SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4hlu'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OS6_A_DXCA75_0
(PPCA)		 4hlu ENERGY-COUPLING
FACTOR TRANSPORTER
ATP-BINDING PROTEIN
ECFA
(Thermotoga
maritima) 		4 / 8 ILE D1058
PHE D1152
LYS D 999
GLY D1001
 None
 1.05A 1os6A-4hluD:
undetectable		 1os6A-4hluD:
12.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S9P_A_DESA459_1
(ESTROGEN-RELATED
RECEPTOR GAMMA)		 4hlu ENERGY-COUPLING
FACTOR TRANSPORTER
ATP-BINDING PROTEIN
ECFA
(Thermotoga
maritima) 		5 / 12 LEU D1051
LEU D1052
ALA D1054
VAL D1017
TYR D1012
 None
None
None
ADP  D1301 (-4.6A)
ADP  D1301 (-3.6A)
 1.13A 1s9pA-4hluD:
undetectable		 1s9pA-4hluD:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S9P_D_DESD600_1
(ESTROGEN-RELATED
RECEPTOR GAMMA)		 4hlu ENERGY-COUPLING
FACTOR TRANSPORTER
ATP-BINDING PROTEIN
ECFA
(Thermotoga
maritima) 		5 / 12 LEU D1051
LEU D1052
ALA D1054
VAL D1017
TYR D1012
 None
None
None
ADP  D1301 (-4.6A)
ADP  D1301 (-3.6A)
 1.14A 1s9pD-4hluD:
undetectable		 1s9pD-4hluD:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD4_A_CHDA803_0
(FERROCHELATASE)		 4hlu ENERGY-COUPLING
FACTOR TRANSPORTER
ATP-BINDING PROTEIN
ECFA
(Thermotoga
maritima) 		4 / 5 LEU D1155
PRO D1158
LEU D1186
ILE D1184
 None
ACT  D1302 (-3.5A)
None
None
 0.83A 2qd4A-4hluD:
undetectable		 2qd4A-4hluD:
23.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_C_TFPC202_1
(PROTEIN S100-A4)		 4hlu ENERGY-COUPLING
FACTOR TRANSPORTER
ATP-BINDING PROTEIN
ECFA
(Thermotoga
maritima) 		5 / 11 LEU D1018
SER D1009
PHE D1010
ILE D1047
PHE D1059
 None
 1.40A 3ko0A-4hluD:
undetectable
3ko0B-4hluD:
undetectable
3ko0C-4hluD:
undetectable
3ko0D-4hluD:
undetectable		 3ko0A-4hluD:
18.46
3ko0B-4hluD:
18.46
3ko0C-4hluD:
18.46
3ko0D-4hluD:
18.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_N_TFPN202_1
(PROTEIN S100-A4)		 4hlu ENERGY-COUPLING
FACTOR TRANSPORTER
ATP-BINDING PROTEIN
ECFA
(Thermotoga
maritima) 		5 / 11 LEU D1018
SER D1009
PHE D1010
ILE D1047
PHE D1059
 None
 1.35A 3ko0K-4hluD:
undetectable
3ko0L-4hluD:
undetectable
3ko0M-4hluD:
undetectable
3ko0N-4hluD:
undetectable		 3ko0K-4hluD:
18.46
3ko0L-4hluD:
18.46
3ko0M-4hluD:
18.46
3ko0N-4hluD:
18.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_O_TFPO202_1
(PROTEIN S100-A4)		 4hlu ENERGY-COUPLING
FACTOR TRANSPORTER
ATP-BINDING PROTEIN
ECFA
(Thermotoga
maritima) 		5 / 11 LEU D1018
SER D1009
PHE D1010
ILE D1047
PHE D1059
 None
 1.45A 3ko0O-4hluD:
undetectable
3ko0P-4hluD:
undetectable
3ko0Q-4hluD:
undetectable
3ko0R-4hluD:
undetectable		 3ko0O-4hluD:
18.46
3ko0P-4hluD:
18.46
3ko0Q-4hluD:
18.46
3ko0R-4hluD:
18.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP6_B_SALB3003_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 4hlu ENERGY-COUPLING
FACTOR TRANSPORTER
ATP-BINDING PROTEIN
ECFA
(Thermotoga
maritima) 		4 / 6 ILE D1170
VAL D1173
LEU D1177
LEU D1153
 None
 0.75A 3kp6A-4hluD:
undetectable
3kp6B-4hluD:
undetectable		 3kp6A-4hluD:
22.18
3kp6B-4hluD:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SJ0_X_DXCX75_0
(CYTOCHROME C7)		 4hlu ENERGY-COUPLING
FACTOR TRANSPORTER
ATP-BINDING PROTEIN
ECFA
(Thermotoga
maritima) 		4 / 7 ILE D1058
PHE D1152
LYS D 999
GLY D1001
 None
 0.98A 3sj0X-4hluD:
undetectable		 3sj0X-4hluD:
12.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F4D_B_CHDB504_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4hlu ENERGY-COUPLING
FACTOR TRANSPORTER
ATP-BINDING PROTEIN
ECFA
(Thermotoga
maritima) 		4 / 4 LEU D1155
PRO D1158
LEU D1186
ILE D1184
 None
ACT  D1302 (-3.5A)
None
None
 0.81A 4f4dB-4hluD:
undetectable		 4f4dB-4hluD:
23.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HBF_A_DXCA75_0
(PPCA)		 4hlu ENERGY-COUPLING
FACTOR TRANSPORTER
ATP-BINDING PROTEIN
ECFA
(Thermotoga
maritima) 		4 / 7 ILE D1058
PHE D1152
LYS D 999
GLY D1001
 None
 0.97A 4hbfA-4hluD:
undetectable		 4hbfA-4hluD:
14.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L78_A_ACTA1327_0
(PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
SYNTHASE)		 4hlu ENERGY-COUPLING
FACTOR TRANSPORTER
ATP-BINDING PROTEIN
ECFA
(Thermotoga
maritima) 		4 / 4 VAL D1187
THR D1188
GLU D1157
GLU D1190
 None
ACT  D1302 (-3.3A)
ACT  D1302 (-4.6A)
ACT  D1302 (-4.9A)
 1.42A 4l78A-4hluD:
undetectable		 4l78A-4hluD:
12.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I73_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		 4hlu ENERGY-COUPLING
FACTOR TRANSPORTER
ATP-BINDING PROTEIN
ECFA
(Thermotoga
maritima) 		5 / 12 ILE D1142
ALA D1143
PHE D1171
GLY D1120
VAL D1159
 None
None
None
None
ACT  D1302 (-3.4A)
 0.93A 5i73A-4hluD:
undetectable		 5i73A-4hluD:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OF1_A_SALA301_1
(SPORE
COAT-ASSOCIATED
PROTEIN N)		 4hlu ENERGY-COUPLING
FACTOR TRANSPORTER
ATP-BINDING PROTEIN
ECFA
(Thermotoga
maritima) 		4 / 5 ALA D1023
VAL D1021
PHE D1025
ILE D1203
 None
 1.04A 5of1A-4hluD:
undetectable		 5of1A-4hluD:
18.47