SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4hl4'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_H_SVRH511_2
(PHOSPHOLIPASE A2)		 4hl4 TBC1 DOMAIN FAMILY
MEMBER 20
(Homo
sapiens) 		4 / 5 VAL A 235
VAL A 236
THR A 223
ARG A 233
 None
 1.27A 3bjwD-4hl4A:
undetectable		 3bjwD-4hl4A:
15.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM0_B_CHDB152_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 4hl4 TBC1 DOMAIN FAMILY
MEMBER 20
(Homo
sapiens) 		4 / 8 ILE A 196
HIS A 276
VAL A 212
GLY A 213
 None
ACT  A 402 (-4.0A)
None
None
 0.82A 3em0B-4hl4A:
undetectable		 3em0B-4hl4A:
18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IA4_C_MTXC164_2
(DIHYDROFOLATE
REDUCTASE)		 4hl4 TBC1 DOMAIN FAMILY
MEMBER 20
(Homo
sapiens) 		4 / 4 ILE A 133
ARG A 109
ILE A 130
THR A 171
 None
 1.22A 3ia4C-4hl4A:
undetectable		 3ia4C-4hl4A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OHT_A_1N1A2000_1
(P38A)		 4hl4 TBC1 DOMAIN FAMILY
MEMBER 20
(Homo
sapiens) 		5 / 12 ILE A 195
VAL A 228
ILE A 251
ALA A 295
TYR A 252
 None
 1.12A 3ohtA-4hl4A:
undetectable
3ohtB-4hl4A:
undetectable		 3ohtA-4hl4A:
22.73
3ohtB-4hl4A:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R24_A_SAMA302_1
(2'-O-METHYL
TRANSFERASE)		 4hl4 TBC1 DOMAIN FAMILY
MEMBER 20
(Homo
sapiens) 		3 / 3 TYR A 142
ASP A 148
ASP A 102
 None
 0.85A 3r24A-4hl4A:
undetectable		 3r24A-4hl4A:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V5W_A_8PRA701_2
(G-PROTEIN COUPLED
RECEPTOR KINASE 2)		 4hl4 TBC1 DOMAIN FAMILY
MEMBER 20
(Homo
sapiens) 		3 / 3 LEU A 266
MET A 207
ASP A 197
 None
 0.90A 3v5wA-4hl4A:
undetectable		 3v5wA-4hl4A:
18.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VN2_A_TLSA501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 4hl4 TBC1 DOMAIN FAMILY
MEMBER 20
(Homo
sapiens) 		5 / 12 HIS A 147
ILE A 130
TYR A 142
LEU A 134
MET A 178
 None
 1.47A 3vn2A-4hl4A:
undetectable		 3vn2A-4hl4A:
24.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A9K_B_TYLB2198_1
(CREB-BINDING PROTEIN)		 4hl4 TBC1 DOMAIN FAMILY
MEMBER 20
(Homo
sapiens) 		4 / 5 VAL A 258
LEU A 203
ILE A 196
VAL A 212
 None
 0.86A 4a9kB-4hl4A:
undetectable		 4a9kB-4hl4A:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G5J_A_0WMA1102_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 4hl4 TBC1 DOMAIN FAMILY
MEMBER 20
(Homo
sapiens) 		4 / 7 PHE A 299
TYR A 252
TYR A 191
PRO A 304
 None
 1.09A 4g5jA-4hl4A:
undetectable		 4g5jA-4hl4A:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XDT_A_ACTA407_0
(FAD:PROTEIN FMN
TRANSFERASE)		 4hl4 TBC1 DOMAIN FAMILY
MEMBER 20
(Homo
sapiens) 		3 / 3 ASP A 102
GLY A 145
ASP A 148
 None
 0.69A 4xdtA-4hl4A:
undetectable		 4xdtA-4hl4A:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DV4_A_NMYA601_1
(CCR4-NOT
TRANSCRIPTION
COMPLEX SUBUNIT
6-LIKE)		 4hl4 TBC1 DOMAIN FAMILY
MEMBER 20
(Homo
sapiens) 		5 / 12 HIS A 227
ASP A 148
LEU A 155
PHE A 110
HIS A 147
 None
 1.29A 5dv4A-4hl4A:
undetectable		 5dv4A-4hl4A:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JWA_H_ACTH614_0
(NADH DEHYDROGENASE,
PUTATIVE)		 4hl4 TBC1 DOMAIN FAMILY
MEMBER 20
(Homo
sapiens) 		4 / 6 ILE A 130
VAL A 166
VAL A 150
SER A 170
 None
 0.96A 5jwaH-4hl4A:
undetectable		 5jwaH-4hl4A:
19.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KXI_A_NCTA402_1
(NEURONAL
ACETYLCHOLINE
RECEPTOR SUBUNIT
ALPHA-4
NEURONAL
ACETYLCHOLINE
RECEPTOR SUBUNIT
BETA-2)		 4hl4 TBC1 DOMAIN FAMILY
MEMBER 20
(Homo
sapiens) 		4 / 8 TYR A 239
TRP A 224
THR A 223
LEU A 174
 None
 1.41A 5kxiA-4hl4A:
undetectable
5kxiB-4hl4A:
undetectable		 5kxiA-4hl4A:
21.41
5kxiB-4hl4A:
21.31