SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4hl6'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JGS_A_SALA256_1
(MULTIPLE ANTIBIOTIC
RESISTANCE PROTEIN
MARR)		 4hl6 UNCHARACTERIZED
PROTEIN YFDE
(Escherichia
coli) 		4 / 7 VAL A 241
THR A 244
LEU A 298
VAL A 317
 None
 0.79A 1jgsA-4hl6A:
undetectable		 1jgsA-4hl6A:
16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V54_C_CHDC3271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE III
CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART)		 4hl6 UNCHARACTERIZED
PROTEIN YFDE
(Escherichia
coli) 		5 / 8 LYS A 291
LEU A 290
GLN A 287
PHE A 277
LEU A 271
 None
 1.43A 1v54C-4hl6A:
undetectable
1v54J-4hl6A:
undetectable		 1v54C-4hl6A:
21.79
1v54J-4hl6A:
10.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V54_P_CHDP4271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE III
CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART)		 4hl6 UNCHARACTERIZED
PROTEIN YFDE
(Escherichia
coli) 		5 / 8 LYS A 291
LEU A 290
GLN A 287
PHE A 277
LEU A 271
 None
 1.43A 1v54P-4hl6A:
undetectable
1v54W-4hl6A:
undetectable		 1v54P-4hl6A:
21.79
1v54W-4hl6A:
10.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VHW_A_ADNA252_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 4hl6 UNCHARACTERIZED
PROTEIN YFDE
(Escherichia
coli) 		5 / 11 ARG A  51
GLY A 372
VAL A  74
GLU A  42
ILE A 375
 None
 1.37A 1vhwA-4hl6A:
2.6
1vhwD-4hl6A:
undetectable		 1vhwA-4hl6A:
22.89
1vhwD-4hl6A:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VHW_C_ADNC252_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 4hl6 UNCHARACTERIZED
PROTEIN YFDE
(Escherichia
coli) 		5 / 11 ARG A  51
GLY A 372
VAL A  74
GLU A  42
ILE A 375
 None
 1.39A 1vhwC-4hl6A:
undetectable
1vhwE-4hl6A:
2.4		 1vhwC-4hl6A:
22.89
1vhwE-4hl6A:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VHW_D_ADND252_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 4hl6 UNCHARACTERIZED
PROTEIN YFDE
(Escherichia
coli) 		5 / 11 ARG A  51
GLY A 372
VAL A  74
GLU A  42
ILE A 375
 None
 1.40A 1vhwA-4hl6A:
2.6
1vhwD-4hl6A:
undetectable		 1vhwA-4hl6A:
22.89
1vhwD-4hl6A:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VHW_E_ADNE252_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 4hl6 UNCHARACTERIZED
PROTEIN YFDE
(Escherichia
coli) 		5 / 11 ARG A  51
GLY A 372
VAL A  74
GLU A  42
ILE A 375
 None
 1.36A 1vhwC-4hl6A:
undetectable
1vhwE-4hl6A:
2.4		 1vhwC-4hl6A:
22.89
1vhwE-4hl6A:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XLX_A_CIOA101_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		 4hl6 UNCHARACTERIZED
PROTEIN YFDE
(Escherichia
coli) 		5 / 12 MET A 106
LEU A  97
ILE A 119
SER A  85
PHE A  87
 None
 1.36A 1xlxA-4hl6A:
undetectable		 1xlxA-4hl6A:
24.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOM_A_CIOA603_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 4hl6 UNCHARACTERIZED
PROTEIN YFDE
(Escherichia
coli) 		5 / 12 MET A 106
LEU A  97
ILE A 119
SER A  85
PHE A  87
 None
 1.32A 1xomA-4hl6A:
undetectable		 1xomA-4hl6A:
25.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOM_B_CIOB601_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 4hl6 UNCHARACTERIZED
PROTEIN YFDE
(Escherichia
coli) 		5 / 12 MET A 106
LEU A  97
ILE A 119
SER A  85
PHE A  87
 None
 1.33A 1xomB-4hl6A:
undetectable		 1xomB-4hl6A:
25.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOQ_A_ROFA502_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 4hl6 UNCHARACTERIZED
PROTEIN YFDE
(Escherichia
coli) 		5 / 12 MET A 106
LEU A  97
ILE A 119
SER A  85
PHE A  87
 None
 1.30A 1xoqA-4hl6A:
undetectable		 1xoqA-4hl6A:
25.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYR_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4hl6 UNCHARACTERIZED
PROTEIN YFDE
(Escherichia
coli) 		5 / 8 LYS A 291
LEU A 290
GLN A 287
PHE A 277
LEU A 271
 None
 1.45A 2dyrC-4hl6A:
undetectable
2dyrJ-4hl6A:
undetectable		 2dyrC-4hl6A:
21.79
2dyrJ-4hl6A:
10.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYR_P_CHDP1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4hl6 UNCHARACTERIZED
PROTEIN YFDE
(Escherichia
coli) 		5 / 8 LYS A 291
LEU A 290
GLN A 287
PHE A 277
LEU A 271
 None
 1.44A 2dyrP-4hl6A:
undetectable
2dyrW-4hl6A:
undetectable		 2dyrP-4hl6A:
21.79
2dyrW-4hl6A:
10.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G70_A_SAMA2001_0
(PHENYLETHANOLAMINE
N-METHYLTRANSFERASE)		 4hl6 UNCHARACTERIZED
PROTEIN YFDE
(Escherichia
coli) 		5 / 12 GLN A 148
ASP A  49
VAL A  21
HIS A  20
ALA A 172
 None
 1.28A 2g70A-4hl6A:
undetectable		 2g70A-4hl6A:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G70_B_SAMB2002_0
(PHENYLETHANOLAMINE
N-METHYLTRANSFERASE)		 4hl6 UNCHARACTERIZED
PROTEIN YFDE
(Escherichia
coli) 		5 / 12 GLN A 148
ASP A  49
VAL A  21
HIS A  20
ALA A 172
 None
 1.34A 2g70B-4hl6A:
undetectable		 2g70B-4hl6A:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QM9_A_TDZA201_1
(FATTY ACID-BINDING
PROTEIN, ADIPOCYTE)		 4hl6 UNCHARACTERIZED
PROTEIN YFDE
(Escherichia
coli) 		5 / 12 ALA A 142
SER A 151
THR A 208
ALA A 172
ASP A 173
 None
 1.43A 2qm9A-4hl6A:
undetectable		 2qm9A-4hl6A:
16.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG2_C_CHDC271_0
(CYTOCHROME C OXIDASE
SUBUNIT 3)		 4hl6 UNCHARACTERIZED
PROTEIN YFDE
(Escherichia
coli) 		4 / 7 LEU A 290
GLN A 287
PHE A 277
LEU A 271
 None
 1.01A 3ag2C-4hl6A:
undetectable		 3ag2C-4hl6A:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG4_P_CHDP1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4hl6 UNCHARACTERIZED
PROTEIN YFDE
(Escherichia
coli) 		4 / 7 LEU A 290
GLN A 287
PHE A 277
LEU A 271
 None
 0.92A 3ag4P-4hl6A:
undetectable
3ag4W-4hl6A:
undetectable		 3ag4P-4hl6A:
21.79
3ag4W-4hl6A:
10.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D90_A_NOGA1001_1
(PROGESTERONE
RECEPTOR)		 4hl6 UNCHARACTERIZED
PROTEIN YFDE
(Escherichia
coli) 		5 / 12 LEU A  30
LEU A  31
LEU A  13
ARG A 191
LEU A 180
 None
 1.39A 3d90A-4hl6A:
undetectable		 3d90A-4hl6A:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RR3_A_FLRA700_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4hl6 UNCHARACTERIZED
PROTEIN YFDE
(Escherichia
coli) 		6 / 12 VAL A  96
LEU A  31
TRP A 113
VAL A 200
ALA A 187
LEU A 188
 None
 1.43A 3rr3A-4hl6A:
undetectable		 3rr3A-4hl6A:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RR3_B_FLRB700_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4hl6 UNCHARACTERIZED
PROTEIN YFDE
(Escherichia
coli) 		6 / 12 VAL A  96
LEU A  31
TRP A 113
VAL A 200
ALA A 187
LEU A 188
 None
 1.44A 3rr3B-4hl6A:
undetectable		 3rr3B-4hl6A:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UAY_A_ADNA236_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 4hl6 UNCHARACTERIZED
PROTEIN YFDE
(Escherichia
coli) 		5 / 10 ARG A  51
GLY A 372
VAL A  74
GLU A  42
ILE A 375
 None
 1.33A 3uayA-4hl6A:
undetectable		 3uayA-4hl6A:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UAY_A_ADNA236_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 4hl6 UNCHARACTERIZED
PROTEIN YFDE
(Escherichia
coli) 		5 / 10 ARG A  51
THR A 367
VAL A  74
GLU A  42
ILE A 375
 None
 1.37A 3uayA-4hl6A:
undetectable		 3uayA-4hl6A:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_A_ACTA502_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 4hl6 UNCHARACTERIZED
PROTEIN YFDE
(Escherichia
coli) 		4 / 5 VAL A  75
SER A  73
GLY A  47
ARG A  51
 None
 1.33A 3v4tA-4hl6A:
undetectable
3v4tD-4hl6A:
undetectable		 3v4tA-4hl6A:
23.31
3v4tD-4hl6A:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3X2Q_P_CHDP307_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4hl6 UNCHARACTERIZED
PROTEIN YFDE
(Escherichia
coli) 		4 / 7 LEU A 290
GLN A 287
PHE A 277
LEU A 271
 None
 0.96A 3x2qP-4hl6A:
undetectable
3x2qW-4hl6A:
undetectable		 3x2qP-4hl6A:
21.79
3x2qW-4hl6A:
10.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O0U_A_ADNA501_1
(AURORA KINASE A)		 4hl6 UNCHARACTERIZED
PROTEIN YFDE
(Escherichia
coli) 		4 / 6 VAL A 317
LEU A 266
THR A 244
LEU A 298
 None
 0.66A 4o0uA-4hl6A:
undetectable		 4o0uA-4hl6A:
23.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_A_SAMA301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 4hl6 UNCHARACTERIZED
PROTEIN YFDE
(Escherichia
coli) 		5 / 12 ASP A 201
ASP A 173
GLY A  24
SER A 127
GLU A  99
 None
 0.91A 5hfjA-4hl6A:
undetectable		 5hfjA-4hl6A:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BOC_A_EU7A102_0
(MATRIX PROTEIN 2)		 4hl6 UNCHARACTERIZED
PROTEIN YFDE
(Escherichia
coli) 		4 / 6 SER A 182
ALA A 187
SER A 186
ALA A 126
 None
 0.99A 6bocA-4hl6A:
undetectable
6bocB-4hl6A:
undetectable
6bocC-4hl6A:
undetectable
6bocD-4hl6A:
undetectable		 6bocA-4hl6A:
5.78
6bocB-4hl6A:
5.78
6bocC-4hl6A:
5.78
6bocD-4hl6A:
5.78