SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4hln'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FML_A_RTLA401_0
(RETINOL DEHYDRATASE)		 4hln STARCH SYNTHASE I
(Hordeum
vulgare) 		5 / 12 LEU A 361
LEU A 360
HIS A 251
LEU A 276
ILE A 337
 None
 1.40A 1fmlA-4hlnA:
undetectable		 1fmlA-4hlnA:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SBR_B_VIBB503_1
(YKOF)		 4hln STARCH SYNTHASE I
(Hordeum
vulgare) 		4 / 7 ILE A 434
ILE A 437
LYS A 438
THR A 468
 None
 0.87A 1sbrB-4hlnA:
undetectable		 1sbrB-4hlnA:
14.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E5D_B_NCAB1502_0
(NICOTINAMIDE
PHOSPHORIBOSYLTRANSF
ERASE)		 4hln STARCH SYNTHASE I
(Hordeum
vulgare) 		4 / 7 TYR A 147
PHE A 208
ARG A 217
ALA A 113
 None
 1.26A 2e5dA-4hlnA:
undetectable
2e5dB-4hlnA:
undetectable		 2e5dA-4hlnA:
21.60
2e5dB-4hlnA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FXD_A_DR7A102_2
(POL PROTEIN)		 4hln STARCH SYNTHASE I
(Hordeum
vulgare) 		4 / 7 ALA A 604
ASP A 607
ILE A 337
PRO A 256
 None
 0.83A 2fxdB-4hlnA:
undetectable		 2fxdB-4hlnA:
10.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_D_SNLD4001_2
(MINERALOCORTICOID
RECEPTOR)		 4hln STARCH SYNTHASE I
(Hordeum
vulgare) 		4 / 5 LEU A 498
MET A 445
CYH A 494
THR A 518
 None
 1.34A 2oaxD-4hlnA:
undetectable		 2oaxD-4hlnA:
16.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VAV_F_CSCF1383_2
(ACETYL-COA--DEACETYL
CEPHALOSPORIN C
ACETYLTRANSFERASE)		 4hln STARCH SYNTHASE I
(Hordeum
vulgare) 		3 / 3 LEU A 497
MET A 499
MET A 445
 None
 1.01A 2vavF-4hlnA:
4.1		 2vavF-4hlnA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EL9_A_DR7A100_1
(PROTEASE)		 4hln STARCH SYNTHASE I
(Hordeum
vulgare) 		4 / 8 ALA A 604
ASP A 607
ILE A 337
PRO A 256
 None
 0.83A 3el9A-4hlnA:
undetectable		 3el9A-4hlnA:
11.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SJ0_X_DXCX75_0
(CYTOCHROME C7)		 4hln STARCH SYNTHASE I
(Hordeum
vulgare) 		4 / 7 ILE A 422
LYS A 473
PHE A 476
GLY A 478
 None
 1.16A 3sj0X-4hlnA:
undetectable		 3sj0X-4hlnA:
7.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WRI_A_CAMA502_0
(CAMPHOR
5-MONOOXYGENASE)		 4hln STARCH SYNTHASE I
(Hordeum
vulgare) 		4 / 5 LEU A 407
GLY A 493
THR A 518
ILE A 422
 None
 0.84A 3wriA-4hlnA:
undetectable		 3wriA-4hlnA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WRI_B_CAMB502_0
(CAMPHOR
5-MONOOXYGENASE)		 4hln STARCH SYNTHASE I
(Hordeum
vulgare) 		4 / 5 LEU A 407
GLY A 493
THR A 518
ILE A 422
 None
 0.84A 3wriB-4hlnA:
undetectable		 3wriB-4hlnA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E7C_D_ACTD504_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 4hln STARCH SYNTHASE I
(Hordeum
vulgare) 		3 / 3 GLY A 127
SER A 128
TRP A 590
 None
 0.80A 4e7cD-4hlnA:
undetectable		 4e7cD-4hlnA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JTQ_A_FLPA401_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 4hln STARCH SYNTHASE I
(Hordeum
vulgare) 		5 / 10 VAL A 192
VAL A 177
ILE A 166
LEU A 234
LEU A 232
 None
 1.50A 4jtqA-4hlnA:
undetectable		 4jtqA-4hlnA:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TZC_D_EF2D505_1
(PROTEIN CEREBLON)		 4hln STARCH SYNTHASE I
(Hordeum
vulgare) 		4 / 8 TYR A 516
THR A 518
HIS A 588
TRP A 380
 None
 1.43A 4tzcB-4hlnA:
undetectable
4tzcD-4hlnA:
undetectable		 4tzcB-4hlnA:
11.32
4tzcD-4hlnA:
11.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UBE_A_2FAA401_2
(ADENOSINE KINASE)		 4hln STARCH SYNTHASE I
(Hordeum
vulgare) 		4 / 4 ALA A 561
VAL A 522
GLY A 526
THR A 534
 None
 1.15A 4ubeA-4hlnA:
6.6		 4ubeA-4hlnA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UDC_A_DEXA1778_1
(GLUCOCORTICOID
RECEPTOR)		 4hln STARCH SYNTHASE I
(Hordeum
vulgare) 		5 / 12 LEU A 360
GLY A 356
TRP A 346
THR A 339
ILE A 278
 None
 1.32A 4udcA-4hlnA:
undetectable		 4udcA-4hlnA:
20.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6GNF_A_QPSA602_1
(-)		 4hln STARCH SYNTHASE I
(Hordeum
vulgare) 		5 / 12 ASN A 373
GLN A 431
GLU A 504
PRO A 505
GLY A 507
 None
 1.36A 6gnfA-4hlnA:
37.6		 6gnfA-4hlnA:
34.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6GNF_C_QPSC602_2
(-)		 4hln STARCH SYNTHASE I
(Hordeum
vulgare) 		5 / 12 ASN A 373
GLN A 431
GLU A 504
PRO A 505
GLY A 507
 None
 1.36A 6gnfC-4hlnA:
38.2		 6gnfC-4hlnA:
34.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6GNF_C_QPSC602_2
(-)		 4hln STARCH SYNTHASE I
(Hordeum
vulgare) 		5 / 12 VAL A 532
GLU A 352
GLN A 431
GLU A 504
GLY A 507
 None
 1.36A 6gnfC-4hlnA:
38.2		 6gnfC-4hlnA:
34.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NKN_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4hln STARCH SYNTHASE I
(Hordeum
vulgare) 		3 / 3 ARG A 217
PHE A 191
PHE A 208
 None
 1.08A 6nknC-4hlnA:
undetectable
6nknJ-4hlnA:
undetectable		 6nknC-4hlnA:
17.43
6nknJ-4hlnA:
6.31