SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4hl0'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IBG_H_OBNH1_1
(IGG2B-KAPPA 40-50
FAB (HEAVY CHAIN))		 4hl0 GALECTIN
(Toxascaris
leonina) 		4 / 6 LEU A  25
TRP A 141
PHE A 128
VAL A 130
 None
 1.02A 1ibgH-4hl0A:
undetectable		 1ibgH-4hl0A:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W98_B_P1ZB1356_1
(PROSTAGLANDIN
REDUCTASE 2)		 4hl0 GALECTIN
(Toxascaris
leonina) 		4 / 8 ILE A 180
TYR A 150
LEU A 154
LEU A 159
 None
 0.79A 2w98B-4hl0A:
undetectable		 2w98B-4hl0A:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GAL_A_1GNA998_1
(GALECTIN-7)		 4hl0 GALECTIN
(Toxascaris
leonina) 		4 / 6 HIS A  57
ASN A  70
TRP A  77
GLU A  80
 None
 0.41A 3galA-4hl0A:
22.6		 3galA-4hl0A:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GAL_A_1GNA998_1
(GALECTIN-7)		 4hl0 GALECTIN
(Toxascaris
leonina) 		6 / 6 HIS A 192
ASN A 194
ARG A 196
ASN A 205
TRP A 212
GLU A 215
 None
 0.27A 3galA-4hl0A:
22.6		 3galA-4hl0A:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GAL_B_1GNB999_1
(GALECTIN-7)		 4hl0 GALECTIN
(Toxascaris
leonina) 		4 / 6 HIS A  57
ASN A  70
TRP A  77
GLU A  80
 None
 0.39A 3galB-4hl0A:
22.4		 3galB-4hl0A:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GAL_B_1GNB999_1
(GALECTIN-7)		 4hl0 GALECTIN
(Toxascaris
leonina) 		6 / 6 HIS A 192
ASN A 194
ARG A 196
ASN A 205
TRP A 212
GLU A 215
 None
 0.32A 3galB-4hl0A:
22.4		 3galB-4hl0A:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP6_B_SALB3001_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 4hl0 GALECTIN
(Toxascaris
leonina) 		4 / 8 GLU A 236
ASN A 235
HIS A 254
ILE A 242
 None
 1.32A 3kp6A-4hl0A:
undetectable
3kp6B-4hl0A:
undetectable		 3kp6A-4hl0A:
18.66
3kp6B-4hl0A:
18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AX8_A_SAMA1474_1
(WBDD)		 4hl0 GALECTIN
(Toxascaris
leonina) 		4 / 6 TYR A 138
ASP A  94
GLU A 112
LEU A  25
 None
 1.40A 4ax8A-4hl0A:
undetectable		 4ax8A-4hl0A:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LS7_B_1X9B503_1
(3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2)		 4hl0 GALECTIN
(Toxascaris
leonina) 		5 / 12 CYH A 229
PHE A 178
THR A 273
LEU A 231
GLY A 228
 None
 1.08A 4ls7A-4hl0A:
undetectable
4ls7B-4hl0A:
undetectable		 4ls7A-4hl0A:
20.18
4ls7B-4hl0A:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WQ5_B_ACTB404_0
(TRNA N6-ADENOSINE
THREONYLCARBAMOYLTRA
NSFERASE)		 4hl0 GALECTIN
(Toxascaris
leonina) 		3 / 3 TYR A 138
ARG A  96
LYS A  28
 None
 0.78A 4wq5B-4hl0A:
undetectable		 4wq5B-4hl0A:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZBR_A_ACTA608_0
(SERUM ALBUMIN)		 4hl0 GALECTIN
(Toxascaris
leonina) 		3 / 3 LYS A  14
ARG A  12
HIS A  43
 None
 1.23A 4zbrA-4hl0A:
undetectable		 4zbrA-4hl0A:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M8R_C_MMSC516_1
(5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE)		 4hl0 GALECTIN
(Toxascaris
leonina) 		4 / 8 HIS A 192
ASN A 194
HIS A 179
GLY A 268
 None
 0.93A 5m8rC-4hl0A:
undetectable		 5m8rC-4hl0A:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B8K_A_W9TA300_0
(GALECTIN-3)		 4hl0 GALECTIN
(Toxascaris
leonina) 		5 / 7 HIS A  57
ASN A  70
TRP A  77
GLU A  80
ARG A  82
 None
 0.82A 6b8kA-4hl0A:
21.5		 6b8kA-4hl0A:
16.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B8K_A_W9TA300_0
(GALECTIN-3)		 4hl0 GALECTIN
(Toxascaris
leonina) 		6 / 7 HIS A 192
ASN A 194
ARG A 196
ASN A 205
TRP A 212
GLU A 215
 None
 0.25A 6b8kA-4hl0A:
21.5		 6b8kA-4hl0A:
16.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B94_A_W9TA201_0
(GALECTIN-1)		 4hl0 GALECTIN
(Toxascaris
leonina) 		4 / 8 HIS A  57
ASN A  70
TRP A  77
GLU A  80
 None
 0.39A 6b94A-4hl0A:
20.5		 6b94A-4hl0A:
18.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B94_A_W9TA201_0
(GALECTIN-1)		 4hl0 GALECTIN
(Toxascaris
leonina) 		4 / 8 HIS A  57
TRP A  77
GLU A  80
ARG A  82
 None
 0.83A 6b94A-4hl0A:
20.5		 6b94A-4hl0A:
18.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B94_A_W9TA201_0
(GALECTIN-1)		 4hl0 GALECTIN
(Toxascaris
leonina) 		6 / 8 HIS A 192
ASN A 194
ARG A 196
ASN A 205
TRP A 212
GLU A 215
 None
 0.35A 6b94A-4hl0A:
20.5		 6b94A-4hl0A:
18.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B94_B_W9TB201_0
(GALECTIN-1)		 4hl0 GALECTIN
(Toxascaris
leonina) 		5 / 10 HIS A  57
ASN A  70
TRP A  77
GLU A  80
ARG A  82
 None
 0.88A 6b94A-4hl0A:
20.5
6b94B-4hl0A:
20.0		 6b94A-4hl0A:
18.03
6b94B-4hl0A:
18.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B94_B_W9TB201_0
(GALECTIN-1)		 4hl0 GALECTIN
(Toxascaris
leonina) 		6 / 10 HIS A 192
ASN A 194
ARG A 196
ASN A 205
TRP A 212
GLU A 215
 None
 0.29A 6b94A-4hl0A:
20.5
6b94B-4hl0A:
20.0		 6b94A-4hl0A:
18.03
6b94B-4hl0A:
18.03