SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4hn3'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NX9_A_AICA5001_1
(ALPHA-AMINO ACID
ESTER HYDROLASE)		 4hn3 LMO1757 PROTEIN
(Listeria
monocytogenes) 		4 / 8 ARG A 298
TYR A 223
GLU A 300
HIS A 269
 None
None
PEG  A 403 (-3.1A)
None
 1.17A 1nx9A-4hn3A:
undetectable		 1nx9A-4hn3A:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NX9_B_AICB5002_1
(ALPHA-AMINO ACID
ESTER HYDROLASE)		 4hn3 LMO1757 PROTEIN
(Listeria
monocytogenes) 		4 / 8 ARG A 298
TYR A 223
GLU A 300
HIS A 269
 None
None
PEG  A 403 (-3.1A)
None
 1.16A 1nx9B-4hn3A:
2.1		 1nx9B-4hn3A:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NX9_C_AICC5003_1
(ALPHA-AMINO ACID
ESTER HYDROLASE)		 4hn3 LMO1757 PROTEIN
(Listeria
monocytogenes) 		4 / 8 ARG A 298
TYR A 223
GLU A 300
HIS A 269
 None
None
PEG  A 403 (-3.1A)
None
 1.15A 1nx9C-4hn3A:
undetectable		 1nx9C-4hn3A:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NX9_D_AICD5004_1
(ALPHA-AMINO ACID
ESTER HYDROLASE)		 4hn3 LMO1757 PROTEIN
(Listeria
monocytogenes) 		4 / 8 ARG A 298
TYR A 223
GLU A 300
HIS A 269
 None
None
PEG  A 403 (-3.1A)
None
 1.15A 1nx9D-4hn3A:
undetectable		 1nx9D-4hn3A:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RI4_A_SAMA299_0
(MRNA CAPPING ENZYME)		 4hn3 LMO1757 PROTEIN
(Listeria
monocytogenes) 		5 / 12 GLY A 226
GLY A 234
ALA A 232
ASP A 229
SER A 170
 None
 1.18A 1ri4A-4hn3A:
undetectable		 1ri4A-4hn3A:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XRZ_A_ACTA1470_0
(DEOXYRIBODIPYRIMIDIN
E PHOTOLYASE)		 4hn3 LMO1757 PROTEIN
(Listeria
monocytogenes) 		4 / 5 ARG A 298
ALA A 305
ASP A 341
GLU A 306
 None
 0.94A 2xrzA-4hn3A:
undetectable		 2xrzA-4hn3A:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FPJ_A_SAMA301_0
(PUTATIVE
UNCHARACTERIZED
PROTEIN)		 4hn3 LMO1757 PROTEIN
(Listeria
monocytogenes) 		5 / 12 ILE A 220
ILE A 162
ALA A 165
LEU A 144
VAL A 203
 None
 0.99A 3fpjA-4hn3A:
undetectable		 3fpjA-4hn3A:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_B_TFPB202_1
(PROTEIN S100-A4)		 4hn3 LMO1757 PROTEIN
(Listeria
monocytogenes) 		3 / 3 GLU A 110
LEU A 113
ASP A 114
 None
 0.22A 3ko0A-4hn3A:
undetectable		 3ko0A-4hn3A:
15.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_S_TFPS202_2
(PROTEIN S100-A4)		 4hn3 LMO1757 PROTEIN
(Listeria
monocytogenes) 		3 / 3 GLU A 110
LEU A 113
ASP A 114
 None
 0.20A 3ko0T-4hn3A:
undetectable		 3ko0T-4hn3A:
15.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP6_A_SALA3005_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 4hn3 LMO1757 PROTEIN
(Listeria
monocytogenes) 		4 / 8 ASN A 275
LEU A 342
ALA A 340
ARG A 358
 None
 0.96A 3kp6A-4hn3A:
undetectable		 3kp6A-4hn3A:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ROZ_A_NCAA266_0
(APOLIPOPROTEIN
A-I-BINDING PROTEIN)		 4hn3 LMO1757 PROTEIN
(Listeria
monocytogenes) 		4 / 6 ASP A 189
LEU A 192
ALA A 238
ASP A 252
 None
 0.98A 3rozA-4hn3A:
undetectable		 3rozA-4hn3A:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TWP_B_SALB404_1
(ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE)		 4hn3 LMO1757 PROTEIN
(Listeria
monocytogenes) 		4 / 7 ASN A 257
ALA A 232
PRO A 233
ARG A  73
 None
 1.10A 3twpB-4hn3A:
undetectable		 3twpB-4hn3A:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HC3_A_DXCA75_0
(PPCA)		 4hn3 LMO1757 PROTEIN
(Listeria
monocytogenes) 		4 / 7 ILE A 356
LEU A 342
LYS A 280
GLY A 295
 None
 0.89A 4hc3A-4hn3A:
undetectable		 4hc3A-4hn3A:
12.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C8T_B_SAMB605_0
(GUANINE-N7
METHYLTRANSFERASE)		 4hn3 LMO1757 PROTEIN
(Listeria
monocytogenes) 		5 / 11 ASP A 285
ALA A 282
PHE A 279
ASN A 289
VAL A 293
 None
 1.48A 5c8tB-4hn3A:
undetectable		 5c8tB-4hn3A:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FSA_A_X2NA590_2
(CYP51 VARIANT1)		 4hn3 LMO1757 PROTEIN
(Listeria
monocytogenes) 		3 / 3 PRO A  93
ILE A 220
SER A  48
 None
 0.70A 5fsaA-4hn3A:
undetectable		 5fsaA-4hn3A:
22.94