SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4hl7'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OLT_A_SAMA501_0
(OXYGEN-INDEPENDENT
COPROPORPHYRINOGEN
III OXIDASE)		 4hl7 NICOTINATE
PHOSPHORIBOSYLTRANSF
ERASE
(Vibrio
cholerae) 		5 / 12 GLU A 393
GLY A 296
ILE A 273
ALA A 275
GLN A 248
 None
 1.27A 1oltA-4hl7A:
undetectable		 1oltA-4hl7A:
25.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z9H_D_IMND476_1
(MEMBRANE-ASSOCIATED
PROSTAGLANDIN E
SYNTHASE-2)		 4hl7 NICOTINATE
PHOSPHORIBOSYLTRANSF
ERASE
(Vibrio
cholerae) 		5 / 12 PRO A 100
ILE A  62
VAL A 135
VAL A 104
LEU A  43
 None
 1.13A 1z9hD-4hl7A:
undetectable		 1z9hD-4hl7A:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E5D_A_NCAA1501_0
(NICOTINAMIDE
PHOSPHORIBOSYLTRANSF
ERASE)		 4hl7 NICOTINATE
PHOSPHORIBOSYLTRANSF
ERASE
(Vibrio
cholerae) 		4 / 7 ARG A 187
ARG A 292
ASP A  20
TYR A  22
 None
 0.99A 2e5dA-4hl7A:
8.9
2e5dB-4hl7A:
6.0		 2e5dA-4hl7A:
23.18
2e5dB-4hl7A:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E5D_B_NCAB1502_0
(NICOTINAMIDE
PHOSPHORIBOSYLTRANSF
ERASE)		 4hl7 NICOTINATE
PHOSPHORIBOSYLTRANSF
ERASE
(Vibrio
cholerae) 		4 / 7 ASP A  20
TYR A  22
ARG A 187
ARG A 292
 None
 0.85A 2e5dA-4hl7A:
9.3
2e5dB-4hl7A:
9.4		 2e5dA-4hl7A:
23.18
2e5dB-4hl7A:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F7F_A_NIOA601_1
(NICOTINATE
PHOSPHORIBOSYLTRANSF
ERASE, PUTATIVE)		 4hl7 NICOTINATE
PHOSPHORIBOSYLTRANSF
ERASE
(Vibrio
cholerae) 		5 / 6 ARG A 187
SER A 214
GLY A 228
THR A 229
ARG A 292
 None
 0.72A 2f7fA-4hl7A:
9.2		 2f7fA-4hl7A:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FKE_A_FK5A108_1
(FK506 BINDING
PROTEIN)		 4hl7 NICOTINATE
PHOSPHORIBOSYLTRANSF
ERASE
(Vibrio
cholerae) 		5 / 11 ASP A 303
ARG A 342
PHE A 321
ILE A 273
TRP A 301
 None
 1.39A 2fkeA-4hl7A:
undetectable		 2fkeA-4hl7A:
13.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W1B_A_DXCA2034_0
(ACRIFLAVIN
RESISTANCE PROTEIN B)		 4hl7 NICOTINATE
PHOSPHORIBOSYLTRANSF
ERASE
(Vibrio
cholerae) 		3 / 3 PHE A 402
SER A 247
LEU A 241
 None
 0.83A 2w1bA-4hl7A:
2.3		 2w1bA-4hl7A:
18.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G4L_A_ROFA901_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 4hl7 NICOTINATE
PHOSPHORIBOSYLTRANSF
ERASE
(Vibrio
cholerae) 		3 / 3 ASP A  56
LEU A  55
GLN A 115
 None
 0.77A 3g4lA-4hl7A:
undetectable		 3g4lA-4hl7A:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IHZ_A_FK5A501_1
(70 KDA
PEPTIDYLPROLYL
ISOMERASE, PUTATIVE)		 4hl7 NICOTINATE
PHOSPHORIBOSYLTRANSF
ERASE
(Vibrio
cholerae) 		5 / 10 ASP A 303
ARG A 342
PHE A 321
ILE A 273
TRP A 301
 None
 1.42A 3ihzA-4hl7A:
undetectable		 3ihzA-4hl7A:
14.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP2_A_PNNA5001_0
(TRANSCRIPTIONAL
REGULATOR TCAR)		 4hl7 NICOTINATE
PHOSPHORIBOSYLTRANSF
ERASE
(Vibrio
cholerae) 		4 / 8 THR A 270
LEU A 271
SER A 247
HIS A 238
 None
 1.11A 3kp2A-4hl7A:
undetectable
3kp2B-4hl7A:
undetectable		 3kp2A-4hl7A:
17.99
3kp2B-4hl7A:
17.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TVX_A_PNXA902_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4A)		 4hl7 NICOTINATE
PHOSPHORIBOSYLTRANSF
ERASE
(Vibrio
cholerae) 		5 / 9 TYR A  41
LEU A 130
ILE A 121
GLN A 103
PHE A  98
 None
 1.22A 3tvxA-4hl7A:
undetectable		 3tvxA-4hl7A:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UF8_A_FK5A114_1
(UBIQUITIN-LIKE
PROTEIN SMT3,
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE)		 4hl7 NICOTINATE
PHOSPHORIBOSYLTRANSF
ERASE
(Vibrio
cholerae) 		5 / 10 ASP A 303
ARG A 342
PHE A 321
ILE A 273
TRP A 301
 None
 1.35A 3uf8A-4hl7A:
undetectable		 3uf8A-4hl7A:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UQA_A_FK5A114_1
(UBIQUITIN-LIKE
PROTEIN SMT3,
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE)		 4hl7 NICOTINATE
PHOSPHORIBOSYLTRANSF
ERASE
(Vibrio
cholerae) 		5 / 10 ASP A 303
ARG A 342
PHE A 321
ILE A 273
TRP A 301
 None
 1.43A 3uqaA-4hl7A:
undetectable		 3uqaA-4hl7A:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VAW_A_FK5A114_1
(UBIQUITIN-LIKE
PROTEIN
SMT3,PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE)		 4hl7 NICOTINATE
PHOSPHORIBOSYLTRANSF
ERASE
(Vibrio
cholerae) 		5 / 11 ASP A 303
ARG A 342
PHE A 321
ILE A 273
TRP A 301
 None
 1.44A 3vawA-4hl7A:
undetectable		 3vawA-4hl7A:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DZ3_B_FK5B201_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE)		 4hl7 NICOTINATE
PHOSPHORIBOSYLTRANSF
ERASE
(Vibrio
cholerae) 		5 / 10 ASP A 303
ARG A 342
PHE A 321
ILE A 273
TRP A 301
 None
 1.44A 4dz3B-4hl7A:
undetectable		 4dz3B-4hl7A:
13.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O8Z_A_BBIA402_1
(NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-3,
MITOCHONDRIAL)		 4hl7 NICOTINATE
PHOSPHORIBOSYLTRANSF
ERASE
(Vibrio
cholerae) 		4 / 5 PHE A 321
HIS A 293
PHE A 339
LEU A 327
 None
 1.34A 4o8zA-4hl7A:
undetectable		 4o8zA-4hl7A:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HUA_A_FK5A201_1
(FK506-BINDING
PROTEIN 1)		 4hl7 NICOTINATE
PHOSPHORIBOSYLTRANSF
ERASE
(Vibrio
cholerae) 		5 / 11 ASP A 303
ARG A 342
PHE A 321
ILE A 273
TRP A 301
 None
 1.38A 5huaA-4hl7A:
undetectable		 5huaA-4hl7A:
13.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HWC_A_FK5A201_1
(FK506-BINDING
PROTEIN 1A)		 4hl7 NICOTINATE
PHOSPHORIBOSYLTRANSF
ERASE
(Vibrio
cholerae) 		5 / 11 ASP A 303
ARG A 342
PHE A 321
ILE A 273
TRP A 301
 None
 1.29A 5hwcA-4hl7A:
undetectable		 5hwcA-4hl7A:
12.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J4N_B_AG2B501_1
(ARGININE/AGMATINE
ANTIPORTER)		 4hl7 NICOTINATE
PHOSPHORIBOSYLTRANSF
ERASE
(Vibrio
cholerae) 		4 / 6 ILE A 230
GLY A 348
MET A 184
ILE A 265
 None
 0.78A 5j4nB-4hl7A:
undetectable		 5j4nB-4hl7A:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WWS_B_SAMB501_0
(PUTATIVE
METHYLTRANSFERASE
NSUN6)		 4hl7 NICOTINATE
PHOSPHORIBOSYLTRANSF
ERASE
(Vibrio
cholerae) 		5 / 12 PRO A 298
GLY A 296
ILE A 345
GLY A 290
ASP A 294
 None
 1.10A 5wwsB-4hl7A:
undetectable		 5wwsB-4hl7A:
25.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZGB_B_PQNB844_1
(PSAB)		 4hl7 NICOTINATE
PHOSPHORIBOSYLTRANSF
ERASE
(Vibrio
cholerae) 		5 / 9 ILE A  30
TRP A 125
MET A 396
LEU A 377
ALA A 378
 None
 1.47A 5zgbB-4hl7A:
0.0		 5zgbB-4hl7A:
11.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZHM_B_SAMB301_0
(TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE)		 4hl7 NICOTINATE
PHOSPHORIBOSYLTRANSF
ERASE
(Vibrio
cholerae) 		4 / 4 ARG A 188
SER A 324
ASP A 294
HIS A 232
 None
 1.26A 5zhmA-4hl7A:
undetectable		 5zhmA-4hl7A:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MKE_A_FK5A201_0
(PEPTIDYLPROLYL
ISOMERASE)		 4hl7 NICOTINATE
PHOSPHORIBOSYLTRANSF
ERASE
(Vibrio
cholerae) 		5 / 12 ASP A 303
ARG A 342
PHE A 321
ILE A 273
TRP A 301
 None
 1.33A 6mkeA-4hl7A:
undetectable
6mkeD-4hl7A:
undetectable		 6mkeA-4hl7A:
13.08
6mkeD-4hl7A:
13.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MKE_C_FK5C201_1
(PEPTIDYLPROLYL
ISOMERASE)		 4hl7 NICOTINATE
PHOSPHORIBOSYLTRANSF
ERASE
(Vibrio
cholerae) 		5 / 10 ASP A 303
ARG A 342
PHE A 321
ILE A 273
TRP A 301
 None
 1.45A 6mkeC-4hl7A:
undetectable		 6mkeC-4hl7A:
13.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MKE_D_FK5D201_1
(PEPTIDYLPROLYL
ISOMERASE)		 4hl7 NICOTINATE
PHOSPHORIBOSYLTRANSF
ERASE
(Vibrio
cholerae) 		5 / 10 ASP A 303
ARG A 342
PHE A 321
ILE A 273
TRP A 301
 None
 1.42A 6mkeD-4hl7A:
undetectable		 6mkeD-4hl7A:
13.08