SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4hlz'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JC9_A_ADNA1497_1
(CYTOSOLIC PURINE
5'-NUCLEOTIDASE)		 4hlz FAB C179 HEAVY CHAIN
(Mus
musculus) 		4 / 7 ARG G  52
ASP G  52
THR G  30
PHE G  99
 None
 1.21A 2jc9A-4hlzG:
undetectable		 2jc9A-4hlzG:
17.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QXT_B_MTXB2000_1
(ANTI-METHOTREXATE
CDR1-3 GRAFT VHH)		 4hlz FAB C179 HEAVY CHAIN
(Mus
musculus) 		6 / 12 VAL G   2
LEU G   4
MET G  34
ARG G  71
VAL G  78
TYR G 102
 None
 0.67A 3qxtB-4hlzG:
19.5		 3qxtB-4hlzG:
53.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QXV_D_MTXD2000_1
(ANTI-METHOTREXATE
CDR1-4 GRAFT VHH)		 4hlz FAB C179 HEAVY CHAIN
(Mus
musculus) 		5 / 12 VAL G   2
MET G  34
ARG G  71
VAL G  78
TYR G 102
 None
 0.78A 3qxvD-4hlzG:
19.0		 3qxvD-4hlzG:
53.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SAN_A_ZMRA901_2
(NEURAMINIDASE)		 4hlz FAB C179 HEAVY CHAIN
(Mus
musculus) 		4 / 5 ASP G  52
ARG G  71
ARG G  52
ILE G  51
 None
 1.43A 3sanA-4hlzG:
undetectable		 3sanA-4hlzG:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SAN_B_ZMRB901_2
(NEURAMINIDASE)		 4hlz FAB C179 HEAVY CHAIN
(Mus
musculus) 		4 / 5 ASP G  52
ARG G  71
ARG G  52
ILE G  51
 None
 1.42A 3sanB-4hlzG:
undetectable		 3sanB-4hlzG:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GRK_A_KTRA713_1
(LACTOTRANSFERRIN)		 4hlz FAB C179 HEAVY CHAIN
(Mus
musculus) 		4 / 5 THR G  82
GLY G  16
VAL G  12
PRO G  14
 None
 0.80A 4grkA-4hlzG:
undetectable		 4grkA-4hlzG:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZPH_A_PRLA501_0
(ARYL HYDROCARBON
RECEPTOR NUCLEAR
TRANSLOCATOR
ENDOTHELIAL PAS
DOMAIN-CONTAINING
PROTEIN 1)		 4hlz FAB C179 HEAVY CHAIN
(Mus
musculus) 		4 / 7 VAL G 183
TRP G 154
LEU G 159
SER G 160
 None
 0.83A 4zphA-4hlzG:
undetectable
4zphB-4hlzG:
undetectable		 4zphA-4hlzG:
19.38
4zphB-4hlzG:
18.41