SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4hmw'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HLW_B_CE3B304_1
(CTX-M-9
EXTENDED-SPECTRUM
BETA-LACTAMASE)		 4hmw PYRIDOXAMINE
5'-PHOSPHATE OXIDASE
(Burkholderia
lata) 		4 / 5 ASN A 122
THR A  90
SER A  83
ARG A  87
 None
None
FMN  A 301 (-3.4A)
None
 1.27A 3hlwB-4hmwA:
undetectable		 3hlwB-4hmwA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RAE_H_LFXH101_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B)		 4hmw PYRIDOXAMINE
5'-PHOSPHATE OXIDASE
(Burkholderia
lata) 		4 / 5 SER A  83
GLY A 174
GLU A 118
GLU A 121
 FMN  A 301 (-3.4A)
None
None
None
 1.38A 3raeB-4hmwA:
undetectable
3raeD-4hmwA:
undetectable		 3raeB-4hmwA:
16.70
3raeD-4hmwA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BBO_B_ACTB1114_0
(BLR5658 PROTEIN)		 4hmw PYRIDOXAMINE
5'-PHOSPHATE OXIDASE
(Burkholderia
lata) 		3 / 3 TRP A  34
TRP A 101
THR A 104
 None
 1.34A 4bboB-4hmwA:
1.6		 4bboB-4hmwA:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XJ7_D_ADND303_1
(5'/3'-NUCLEOTIDASE
SURE)		 4hmw PYRIDOXAMINE
5'-PHOSPHATE OXIDASE
(Burkholderia
lata) 		5 / 10 LEU A  51
LEU A  49
GLY A  97
SER A 111
ILE A  65
 None
None
None
None
FMN  A 301 (-4.0A)
 1.14A 4xj7C-4hmwA:
undetectable
4xj7D-4hmwA:
undetectable		 4xj7C-4hmwA:
23.27
4xj7D-4hmwA:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YPM_A_BO2A801_1
(LON PROTEASE)		 4hmw PYRIDOXAMINE
5'-PHOSPHATE OXIDASE
(Burkholderia
lata) 		5 / 12 ALA A  95
THR A  53
LEU A  51
THR A  79
PRO A 179
 None
None
None
FMN  A 301 (-3.7A)
None
 1.18A 4ypmA-4hmwA:
undetectable		 4ypmA-4hmwA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTA_G_MFXG101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 4hmw PYRIDOXAMINE
5'-PHOSPHATE OXIDASE
(Burkholderia
lata) 		4 / 7 ARG A  84
GLY A  86
THR A  55
GLU A  88
 None
 0.95A 5btaA-4hmwA:
undetectable
5btaC-4hmwA:
undetectable
5btaD-4hmwA:
undetectable		 5btaA-4hmwA:
18.45
5btaC-4hmwA:
18.45
5btaD-4hmwA:
23.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTC_G_CPFG101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 4hmw PYRIDOXAMINE
5'-PHOSPHATE OXIDASE
(Burkholderia
lata) 		4 / 6 ARG A  84
GLY A  86
THR A  55
GLU A  88
 None
 0.96A 5btcA-4hmwA:
undetectable
5btcC-4hmwA:
undetectable
5btcD-4hmwA:
undetectable		 5btcA-4hmwA:
18.45
5btcC-4hmwA:
18.45
5btcD-4hmwA:
23.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTF_F_GFNF101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 4hmw PYRIDOXAMINE
5'-PHOSPHATE OXIDASE
(Burkholderia
lata) 		4 / 7 ARG A  84
GLY A  86
THR A  55
GLU A  88
 None
 0.95A 5btfA-4hmwA:
undetectable
5btfB-4hmwA:
undetectable
5btfC-4hmwA:
undetectable		 5btfA-4hmwA:
18.45
5btfB-4hmwA:
23.57
5btfC-4hmwA:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTF_G_GFNG101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 4hmw PYRIDOXAMINE
5'-PHOSPHATE OXIDASE
(Burkholderia
lata) 		4 / 7 ARG A  84
GLY A  86
THR A  55
GLU A  88
 None
 0.85A 5btfA-4hmwA:
undetectable
5btfC-4hmwA:
undetectable
5btfD-4hmwA:
undetectable		 5btfA-4hmwA:
18.45
5btfC-4hmwA:
18.45
5btfD-4hmwA:
23.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTI_E_LFXE101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
GGTCATGAATGACTATGCAC
GTAA)		 4hmw PYRIDOXAMINE
5'-PHOSPHATE OXIDASE
(Burkholderia
lata) 		4 / 5 ARG A  84
GLY A  86
THR A  55
GLU A  88
 None
 0.85A 5btiA-4hmwA:
undetectable
5btiB-4hmwA:
undetectable		 5btiA-4hmwA:
18.45
5btiB-4hmwA:
23.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTI_F_LFXF101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 4hmw PYRIDOXAMINE
5'-PHOSPHATE OXIDASE
(Burkholderia
lata) 		4 / 5 ARG A  84
GLY A  86
THR A  55
GLU A  88
 None
 0.85A 5btiC-4hmwA:
undetectable
5btiD-4hmwA:
undetectable		 5btiC-4hmwA:
18.45
5btiD-4hmwA:
23.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FSA_B_X2NB590_2
(CYP51 VARIANT1)		 4hmw PYRIDOXAMINE
5'-PHOSPHATE OXIDASE
(Burkholderia
lata) 		3 / 3 PRO A 169
LEU A 162
SER A 137
 None
 0.68A 5fsaB-4hmwA:
undetectable		 5fsaB-4hmwA:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JO9_A_SORA302_0
(RIBITOL
2-DEHYDROGENASE)		 4hmw PYRIDOXAMINE
5'-PHOSPHATE OXIDASE
(Burkholderia
lata) 		5 / 12 SER A  83
THR A  53
VAL A 173
PHE A  77
LEU A  51
 FMN  A 301 (-3.4A)
None
None
None
None
 1.15A 5jo9A-4hmwA:
undetectable		 5jo9A-4hmwA:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OS7_A_ACTA402_0
(CASEIN KINASE II
SUBUNIT ALPHA)		 4hmw PYRIDOXAMINE
5'-PHOSPHATE OXIDASE
(Burkholderia
lata) 		3 / 3 HIS A  80
SER A  83
LYS A  85
 None
FMN  A 301 (-3.4A)
FMN  A 301 (-1.9A)
 1.39A 5os7A-4hmwA:
0.9		 5os7A-4hmwA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AUU_A_ACTA804_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4hmw PYRIDOXAMINE
5'-PHOSPHATE OXIDASE
(Burkholderia
lata) 		3 / 3 GLN A 106
TRP A 101
VAL A  43
 None
 1.16A 6auuA-4hmwA:
undetectable		 6auuA-4hmwA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EBP_B_DAHB123_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT)		 4hmw PYRIDOXAMINE
5'-PHOSPHATE OXIDASE
(Burkholderia
lata) 		5 / 10 PHE A  67
LEU A  49
GLY A  74
ILE A  70
ILE A 108
 None
 1.25A 6ebpB-4hmwA:
undetectable		 6ebpB-4hmwA:
15.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EBP_C_DAHC123_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT)		 4hmw PYRIDOXAMINE
5'-PHOSPHATE OXIDASE
(Burkholderia
lata) 		5 / 10 PHE A  67
LEU A  49
GLY A  74
ILE A  70
ILE A 108
 None
 1.20A 6ebpC-4hmwA:
undetectable		 6ebpC-4hmwA:
15.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GMD_B_ACTB402_0
(CASEIN KINASE II
SUBUNIT ALPHA)		 4hmw PYRIDOXAMINE
5'-PHOSPHATE OXIDASE
(Burkholderia
lata) 		3 / 3 HIS A  80
SER A  83
LYS A  85
 None
FMN  A 301 (-3.4A)
FMN  A 301 (-1.9A)
 1.39A 6gmdB-4hmwA:
0.9		 6gmdB-4hmwA:
21.05