SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4hkx'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTI_B_CCSB47_0
(GLUTATHIONE
S-TRANSFERASE)		 4hkx HEMAGGLUTININ HA1
(Influenza
A
virus) 		4 / 7 LEU E 194
THR E 155
LEU E 251
GLY E 249
 None
 0.87A 1gtiB-4hkxE:
undetectable		 1gtiB-4hkxE:
23.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_A_BEZA501_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 4hkx HEMAGGLUTININ HA1
(Influenza
A
virus) 		4 / 7 ALA E 200
TYR E 195
ILE E 217
PRO E 215
 None
 1.08A 1oniA-4hkxE:
undetectable
1oniB-4hkxE:
undetectable		 1oniA-4hkxE:
20.39
1oniB-4hkxE:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_B_BEZB503_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 4hkx HEMAGGLUTININ HA1
(Influenza
A
virus) 		4 / 6 ALA E 200
TYR E 195
ILE E 217
PRO E 215
 None
 1.15A 1oniB-4hkxE:
undetectable
1oniC-4hkxE:
undetectable		 1oniB-4hkxE:
20.39
1oniC-4hkxE:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_I_BEZI517_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 4hkx HEMAGGLUTININ HA1
(Influenza
A
virus) 		4 / 7 TYR E 195
ILE E 217
PRO E 215
ALA E 200
 None
 1.09A 1oniG-4hkxE:
undetectable
1oniI-4hkxE:
undetectable		 1oniG-4hkxE:
20.39
1oniI-4hkxE:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X91_A_LPRA1615_2
(ANGIOTENSIN
CONVERTING ENZYME)		 4hkx HEMAGGLUTININ HA1
(Influenza
A
virus) 		3 / 3 SER E 210
THR E 235
PHE E 121
 None
 0.74A 2x91A-4hkxE:
undetectable		 2x91A-4hkxE:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP6_B_SALB3001_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 4hkx HEMAGGLUTININ HA1
(Influenza
A
virus) 		4 / 8 GLU E  72
ASN E  68
ASN E 150
ILE E  65
 None
NAG  E 301 (-3.5A)
None
None
 1.30A 3kp6A-4hkxE:
undetectable
3kp6B-4hkxE:
undetectable		 3kp6A-4hkxE:
21.15
3kp6B-4hkxE:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP6_B_SALB3006_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 4hkx HEMAGGLUTININ HA1
(Influenza
A
virus) 		4 / 6 ASN E 150
ILE E  65
GLU E  72
ASN E  68
 None
None
None
NAG  E 301 (-3.5A)
 1.35A 3kp6A-4hkxE:
undetectable
3kp6B-4hkxE:
undetectable		 3kp6A-4hkxE:
21.15
3kp6B-4hkxE:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EQ4_A_SALA601_1
(4-SUBSTITUTED
BENZOATES-GLUTAMATE
LIGASE GH3.12)		 4hkx HEMAGGLUTININ HA1
(Influenza
A
virus) 		4 / 7 LEU E 194
TYR E 195
ILE E 252
GLY E 134
 None
 0.81A 4eq4A-4hkxE:
undetectable		 4eq4A-4hkxE:
16.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EQL_A_SALA602_1
(4-SUBSTITUTED
BENZOATES-GLUTAMATE
LIGASE GH3.12)		 4hkx HEMAGGLUTININ HA1
(Influenza
A
virus) 		4 / 7 LEU E 194
TYR E 195
ILE E 252
GLY E 134
 None
 0.82A 4eqlA-4hkxE:
undetectable		 4eqlA-4hkxE:
16.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EQL_B_SALB602_1
(4-SUBSTITUTED
BENZOATES-GLUTAMATE
LIGASE GH3.12)		 4hkx HEMAGGLUTININ HA1
(Influenza
A
virus) 		4 / 7 LEU E 194
TYR E 195
ILE E 252
GLY E 134
 None
 0.83A 4eqlB-4hkxE:
undetectable		 4eqlB-4hkxE:
16.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L39_A_SALA602_1
(4-SUBSTITUTED
BENZOATES-GLUTAMATE
LIGASE GH3.12)		 4hkx HEMAGGLUTININ HA1
(Influenza
A
virus) 		4 / 6 LEU E 194
TYR E 195
ILE E 252
GLY E 134
 None
 0.84A 4l39A-4hkxE:
undetectable		 4l39A-4hkxE:
16.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L39_B_SALB601_1
(4-SUBSTITUTED
BENZOATES-GLUTAMATE
LIGASE GH3.12)		 4hkx HEMAGGLUTININ HA1
(Influenza
A
virus) 		4 / 7 LEU E 194
TYR E 195
ILE E 252
GLY E 134
 None
 0.84A 4l39B-4hkxE:
undetectable		 4l39B-4hkxE:
16.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESG_A_1YNA701_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 4hkx HEMAGGLUTININ HA1
(Influenza
A
virus) 		4 / 4 LEU E 177
TYR E 148
PRO E 254
ILE E 120
 None
 1.33A 5esgA-4hkxE:
undetectable		 5esgA-4hkxE:
17.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IY5_P_CHDP307_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4hkx HEMAGGLUTININ HA1
(Influenza
A
virus) 		4 / 5 ARG E 262
LEU E 260
PHE E 258
LEU E 236
 None
 1.10A 5iy5P-4hkxE:
undetectable
5iy5W-4hkxE:
undetectable		 5iy5P-4hkxE:
21.74
5iy5W-4hkxE:
15.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TRQ_B_ACTB306_0
(WELO5)		 4hkx HEMAGGLUTININ HA1
(Influenza
A
virus) 		3 / 3 GLU E 119
ARG E 255
TYR E 256
 None
 0.53A 5trqB-4hkxE:
undetectable		 5trqB-4hkxE:
23.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDX_C_CHDC308_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT VIIA-HEART)		 4hkx HEMAGGLUTININ HA1
(Influenza
A
virus) 		4 / 5 ARG E 262
LEU E 260
PHE E 258
LEU E 236
 None
 1.10A 5xdxC-4hkxE:
undetectable
5xdxJ-4hkxE:
undetectable		 5xdxC-4hkxE:
21.74
5xdxJ-4hkxE:
14.29