenes) 		3 / 3 THR A 144
HIS A 150
ASN A 151
 None
 0.88A 5n4tA-4hkuA:
undetectable		 5n4tA-4hkuA:
20.94