SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4hn8'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F8L_A_SAMA400_0
(HYPOTHETICAL PROTEIN
LMO1582)		 4hn8 D-GLUCARATE
DEHYDRATASE
(Pseudomonas
mendocina) 		5 / 12 GLY A 350
VAL A 345
GLY A 343
ASP A 325
PRO A 327
 None
 1.15A 2f8lA-4hn8A:
2.1		 2f8lA-4hn8A:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V2G_A_BEZA1222_0
(PEROXIREDOXIN 6)		 4hn8 D-GLUCARATE
DEHYDRATASE
(Pseudomonas
mendocina) 		4 / 7 THR A   9
PRO A  10
VAL A  79
SER A  78
 None
 1.03A 2v2gA-4hn8A:
undetectable
2v2gB-4hn8A:
undetectable		 2v2gA-4hn8A:
19.87
2v2gB-4hn8A:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V2G_B_BEZB1220_0
(PEROXIREDOXIN 6)		 4hn8 D-GLUCARATE
DEHYDRATASE
(Pseudomonas
mendocina) 		4 / 7 THR A   9
PRO A  10
VAL A  79
SER A  78
 None
 1.01A 2v2gA-4hn8A:
undetectable
2v2gB-4hn8A:
undetectable		 2v2gA-4hn8A:
19.87
2v2gB-4hn8A:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V2G_C_BEZC1222_0
(PEROXIREDOXIN 6)		 4hn8 D-GLUCARATE
DEHYDRATASE
(Pseudomonas
mendocina) 		4 / 7 THR A   9
PRO A  10
VAL A  79
SER A  78
 None
 1.02A 2v2gC-4hn8A:
undetectable
2v2gD-4hn8A:
undetectable		 2v2gC-4hn8A:
19.87
2v2gD-4hn8A:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V2G_D_BEZD1221_0
(PEROXIREDOXIN 6)		 4hn8 D-GLUCARATE
DEHYDRATASE
(Pseudomonas
mendocina) 		4 / 7 THR A   9
PRO A  10
VAL A  79
SER A  78
 None
 1.00A 2v2gC-4hn8A:
undetectable
2v2gD-4hn8A:
undetectable		 2v2gC-4hn8A:
19.87
2v2gD-4hn8A:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V41_D_BEZD1222_0
(PEROXIREDOXIN 6.)		 4hn8 D-GLUCARATE
DEHYDRATASE
(Pseudomonas
mendocina) 		4 / 8 THR A   9
PRO A  10
VAL A  79
SER A  78
 None
 1.01A 2v41C-4hn8A:
undetectable
2v41D-4hn8A:
undetectable		 2v41C-4hn8A:
19.87
2v41D-4hn8A:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V41_E_BEZE1222_0
(PEROXIREDOXIN 6.)		 4hn8 D-GLUCARATE
DEHYDRATASE
(Pseudomonas
mendocina) 		4 / 7 THR A   9
PRO A  10
VAL A  79
SER A  78
 None
 0.99A 2v41E-4hn8A:
undetectable
2v41F-4hn8A:
undetectable		 2v41E-4hn8A:
19.87
2v41F-4hn8A:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V41_F_BEZF1222_0
(PEROXIREDOXIN 6.)		 4hn8 D-GLUCARATE
DEHYDRATASE
(Pseudomonas
mendocina) 		4 / 7 THR A   9
PRO A  10
VAL A  79
SER A  78
 None
 1.01A 2v41E-4hn8A:
undetectable
2v41F-4hn8A:
undetectable		 2v41E-4hn8A:
19.87
2v41F-4hn8A:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V41_H_BEZH1222_0
(PEROXIREDOXIN 6.)		 4hn8 D-GLUCARATE
DEHYDRATASE
(Pseudomonas
mendocina) 		4 / 8 THR A   9
PRO A  10
VAL A  79
SER A  78
 None
 1.01A 2v41G-4hn8A:
undetectable
2v41H-4hn8A:
undetectable		 2v41G-4hn8A:
19.87
2v41H-4hn8A:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZM9_A_ACAA502_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 4hn8 D-GLUCARATE
DEHYDRATASE
(Pseudomonas
mendocina) 		4 / 8 TYR A 181
HIS A  34
GLY A 172
ILE A 171
 None
GOL  A 502 (-4.3A)
None
None
 0.81A 2zm9A-4hn8A:
undetectable		 2zm9A-4hn8A:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AXT_A_SAMA397_0
(PROBABLE
N(2),N(2)-DIMETHYLGU
ANOSINE TRNA
METHYLTRANSFERASE
TRM1)		 4hn8 D-GLUCARATE
DEHYDRATASE
(Pseudomonas
mendocina) 		5 / 12 LEU A 400
ARG A 401
ASP A 362
ILE A 363
ALA A 366
 None
 1.26A 3axtA-4hn8A:
undetectable		 3axtA-4hn8A:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JQA_A_DX4A270_0
(PTERIDINE REDUCTASE
1)		 4hn8 D-GLUCARATE
DEHYDRATASE
(Pseudomonas
mendocina) 		4 / 6 ARG A 439
SER A 357
ASP A 252
TYR A 167
 GOL  A 502 (-3.5A)
None
None
None
 1.44A 3jqaA-4hn8A:
undetectable		 3jqaA-4hn8A:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JQA_B_DX4B270_0
(PTERIDINE REDUCTASE
1)		 4hn8 D-GLUCARATE
DEHYDRATASE
(Pseudomonas
mendocina) 		4 / 6 ARG A 439
SER A 357
ASP A 252
TYR A 167
 GOL  A 502 (-3.5A)
None
None
None
 1.42A 3jqaB-4hn8A:
undetectable		 3jqaB-4hn8A:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JQA_C_DX4C270_0
(PTERIDINE REDUCTASE
1)		 4hn8 D-GLUCARATE
DEHYDRATASE
(Pseudomonas
mendocina) 		4 / 6 ARG A 439
SER A 357
ASP A 252
TYR A 167
 GOL  A 502 (-3.5A)
None
None
None
 1.43A 3jqaC-4hn8A:
undetectable		 3jqaC-4hn8A:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JQA_D_DX4D270_0
(PTERIDINE REDUCTASE
1)		 4hn8 D-GLUCARATE
DEHYDRATASE
(Pseudomonas
mendocina) 		4 / 6 ARG A 439
SER A 357
ASP A 252
TYR A 167
 GOL  A 502 (-3.5A)
None
None
None
 1.43A 3jqaD-4hn8A:
undetectable		 3jqaD-4hn8A:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S8P_B_SAMB500_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV420H1)		 4hn8 D-GLUCARATE
DEHYDRATASE
(Pseudomonas
mendocina) 		3 / 3 HIS A 356
SER A 364
ASN A 359
 None
None
GOL  A 502 (-4.2A)
 0.90A 3s8pB-4hn8A:
undetectable		 3s8pB-4hn8A:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TWP_B_SALB404_1
(ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE)		 4hn8 D-GLUCARATE
DEHYDRATASE
(Pseudomonas
mendocina) 		4 / 7 ALA A  35
PRO A  36
ARG A 174
ALA A 177
 None
 0.82A 3twpB-4hn8A:
undetectable		 3twpB-4hn8A:
24.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TWP_C_SALC404_1
(ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE)		 4hn8 D-GLUCARATE
DEHYDRATASE
(Pseudomonas
mendocina) 		4 / 7 ALA A  35
PRO A  36
ARG A 174
ALA A 177
 None
 0.70A 3twpC-4hn8A:
undetectable		 3twpC-4hn8A:
24.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B7N_A_ZMRA601_2
(NEURAMINIDASE)		 4hn8 D-GLUCARATE
DEHYDRATASE
(Pseudomonas
mendocina) 		3 / 3 ARG A 195
ARG A 215
TRP A 191
 None
 1.37A 4b7nA-4hn8A:
undetectable		 4b7nA-4hn8A:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_C_ZMRC1470_2
(NEURAMINIDASE)		 4hn8 D-GLUCARATE
DEHYDRATASE
(Pseudomonas
mendocina) 		3 / 3 ARG A 195
ARG A 215
TRP A 191
 None
 1.36A 4cpzC-4hn8A:
undetectable		 4cpzC-4hn8A:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_E_ZMRE1471_2
(NEURAMINIDASE)		 4hn8 D-GLUCARATE
DEHYDRATASE
(Pseudomonas
mendocina) 		3 / 3 ARG A 195
ARG A 215
TRP A 191
 None
 1.32A 4cpzE-4hn8A:
undetectable		 4cpzE-4hn8A:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_F_ZMRF1470_2
(NEURAMINIDASE)		 4hn8 D-GLUCARATE
DEHYDRATASE
(Pseudomonas
mendocina) 		3 / 3 ARG A 195
ARG A 215
TRP A 191
 None
 1.31A 4cpzF-4hn8A:
undetectable		 4cpzF-4hn8A:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_G_ZMRG1471_2
(NEURAMINIDASE)		 4hn8 D-GLUCARATE
DEHYDRATASE
(Pseudomonas
mendocina) 		3 / 3 ARG A 195
ARG A 215
TRP A 191
 None
 1.32A 4cpzG-4hn8A:
undetectable		 4cpzG-4hn8A:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_H_ZMRH1470_2
(NEURAMINIDASE)		 4hn8 D-GLUCARATE
DEHYDRATASE
(Pseudomonas
mendocina) 		3 / 3 ARG A 195
ARG A 215
TRP A 191
 None
 1.37A 4cpzH-4hn8A:
undetectable		 4cpzH-4hn8A:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I1R_A_LZUA801_1
(MUCOSA-ASSOCIATED
LYMPHOID TISSUE
LYMPHOMA
TRANSLOCATION
PROTEIN 1)		 4hn8 D-GLUCARATE
DEHYDRATASE
(Pseudomonas
mendocina) 		5 / 12 VAL A 340
ALA A 135
LEU A 152
LEU A 153
LEU A  86
 None
 1.19A 4i1rA-4hn8A:
undetectable		 4i1rA-4hn8A:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JLT_A_8PRA505_1
(CYTOCHROME P450 2B4)		 4hn8 D-GLUCARATE
DEHYDRATASE
(Pseudomonas
mendocina) 		4 / 8 ILE A 379
ALA A 371
VAL A 162
PRO A 163
 None
 0.69A 4jltA-4hn8A:
undetectable		 4jltA-4hn8A:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRX_A_LURA706_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4hn8 D-GLUCARATE
DEHYDRATASE
(Pseudomonas
mendocina) 		5 / 12 VAL A 149
LEU A 153
LEU A  86
TYR A  82
ALA A 135
 None
 1.00A 4rrxA-4hn8A:
undetectable		 4rrxA-4hn8A:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRX_B_LURB706_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4hn8 D-GLUCARATE
DEHYDRATASE
(Pseudomonas
mendocina) 		5 / 12 VAL A 149
LEU A 153
LEU A  86
TYR A  82
ALA A 135
 None
 1.06A 4rrxB-4hn8A:
undetectable		 4rrxB-4hn8A:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WBO_B_ANWB601_0
(RHODOPSIN KINASE)		 4hn8 D-GLUCARATE
DEHYDRATASE
(Pseudomonas
mendocina) 		4 / 8 LEU A 208
ALA A 199
ILE A 171
ALA A 166
 None
 0.56A 4wboB-4hn8A:
undetectable		 4wboB-4hn8A:
24.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WOZ_B_MN9B401_0
(N-ACETYLNEURAMINATE
LYASE)		 4hn8 D-GLUCARATE
DEHYDRATASE
(Pseudomonas
mendocina) 		4 / 6 SER A 258
LEU A 259
ASP A 260
TYR A 286
 None
 0.91A 4wozA-4hn8A:
11.8
4wozB-4hn8A:
11.8		 4wozA-4hn8A:
22.54
4wozB-4hn8A:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CPR_B_SAMB402_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV420H1)		 4hn8 D-GLUCARATE
DEHYDRATASE
(Pseudomonas
mendocina) 		3 / 3 HIS A 356
SER A 364
ASN A 359
 None
None
GOL  A 502 (-4.2A)
 0.91A 5cprB-4hn8A:
undetectable		 5cprB-4hn8A:
16.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5F1A_A_SALA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4hn8 D-GLUCARATE
DEHYDRATASE
(Pseudomonas
mendocina) 		4 / 8 VAL A 149
LEU A 153
LEU A  86
ALA A 135
 None
 0.77A 5f1aA-4hn8A:
undetectable		 5f1aA-4hn8A:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FXT_A_0LAA1376_1
(DNA POLYMERASE III
SUBUNIT BETA)		 4hn8 D-GLUCARATE
DEHYDRATASE
(Pseudomonas
mendocina) 		4 / 7 LEU A 400
THR A 369
PRO A 410
MET A 336
 None
 1.03A 5fxtA-4hn8A:
undetectable		 5fxtA-4hn8A:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GQB_A_GCSA602_1
(CHITINASE)		 4hn8 D-GLUCARATE
DEHYDRATASE
(Pseudomonas
mendocina) 		3 / 3 TRP A 257
GLU A 233
ASP A 252
 None
 0.55A 5gqbA-4hn8A:
5.0		 5gqbA-4hn8A:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N5D_A_SAMA306_1
(METHYLTRANSFERASE)		 4hn8 D-GLUCARATE
DEHYDRATASE
(Pseudomonas
mendocina) 		4 / 7 LEU A  30
ILE A 237
GLU A 233
ASP A 252
 None
 0.98A 5n5dA-4hn8A:
undetectable		 5n5dA-4hn8A:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X23_A_LSNA502_1
(CYTOCHROME P450 2C9)		 4hn8 D-GLUCARATE
DEHYDRATASE
(Pseudomonas
mendocina) 		5 / 12 ASN A  41
LEU A  67
GLY A  55
ALA A 135
LEU A  86
 None
 1.23A 5x23A-4hn8A:
undetectable		 5x23A-4hn8A:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7P_A_ACRA1431_1
(GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE)		 4hn8 D-GLUCARATE
DEHYDRATASE
(Pseudomonas
mendocina) 		4 / 7 HIS A  34
ASP A 252
GLY A 225
ASN A  29
 GOL  A 502 (-4.3A)
None
None
GOL  A 502 (-3.5A)
 1.10A 5x7pA-4hn8A:
undetectable		 5x7pA-4hn8A:
16.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7P_B_ACRB1431_1
(GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE)		 4hn8 D-GLUCARATE
DEHYDRATASE
(Pseudomonas
mendocina) 		4 / 5 HIS A  34
ASP A 252
GLY A 225
ASN A  29
 GOL  A 502 (-4.3A)
None
None
GOL  A 502 (-3.5A)
 1.09A 5x7pB-4hn8A:
undetectable		 5x7pB-4hn8A:
16.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BPL_B_PA1B605_1
(LIPID A EXPORT
ATP-BINDING/PERMEASE
PROTEIN MSBA)		 4hn8 D-GLUCARATE
DEHYDRATASE
(Pseudomonas
mendocina) 		3 / 3 ARG A 248
ARG A 161
ARG A 378
 None
 1.10A 6bplA-4hn8A:
undetectable
6bplB-4hn8A:
undetectable		 6bplA-4hn8A:
10.99
6bplB-4hn8A:
10.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EU9_B_REAB601_1
(RETINOIC ACID
RECEPTOR)		 4hn8 D-GLUCARATE
DEHYDRATASE
(Pseudomonas
mendocina) 		5 / 10 VAL A 227
LEU A  30
SER A 460
LEU A 448
GLY A 172
 None
 1.19A 6eu9B-4hn8A:
undetectable		 6eu9B-4hn8A:
9.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_F_TA1F502_2
(TUBULIN BETA CHAIN)		 4hn8 D-GLUCARATE
DEHYDRATASE
(Pseudomonas
mendocina) 		4 / 5 LEU A 395
THR A  39
PRO A 180
ARG A 174
 None
 1.05A 6ew0F-4hn8A:
undetectable		 6ew0F-4hn8A:
9.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_G_TA1G501_2
(TUBULIN BETA CHAIN)		 4hn8 D-GLUCARATE
DEHYDRATASE
(Pseudomonas
mendocina) 		4 / 6 LEU A 395
THR A  39
PRO A 180
ARG A 174
 None
 1.05A 6ew0G-4hn8A:
undetectable		 6ew0G-4hn8A:
9.96